scholarly journals Ethnic differences in the impact of advanced maternal age on birth prevalence of Down syndrome

2000 ◽  
Vol 90 (11) ◽  
pp. 1778-1781 ◽  
2019 ◽  
Vol 317 (2) ◽  
pp. H387-H394 ◽  
Author(s):  
Christy-Lynn M. Cooke ◽  
Sandra T. Davidge

Delaying pregnancy, which is on the rise, may increase the risk of cardiovascular disease in both women and their children. The physiological mechanisms that lead to these effects are not fully understood but may involve inadequate adaptations of the maternal cardiovascular system to pregnancy. Indeed, there is abundant evidence in the literature that a fetus developing in a suboptimal in utero environment (such as in pregnancies complicated by fetal growth restriction, preterm birth, and/or preeclampsia) is at an increased risk of cardiovascular disease in adulthood, the developmental origins of health and disease theory. Although women of advanced age are at a significantly increased risk of pregnancy complications, there is limited information as to whether advanced maternal age constitutes an added stressor on the prenatal environment of the fetus, and whether or not this is secondary to impaired cardiovascular function during pregnancy. This review summarizes the current literature available on the impact of advanced maternal age on cardiovascular adaptations to pregnancy and the role of maternal age on long-term health risks for both the mother and offspring.


2005 ◽  
Vol 25 (8) ◽  
pp. 665-670 ◽  
Author(s):  
Hei-Jen Jou ◽  
Yih-Shing Kuo ◽  
Jenn-Jeih Hsu ◽  
Ming-Kwang Shyu ◽  
T'sang-T'ang Hsieh ◽  
...  

2013 ◽  
Vol 23 (7) ◽  
pp. 428-434 ◽  
Author(s):  
Sarka Lisonkova ◽  
K.S. Joseph ◽  
Ruth Bell ◽  
Svetlana V. Glinianaia

1995 ◽  
Vol 15 (5) ◽  
pp. 455-465 ◽  
Author(s):  
Jane L. Halliday ◽  
Lyndsey F. Watson ◽  
Judith Lumley ◽  
David M. Danks ◽  
Leslie J. Sheffield

2001 ◽  
Vol 185 (6) ◽  
pp. S205
Author(s):  
Janice Hartnett ◽  
Adam Borgida ◽  
Peter Benn ◽  
Michael Barsoom ◽  
Michael Deroche ◽  
...  

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