scholarly journals Gene Expression and the Physiological Role of Transforming Growth Factor-α in the Mouse Pituitary

2003 ◽  
Vol 20 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Seema Sharma ◽  
Souichi Oomizu ◽  
Tomoshi Kakeya ◽  
Tohru Masui ◽  
Sakae Takeuchi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Physiological Role ◽  
Transforming Growth Factor Α ◽  
Mouse Pituitary ◽  
Factor Α

scholarly journals Gene expression of transforming growth factor-α in human endometrium during decidualization

1997 ◽  
Vol 14 (4) ◽  
pp. 218-222 ◽  
Author(s):  
Michiyoshi Taga ◽  
Hideya Sakakibara ◽  
Kumiko Suyama ◽  
Mario Ikeda ◽  
Hiroshi Minaguchi
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Human Endometrium ◽  
Transforming Growth Factor Α ◽  
Factor Α

Epidermal growth factor regulation of glutathione S-transferase gene expression in the rat is mediated by class Pi glutathione S-transferase enhancer I

2000 ◽  
Vol 349 (1) ◽  
pp. 225-230 ◽  
Author(s):  
Michi MATSUMOTO ◽  
Masayoshi IMAGAWA ◽  
Yasunobu AOKI
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Transforming Growth Factor ◽  
Signal Transduction Pathway ◽  
Glutathione S Transferase ◽  
Transforming Growth Factor Α ◽  
Epidermal Growth ◽  
Factor Α ◽  
Stimulation Of

Using chloramphenicol acetyltransferase assays we showed that epidermal growth factor (EGF), transforming growth factor α (TGFα), and 3,3ʹ,4,4ʹ,5-pentachlorobiphenyl (PenCB) induce class Pi glutathione S-transferase (GSTP1) in primary cultured rat liver parenchymal cells. GSTP1 enhancer I (GPEI), which is required for the stimulation of GSTP1 expression by PenCB, also mediates EGF and TGFα stimulation of GSTP1 gene expression. However, hepatocyte growth factor and insulin did not stimulate GPEI-mediated gene expression. On the other hand, the antioxidant reagents butylhydroxyanisole and t-butylhydroquinone, stimulated GPEI-mediated gene expression, but the level of GSTP1 mRNA was not elevated. Our observations suggest that EGF and TGFα induce GSTP1 by the same signal transduction pathway as PenCB. Since the sequence of GPEI is similar to that of the antioxidant responsive element (ARE), some factors which bind to ARE might play a role in GPEI-mediated gene expression.

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