Reduced Proliferative and Differentiative Activity of Mouse Pink-Eyed Dilution Melanoblasts is Related to Apoptosis

2012 ◽  
Vol 29 (11) ◽  
pp. 725-732 ◽  
Author(s):  
Tomohisa Hirobe ◽  
Emi Terunuma
Keyword(s):  
Pink Eyed Dilution

Gene expression at the pink-eyed dilution (p) locus in the mouse is confirmed to be pigment cell autonomous using recombinant embryonic skin grafts

Development ◽  
1985 ◽  
Vol 87 (1) ◽  
pp. 65-73
Author(s):  
Dennis A. Stephenson ◽  
Janet E. Hornby
Keyword(s):  
Gene Expression ◽  
Environmental Influence ◽  
Pigment Cell ◽  
Epistatic Effect ◽  
Skin Grafts ◽  
Experimental Systems ◽  
Grafting Technique ◽  
Embryonic Skin ◽  
Pink Eyed Dilution ◽  
P Locus

Sash (Wsh), a viable and fully fertile allele of the dominant spotting (W) locus (Lyon & Glenister, 1982) has been expression at the pink-eyed dilution (p) locus. Reciprocal recombinant epidermal//dermal skin grafts were constructed from 13-day embryonic skin of p and Wsh homozygotes. Thus in the reciprocal experiments pink-eyed dilution melanocytes were exposed to any environmental influence from the wild-type allele of thep locus in either the epidermis (when WshWsh) or the dermis (when WshWsh). The hair pigmentation of the grafts recovered after three weeks beneath the testicular tunica of adult male mice was always typical of the p phenotype showing thatp is melanocyte autonomous. This result was supported by experiments using a modification of Mayer's (1965) neural crest grafting technique and the construction of 14-day recombinant skin grafts. Sash (WshWsh) epidermis can support melanocyte differentiation and pigment production but lacks functional melanocytes. The advantages of Wsh in experimental systems for testing the site of pigment gene expression have been demonstrated. Control experiments confirmed the dermal influence of agouti (A) over non-agouti (a) epidermis but non-agouti dermis did not overrule agouti pink-eyed dilution (AA pp) epidermis suggesting an epistatic effect ofp in the melanocyte.

scholarly journals A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2p) in mice

2015 ◽  
Vol 64 (2) ◽  
pp. 171-179 ◽  
Author(s):  
Haruka SHOJI ◽  
Yukiko KINIWA ◽  
Ryuhei OKUYAMA ◽  
Mu YANG ◽  
Keiichi HIGUCHI ◽  
...  
Keyword(s):  
Nucleotide Substitution ◽  
Oculocutaneous Albinism ◽  
Pink Eyed Dilution

Molecular analysis of the cDNAs encoded by the p un and p J alleles of the pink-eyed dilution locus

1996 ◽  
Vol 7 (4) ◽  
pp. 315-316 ◽  
Author(s):  
R. J. Oakey ◽  
N. M. Keiper ◽  
A. S. Ching ◽  
M. H. Brilliant
Keyword(s):  
Molecular Analysis ◽  
Pink Eyed Dilution

Effects of genic substitution at the pink-eyed dilution locus on the proliferation and differentiation of mouse epidermal melanocytes in vivo and in vitro

2002 ◽  
Vol 292 (4) ◽  
pp. 351-366 ◽  
Author(s):  
Tomohisa Hirobe ◽  
Yoko Kawa ◽  
Masako Mizoguchi ◽  
Shosuke Ito ◽  
Kazumasa Wakamatsu
Keyword(s):  
Proliferation And Differentiation ◽  
Pink Eyed Dilution

scholarly journals Allele variations in the OCA2 gene (pink-eyed-dilution locus) are associated with genetic susceptibility to melanoma

2005 ◽  
Vol 13 (8) ◽  
pp. 913-920 ◽  
Author(s):  
Anne-Sophie Jannot ◽  
Roubila Meziani ◽  
Guylene Bertrand ◽  
Benedicte Gérard ◽  
Vincent Descamps ◽  
...  
Keyword(s):  
Genetic Susceptibility ◽  
Pink Eyed Dilution ◽  
Oca2 Gene

scholarly journals Identification of a melanosomal membrane protein encoded by the pink-eyed dilution (type II oculocutaneous albinism) gene.

1994 ◽  
Vol 91 (25) ◽  
pp. 12071-12075 ◽  
Author(s):  
S. Rosemblat ◽  
D. Durham-Pierre ◽  
J. M. Gardner ◽  
Y. Nakatsu ◽  
M. H. Brilliant ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Oculocutaneous Albinism ◽  
Type Ii ◽  
Pink Eyed Dilution

scholarly journals The effects of mutant p-alleles on the reproductive system in mice

1974 ◽  
Vol 23 (3) ◽  
pp. 319-325 ◽  
Author(s):  
Roger W. Melvold
Keyword(s):  
Mus Musculus ◽  
Reproductive System ◽  
Pleiotropic Effects ◽  
Corpora Lutea ◽  
Gonadotropic Cells ◽  
Large Numbers ◽  
Pink Eyed Dilution

SUMMARYThe p6H, p25H, and pbs alleles at the pink-eyed dilution locus in mice (Mus musculus) cause sterility in males and semi-fertility in females when homozygous, while the pd, pun, p, and + alleles do not reduce fertility. Pituitaries from sterile males had significantly lower proportions of gonadotropic cells than pituitaries from fertile males. Ovaries from semi-fertile females contained large numbers of developing follicles, but no corpora lutea or corpora hemorrhagica were found. The proportion of polyovular follicles in ovaries of semifertile females was abnormally high.Pituitary gonadotropins appear to be reduced in the sterile genotypes although the lesion cannot be localized. Possible relationships between these and other pleiotropic effects of mutant p-alleles are discussed.

scholarly journals A New Spontaneous Allele at the Pink-Eyed Dilution (p) Locus Discovered in Mus musculus castaneus.

1995 ◽  
Vol 44 (4) ◽  
pp. 347-351 ◽  
Author(s):  
Atsushi TSUJI ◽  
Takao WAKAYAMA ◽  
Akira ISHIKAWA
Keyword(s):  
Mus Musculus ◽  
Pink Eyed Dilution ◽  
P Locus
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