scholarly journals Synthesis, spectroscopic study of Pt (IV), Au (III), Rh(III),Co(II) and V (IV) complexes with sodium[5-(p-nitro phenyl) -/4- phenyl-1,2,4-triazole-3-dithiocarbamato hydrazide] and cytotoxicity assay on rhabdomyosarcoma cell line of heavy metals

2012 ◽  
Vol 9 (4) ◽  
pp. 668-679 ◽  
Author(s):  
Baghdad Science Journal
Keyword(s):  
Cell Line ◽  
Molar Absorptivity ◽  
Molar Ratio ◽  
Ratio Method ◽  
Ethanolic Solution ◽  
Flame Atomic Absorption ◽  
Square Planar ◽  
Vis Spectroscopy ◽  
Molar Ratio Method ◽  
Ft Ir

All the prepared metal complexes of Pt (IV), Au(III), Rh (III), Co (II) and V(IV) with new ligand sodium [5-(p-nitro phenyl)-/4-phenyl-1,2,4-triazole-3-dithiocarbamato hydrazide] (TRZ.DTC) have been synthesized and characterized in solid state by using flame atomic absorption, elemental analysis C.H.N.S, FT-IR ,UV-Vis Spectroscopy, conductivity and magnetic susceptibility measurements. The nature of the complexes formed in ethanolic solution has been studied following the molar ratio method also was studied stability constant and found to be stable in molar ratio1:1 of VL (IV) and CoL(II) while Pt(IV), Au(III) and Rh(III) complexes stable in molar ratio 1:2 as well as the molar absorptivity for these complexes were calculated. From the previous analyses, octahedral geometry was suggested for Pt (IV), Rh (III) and Co (II) complexes, square planar was suggested for Au(III) complex while V(IV) complex has a square pyramidal. Cytotoxic effect of PtL, AuL and RhL as well as ligand has been evaluated against RD cell line by using four different concentrations (500, 250, 125 & 62.5 µg/ml) respectively in three exposure times 24, 48 and 72 hrs and compared this effect with control positive Cis-Pt.

scholarly journals Synthesis, Characterization and Stability Study of V(IV), Zr(IV), Rh(III), Pd(II), Cd(II) and Hg(II) Complexes with Pyrazol Derivative

2014 ◽  
Vol 11 (4) ◽  
pp. 1592-1603
Author(s):  
Baghdad Science Journal
Keyword(s):  
Schiff Base ◽  
Elemental Analysis ◽  
Uv Spectroscopy ◽  
Molar Absorptivity ◽  
Stability Study ◽  
Molar Ratio ◽  
Ratio Method ◽  
Flame Atomic Absorption ◽  
Vis Spectroscopy ◽  
Ft Ir

In this work lactone (1) was prepared from the reaction of p-nitro phenyl hydrazine with ethylacetoacetate, which upon treatment with benzoyl chloride afforded the lactame (2). The reaction of (2) with 2-amino phenol produced a new Schiff base (L) in good yield. Complexes of V(IV), Zr(IV), Rh(III), Pd(II), Cd(II) and Hg(II) with the new Schiff base (L) have been prepared. The compounds (1, 2) were characterized by FT-IR and UV spectroscopy, as well as characterizing ligand (L) by the same techniques with elemental analysis (C.H.N) and (1H-NMR). The prepared complexes were identified and their structural geometries were suggested by using elemental analysis (C.H.N), flame atomic absorption technique, FT-IR and UV-Vis spectroscopy, in addition to magnetic susceptibility and conductivity measurements. Metal to ligand [M:L] ratio was obtained for all complexes in ethanol using molar ratio method, which gave comparable results with those obtained for the solid complexes. As well as the apparent stability constant of the complexes have been studied with the time and their color were stable for more than 4 hrs., furthermore the molar absorptivity have been calculated.

scholarly journals Preparation, Characterization and Antimicrobial Activity Study of Some Transition Metal Complexes of 4-Flourophenyl -4-Nitrobenzylidene

2010 ◽  
Vol 7 (2) ◽  
pp. 1006-1013
Author(s):  
Baghdad Science Journal
Keyword(s):  
Metal Complexes ◽  
Metal Ion ◽  
Synergetic Effect ◽  
Free Ligand ◽  
Molar Ratio ◽  
Ratio Method ◽  
Flame Atomic Absorption ◽  
Vis Spectroscopy ◽  
Molar Ratio Method ◽  
The Difference

A new Schiff base of 4- flourophenyl-4- nitrobenzyliden (L) ,was prepared and used to prepare a number of metal complexes with Cr (III) , Fe (III), Co(II) ,Ni (II) and Cu (II). These complexes were isolated and characterized by (FITR),UV-Vis spectroscopy and flame atomic absorption techniques in addition to magnetic susceptibility, and conductivity measurements. The study of the nature of the complexes formed in ethanol was done following the molar ratio method gave results, agreed with those obtained from isolated solid state studies. The antibacterial activity for the ligand and its metal complexes were examined against two selected microorganisms, Pseudomonas aeruginosa and Staphylococcus aureus.The results indicated that the complexes show the enhanced activity in comparison to the free ligand; these were attributed to the synergetic effect between the metal ion and the ligand in addition to the difference in the structural varieties.

scholarly journals Synthesis and Characterization of Some Metal Complexes with their Sulfamethoxazoleand 4,4'-dimethyl-2,2'-bipyridyl and study Cytotoxic Effect on Hep-2 Cell Line

2015 ◽  
Vol 12 (4) ◽  
pp. 740-752 ◽  
Author(s):  
Baghdad Science Journal
Keyword(s):  
Metal Complexes ◽  
Cell Line ◽  
Cytotoxic Effect ◽  
Molar Ratio ◽  
Ratio Method ◽  
Reference Drug ◽  
Alcoholic Medium ◽  
Pyramidal Geometry ◽  
Flame Atomic Absorption ◽  
Vis Spectroscopy

The ligand 4-amino-N-(5-methylisoxazole-3-yl)-benzene-sulfonamide(L1) (as a chelating ligand) was treated with Pd(II),Pt (IV) and Au(III) ions in alcoholic medium in order to prepare a series of new metal complexes. Mixed ligand complexes of this primary ligand were prepared in alcoholic medium in presence of the co-ligand 4,4'-dimethyl-2,2'-bipyridyl(L2) with Cu(II) ,Pd(II) and Au(III) ions. The complexes were characterized in solid state using flame atomic absorption, elemental analysis C.H.N.S, FT-IR, UV-Vis Spectroscopy, conductivity and magnetic susceptibility measurements. The nature of some complexes formed in ethanolic solution has been studied following the molar ratio method, also stability constant was studied and the complexes found to be stable in molar ratio1:1.an octahedral geometry was suggested for PdL1L2, PtL1and AuL1L2 complexes, square planar was suggested for AuL1 and PdL1complexes,while CuL1L2 complex has a square pyramidal geometry. Cytotoxic effect of theprepared complexes as well as ligands was evaluated against Hep-2 cell line using four different concentrations (625, 1250, 2500&5000 µg/ml) respectively in an exposure time 48 hrs comparing this effect with control positive Cis-Pt as reference drug. The obtained results refers to the higher inhibition rates of all complexes and their ligands and ligand (L1) and its complexes give more activity against tested cell than ligand (L2) and its complexes comparable with control positive .

scholarly journals Synthesis and characterization of VO(II), Cr(III),Mn(II), Fe(II),Zn(II),Cd(II),Hg(II) and UO2(VI) complexes with ligands containing (ONO) and (ON) donor set atoms

2008 ◽  
Vol 5 (2) ◽  
pp. 285-296
Author(s):  
Baghdad Science Journal
Keyword(s):  
Conductivity Measurement ◽  
Molar Ratio ◽  
Ratio Measurement ◽  
Mixed Ligands ◽  
Flame Atomic Absorption ◽  
State Study ◽  
Vis Spectroscopy ◽  
Atomic Absorption Technique ◽  
Ft Ir ◽  
Hydroxy Quinoline

A new Schiff base o-hydroxybenzylidene-1-phenyl-2,3-dimethyl-4-amino-3-pyrazolin-5-on (HL) ,have been prepared and characterization.(HL) has been used as a chelating ligand to prepare a number of metal complexes VO(II) ,Cr(III) ,Mn(II),Fe(II),Hg(II) and UO2(II) .and mixed ligands complexes have been prepared between o-hydroxybenzylidene-1-phenyl-2,3-dimethyl-4-amino-3-pyrazolin-5-on and 8- hydroxy quinoline with VO(II),Zn(II),Cd(II), Hg(II) and UO2(II) the prepared complexes were isolated and characterized by (FT-IR)and (UV-Vis) spectroscopy. Elemental analysis (C.H.N) Chloride contents, Flame atomic absorption technique. in addition to magnetic susceptibility and conductivity measurement. Molar ratio measurement in solution gave comparable results with those obtained from solid state study.

scholarly journals Spectrophotometric Determination of Selenium in Various Samples Using 5,6-Diaminouracil Hydrochloride (DAUH)

2015 ◽  
Vol 61 ◽  
pp. 128-136 ◽  
Author(s):  
Salwa Fares Rassi
Keyword(s):  
Acidic Medium ◽  
Metal Ion ◽  
Molar Absorptivity ◽  
Molar Ratio ◽  
Ratio Method ◽  
Colored Complex ◽  
Molar Ratio Method ◽  
Analytical Reagent ◽  
Color Reactions

A simple, rapid and sensitive spectrophotometric method was developed for the determination of Se (IV) using 5,6-diaminouracil hydrochloride (DAUH) as an analytical reagent. The reagent has been synthesized and characterized using IR, 1H NMR. The metal ion in aqueous medium forms yellow colored complex with DAUH showing maximum absorbance at 343 nm. Hence, analytical studies were further carried out at 343 nm. The reagent reacts with selenium in acidic medium to form yellow colored 1:1 (M:L) complex . The color reactions are instantaneous and absorbance values remain constant for one week. The composition of the Se (IV) complex with DAUH was studied by the method of job’s continuous variation and molar ratio method. Beer’s law was obeyed in the range 0.2-15.0 μg mL−1of Se (IV). The molar absorptivity and Sandell’s sensitivity of the method were found to be 0.5×10+4 L.mol-1.cm-1and 0.031μg.cm-2 respectively. Since DAUH method is more sensitive, it was applied for the determination of selenium in samples.

scholarly journals Spectrophotometric Determination of Cu(II) in Analytical Sample Using a New Chromogenic Reagent (HPEDN)

2020 ◽  
Vol 20 (5) ◽  
pp. 1080
Author(s):  
Esraa Raafid ◽  
Muneer A. Al-Da’amy ◽  
Salih Hadi Kadhim
Keyword(s):  
Schiff Base ◽  
Absorption Spectrometry ◽  
Molar Ratio ◽  
Ratio Method ◽  
Chromogenic Reagent ◽  
Flame Atomic Absorption ◽  
Vis Spectroscopy ◽  
Masking Agents ◽  
Good Agreement

The sensitive, accurate and rapid spectrophotometric method that can be used for determination of Cu(II) in the analytical samples using a new chromogenic reagent azo-Schiff base 1-((4-(1-(2-hydroxyphenylimino)ethyl)-phenyl)diazenyl) naphthalene-2-ol (HPEDN). The synthesized new (azo-Schiff base) ligand was complexed with copper(II) and characterized using UV/Vis spectroscopy, IR spectra, 1H-NMR, 13CN-MR spectra, Molar electrical connectivity, and measuring of their melting points. Then obtained complex showed a brown color with maximum absorption at λmax = 500 nm at pH = 9. Beer’s law is obeyed in the concentration in the range of 1.7 to 5.4 μg/mL. The molar absorption and Sandell’s sensitivity values of Cu(II) complex were found to be 0.5038 × 104 L mol–1 cm–1 and 0.0039 μg cm–2, respectively. Structure of the prepared complex was investigated by using the continuous variation, mole ratio method and slope analysis method. The obtained results showed that the complex has (1:2) (M:L) molar ratio and these results showed that this method were more sensitive, more precise and accuracy through the calculation of (Re, Erel, R.S.D)%. The most important interferences were due to, Co2+, Cd2+, Zn2+, Ni2+, Mn2+, Pd2+, Fe3+ and these were studied, and suitable masking agents were used. This method was applied for the determination of Cu(II) in alloy. The obtained results were compared with flame atomic absorption spectrometry method and these results were in a good agreement in these two cases.

scholarly journals Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid

2020 ◽  
Vol 20 (6) ◽  
pp. 1311
Author(s):  
Shatha Mohammed Hassan Obaid ◽  
Jasim Shihab Sultan ◽  
Abbas Ali Salih Al-Hamdani
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Complexes ◽  
Molar Ratio ◽  
Spectral Studies ◽  
Physical Analysis ◽  
Flame Atomic Absorption ◽  
Vis Spectroscopy ◽  
Ft Ir

The reaction of methyldopa with o-vanillin in refluxing ethanol afforded Schiff base and characterized through physical analysis with a number of spectra also the study of biological activity. The geometry of the Schiff base was identified through using (C.H.N) analysis, Mass, 1H-NMR, FT-IR, UV-Vis spectroscopy. Metal complexes of Cr3+, Mn2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+ and Hg2+ with Schiff base have been prepared in the molar ratio 2:1 (Metal:L), (L = Schiff base ligand) except Hg2+ at molar ratio 1:1 (Hg:L). The prepared complexes were characterized by using Mass, FT-IR and UV-Vis spectral studies, on other than magnetic properties and flame atomic absorption, conductivity measurements. According to the results a dinuclear octahedral geometry has been suggested for Cr3+, Mn2+, Co2+, Ni2+, Cu2+ and Zn2+ complexes, dinuclear tetrahedral for Cd2+ and mononuclear tetrahedral for Hg2+ complex. This work highlights the relevance of metal complexation strategy to stabilize the ligands and improve their bioactivity. Schiff base complexes have been screen for their antibacterial activity against Gram negative and positive bacteria and antifungal activity showing promising antibacterial and biological activity.

scholarly journals Microwave Assisted Synthesis, Solution State, Spectral Studies and Theoretical Treatment of Pd(II) , Pt(IV) and Au(III) ions Complexes Containing 2-Benzamide Benzothiazole

2015 ◽  
Vol 12 (3) ◽  
pp. 527-535
Author(s):  
Baghdad Science Journal
Keyword(s):  
Solid State ◽  
Gas Phase ◽  
Molar Ratio ◽  
Ratio Method ◽  
Spectral Studies ◽  
Microwave Assisted Synthesis ◽  
Theoretical Treatment ◽  
Microwave Assisted ◽  
Flame Atomic Absorption ◽  
Vis Spectroscopy

2-benzamide benzothiazole complexes of Pd(II) , Pt(IV) and Au(III) ions were prepared by microwave assisted radiation. The ligand and the complexes were isolated and characterized in solid state by using FT-IR, UV-Vis spectroscopy, flame atomic absorption, elemental analysis CHNS , magnetic susceptibility measurements , melting points and conductivity measurements. The nature of complexes in liquid state was studied by following the molar ratio method which gave results approximately identical to those obtained from isolated solid state; also, stability constant of the prepared complexes were studied and found that they were stable in molar ratio 1:1.The complexes have a sequar planner geometry except Pt(IV) complex has octahedral . A theoretical treatment of ligand and its metal complexes in gas phase were studied using HyperChem-8 program, moreover, ligand in gas phase also has been studied using Gaussian program(GaussView Currently Available Version (5.0.9) along with Gaussian 09 which was the latest in the Gaussian series of programs).

scholarly journals Synthesis,Structural and Biological studies of 4-[(1-phenyl-2,3-dimethyl-3-pyrozoline-5-one)azo]-N,N-dimethyl anline with some transition metal ions

2010 ◽  
Vol 7 (3) ◽  
pp. 1202-1213
Author(s):  
Baghdad Science Journal
Keyword(s):  
Solid State ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Uv Spectroscopy ◽  
Transition Metal Ions ◽  
Ratio Method ◽  
Flame Atomic Absorption ◽  
Biological Studies ◽  
Vis Spectroscopy ◽  
Ft Ir

The present work includes the preparation and characterization of{Co(II) , Ni(II), Pd(II), Fe(III) , Ru(III),Rh(III), Os(III) , Ir(III) , Pt(IV) and VO(IV)}complexes of a new ligand 4-[(1-phenyl-2,3-dimethyl-3-pyrozoline-5-one)azo]-N,N-dimethylanline (PAD). The product (PAD) was isolated,studies and characterized by phsical measurements,i.e., (FT-IR), (UV) Spectroscopy and elemental analysis(C.H.N). The prepared complexes were identified and their structural geometric were suggested in solid state by using flame atomic absorption, elemental analysis(C.H.N), (FT-IR) and (UV-Vis) Spectroscopy, as well as magnetic susceptibility and conductivity measurements . The study of the nature of the complexes formed in( ethanolic solution) following the mole ratio method,gave results which were compared successfully with those obtained from solid state studies. The apparent stability constant of the complexes have been studied with the time and their color were stable for more than ( 6 ) hours , as well as the molar absorptivities have been calculated.The antibacterial activity for the ligand (PAD) and their metal complexes were studied against two selected micro - organisms [(Klesbiella pneumonia) as gram negative] and[( Streptococcus faecalis) as gram positive]. Further more the antifungl activity against two micro-organism (Candida albicans and Aspergillus flavus) were studied for the ligand (PAD) and their metal complexes .

scholarly journals Determination of Ni(II) in Alloy by Spectrophotometric method with anew chromogenic reagent (IDPBS)

2013 ◽  
Vol 11 (01) ◽  
pp. 20-22
Author(s):  
Esraa R. Abbas ◽  
Salih H. Kadhim ◽  
Muneer A. Abbas AL-Da,amy
Keyword(s):  
Spectrophotometric Method ◽  
Absorption Spectrometry ◽  
Molar Absorptivity ◽  
Molar Ratio ◽  
Colored Complex ◽  
Chromogenic Reagent ◽  
Flame Atomic Absorption ◽  
Highly Sensitive ◽  
Ft Ir

A new chromogenic reagent 4-((imidazole-2-yl)diazenyl)-N-(pyrimidin-2-yl)benzenesulfonamide was synthesized by the reaction between imidazole and Sulphadiazine as azo reagent and used as new spectrophotometric method with highly sensitive to determined Nickel (II). The reagent reacts with nickel(II) in aqueous solution at pH= 7 to form dark- brown colored complex. The reagent and its complex were identified by Fourier transform infrared (FT-IR), Uv-visible,1HNMR, and 13CNMR spectroscopies and investigate the formula and charge of the prepared complex by molar ratio and molar conductivity measurements. The complex shows λmax at 486 nm with a molar absorptivity 0.3299 x 104 L.mo1-1.cm-1 and Sandell’s sensitivity 0.0177μg.cm-2.Beer’s law is obeyed in the concentration range (0.5-7.6μg.mL-1) of Ni (II) with excellent linearity depicted by correlation coefficient value of 0.9995 with a detection limit of 0.1927μg.ml-1. Recovery and relative error values of precision and accuracy of method were found to be R.S.D.% = 0.39221, Re=98.7% and Erel = -1.3% . The nature of the complex showed that (M:L) ratio was 1:2. This method was applied for the determination of Ni(II) in alloy due to Sensitive, accurate, and rapid spectrophotometric method. The results obtained were compared with the flame atomic absorption spectrometry method, and results are in conformity.

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