scholarly journals Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases

10.21149/8140 ◽  
2017 ◽  
Vol 60 (1, ene-feb) ◽  
pp. 77 ◽  
Author(s):  
Federico Alonso Zumaya-Estrada ◽  
María Carmen Rodríguez ◽  
Mario Henry Rodríguez
Keyword(s):  
Control Strategies ◽  
Transmission Blocking ◽  
Vector Borne Diseases ◽  
Vector Borne

scholarly journals Wolbachia: endosymbiont of onchocercid nematodes and their vectors

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Ranju Ravindran Santhakumari Manoj ◽  
Maria Stefania Latrofa ◽  
Sara Epis ◽  
Domenico Otranto
Keyword(s):  
Control Strategies ◽  
Molecular Data ◽  
Scientific Data ◽  
Growth And Survival ◽  
Vector Borne Diseases ◽  
Wide Range ◽  
Veterinary Importance ◽  
Wolbachia Endosymbiont ◽  
Vector Borne ◽  
And Control

Abstract Background Wolbachia is an obligate intracellular maternally transmitted, gram-negative bacterium which forms a spectrum of endosymbiotic relationships from parasitism to obligatory mutualism in a wide range of arthropods and onchocercid nematodes, respectively. In arthropods Wolbachia produces reproductive manipulations such as male killing, feminization, parthenogenesis and cytoplasmic incompatibility for its propagation and provides an additional fitness benefit for the host to protect against pathogens, whilst in onchocercid nematodes, apart from the mutual metabolic dependence, this bacterium is involved in moulting, embryogenesis, growth and survival of the host. Methods This review details the molecular data of Wolbachia and its effect on host biology, immunity, ecology and evolution, reproduction, endosymbiont-based treatment and control strategies exploited for filariasis. Relevant peer-reviewed scientic papers available in various authenticated scientific data bases were considered while writing the review. Conclusions The information presented provides an overview on Wolbachia biology and its use in the control and/or treatment of vectors, onchocercid nematodes and viral diseases of medical and veterinary importance. This offers the development of new approaches for the control of a variety of vector-borne diseases. Graphic Abstract

‘Swimming mosquitoes’: a key stepping stone to prevent Dengue, Zika and Chikungunya: an educative experience in Colima, Mexico

2019 ◽  
Vol 34 (4) ◽  
pp. 389-399 ◽  
Author(s):  
Paula Medone ◽  
Carlos M Hern�ndez-Su�rez
Keyword(s):  
Risk Perception ◽  
Control Strategies ◽  
Social Representations ◽  
Adult Mosquito ◽  
Breeding Sites ◽  
Stepping Stone ◽  
Public Issues ◽  
Vector Borne Diseases ◽  
The People ◽  
Vector Borne

Abstract Dengue, Zika and Chikungunya arboviruses (DZC), mainly transmitted by mosquito Aedes aegypti, are global health public issues affecting 390 million people each year. In most endemic countries, vector control strategies have been focused on reducing breeding sites and adult mosquito populations. Most health communication strategies have pointed out adult mosquito as the main responsible of the transmission, persuading people to eliminate domestic containers. However, it is not clear how should people understand the relationship between adult mosquitoes and water domestic containers. So, the main goal of the present study was to assess the people understanding of this relationship. Results showed that most people associate adult mosquitoes with DZC, but only few could associate swimming larvae with mosquitoes. The unawareness of larva presence leads to an underestimation of risk perception about DZC transmission. In this context, we consider that educative interventions for health promotion, based on meaningful knowledge and social representations arise as long-term strategies to control transmission of vector-borne diseases. Here, we propose innovative health strategies focused on increase the risk perception about swimming larvae, considering social representations, which may be a key stepping stone to increase people adherence to massive campaigns and reducing DZC burden.

scholarly journals The use of islands and cluster-randomized trials to investigate vector control interventions: a case study on the Bijagós archipelago, Guinea-Bissau

2020 ◽  
Vol 376 (1818) ◽  
pp. 20190807 ◽  
Author(s):  
Robert T. Jones ◽  
Elizabeth Pretorius ◽  
Thomas H. Ant ◽  
John Bradley ◽  
Anna Last ◽  
...  
Keyword(s):  
Vector Control ◽  
Statistical Power ◽  
Randomized Trials ◽  
Control Strategies ◽  
Cluster Randomized Trials ◽  
Vector Borne Diseases ◽  
Guinea Bissau ◽  
Vector Borne ◽  
Cluster Randomized

Vector-borne diseases threaten the health of populations around the world. While key interventions continue to provide protection from vectors, there remains a need to develop and test new vector control tools. Cluster-randomized trials, in which the intervention or control is randomly allocated to clusters, are commonly selected for such evaluations, but their design must carefully consider cluster size and cluster separation, as well as the movement of people and vectors, to ensure sufficient statistical power and avoid contamination of results. Island settings present an opportunity to conduct these studies. Here, we explore the benefits and challenges of conducting intervention studies on islands and introduce the Bijagós archipelago of Guinea-Bissau as a potential study site for interventions intended to control vector-borne diseases. This article is part of the theme issue ‘Novel control strategies for mosquito-borne diseases'.

scholarly journals Mosquito Mycobiota: An Overview of Non-Entomopathogenic Fungal Interactions

Pathogens ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 564 ◽  
Author(s):  
Simon Malassigné ◽  
Claire Valiente Moro ◽  
Patricia Luis
Keyword(s):  
Mosquito Control ◽  
Control Strategies ◽  
Vector Competence ◽  
Anopheles Species ◽  
Vector Borne Diseases ◽  
Vector Borne ◽  
Fungal Interactions ◽  
And Behavior ◽  
The Impact ◽  
Alternative Control Methods

The growing expansion of mosquito vectors leads to the emergence of vector-borne diseases in new geographic areas and causes major public health concerns. In the absence of effective preventive treatments against most pathogens transmitted, vector control remains one of the most suitable strategies to prevent mosquito-borne diseases. Insecticide overuse raises mosquito resistance and deleterious impacts on the environment and non-target species. Growing knowledge of mosquito biology has allowed the development of alternative control methods. Following the concept of holobiont, mosquito-microbiota interactions play an important role in mosquito biology. Associated microbiota is known to influence many aspects of mosquito biology such as development, survival, immunity or even vector competence. Mosquito-associated microbiota is composed of bacteria, fungi, protists, viruses and nematodes. While an increasing number of studies have focused on bacteria, other microbial partners like fungi have been largely neglected despite their huge diversity. A better knowledge of mosquito-mycobiota interactions offers new opportunities to develop innovative mosquito control strategies. Here, we review the recent advances concerning the impact of mosquito-associated fungi, and particularly nonpathogenic fungi, on life-history traits (development, survival, reproduction), vector competence and behavior of mosquitoes by focusing on Culex, Aedes and Anopheles species.

scholarly journals New records of mosquito species (Diptera: Culicidae) in La Comarca Lagunera, Durango, Mexico

Nova Scientia ◽  
2020 ◽  
Vol 12 (25) ◽  
Author(s):  
Rafael Vázquez-Marroquín ◽  
Mónica Duarte-Andrade ◽  
Luis Miguel Hernández-Triana ◽  
Aldo Iván Ortega-Morales ◽  
Rahuel Jeremías Chan-Chable
Keyword(s):  
New Records ◽  
Control Strategies ◽  
Mosquito Species ◽  
Abundant Species ◽  
Health Ministry ◽  
Vector Borne Diseases ◽  
Resting Sites ◽  
Veterinary Importance ◽  
Vector Borne ◽  
Biology Laboratory

Introduction: Many mosquitoes are of great medical and veterinary importance because they transmit numerous pathogens which cause diseases in animals and humans; thus, knowing their taxonomy and distribution is pivotal for implementing the correct control strategies. The aim of this study was to determine the occurrence of mosquito species and their distribution in La Comarca Lagunera in the state of Durango, Mexico.Method: Adult mosquitoes were collected at different resting sites in four municipalities between August and November 2018 using Insectzookas. Aquatic habitats were also sampled for immature stages. Adult specimens were killed using lethal chambers with triethylamine vapors; while larvae and pupae were stored in individual tubes to obtain the adult stages and associated exuviae. All material was transported to the Molecular Biology Laboratory of the Parasitology Department of the Universidad Autónoma Agraria Antonio Narro, Unidad Laguna (UAAAN-UL) for mounting and taxonomical identification. Species were identified using taxonomic keys for the region.Results: In total, 689 mosquito specimens (286 males and 403 females) were collected belonging to 15 species, among them Anopheles franciscanus McCracken, Culex erythrothorax Dyar, and Toxorhynchites moctezuma (Dyar and Knab) are new records for Durango State. The most abundant species was Cx. quinquefasciatus Say with 364 (56.2%) specimens, followed by Aedes aegypti (Linnaeus) (21.3%) and Ae. vexans (Meigen) (7.7%).Conclusion: 13 out of 15 species collected are associated with the transmission of an arbovirus of relevant medical or veterinary importance in Mexico. There are now 38 species recorded for Durango. The information in this study is directly relevant for the Health Ministry in Durango State for the control of vector borne diseases in the region.

scholarly journals Small-molecule control of super-Mendelian inheritance in gene drives

2019 ◽  
Author(s):  
Víctor López Del Amo ◽  
Brittany S. Leger ◽  
Kurt J. Cox ◽  
Shubhroz Gill ◽  
Alena L. Bishop ◽  
...  
Keyword(s):  
Small Molecule ◽  
Chemical Control ◽  
Control Strategies ◽  
Mendelian Inheritance ◽  
Drive System ◽  
Gene Drive ◽  
Crop Pests ◽  
Vector Borne Diseases ◽  
Vector Borne ◽  
Gene Drives

ABSTRACTBy surpassing the 50% inheritance limit of Mendel’s law of independent assortment, CRISPR-based gene drives have the potential to fight vector-borne diseases or suppress crop pests. However, contemporary gene drives could spread unchecked, posing safety concerns that limit their use in both laboratory and field settings. Current technologies also lack chemical control strategies, which could be applied in the field for dose, spatial and temporal control of gene drives. We describe in Drosophila the first gene-drive system controlled by an engineered Cas9 and a synthetic, orally-available small molecule.Graphical Abstract

scholarly journals Vector-borne disease problems in rapid urbanization

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A Zayed
Keyword(s):  
Control Strategies ◽  
Geographic Area ◽  
Disease Vectors ◽  
Continuous Change ◽  
Rapid Urbanization ◽  
Flexible Control ◽  
Vector Borne Diseases ◽  
Planning Decisions ◽  
Vector Borne ◽  
Change Vector

Abstract Habitat change of disease vectors has a great impact on their effectiveness to transmit vector borne diseases (VBD). This may result from man-made or natural factors. Urbanization, though it reflects development, is one crucial factor affecting the competence of existing vectors in certain geographic area, or allow for introducing and/or increasing the vectorial capacity of subsidiary vectors. Developing countries, challenging areas with political constrains and those affected by natural disasters are the most threatened areas in terms of VBD continuous change. Vector control strategies are mainly based on having an up-to-date complete knowledge of the spatial and temporal composition of disease vectors. Flexible control and planning decisions, and evidence-based interventions may help containing changes in VBD status due to the rapid urbanization.

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