Predictors of tuberculosis infection among adults visiting anti-retroviral treatment center in east and west Gojjam, northwest, Ethiopia, 2017
Abstract Background Tuberculosis is a serious health threat, especially for people living with human immune deficiency virus and is more likely than others to become sick with tuberculosis are. Objective Predictors of tuberculosis infection among adults visiting anti-retroviral treatment center in Gojjam, Northwest Ethiopia, 2017 Methods An institution based unmatched case-control study was conducted in East and West Gojjam Zone, Northwest, Ethiopia from March 7-April 15, 2017. Cases were 139 tuberculosis infected human immune deficiency virus positives and controls were 413 non-TB infected HIV positives i.e. 1:3 proportion. All cases in each health facility were included. but controls were selected by using simple random sampling technique and the data were collected with Face to face interview as well as patient medical record were used and the quality of the data were assured, the data were checked, coded, cleaned and entered in EPI-Data version 3.1 and exported to SPSS version 20 for the analysis. Result of the total sample (556), just about 552(99.2%) were participated in the study (female=47.5% and rural=58.9%). Behavioral and modifiable biological risk factors: alcohol users (AOR=2.33; 95% CI:1.34,4.07), BMI<18.5kg/m2 (AOR=3.03;95%CI:1.79,5.14), CD4 count ≤200 cells/µl (AOR=2.34;95%CI:1.89,2.79) and between 201-499 cells/µl (AOR=2.63; 95%CI: 1.01,6.84), bedridden and ambulatory (AOR=3.3;95%CI:1.70,6.29 and AOR=8.2;95%CI:4.34,15.64),respectively and TB history in the family (AOR=3.00; 95%CI:1.57,5.74) were predictors for TB infection. Taking CPT (AOR=0.36; 95%CI: 0.21, 0.62) and having early WHO clinical stage I or II (AOR=0.34; 95%CI: 0.20, 0.56) had protective effect against TB infection. Conclusion &Recommendation Behavioral, biological, clinical and TB history in the family were highly prevalent in the study area. Strengthen screening more frequently, CPT Prophlaxysis and treated promptly important to reduce TB co-morbidity.