scholarly journals Predictors of tuberculosis infection among adults visiting anti-retroviral treatment center in east and west Gojjam, northwest, Ethiopia, 2017

2020 ◽  
Author(s):  
Habtamu Belew Mera ◽  
Moges Wubie ◽  
Getaye Tizazu ◽  
Abebaw Bitew ◽  
Tesfa Birlew
Keyword(s):  
Clinical Stage ◽  
Northwest Ethiopia ◽  
Cd4 Count ◽  
Tuberculosis Infection ◽  
Treatment Center ◽  
Human Immune Deficiency Virus ◽  
Co Morbidity ◽  
West Gojjam ◽  
East And West ◽  
Alcohol Users

Abstract Introduction: Tuberculosis is a serious health risk, for people living with human immune deficiency virus worldwide, and the burden of TB/HIV infection is still high in Ethiopia in particular. Therefore, the aim of this study was to determine the predictors of tuberculosis infection among adults visiting anti-retroviral treatment center in East and West Gojjam Zone, northwest, Ethiopia. Methods and Materials: Institution based unmatched case-control study was employed to determine the predictors of tuberculosis infection among adults visiting anti-retroviral treatment center in east and west Gojjam, Northwest, Ethiopia from March 7-April 15, 2017. A total of 552 participants were participated in the study (139 Cases and 413 controls). Cases were confirmed with active TB and infected with HIV, and controls were HIV positive adults with non-TB. All cases in each health facility who confirmed by acid-fast bacilli, culture and gene expert were considered as TB positive. However, controls were selected by using simple random sampling technique through the above diagnostic criteria and the data were collected with Face to face interview as well as patient medical record were utilized, and the quality of the data were assured, checked, coded, cleaned and entered in EPI-Data version 3.1 and exported to SPSS version 20 for the analysis. Result: Of the total sample (556), just about 552(99.2%) were participated in the study. 47.5% were females and 58.9% were rural dweller. Behavioral and modifiable biological risk factors: alcohol users (AOR=2.33; 95%CI:1.34,4.07),BMI<18.5kg/m2 (AOR=3.03;95%CI:1.79,5.14), CD4 count ≤200 cells/µl (AOR=2.34;95%CI:1.89,2.79) and between 201-499 cells/µl (AOR=2.63; 95%CI: 1.01,6.84), bedridden and ambulatory (AOR=3.3;95%CI:1.70,6.29 and AOR=8.2;95%CI:4.34,15.64),respectively. TB history in the family (AOR=3.00; 95%CI: 1.57, 5.74) were predictors for TB infection. Taking CPT (AOR=0.36; 95%CI: 0.21, 0.62) and having early WHO clinical stage I or II (AOR=0.34; 95%CI: 0.20, 0.56) had protective effect against TB infection. Conclusion: From this study, it has been concluded that alcohol users, BMI<18.5kg/m², CD4 count <499 cells/µl, bedridden and ambulatory and TB history were highly associated in TB-HIV co-infected adults. Strengthen screening more frequently, CPT Prophlaxysis and treated promptly important to reduce TB co-morbidity.

scholarly journals Predictors of tuberculosis infection among adults visiting anti-retroviral treatment center in East and West Gojjam zone, northwest, Ethiopia, 2017

2020 ◽  
Author(s):  
Habtamu Belew Mera ◽  
Moges Wubie ◽  
Getaye Tizazu ◽  
Abebaw Bitew ◽  
Tesfa Birlew
Keyword(s):  
Northwest Ethiopia ◽  
Cd4 Count ◽  
Tuberculosis Infection ◽  
Treatment Center ◽  
Human Immune Deficiency Virus ◽  
Co Morbidity ◽  
West Gojjam ◽  
East And West ◽  
Alcohol Users ◽  
West Gojjam Zone

Abstract Background: Tuberculosis is a serious health risk, for people living with human immune deficiency virus worldwide, and the burden of TB/HIV infection is still high in Ethiopia in particular. Therefore, the aim of this study was to determine the predictors of tuberculosis infection among adults visiting anti-retroviral treatment center in East and West Gojjam Zone, northwest, Ethiopia. Methods: Institution based unmatched case-control study was employed to determine the predictors of tuberculosis infection among adults visiting anti-retroviral treatment center in East and West Gojjam Zone, Northwest, Ethiopia from March 7-April 15, 2017. A total of 552 participants were participated in the study (139 Cases and 413 controls). Cases were confirmed with active TB and infected HIV, and controls were HIV positive adults with non-TB. All cases in each health facility who confirmed by acid-fast bacilli, culture and gene expert were considered as TB positive. However, controls were selected by using simple random sampling technique through the above diagnostic criteria and the data were collected with Face to face interview as well as patient medical record were utilized, and the quality of the data were assured, checked, coded, cleaned and entered in EPI-Data version 3.1 and exported to SPSS version 20 for the analysis. Result: Of the total sample (556), just about 552(99.2%) were participated in the study among this 47.5% were females and 58.9% were rural. Behavioral and modifiable biological risk factors: alcohol users (AOR=2.33; 95%CI:1.34,4.07),BMI<18.5kg/m2 (AOR=3.03;95%CI:1.79,5.14), CD4 count ≤200 cells/µl (AOR=2.34;95%CI:1.89,2.79) and between 201-499 cells/µl (AOR=2.63; 95%CI: 1.01,6.84), bedridden and ambulatory (AOR=3.3;95%CI:1.70,6.29 and AOR=8.2;95%CI:4.34,15.64),respectively. TB history in the family (AOR=3.00; 95%CI: 1.57, 5.74) were predictors for TB infection. Taking CPT (AOR=0.36; 95%CI: 0.21, 0.62) and having early WHO clinical stage I or II (AOR=0.34; 95%CI: 0.20, 0.56) had protective effect against TB infection. Conclusion: From this study, it has been concluded that alcohol users, BMI<18.5kg/m², CD4 count <499 cells/µl, bedridden and ambulatory and TB history were highly associated in TB-HIV co-infected adults. Strengthen screening more frequently, CPT Prophlaxysis and treated promptly important to reduce TB co-morbidity.

scholarly journals Predictors of tuberculosis infection among adults visiting anti-retroviral treatment center in east and west Gojjam, northwest, Ethiopia, 2017

2019 ◽  
Author(s):  
Habtamu Belew Mera ◽  
Moges Wubie ◽  
Getaye Tizazu ◽  
Abebaw Bitew ◽  
Tesfa Birlew
Keyword(s):  
Immune Deficiency ◽  
Northwest Ethiopia ◽  
Tuberculosis Infection ◽  
Treatment Center ◽  
Human Immune Deficiency Virus ◽  
Co Morbidity ◽  
The Family ◽  
West Gojjam ◽  
Human Immune ◽  
East And West

Abstract Background Tuberculosis is a serious health threat, especially for people living with human immune deficiency virus and is more likely than others to become sick with tuberculosis are. Objective Predictors of tuberculosis infection among adults visiting anti-retroviral treatment center in Gojjam, Northwest Ethiopia, 2017 Methods An institution based unmatched case-control study was conducted in East and West Gojjam Zone, Northwest, Ethiopia from March 7-April 15, 2017. Cases were 139 tuberculosis infected human immune deficiency virus positives and controls were 413 non-TB infected HIV positives i.e. 1:3 proportion. All cases in each health facility were included. but controls were selected by using simple random sampling technique and the data were collected with Face to face interview as well as patient medical record were used and the quality of the data were assured, the data were checked, coded, cleaned and entered in EPI-Data version 3.1 and exported to SPSS version 20 for the analysis. Result of the total sample (556), just about 552(99.2%) were participated in the study (female=47.5% and rural=58.9%). Behavioral and modifiable biological risk factors: alcohol users (AOR=2.33; 95% CI:1.34,4.07), BMI<18.5kg/m2 (AOR=3.03;95%CI:1.79,5.14), CD4 count ≤200 cells/µl (AOR=2.34;95%CI:1.89,2.79) and between 201-499 cells/µl (AOR=2.63; 95%CI: 1.01,6.84), bedridden and ambulatory (AOR=3.3;95%CI:1.70,6.29 and AOR=8.2;95%CI:4.34,15.64),respectively and TB history in the family (AOR=3.00; 95%CI:1.57,5.74) were predictors for TB infection. Taking CPT (AOR=0.36; 95%CI: 0.21, 0.62) and having early WHO clinical stage I or II (AOR=0.34; 95%CI: 0.20, 0.56) had protective effect against TB infection. Conclusion &Recommendation Behavioral, biological, clinical and TB history in the family were highly prevalent in the study area. Strengthen screening more frequently, CPT Prophlaxysis and treated promptly important to reduce TB co-morbidity.

scholarly journals Predictors of tuberculosis infection among adults visiting anti-retroviral treatment center in East and West Gojjam Zone, northwest, Ethiopia, 2017

2019 ◽  
Author(s):  
Habtamu Belew Mera ◽  
Moges Wubie ◽  
Getaye Tizazu ◽  
Abebaw Bitew ◽  
Tesfa Birlew
Keyword(s):  
Immune Deficiency ◽  
Northwest Ethiopia ◽  
Tuberculosis Infection ◽  
Treatment Center ◽  
Human Immune Deficiency Virus ◽  
The Family ◽  
West Gojjam ◽  
Human Immune ◽  
East And West ◽  
West Gojjam Zone

Abstract Background: Tuberculosis is a serious health threat, especially for people living with human immune deficiency virus worldwide and the burden of TB/HIV infection is still high in Ethiopia in particular. Objective: To determine the predictors of tuberculosis infection among adults visiting anti-retroviral treatment center in East and west Gojjam, Northwest Ethiopia, 2017Methods: An institution based unmatched case-control study was conducted in East and West Gojjam Zone, Northwest, Ethiopia from March 7-April 15, 2017. Cases were 139 tuberculosis infected human immune deficiency virus positives and controls were 413 non-TB infected HIV positives i.e. 1:3 proportion. All cases in each health facility who confirmed by acid-fast bacilli (direct microscopy), culture and gene expert were considered as TB positive fine needle aspiration. However controls were selected by using simple random sampling technique through the above diagnostic criteria and the data were collected with Face to face interview as well as patient medical record were used and the quality of the data were assured, checked, coded, cleaned and entered in EPI-Data version 3.1 and exported to SPSS version 20 for the analysis. Result: Of the total sample (556), just about 552(99.2%) were participated in the study among this 47.5% were females and 58.9% were rural. Behavioral and modifiable biological risk factors: alcohol users (AOR=2.33; 95% CI:1.34,4.07), BMI<18.5kg/m2 (AOR=3.03;95%CI:1.79,5.14), CD4 count ≤200 cells/µl (AOR=2.34;95%CI:1.89,2.79) and between 201-499 cells/µl (AOR=2.63; 95%CI: 1.01,6.84), bedridden and ambulatory (AOR=3.3;95%CI:1.70,6.29 and AOR=8.2;95%CI:4.34,15.64),respectively. TB history in the family (AOR=3.00; 95%CI: 1.57, 5.74) were predictors for TB infection. Taking CPT (AOR=0.36; 95%CI: 0.21, 0.62) and having early WHO clinical stage I or II (AOR=0.34; 95%CI: 0.20, 0.56) had protective effect against TB infection. Conclusion &Recommendation: Behavioral, biological, clinical and TB history in the family were highly prevalent in the study area. Strengthen screening more frequently, CPT Prophlaxysis and treated promptly important to reduce TB co-morbidity.

scholarly journals Neuro-psychiatric co morbidity in HIV/AIDS; and effect of alcohol in CD4 count in HIV patients

2014 ◽  
Vol 14 (S3) ◽  
Author(s):  
Biswadeep Borthakur ◽  
Dhruba Jyoti Borah ◽  
Supria Kumar Mandal ◽  
Kamala Deka ◽  
Saumitra Ghosh ◽  
...  
Keyword(s):  
Cd4 Count ◽  
Hiv Patients ◽  
Co Morbidity ◽  
Hiv Aids

scholarly journals Body mass index increases CD4+ count in HIV/AIDS patients on first-line therapy

2020 ◽  
Vol 39 (2) ◽  
pp. 121
Author(s):  
Mirna Widiyanti ◽  
Moch Irfan Hadi ◽  
Mei Lina Fitri Kumalasari ◽  
Evi Iriani Natalia ◽  
Dedi Ananta Purba ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Antiretroviral Therapy ◽  
Body Mass ◽  
Influencing Factor ◽  
Clinical Stage ◽  
Cd4 Count ◽  
First Line ◽  
Aids Patients ◽  
Cd4 Counts ◽  
Hiv Aids

Background<br />The body mass index (BMI) may contribute somewhat to drug metabolism, thus affecting the efficacy of antiretroviral therapy (ART). CD4+ counts   in people infected with HIV are essential in determining the stage of the disease, initiation of antiretroviral therapy, opportunistic infections and evaluating treatment outcomes. The aim of this study was to determine the association of BMI and clinical stage with CD4+ counts in HIV patients seeking treatment using first-line antiretroviral therapy (ART).<br /><br />Methods<br />An analytic study with a cross-sectional approach was conducted involving 251 HIV/AIDS patients who had received first-line antiretrovirals over six months. BMI, clinical staging according to WHO and CD4 + were collected. Multiple linear regression was used to evaluate the relationship between BMI, clinical stage and CD4+.<br /><br />Results<br />Among the enrolled patients, the median age was 36 years, 135 (55%) of the patients was female, 102 (40.6%) was overweight/obese, 161 (64.1%) was in stage 3 of the disease, and the median CD4+ count was 389 cells/mm3. Multiple linear regression test showed two variables with a significant effect on CD4+ count, namely BMI (B=69.247; 95 % CI : 42.886-95.608) and clinical stage (B=61.590; 28.910-94.270). BMI was the most influencing factor for CD4+ count (β=0.307) compared to clinical stage (β=0.216). <br /><br />Conclusions<br />Body mass index was the most influencing factor for CD4 + counts of HIV/AIDS patients. Regular ART can increase CD4+ counts and maintain the health of HIV/AIDS patients.

scholarly journals Effect of Isoniazid Preventive Therapy on the Incidence of Tuberculosis among Seropositive Children Attending HIV/AIDS Care in Two General Hospitals, Northwest Ethiopia, 2021

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Fassikaw Kebede ◽  
Birhanu Kebede ◽  
Tsehay Kebede ◽  
Melaku Agmasu
Keyword(s):  
Cox Regression ◽  
Data Entry ◽  
Concomitant Administration ◽  
Preventive Therapy ◽  
Northwest Ethiopia ◽  
Isoniazid Preventive Therapy ◽  
Categorical Variables ◽  
P Value ◽  
Human Immune Deficiency Virus

The human immune deficiency virus (HIV) is the strongest risk factor for the incidence of tuberculosis (TB) by way of reactivation of latent or new infection. The provision of isoniazid preventive therapy (IPT) is one of the public health interventions for the prevention of TB. To date, there have been limited clinical data regarding the effectiveness of isoniazid preventive therapy (IPT) on TB incidence. This study aimed to assess the effect of isoniazid preventive therapy on the incidence of tuberculosis for seropositive children in Northwest Ethiopia. Methods. A facility-based retrospective follow-up was employed for reviewing 421 files from 1 January 2015 up to 30 December 2019. EpiData version 3.2 and Stata/14 software were used for data entry and analysis, respectively. Categorical variables at bivariable Cox regression were assessed for candidates transferred at P value <0.25 for multivariable Cox regression to claiming predictors associated with TB incidence rate at 95% CI at P < 0.005 . Result. The overall incidence of TB was found to be 4.99 cases per 100 person-years at 95% CI (3.89–6.53). Missed IPT (AHR = 7.45, 95% CI: 2.96, 18.74, P < 0.001 ), missed cotrimoxazole preventive therapy (CPT) (AHR = 2.4, 95% CI: 1.84–4.74, P < 0.022 ), age ≥ 11 years (AHR = 4.2, 95% CI: 1.04–7.03, P < 0.048 ), MUAC ≤ 11.5 cm (AHR = 4.36, 95% CI: 1.97–9.97, P < 0.001 ), WHO stages III and IV (AHR = 2.04, 95% CI: 1.12–3.74, P < 0.022 ), and CD4 count ≤100 cells/μl (AHR = 3.96, 95% CI: 1.52–10.34, P < 0.005 ) were significantly associated with TB incidence. Conclusion. Concomitant administration of ART with IPT had demoted more than ninety-six percent of new TB incidences for this report. Undertaking in-depth TB screening and frequent follow-up among all these children is critical in order to prevent and control tuberculosis.

Sign in / Sign up

Export Citation Format

Share Document