scholarly journals Oxytocin Receptor Gene, Childhood Maltreatment and Borderline Personality Disorder among Male Inmates in China

2019 ◽  
Author(s):  
Min Zhang ◽  
Na Liu ◽  
Haocheng Chen ◽  
Ning Zhang
Keyword(s):  
Sexual Abuse ◽  
Borderline Personality Disorder ◽  
High Risk ◽  
Personality Disorder ◽  
Physical Abuse ◽  
Childhood Maltreatment ◽  
Oxytocin Receptor ◽  
Borderline Personality ◽  
Genotype Frequency ◽  
Male Inmates

Abstract Background: Borderline personality disorder (BPD) is caused by a variety of biological and environmental factors. Accumulating evidence suggests that childhood maltreatment is a risk environmental factor in the development of BPD, but research on the genetic pathology of BPD is still in its early stages, and very little is known about the oxytocin receptor (OXTR) gene. The purpose of this study is to further explore the interactive effects between OXTR gene polymorphisms and childhood maltreatment on BPD risk. Methods: Among the 1804 male inmates, 765 inmates with high risk were included in this study. Childhood maltreatment, BPD, antisocial personality disorder (ASPD) and impulsivity were measured by self-reported questionnaires. Peripheral venous blood was collected for the genotype test. Results: Analyses revealed that the BP group had higher rs53576 AA genotype frequency and rs237987 AA genotype frequency than the non-BP group. Total childhood maltreatment score, emotional abuse and neglect could positively predict BPD risk. Among the high-risk samples, rs53576 GG genotype carriers had higher BPD scores at higher levels of physical abuse and sexual abuse and had lower BPD scores at lower levels of physical abuse and sexual abuse. Conclusions: The findings suggest that the interaction between OXTR gene variations and childhood maltreatment is an important mechanism for the development of BPD. The moderating role of the OXTR gene provides evidence for gene plasticity.

scholarly journals Oxytocin Receptor Gene, Childhood Maltreatment and Borderline Personality Disorder Features among Male Inmates in China

2020 ◽  
Author(s):  
Min Zhang ◽  
Na Liu ◽  
Haocheng Chen ◽  
Ning Zhang
Keyword(s):  
Sexual Abuse ◽  
Borderline Personality Disorder ◽  
High Risk ◽  
Personality Disorder ◽  
Antisocial Personality Disorder ◽  
Childhood Maltreatment ◽  
Oxytocin Receptor ◽  
Borderline Personality ◽  
Antisocial Personality ◽  
Male Inmates

Abstract Background: Borderline personality disorder (BPD) is caused by a variety of biological and environmental factors. Accumulating evidence suggests that childhood maltreatment is a risk environmental factor in the development of BPD, but research on the genetic pathology of BPD is still in its early stages, and very little is known about the oxytocin receptor (OXTR) gene. The purpose of this study is to further explore the interactive effects between OXTR gene polymorphisms and childhood maltreatment on BPD risk. Methods: Among the 1804 male inmates, 765 inmates who had BPD or antisocial personality disorder (ASPD) or highly impulsive or violent crime were considered as high-risk inmates and included in this study. Childhood maltreatment, BPD, antisocial personality disorder (ASPD) and impulsivity were measured by self-reported questionnaires. Peripheral venous blood was collected for the genotype test. Results: Analyses revealed that the BP group (inmates with BPD features) had higher rs53576 AA genotype frequency and rs237987 AA genotype frequency than the non-BP group, while the statistical significances were lost after Bonferroni correction. Total childhood maltreatment score, emotional abuse and neglect could positively predict BPD risk. Among the high-risk samples, rs53576 GG genotype carriers had higher BPD scores at higher levels of physical abuse and sexual abuse and had lower BPD scores at lower levels of physical abuse and sexual abuse. Conclusions: The findings suggest that the interaction between OXTR gene variations and childhood maltreatment is an important mechanism for the development of BPD. The moderating role of the OXTR gene provides evidence for gene plasticity.

scholarly journals Oxytocin Receptor Gene, Childhood Maltreatment and Borderline Personality Disorder among Male Inmates in China

2019 ◽  
Author(s):  
Min Zhang ◽  
Na Liu ◽  
Haocheng Chen ◽  
Ning Zhang
Keyword(s):  
Sexual Abuse ◽  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Physical Abuse ◽  
Childhood Maltreatment ◽  
Emotional Abuse ◽  
Receptor Gene ◽  
Oxytocin Receptor ◽  
Borderline Personality ◽  
Genotype Frequency

Abstract Background Borderline personality disorder (BPD) is caused by a variety of biological and environmental factors. Accumulating evidence suggests that childhood maltreatment is a risk environmental factor in the development of BPD, but research on the genetic pathology of BPD is still in its early stages, and very little is known about the oxytocin receptor (OXTR) gene. The purpose of this study is to further explore the interaction between OXTR gene polymorphism and childhood maltreatment in BPD. Methods A total of 1804 prison inmates and 196 normal controls participated in this study. Childhood maltreatment was measured by a self-reported questionnaire, as was BPD. Venous blood was collected for the genotype test. Results Analyses revealed that the BP group had higher rs53576 AA genotype frequency and rs237987 AA genotype frequency than the non-BP group. Childhood maltreatment and its dimension could positively predict BPD risk. Among the prison samples, rs53576 GG genotype carriers had higher BPD scores at higher levels of emotional abuse, physical abuse and sexual abuse and lower BPD scores at lower levels of physical abuse and sexual abuse. Conclusions The finding suggests that the interaction between childhood maltreatment and OXTR gene variations is an important mechanism for the development of BPD. The moderating role of the OXTR gene provides evidence for gene plasticity.

scholarly journals Childhood abuse and borderline personality disorder features in Chinese undergraduates: the role of self-esteem and resilience

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Guo-Die Xie ◽  
Jun-Jie Chang ◽  
Meng-Yuan Yuan ◽  
Geng-Fu Wang ◽  
Yang He ◽  
...  
Keyword(s):  
Sexual Abuse ◽  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Physical Abuse ◽  
Childhood Abuse ◽  
Emotional Abuse ◽  
Self Esteem ◽  
Borderline Personality ◽  
Mediating Role

Abstract Background Although childhood abuse is considered to be related to borderline personality disorder (BPD), few studies have elaborated on the mediating role of self-esteem and resilience in it. Thus, the present study aimed to explore the potential mediating role of resilience and self-esteem between childhood abuse and BPD. Methods This cross-sectional study was conducted with 4034 college students in Anhui Province, China. Participants were asked to complete Chinese versions of the following instruments: Childhood Trauma Questionnaire–Short Form (CTQ-SF), Mclean Screening Instrument for Borderline Personality Disorder (MSI-BPD), Connor-Davidson Resilience Scale (CD-RISC), and Rosenberg Self-Esteem Scale (RSES). Structural equation modeling (SEM) was used to test the mediation effects. Results Resilience and self-esteem were found to be mediators of all three types of childhood abuse (emotional abuse, physical abuse and sexual abuse) when the types were examined separately; however, when all three types of childhood abuse were entered into the model simultaneously, neither the indirect effects nor direct effects of physical abuse or sexual abuse were found to be significant, only the association between emotional abuse and BPD features was partially mediated by resilience and self-esteem. Conclusions Self-esteem and resilience mediate the links between childhood abuse and BPD features, and emotional abuse is uniquely associated with BPD features.

scholarly journals Childhood maltreatment, personality vulnerability profiles, and borderline personality disorder symptoms in adolescents

2021 ◽  
pp. 1-14
Author(s):  
Daniela Marchetti ◽  
Pasquale Musso ◽  
Maria Cristina Verrocchio ◽  
Giovanna Manna ◽  
Daniel C. Kopala-Sibley ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Childhood Maltreatment ◽  
Significant Risk ◽  
Borderline Personality ◽  
Personality Profiles ◽  
Childhood Experiences ◽  
Mediation Analyses ◽  
Personality Vulnerability ◽  
Personality Vulnerabilities

Abstract Adverse childhood experiences are significant risk factors in the development of adolescent borderline personality disorder symptoms (BPDs). Theorists have posited that two personality vulnerabilities factors, self-criticism and dependency, may inform our understanding of this relationship. However, no research has examined the associations between early negative experiences, personality vulnerabilities, and adolescent BPDs. The current study aimed to identify profiles of dependency and self-criticism to examine the associations of these profiles with cumulative forms of childhood maltreatment (CM) and BPDs as well as to explore the mediating and moderating role of vulnerable personality profiles in the relationship between cumulative CM and BPDs. Two hundred and forty-one nonclinical and clinical adolescents participated in the study (Mage = 16.37, SD = 1.84). The findings indicated three different profiles: average dependent profile, dependent and self-critical profile, and self-critical profile. Individuals in the average dependent profile presented lower levels of CM and BPDs. Mediation analyses showed that relative to the average dependent profile, a higher cumulative CM history predicted a higher probability of belonging in the dependent and self-critical profile or the self-critical profile and, in turn, this was associated with higher levels of BPDs. No moderating effects of profiles of dependency and self-criticism were found.

scholarly journals Gyermekkori traumatizáció, disszociáció és szándékos fizikai önsértő viselkedés borderline személyiségzavarban

2017 ◽  
Vol 158 (19) ◽  
pp. 740-747 ◽  
Author(s):  
Katalin Merza ◽  
János Harmatta ◽  
Gábor Papp ◽  
Ildikó Kuritárné Szabó
Keyword(s):  
Sexual Abuse ◽  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Significant Role ◽  
Borderline Personality ◽  
Cumulative Trauma ◽  
Self Injury ◽  
Borderline Patients ◽  
Trauma Score ◽  
Nonsuicidal Self Injury

Abstract: Introduction: Childhood traumatization plays a significant role in the etiology of borderline personality disorder. Studies found a significant association between childhood traumatization, dissociation, and nonsuicidal self-injurious behavior. Aim: The aim of our study was to assess dissociation and nonsuicidal self-injury among borderline inpatients and to reveal the association between childhood traumatization, dissociation, and self-injurious behavior. Method: The sample consisted of 80 borderline inpatients and 73 depressed control patients. Childhood traumatization, dissociation and self-injurious behavior were assessed by questionnaires. Results: Borderline patients reported severe and multiplex childhood traumatization. Cumulative trauma score and sexual abuse were the strongest predictors of dissociation. Furthermore, we have found that cumulative trauma score and dissociation were highly predictive of self-injurious behavior. Conclusion: Our results suggest that self-injurious behavior and dissociation in borderline patients can be regarded as indicators of childhood traumatization. Orv Hetil. 2017; 158(19): 740–747.

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