Risk factors of nosocomial infection after cardiac surgery in children with congenital heart disease
Abstract Background: The aim of our study was to analyze the risk factors of nosocomial infection after cardiac surgery in children with congenital heart disease (CHD). Methods: We performed a retrospective cohort study, and children with CHD who underwent open-heart surgeries at Shanghai Children’s Medical Center from January 1, 2012 to December 31, 2018 were included. The baseline characteristics of these patients of different ages, including neonates (0-1 months old), infants (1-12 months old) and children (1-10 years old), were analyzed, and the association of risk factors with postoperative nosocomial infection were assessed. Results: A total of 11937 subjects were included in the study. The overall nosocomial infection rate was 11.10%. Nosocomial infection rates in neonates, infants, and children with congenital heart disease were 25.41%, 15.78%, and 5.31%, respectively. Multivariate logistic regression analysis found age (OR 0.804, 95%CI: 0.776-0.834; P<0.001), STS risk grade (OR 1.308, 95%CI: 1.203-1.423; P<0.001), body mass index (BMI)