scholarly journals Better pulmonary function is associated with greater handgrip strength in a healthy Chinese Han population

2020 ◽  
Author(s):  
Liangmei Chen ◽  
Xiaomin Liu ◽  
Qian Wang ◽  
Linpei Jia ◽  
Kangkang Song ◽  
...  
Keyword(s):  
Linear Regression ◽  
Pulmonary Function ◽  
Vital Capacity ◽  
Handgrip Strength ◽  
Multivariate Linear Regression ◽  
Chinese Han Population ◽  
Categorical Variables ◽  
Chinese Han ◽  
Han Population ◽  
Healthy Chinese

Abstract Background: Handgrip strength (HGS) has been widely studied in clinical and epidemiological settings, but the relationship between HGS and pulmonary function is still controversial. This study analyzed pulmonary function and HGS stratified by sex and age in a healthy Chinese Han population, as well as the associations between HGS and pulmonary function parameters. Methods: HGS was measured by a Jamar dynamometer and pulmonary function was tested using a portable spirometer. Frequencies and variables are presented as percentages and means ± standard deviations, respectively. Chi-square tests were used for comparisons of categorical variables, and Student’s t-tests or Mann–Whitney U-tests were used for continuous variables. Pearson correlation and multivariate linear regression models were employed to explore the relationships between HGS and parameters of pulmonary function. The statistical significance was set at p <0.01. Results: Cross-sectional data were available for 1519 subjects (59.0% females, 57.9±13.1 years old). Males had higher average HGS than females (40.2 vs 25.0 kg, p <0.01 ), as well as better pulmonary function. Both HGS and pulmonary function parameters were significantly inversely correlated with age (r=-0.30, p < 0.01). Maximum value of vital capacity, forced expiratory volume in 3 second and forced vital capacity were strongly correlated with HGS among the pulmonary function indices (r=0.72, 0.70 and 0.69, respectively, p <0.001). In multivariate linear regression analysis, HGS and height were positively correlated, while age and pulse pressure were negatively correlated with HGS. Conclusions: Both pulmonary function and HGS were inversely correlated with age, and better pulmonary function was associated with greater handgrip strength.

scholarly journals Better pulmonary function is associated with greater handgrip strength in a healthy Chinese Han population

2020 ◽  
Author(s):  
Liangmei Chen ◽  
Xiaomin Liu ◽  
Qian Wang ◽  
Linpei Jia ◽  
Kangkang Song ◽  
...  
Keyword(s):  
Linear Regression ◽  
Pulmonary Function ◽  
Vital Capacity ◽  
Handgrip Strength ◽  
Correlation Coefficients ◽  
Multivariate Linear Regression ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Healthy Chinese

Abstract Background: Handgrip strength (HGS) has been widely studied in clinical and epidemiological settings, but the relationship between HGS and pulmonary function is still controversial. This study analysed pulmonary function and HGS stratified by sex and age in a healthy Chinese Han population, as well as the associations between HGS and pulmonary function parameters. Methods: HGS was measured by a Jamar dynamometer and pulmonary function was tested using a portable spirometer. Frequencies and variables are presented as percentages and means ± standard deviations, respectively. Chi-square tests were used for comparisons of categorical variables, and Student’s t-tests or Mann–Whitney U-tests were used for continuous variables. Pearson's correlation coefficients were used to analyse the normally distributed variables, and Spearman correlation coefficients were used to analyse the non-normally distributed variables. Multivariate linear regression models were employed to explore the relationships between HGS and parameters of pulmonary function. The statistical significance was set at p <0.01. Results: Cross-sectional data were available for 1519 subjects (59.0% females, 57.9±13.1 years old). Males had higher average HGS than females (40.2 vs. 25.0 kg, p <0.01 ), as well as better pulmonary function. Both HGS and pulmonary function parameters were significantly inversely correlated with age (r ≤ -0.30, p < 0.01). The maximum value of vital capacity (VC max), forced expiratory volume in 3 second (FEV3) and forced vital capacity (FVC) were strongly correlated with HGS among the pulmonary function indices (r=0.72, 0.70 and 0.69, respectively, p <0.001). In the multivariate linear regression analysis, HGS and height were positively correlated, while age and pulse pressure were negatively correlated with HGS. In males, the FVC, VC max and FEV3 increased by 0.02L, 0.023L and 0.03L in per 1 kg increase in HGS, respectively. The HGS coefficients for females were smaller than those for males. Conclusions: Both pulmonary function and HGS were inversely correlated with age, and better pulmonary function was associated with greater handgrip strength.

scholarly journals Better pulmonary function is associated with greater handgrip strength in a healthy Chinese Han population

2020 ◽  
Author(s):  
Liangmei Chen ◽  
Xiaomin Liu ◽  
Qian Wang ◽  
Linpei Jia ◽  
Kangkang Song ◽  
...  
Keyword(s):  
Linear Regression ◽  
Correlation Analysis ◽  
Pulmonary Function ◽  
Vital Capacity ◽  
Handgrip Strength ◽  
Multivariate Linear Regression ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Healthy Chinese

Abstract Background: Handgrip strength (HGS) has been widely studied in clinical and epidemiological settings, but the relationship between HGS and pulmonary function is still controversial. This study analyzed pulmonary function and HGS stratified by sex and age in a healthy Chinese Han population, as well as the associations between HGS and pulmonary function parameters. Methods: HGS was measured by a Jamar dynamometer and pulmonary function was tested using a portable spirometer. Frequencies and variables are presented as percentages and means ± standard deviations, respectively. Chi-square tests were used for comparisons of categorical variables, and Student’s t-tests or Mann–Whitney U-tests were used for continuous variables. Pearson correlation analysis was used between normally distributed variables, and Spearman correlation analysis was used for non-normally distributed variables. Multivariate linear regression models were employed to explore the relationships between HGS and parameters of pulmonary function. The statistical significance was set at p <0.01. Results: Cross-sectional data were available for 1519 subjects (59.0% females, 57.9±13.1 years old). Males had higher average HGS than females (40.2 vs 25.0 kg, p <0.01 ), as well as better pulmonary function. Both HGS and pulmonary function parameters were significantly inversely correlated with age (r ≤ -0.30, p < 0.01). Maximum value of vital capacity (VC max), forced expiratory volume in 3 second (FEV3) and forced vital capacity (FVC) were strongly correlated with HGS among the pulmonary function indices (r=0.72, 0.70 and 0.69, respectively, p <0.001). In multivariate linear regression analysis, HGS and height were positively correlated, while age and pulse pressure were negatively correlated with HGS. In male, FVC, VC max and FEV3 increased by 0.02L, 0.023L and 0.03L in per 1 kg increase in HGS, respectively. The coefficients of HGS in female was smaller than those in male. Conclusions: Both pulmonary function and HGS were inversely correlated with age, and better pulmonary function was associated with greater handgrip strength.

scholarly journals Better pulmonary function is associated with greater handgrip strength in a healthy Chinese Han population

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Liangmei Chen ◽  
Xiaomin Liu ◽  
Qian Wang ◽  
Linpei Jia ◽  
Kangkang Song ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Handgrip Strength ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Healthy Chinese

An Association Study on the Polymorphisms of Dopaminergic Genes with Working Memory in a Healthy Chinese Han Population

2012 ◽  
Vol 32 (6) ◽  
pp. 1011-1019 ◽  
Author(s):  
Pingyuan Gong ◽  
Hang Zhang ◽  
Wanyu Chi ◽  
Wanhua Ge ◽  
Kejin Zhang ◽  
...  
Keyword(s):  
Working Memory ◽  
Association Study ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Healthy Chinese ◽  
Dopaminergic Genes

scholarly journals Association of handgrip strength with the prevalence of hypertension in a Chinese Han population

2019 ◽  
Vol 5 (2) ◽  
pp. 113-121 ◽  
Author(s):  
Manthar Ali Mallah ◽  
Min Liu ◽  
Yu Liu ◽  
Hai-Feng Xu ◽  
Xiao-Jun Wu ◽  
...  
Keyword(s):  
Handgrip Strength ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Age- and Sex-Specific Reference Intervals for Myocardial Enzyme Activity in Healthy Chinese Han Population Aged 1∼<18 years

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Wenjia Guo ◽  
Qi Zhou ◽  
Yanan Jia ◽  
Jiancheng Xu
Keyword(s):  
Enzyme Activity ◽  
Children And Adolescents ◽  
Reference Intervals ◽  
Integrated System ◽  
Chinese Han Population ◽  
Specific Reference ◽  
Chinese Han ◽  
Han Population ◽  
Healthy Chinese ◽  
Age And Sex

Age- and sex-specific reference intervals (RIs) for myocardial enzyme activity of children and adolescents are not available in China. Our study aimed to establish age- and gender-related RIs for AST, LDH, CK, and CKMB activity in healthy Chinese Han population aged 1∼<18 years. Healthy Han children and adolescents (n = 6322, 1∼<18 years old) were assessed from completed questionnaires and defined criteria from communities and schools in 5 administrative districts of Jilin Province from September 2017 to December 2018. Measurements of AST, LDH, CK, and CKMB activity were performed on the VITROS 5600 Integrated System. Percentiles of enzyme activity were completed by LMS. RIs were established by Medcalc according to the EP28-A3c guidelines issued by the Clinical and Laboratory Standards Institute. AST declined rapidly during 1∼<6 years and had been subsided during 11∼<18 years, though LDH decreased at a steady rate. CK activity stabilized while CKMB showed a downward trend. Sex differences started after age 12 when males presented higher results. There were significant differences comparing with domestic and other countries’ experiments which applied similar methodologies. Enzymes were associated with age and sex, while age had greater impact. We established age- and sex-specific RIs of serum AST, LDH, CK, and CKMB activities for Chinese children and adolescents using the VITROS 5600 Integrated System for the first time. These data will lay the groundwork for the next horizon in pediatric RIs as well as improve test result interpretation for pediatric illness.

scholarly journals Genotype Distribution of CNDP1 Polymorphisms in the Healthy Chinese Han Population: Association with HbA1c and Fasting Blood Glucose

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Shiqi Zhang ◽  
Juan Xu ◽  
Di Cui ◽  
Shujuan Jiang ◽  
Xin Xu ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Serum Glucose ◽  
Chinese Han Population ◽  
Metabolic Parameters ◽  
Genotype Distribution ◽  
Chinese Han ◽  
Allele Distribution ◽  
Han Population ◽  
Healthy Chinese

We have previously reported that the CNDP1 (CTG)5 allele affords protection against diabetic nephropathy (DN) in patients with Type 2 diabetes (T2DM) of Caucasian origin. Because the incidence of ESRD attributable to both Type 1 diabetes (T1DM) and T2DM is higher among South Asian than Caucasian people, the present study assessed relevant CNDP1 polymorphisms and their association with metabolic parameters in the Chinese Han population. To this end, the (CTG)n allele distribution along with 5 relevant SNPs in the CNDP1 gene, previously reported to be associated with DN in non (CTG)5 carriers of Afro-American ethnicity, were determined in 663 healthy individuals. The (CTG)6 homozygous genotype was the most prevalent (84.5%) genotype in the Chinese Han population. The (CTG)5 and (CTG)4 alleles were present in a small minority of individuals accounting for 15.2% and 0.3% of genotypes with at least one (CTG)5 or one (CTG)4 allele, respectively. Only 0.5% of individuals carried the homozygous (CTG)5 genotype and individuals carrying the homozygous (CTG)4 genotype were not found. The minor allele frequencies (MAFs) of the 5 SNP were 0.197 (C allele for rs4892247), 0.0855 (C allele for rs62099905), 0.085 (G allele for rs62099906), 0.066 (T allele for rs62099907), and 0.18 (A allele for rs72979715). All the SNPs except rs4892247 genotypes were in the Hardy-Weinberg equilibrium. Neither the (CTG)n polymorphism nor the latter three SNPs reached significance when compared with different metabolic parameters. In contrast, individuals with the TT genotype of rs62099905 presented lower fasting blood glucose but higher HbA1c levels. In conclusion, the rs62099905 in the CNDP1 gene is associated with serum glucose levels in the healthy Chinese Han population, while for the CNDP1 (CTG)n polymorphism, no association with serological parameters was found.

scholarly journals Better pulmonary function is associated with increased handgrip strength in a healthy Chinese Han population

2019 ◽  
Author(s):  
Liangmei Chen ◽  
Xiaomin Liu ◽  
Qian Wang ◽  
Linpei Jia ◽  
Kangkang Song ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Pulmonary Function ◽  
Vital Capacity ◽  
Handgrip Strength ◽  
Linear Regression Analysis ◽  
The Elderly ◽  
Multiple Linear Regression Analysis ◽  
Forced Expiratory Volume ◽  
Chinese Han ◽  
The Relationship

Abstract Background: The association between handgrip strength (HGS) and pulmonary function is still controversial, and this relationship has not yet been established among the healthy Chinese Han population.Methods: Data from 1519 healthy Han community dwellers in Beijing were analysed. Subjects were divided into two groups by age: the younger group (<60 years) and the elderly group (≥60 years). Bivariate correlation tests were run between parameters, and variables with a correlation coefficient ǀrǀ≥0.30 and p<0.01 were considered to be significantly correlated. Multiple linear regression analysis was used to adjust covariates in the relationship between HGS and pulmonary function.Results: The study included 623 males and 896 females. The values of HGS were greater in males than in females (40.2 kg vs 25.0 kg, p<0.01) and greater in the younger group than in the elderly group (33.3 kg vs 27.6 kg, p<0.01). HGS and parameters of pulmonary function were highly negatively correlated with age, especially forced expiratory volume in 1 second (r=-0.55, p<0.01), forced expiratory volume in 2 second (r=-0.53, p<0.01) and forced vital capacity (FVC) (r=-0.50, p<0.01). Parameters of pulmonary function were positively associated with HGS, especially the maximum value of vital capacity (VC max) (r=-0.72, p<0.01), forced expiratory volume in 3 second (FEV 3) (r=0.70, p<0.01) and FVC (r=0.69, p<0.01). Therefore, we selected VC max, FEV 3 and FVC as three representative parameters to analyse the relationship between HGS and pulmonary function. In the relationship between HGS and pulmonary function, in addition to gender and age, there were other covariates: height, pulse pressure and systolic blood pressure. After adjusting covariates in the multiple linear regression analysis, the standardized coefficients of HGS on VC max were 0.254 in males and 0.175 in females, and the standardized coefficients of HGS on FVC were 0.225 in males and 0.182 in females.Conclusions: Pulmonary function and HGS were both declined with age. HGS was an independent factor that affected pulmonary function, apart from age. Training in HGS may help to improve pulmonary function in healthy people.

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