Effect of BDNF Val66Met Polymorphism on Digital Working Memory and Spatial Localization in a Healthy Chinese Han Population

Abstract Background: Handgrip strength (HGS) has been widely studied in clinical and epidemiological settings, but the relationship between HGS and pulmonary function is still controversial. This study analyzed pulmonary function and HGS stratified by sex and age in a healthy Chinese Han population, as well as the associations between HGS and pulmonary function parameters. Methods: HGS was measured by a Jamar dynamometer and pulmonary function was tested using a portable spirometer. Frequencies and variables are presented as percentages and means ± standard deviations, respectively. Chi-square tests were used for comparisons of categorical variables, and Student’s t-tests or Mann–Whitney U-tests were used for continuous variables. Pearson correlation and multivariate linear regression models were employed to explore the relationships between HGS and parameters of pulmonary function. The statistical significance was set at p <0.01. Results: Cross-sectional data were available for 1519 subjects (59.0% females, 57.9±13.1 years old). Males had higher average HGS than females (40.2 vs 25.0 kg, p <0.01 ), as well as better pulmonary function. Both HGS and pulmonary function parameters were significantly inversely correlated with age (r=-0.30, p < 0.01). Maximum value of vital capacity, forced expiratory volume in 3 second and forced vital capacity were strongly correlated with HGS among the pulmonary function indices (r=0.72, 0.70 and 0.69, respectively, p <0.001). In multivariate linear regression analysis, HGS and height were positively correlated, while age and pulse pressure were negatively correlated with HGS. Conclusions: Both pulmonary function and HGS were inversely correlated with age, and better pulmonary function was associated with greater handgrip strength.

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Better pulmonary function is associated with greater handgrip strength in a healthy Chinese Han population

10.21203/rs.2.14697/v4 ◽

2020 ◽

Author(s):

Liangmei Chen ◽

Xiaomin Liu ◽

Qian Wang ◽

Linpei Jia ◽

Kangkang Song ◽

...

Keyword(s):

Linear Regression ◽

Pulmonary Function ◽

Vital Capacity ◽

Handgrip Strength ◽

Correlation Coefficients ◽

Multivariate Linear Regression ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population ◽

Healthy Chinese

Abstract Background: Handgrip strength (HGS) has been widely studied in clinical and epidemiological settings, but the relationship between HGS and pulmonary function is still controversial. This study analysed pulmonary function and HGS stratified by sex and age in a healthy Chinese Han population, as well as the associations between HGS and pulmonary function parameters. Methods: HGS was measured by a Jamar dynamometer and pulmonary function was tested using a portable spirometer. Frequencies and variables are presented as percentages and means ± standard deviations, respectively. Chi-square tests were used for comparisons of categorical variables, and Student’s t-tests or Mann–Whitney U-tests were used for continuous variables. Pearson's correlation coefficients were used to analyse the normally distributed variables, and Spearman correlation coefficients were used to analyse the non-normally distributed variables. Multivariate linear regression models were employed to explore the relationships between HGS and parameters of pulmonary function. The statistical significance was set at p <0.01. Results: Cross-sectional data were available for 1519 subjects (59.0% females, 57.9±13.1 years old). Males had higher average HGS than females (40.2 vs. 25.0 kg, p <0.01 ), as well as better pulmonary function. Both HGS and pulmonary function parameters were significantly inversely correlated with age (r ≤ -0.30, p < 0.01). The maximum value of vital capacity (VC max), forced expiratory volume in 3 second (FEV3) and forced vital capacity (FVC) were strongly correlated with HGS among the pulmonary function indices (r=0.72, 0.70 and 0.69, respectively, p <0.001). In the multivariate linear regression analysis, HGS and height were positively correlated, while age and pulse pressure were negatively correlated with HGS. In males, the FVC, VC max and FEV3 increased by 0.02L, 0.023L and 0.03L in per 1 kg increase in HGS, respectively. The HGS coefficients for females were smaller than those for males. Conclusions: Both pulmonary function and HGS were inversely correlated with age, and better pulmonary function was associated with greater handgrip strength.

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Lack of Association between the BDNF Gene Val66Met Polymorphism and Alzheimer Disease in a Chinese Han Population

Neuropsychobiology ◽

10.1159/000106473 ◽

2007 ◽

Vol 55 (3-4) ◽

pp. 151-155 ◽

Cited By ~ 15

Author(s):

Xiao-ming He ◽

Zhen-xin Zhang ◽

Jun-wu Zhang ◽

Yong-tao Zhou ◽

Mou-ni Tang ◽

...

Keyword(s):

Alzheimer Disease ◽

Chinese Han Population ◽

Bdnf Gene ◽

Chinese Han ◽

Val66met Polymorphism ◽

Han Population

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BDNF Val66Met polymorphism and plasma levels in Chinese Han population with obsessive-compulsive disorder and generalized anxiety disorder

Journal of Affective Disorders ◽

10.1016/j.jad.2015.07.023 ◽

2015 ◽

Vol 186 ◽

pp. 7-12 ◽

Cited By ~ 24

Author(s):

Yuan Wang ◽

Haiyin Zhang ◽

Ying Li ◽

Zhen Wang ◽

Qing Fan ◽

...

Keyword(s):

Anxiety Disorder ◽

Generalized Anxiety Disorder ◽

Plasma Levels ◽

Generalized Anxiety ◽

Obsessive Compulsive ◽

Chinese Han ◽

Val66met Polymorphism ◽

Han Population ◽

Compulsive Disorder ◽

Bdnf Val66met Polymorphism

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Age- and Sex-Specific Reference Intervals for Myocardial Enzyme Activity in Healthy Chinese Han Population Aged 1∼<18 years

BioMed Research International ◽

10.1155/2019/2018598 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Wenjia Guo ◽

Qi Zhou ◽

Yanan Jia ◽

Jiancheng Xu

Keyword(s):

Enzyme Activity ◽

Children And Adolescents ◽

Reference Intervals ◽

Integrated System ◽

Chinese Han Population ◽

Specific Reference ◽

Chinese Han ◽

Han Population ◽

Healthy Chinese ◽

Age And Sex

Age- and sex-specific reference intervals (RIs) for myocardial enzyme activity of children and adolescents are not available in China. Our study aimed to establish age- and gender-related RIs for AST, LDH, CK, and CKMB activity in healthy Chinese Han population aged 1∼<18 years. Healthy Han children and adolescents (n = 6322, 1∼<18 years old) were assessed from completed questionnaires and defined criteria from communities and schools in 5 administrative districts of Jilin Province from September 2017 to December 2018. Measurements of AST, LDH, CK, and CKMB activity were performed on the VITROS 5600 Integrated System. Percentiles of enzyme activity were completed by LMS. RIs were established by Medcalc according to the EP28-A3c guidelines issued by the Clinical and Laboratory Standards Institute. AST declined rapidly during 1∼<6 years and had been subsided during 11∼<18 years, though LDH decreased at a steady rate. CK activity stabilized while CKMB showed a downward trend. Sex differences started after age 12 when males presented higher results. There were significant differences comparing with domestic and other countries’ experiments which applied similar methodologies. Enzymes were associated with age and sex, while age had greater impact. We established age- and sex-specific RIs of serum AST, LDH, CK, and CKMB activities for Chinese children and adolescents using the VITROS 5600 Integrated System for the first time. These data will lay the groundwork for the next horizon in pediatric RIs as well as improve test result interpretation for pediatric illness.

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