scholarly journals Association of ABO blood groups with craniofacial morphology among orthodontic patients of Kathmandu district

2019 ◽  
Author(s):  
Sanjay Prasad Gupta

Abstract The authors have withdrawn this preprint from Research Square

2019 ◽  
Author(s):  
Sanjay Prasad Gupta

Abstract Background: The craniofacial morphology and blood groups both are related to genetic components, hence it can be hypothesized that blood groups have an association with craniofacial morphology. Some studies showed the relationship whereas others could not find any relationship that may be due to geographic diversity of the population. The aim of this study was to find out the relationship between ABO blood groups and craniofacial morphology among orthodontic patients of Kathmandu district. Materials and Methods: In this cross sectional study, a total of 385 participants (age range from 13-45 years) were selected among the orthodontic patients who came for orthodontic treatment in private orthodontic clinics. After obtaining written consent, all the patient’s demographic information were recorded and lateral cephalograms were obtained from the patient’s record. Blood group of all the participants was recorded. Results: The study found that among the total of 385 participants, 162 (42.07%) were male while 223 (57.93%) were female and the mean age was 16.31±4.38 years. Twenty cephalometric parameters depicting craniofacial morphology were digitally analyzed using lateral cephalogram. The prevalence of blood group O patients was highest (32.20%) followed by blood group B (30.64%), blood group A (29.88%) and blood group AB (7.28%). Statistical analysis with one way ANOVA was used for association of numerical data and blood groups that revealed nine out of twenty cephalometric parameters were statistically significant among different blood groups (p<0.05). Tukey post hoc test was done to find out where the significant difference occurs among the groups. Conclusions: The evaluation of the relationship between blood group and craniofacial morphology revealed that blood groups have association with some craniofacial parameters. This suggest, there may be some genetic influence of ABO blood group on craniofacial morphology. Keywords ABO blood groups, Craniofacial morphology, Association, Orthodontic patients


2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Ali H. Ad’hiah ◽  
Risala H. Allami ◽  
Raghdan H. Mohsin ◽  
Maha H. Abdullah ◽  
Ali J. R. AL-Sa’ady ◽  
...  

Abstract Background Susceptibility to the pandemic coronavirus disease 2019 (COVID-19) has recently been associated with ABO blood groups in patients of different ethnicities. This study sought to understand the genetic association of this polymorphic system with risk of disease in Iraqi patients. Two outcomes of COVID-19, recovery and death, were also explored. ABO blood groups were determined in 300 hospitalized COVID-19 Iraqi patients (159 under therapy, 104 recovered, and 37 deceased) and 595 healthy blood donors. The detection kit for 2019 novel coronavirus (2019-nCoV) RNA (PCR-Fluorescence Probing) was used in the diagnosis of disease. Results Mean age was significantly increased in patients compared to controls (49.8 ± 11.7 vs. 28.9 ± 6.6 years; p < 0.001). A similar observation was made in recovered (42.1 ± 10.4 vs. 28.9 ± 6.6 years; p < 0.001) and deceased (53.6 ± 9.7 vs. 28.9 ± 6.6 years; p < 0.001) cases. The mean age was also significantly increased in deceased cases compared to recovered cases (53.6 ± 9.7 vs. 42.1 ± 10.4 years; p < 0.001). There were gender-dependent differences in COVID-19 prevalence. The percentage of COVID-19 was higher in males than in females (all cases: 59.7 vs. 40.3%; recovered cases: 55.8 vs. 44.2%). Such male-gender preponderance was more pronounced in deceased cases (67.6 vs. 32.4%). Logistic regression analysis revealed that groups AB and B + AB were significantly associated with increased risk to develop COVID-19 (OR = 3.10; 95% CI 1.59–6.05; pc = 0.007 and OR = 2.16; 95% CI 1.28–3.63; pc = 0.028, respectively). No ABO-associated risk was observed in recovered cases. On the contrary, groups A (OR = 14.60; 95% CI 2.85–74.88; pc = 0.007), AB (OR = 12.92; 95% CI 2.11–79.29; pc = 0.042), A + AB (OR = 14.67; 95% CI 2.98–72.33; pc = 0.007), and A + B + AB (OR = 9.67; 95% CI 2.02–46.24; pc = 0.035) were associated with increased risk of death in deceased cases. Conclusions The findings of this study suggest that group AB may be a susceptibility biomarker for COVID-19, while group A may be associated with increased risk of death.


Author(s):  
Agnieszka Jankowska ◽  
Joanna Janiszewska-Olszowska ◽  
Katarzyna Grocholewicz

Nose shape, size, and inclination influence facial appearance, but few studies concern the relationship between the nasal profile and craniofacial structures. The objective of this study was to analyze association of nasal cephalometric variables with skeletal structures, age, and sex. Cephalometric and nasal analysis was performed in 386 Polish orthodontic patients (aged 9–25 years). Student t-test and Mann–Whitney test were used to compare quantitative variables and Pearson’s or Spearman’s correlation coefficients—to find correlations. Soft tissue facial convexity angle correlates to Holdaway ratio, ANB (A-Nasion-B), and Wits appraisal. Nasal dorsum axis, nose length, nose depth (1) and nose depth (2), nose hump, lower dorsum convexity, and columella convexity increase with age. Nasal base angle, nasolabial angle, nasomental angle, soft tissue facial convexity and nasal bone angle decrease with age. Nasal base angle and nasomental angle are smaller in females. Thus, a relationship exists between nasal morphology and sagittal jaw configuration. Nasal parameters significantly change with age. Sexual dimorphism characterizes nasal bone angle and nasomental angle.


2015 ◽  
Vol 67 ◽  
pp. 485-489 ◽  
Author(s):  
Julaluk Noiphung ◽  
Kwanrutai Talalak ◽  
Irin Hongwarittorrn ◽  
Naricha Pupinyo ◽  
Pannawich Thirabowonkitphithan ◽  
...  

Blood ◽  
1982 ◽  
Vol 59 (6) ◽  
pp. 1286-1291 ◽  
Author(s):  
H Ludwig ◽  
W Mayr

Abstract An up-dated survey of the information pertaining to the role of genetic factors in susceptibility to multiple myeloma is attempted. Our own results include the HLA-A, B, and C types in 68 patients, the G1m and Km allotypes in 86 patients, and the frequencies of ABO blood groups in 126 patients with multiple myeloma. The allotype G1m(x) was significantly (p less than 0.05) more frequent in the patient group. Since the results in the literature on a possible HLA association have been inconsistent, all relevant available data were combined for an assessment of 379 patients versus 5041 controls. In this comparatively large patient group, the previously reported increase of HLA-4c (HLA-B5 + B18 + Bw35) complex could be confirmed and identified as a weak (RR = 1.7) but significant (p less than 0.05) association of susceptibility to multiple myeloma with HLA-B5. Evaluation of G1m allotypes in the combined sample of 258 patients and 4550 controls and Km in 179 and 2457, respectively yielded no significant differences.


2015 ◽  
Vol 42 (02) ◽  
pp. 112-117 ◽  
Author(s):  
Giuseppe Lippi ◽  
Massimo Franchini

1966 ◽  
Vol 3 (4) ◽  
pp. 274-275 ◽  
Author(s):  
R. R. Strang ◽  
D. Tovi ◽  
J. Lopez

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