RIPK1 Polymorphisms Alter the Susceptibility to Cervical Cancer among the Uyghur population in China

Abstract Background: RIPK1 (receptor-interacting protein kinase-1) plays a role in cancer development, whereas no clear studies focused on the cervical cancer. The objective of this study was to evaluate the relationship between RIPK1 polymorphisms and cervical cancer risk among the Uyghur population. Methods: We performed a case-control study including 342 cervical cancer patients and 498 age-matched healthy controls. Four RIPK1 genetic variants (rs6907943, rs2077681, rs9503400 and rs17548629) were genotyped with Agena MassARRAY platform. The associations between RIPK1 polymorphisms and cervical cancer risk were assessed under Binary logistic regression models. False discovery rate (FDR) was used to improve the results reliability. Results: The results showed rs2077681 was significantly associated with cervical cancer risk under various genetic models (codominant: OR = 3.14, 95% CI = 1.40-7.07, p = 0.006, FDR- p = 0.018; recessive: OR = 3.20, 95% CI = 1.43-7.16, p = 0.005, FDR-0.018). The stratified analysis indicated that the relationships of rs6907946, rs9503400 and rs17548629 with cervical cancer risk were statistically significant in the subgroup of clinical stage ( p < 0.05). Conclusion: Our findings demonstrated that RIPK1 polymorphisms were associated with cervical cancer susceptibility among the Uyghur population in China, and RIPK1 polymorphisms might be involved in the development of cervical cancer.

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RIPK1 Polymorphisms Alter the Susceptibility to Cervical Cancer among the Uyghur population in China

10.21203/rs.2.15722/v1 ◽

2019 ◽

Author(s):

Lili Han ◽

Sulaiya Husaiyin ◽

Chunhua Ma ◽

Mayinuer Niyazi

Keyword(s):

Cervical Cancer ◽

Cancer Risk ◽

Cancer Susceptibility ◽

Interacting Protein ◽

Logistic Regression Models ◽

Cervical Cancer Risk ◽

Codominant Model ◽

Uyghur Population ◽

Stratified Analysis ◽

The Relationship

Abstract Background: RIPK1 (receptor-interacting protein kinase-1) plays a role in cancer development, whereas no clear studies focused on the cervical cancer. The objective of this study was to evaluate the relationship between RIPK1 polymorphisms and cervical cancer risk among the Uyghur population. Methods: We performed a case-control study including 342 cervical cancer patients and 498 age-matched healthy controls. Five RIPK1 genetic variants (rs6907943, rs3736724, rs2077681, rs9503400 and rs17548629) were genotyped with Agena MassARRAY platform. The associations between RIPK1 polymorphisms and cervical cancer risk were assessed under multivariate logistic regression models. Results: The results showed rs3736724 and rs2077681 were significantly associated with cervical cancer risk under various genetic models ( p < 0.05). The stratified analysis indicated that the relationships of rs2077681 and rs17548629 with cervical cancer risk were statistically significant in the subgroups of elderly individuals (age > 43 years) and stage. Additional, rs3736724 decreased the cervical cancer risk among the subjects aged ≤ 43 years in codominant model ( p = 0.043). Rs6907943 and rs9503400 could influence the susceptibility of cervical cancer for the patients with different stage ( p < 0.05). Conclusion: Our findings demonstrated that RIPK1 polymorphisms are associated with cervical cancer susceptibility among the Uyghur population in China, and may be involved in the development of cervical cancer.

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Interleukin 10 Polymorphisms and Cervical Cancer Risk: A Meta-Analysis

International Journal of Gynecological Cancer ◽

10.1097/igc.0b013e318274b1a2 ◽

2013 ◽

Vol 23 (1) ◽

pp. 126-133 ◽

Cited By ~ 21

Author(s):

Jing Ni ◽

Yang Ye ◽

Fang Teng ◽

Qiang Wu

Keyword(s):

Cervical Cancer ◽

Cancer Risk ◽

Fixed Effects ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Interleukin 10 ◽

Random Effects Models ◽

Weinberg Equilibrium ◽

Cervical Cancer Risk ◽

Hardy Weinberg Equilibrium

BackgroundA debate exists about whether interleukin 10 (IL-10) polymorphisms (IL-10−1082G/A and IL-10−592C/A) confer additional risk for cervical cancer. To derive a more precise estimation of the relationship between IL-10 polymorphisms and cervical cancer risk, we conducted a meta-analysis of all available studies relating the −1082G/A and −592C/A polymorphisms of the IL-10 gene to the risk of developing cervical cancer.MethodsEight studies were eligible for IL-10 −1082G/A (1498 cases and 1608 controls), and 5 studies were eligible for IL-10 −592C/A (2396 cases and 1388 controls). Pooled odds ratios (ORs) were appropriately derived from fixed-effects or random-effects models. Subgroup analyses were performed by ethnicity and Hardy-Weinberg equilibrium in the controls.ResultsIn the overall analysis, no significant association between the IL-10−1082G/A polymorphism and the risk of cervical cancer was observed. In the subgroup analysis by ethnicity, IL-10 −1082A allele was associated with decreased cervical cancer susceptibility among whites (A vs G: OR, 0.39; 95% confidence interval [CI], 0.32–0.47). Studies with controls deviated from Hardy-Weinberg equilibrium showed an evident association in dominant model (GA/AA vs GG: OR, 1.73 [95% CI, 1.04–2.89]). On the other hand, with respect to −592C/A polymorphism, significantly elevated cervical cancer risk was found in the overall analysis (A vs C: OR, 1.16 [95% CI, 1.04–1.31]; AA vs CC: OR, 1.36 [95% CI, 1.00–1.84]; CA/AA vs CC: OR, 1.18 [95% CI, 1.01–1.39]; AA vs CC/CA: OR, 1.25 [95% CI, 1.01–1.55]). Stratified analysis indicated that significantly increased risks were also found among Asians in the allelic model (A vs C: OR, 1.23 [95% CI, 1.01–1.49]).ConclusionsInterleukin 10−1082 G/A polymorphism showed no effect on cervical cancer risk in the overall analysis. The genetic polymorphism in IL-10−592C/A is a risk factor for developing cervical cancer, especially for Asians.

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Association of the s1799724 and rs1800629 Polymorphisms of the TNF-α Gene with Susceptibility to Cervical Cancer: a Systematic Review and Meta-Analysis based on 24 Case-Control Studies

Asian Pacific Journal of Cancer Care ◽

10.31557/apjcc.2017.2.2.29 ◽

2017 ◽

Vol 2 (2) ◽

pp. 29

Author(s):

Sedigheh Hamadani ◽

Mahdieh Kamali ◽

Sedigheh Hantoushzadeh ◽

Razieh Sadat Tabatabaee ◽

Hossein Neamatzadeh ◽

...

Keyword(s):

Systematic Review ◽

Cervical Cancer ◽

Cancer Risk ◽

Meta Analysis ◽

Case Control ◽

Genetic Models ◽

Case Control Studies ◽

Cervical Cancer Risk ◽

Tnf Α ◽

Stratified Analysis

Objective: Some studies have recently focused on the association between TNF-α polymorphisms and cervical cancer; however, results have been inconsistent. In order to drive a more precise estimation, the present systematic review and meta-analysis is performed to investigate the relationship of the TNF-α rs1800629 and s1799724 polymorphisms with cervical cancer risk. Methods: An electronic search was conducted on PubMed, Web of Science, and Google scholar databases, for papers that describe the association between TNF-α polymorphisms and cervical cancer risk. Results: A number of 24 case-control studies in 22 publications were identified according to the inclusion criteria. The results showed that rs1800629 polymorphism was significantly associated with the increased cervical cancer risk under four genetic models (A vs. G: OR = 1.277, 95% CI: 1.104-1.477, p = 0.001; AA vs. GG: OR = 1.333, 95% CI: 1.062-1.674, p = 0.013; AG vs. GG: OR = 1.307, 95% CI: 1.064-1.605, p = 0.011; and AA+AG vs. GG: OR = 1.324, 95% CI: 1.104-1.587, p = 0.002). In stratified analysis, there was a significant association between rs1800629 polymorphism and cervical cancer risk in the subgroup of Caucasians and African, but not in Asians. However, no statistically significant association was observed between the s1799724 and cervical cancer risk under all genetic models. Furthermore, stratification by ethnicity indicated no association between the s1799724 and cervical cancer risk.Conclusion: the present meta-analysis suggests that the rs1800629 polymorphism of the TNF-α gene was significantly associated with cervical cancer risk, but not s1799724.

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The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility

Mediators of Inflammation ◽

10.1155/2018/9127146 ◽

2018 ◽

Vol 2018 ◽

pp. 1-11 ◽

Cited By ~ 1

Author(s):

Sijuan Tian ◽

Liping Zhang ◽

Ting Yang ◽

Xing Wei ◽

Li Zhang ◽

...

Keyword(s):

Cervical Cancer ◽

Cancer Risk ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Cochrane Library ◽

Cancer Case ◽

Type Model ◽

Toll Like Receptor ◽

Case Control Studies ◽

Cervical Cancer Risk

This meta-analysis systematically reviews the association between Toll-like receptor 9 polymorphisms and the risk of cervical cancer. Case-control studies focused on the association were collected from the PubMed, Web of Science, Cochrane Library, Embase, MEDLINE, CNKI, VIP, and Wanfang databases from inception to July 2017. We screened the studies and assessed the methodological quality of the included studies and extracted data. A meta-analysis was performed using RevMan 5.3 and Stata 12.0 software. Pooled odds ratios and 95% confidence intervals were employed to evaluate the strength of the associations between Toll-like receptor 9 polymorphisms and cervical cancer risk. A total of 9 studies comprising 3331 cervical cancer patients and 4109 healthy controls met the inclusion criteria. Of these, 8 studies contained information about G2848A (rs352140) and 4 studies contained information about −1486T/C (rs187084). Our results revealed that the associations between rs187084 and cervical cancer risk in the dominant model (p=0.002) and heterozygous model (p=0.002) were significant, with 1.30- and 1.32-fold increases in susceptibility, respectively, compared to that in the wild-type model. However, rs352140 was not related to cervical cancer regardless of whether the subgroup analysis was conducted (p>0.05). In conclusion, there is a significant correlation between rs187084 and cervical cancer risk with the minor C allele increasing the risk of occurrence of cervical cancer. However, rs352140 is not associated with the occurrence of cervical cancer.

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