Interleukin 10 Polymorphisms and Cervical Cancer Risk: A Meta-Analysis

BackgroundA debate exists about whether interleukin 10 (IL-10) polymorphisms (IL-10−1082G/A and IL-10−592C/A) confer additional risk for cervical cancer. To derive a more precise estimation of the relationship between IL-10 polymorphisms and cervical cancer risk, we conducted a meta-analysis of all available studies relating the −1082G/A and −592C/A polymorphisms of the IL-10 gene to the risk of developing cervical cancer.MethodsEight studies were eligible for IL-10 −1082G/A (1498 cases and 1608 controls), and 5 studies were eligible for IL-10 −592C/A (2396 cases and 1388 controls). Pooled odds ratios (ORs) were appropriately derived from fixed-effects or random-effects models. Subgroup analyses were performed by ethnicity and Hardy-Weinberg equilibrium in the controls.ResultsIn the overall analysis, no significant association between the IL-10−1082G/A polymorphism and the risk of cervical cancer was observed. In the subgroup analysis by ethnicity, IL-10 −1082A allele was associated with decreased cervical cancer susceptibility among whites (A vs G: OR, 0.39; 95% confidence interval [CI], 0.32–0.47). Studies with controls deviated from Hardy-Weinberg equilibrium showed an evident association in dominant model (GA/AA vs GG: OR, 1.73 [95% CI, 1.04–2.89]). On the other hand, with respect to −592C/A polymorphism, significantly elevated cervical cancer risk was found in the overall analysis (A vs C: OR, 1.16 [95% CI, 1.04–1.31]; AA vs CC: OR, 1.36 [95% CI, 1.00–1.84]; CA/AA vs CC: OR, 1.18 [95% CI, 1.01–1.39]; AA vs CC/CA: OR, 1.25 [95% CI, 1.01–1.55]). Stratified analysis indicated that significantly increased risks were also found among Asians in the allelic model (A vs C: OR, 1.23 [95% CI, 1.01–1.49]).ConclusionsInterleukin 10−1082 G/A polymorphism showed no effect on cervical cancer risk in the overall analysis. The genetic polymorphism in IL-10−592C/A is a risk factor for developing cervical cancer, especially for Asians.

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Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility

Bioscience Reports ◽

10.1042/bsr20181071 ◽

2018 ◽

Vol 38 (5) ◽

Cited By ~ 2

Author(s):

Hai-Xia Duan ◽

You-Yi Chen ◽

Juan-Zi Shi ◽

Nan-Nan Ren ◽

Xiao-Juan Li

Keyword(s):

Cervical Cancer ◽

Large Scale ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

Cervical Cancer Risk ◽

Hardy Weinberg Equilibrium ◽

The Relationship ◽

Multifunctional Cytokine

Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the etiology of cancer. Several case–control studies have been conducted to assess the association of IL-6 -174G>C (rs1800795) polymorphism with the risk of cervical cancer, yet with conflicting conclusions. To derive a more precise estimation of the relationship, we performed this meta-analysis updated to June 2018. A total of seven original publications were identified covering IL-6 -174G>C (rs1800795) polymorphism. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the relationship strengths. Statistically significant relationship was observed between IL-6 -174G>C polymorphism and cervical cancer risk (OR = 0.61, 95% CI: 0.40–0.94 for GG vs. CC, and OR = 0.77, 95% CI: 0.64–0.93 for G vs. C). Moreover, the significant association was found among Asians (OR = 0.46, 95% CI: 0.29–0.75 for GG vs. CC, and OR = 0.70, 95% CI: 0.57–0.89 for G vs. C); hospital-based subgroup (OR = 0.53, 95% CI: 0.38–0.72 for GG vs. CC, and OR = 0.73, 95% CI: 0.61–0.87 for G vs. C); and Hardy–Weinberg equilibrium ≤0.05 (OR = 0.56, 95% CI: 0.37–0.86 for GG vs. GC, and OR = 0.66, 95% CI: 0.47–0.93 for G vs. C). This meta-analysis showed the evidence that the IL-6 -174G>C polymorphism was a low-penetrance susceptibility variant for cervical cancer. Further large-scale case–control studies are needed to confirm these results.

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Association Between the IL-6 rs1800795 Polymorphism and the Risk of Cervical Cancer: A Meta-Analysis of 1210 Cases and 1525 Controls

Technology in Cancer Research & Treatment ◽

10.1177/1533034616672806 ◽

2016 ◽

Vol 16 (5) ◽

pp. 662-667 ◽

Cited By ~ 7

Author(s):

Haiping Liu ◽

Dan Lyu ◽

Yan Zhang ◽

Lianbing Sheng ◽

Ning Tang

Keyword(s):

Cervical Cancer ◽

Cancer Risk ◽

Interleukin 6 ◽

Fixed Effects ◽

Meta Analysis ◽

Developed Countries ◽

Nucleotide Polymorphisms ◽

Fixed Effects Model ◽

Cervical Cancer Risk ◽

Knowledge Infrastructure

Cervical cancer is the second most common cancer and the third leading cause of cancer-related death among females in less developed countries. Studies have shown that the single-nucleotide polymorphisms of interleukin 6 might be associated with cervical cancer risk. A total of 710 articles from EMBASE, EBSCO, Web of science, PubMed, Springer link, and Chinese National Knowledge Infrastructure databases were reviewed in our study. A meta-analysis on the associations between interleukin 6 rs1800795 polymorphism and cervical cancer risk was carried out by comparison using 5 genetic models. In this systematic review, 5 studies were analyzed. The pooled population included 2735 participants (1210 cases and 1525 controls). The overall odds ratio (G vs C alleles) using fixed-effects model was 0.85 (95% confidence interval 0.75-0.97), P = .02. Our results show that the C genotype of interleukin 6 rs1800795 is associated with higher cervical cancer risk. Our results indicate that interleukin 6 rs1800795 polymorphism might be associated with susceptibility to cervical cancer.

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P21 Ser31Arg Polymorphism and Cervical Cancer Risk: A Meta-Analysis

International Journal of Gynecological Cancer ◽

10.1097/igc.0b013e31820da58b ◽

2011 ◽

Vol 21 (3) ◽

pp. 445-451 ◽

Cited By ~ 5

Author(s):

Ya Li ◽

Fei Liu ◽

Shiqiao Tan ◽

Shangwei Li

Keyword(s):

Cervical Cancer ◽

Fixed Effects ◽

Meta Analysis ◽

Asian Population ◽

Recessive Model ◽

Dominant Model ◽

Fixed Effects Model ◽

Case Control Studies ◽

Weinberg Equilibrium ◽

Hardy Weinberg Equilibrium

BackgroundStudies investigating the association between p21 genetic polymorphism Ser31Arg and cervical cancer (CC) risk report conflicting results. The aim of this study was to quantitatively summarize the evidence for p21 polymorphism and CC risk.MethodsTwo investigators independently searched the MEDLINE, Embase, CNKI, and Chinese Biomedicine databases. Summary odds ratios (ORs) and 95% confidence intervals (CIs) for p21 polymorphism and CC were calculated in a fixed effects model (the Mantel-Haenszel method) and a random effects model (the DerSimonian and Laird method) when appropriate. The pooled ORs were performed for codominant model (Arg/Arg vs Ser/Ser and Arg/Ser vs Ser/Ser), dominant model (Arg/Arg + Arg/Ser vs Ser/Ser), and recessive model (Arg/Arg vs Arg/Ser + Ser/Ser). Subgroup analyses were performed by country, matched controls, and Hardy-Weinberg equilibrium in the controls and study sample size.ResultsThis meta-analysis included 10 case-control studies from an Asian population, which included 1415 CC cases and 1947 controls. Overall, the variant genotypes (Arg/Arg and Arg/Ser) of Ser31Arg were not associated with CC risk, when compared with the wild-type homozygote Ser/Ser (Arg/Arg vs Ser/Ser: OR, 1.30; 95% CI, 0.81-2.08; Arg/Ser vs Ser/Ser: OR, 1.06; 95% CI, 0.72-1.55). Similarly, no associations were found in the dominant and recessive models (dominant model: OR, 1.05; 95% CI, 0.73-1.51; recessive model: OR, 1.28; 95% CI, 0.86-1.90). Stratified analyses also detected no significant association in any subgroup, except among those studies from "other" country and those studies with controls deviated from Hardy-Weinberg equilibrium.ConclusionNo association was found between the p21 polymorphism Arg31Ser and risk of CC among Asians. In the future, additional studies based on white and African American patients should be performed to re-evaluate the association.

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Significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis

Oncotarget ◽

10.18632/oncotarget.24193 ◽

2018 ◽

Vol 9 (15) ◽

pp. 12365-12375 ◽

Cited By ~ 7

Author(s):

Chong Guo ◽

Li Wen ◽

Ju-Kun Song ◽

Weng-Jing Zeng ◽

Chao Dan ◽

...

Keyword(s):

Cervical Cancer ◽

Cancer Risk ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Interleukin 10 ◽

Cervical Cancer Risk

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The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility

Mediators of Inflammation ◽

10.1155/2018/9127146 ◽

2018 ◽

Vol 2018 ◽

pp. 1-11 ◽

Cited By ~ 1

Author(s):

Sijuan Tian ◽

Liping Zhang ◽

Ting Yang ◽

Xing Wei ◽

Li Zhang ◽

...

Keyword(s):

Cervical Cancer ◽

Cancer Risk ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Cochrane Library ◽

Cancer Case ◽

Type Model ◽

Toll Like Receptor ◽

Case Control Studies ◽

Cervical Cancer Risk

This meta-analysis systematically reviews the association between Toll-like receptor 9 polymorphisms and the risk of cervical cancer. Case-control studies focused on the association were collected from the PubMed, Web of Science, Cochrane Library, Embase, MEDLINE, CNKI, VIP, and Wanfang databases from inception to July 2017. We screened the studies and assessed the methodological quality of the included studies and extracted data. A meta-analysis was performed using RevMan 5.3 and Stata 12.0 software. Pooled odds ratios and 95% confidence intervals were employed to evaluate the strength of the associations between Toll-like receptor 9 polymorphisms and cervical cancer risk. A total of 9 studies comprising 3331 cervical cancer patients and 4109 healthy controls met the inclusion criteria. Of these, 8 studies contained information about G2848A (rs352140) and 4 studies contained information about −1486T/C (rs187084). Our results revealed that the associations between rs187084 and cervical cancer risk in the dominant model (p=0.002) and heterozygous model (p=0.002) were significant, with 1.30- and 1.32-fold increases in susceptibility, respectively, compared to that in the wild-type model. However, rs352140 was not related to cervical cancer regardless of whether the subgroup analysis was conducted (p>0.05). In conclusion, there is a significant correlation between rs187084 and cervical cancer risk with the minor C allele increasing the risk of occurrence of cervical cancer. However, rs352140 is not associated with the occurrence of cervical cancer.

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X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Cervical Cancer Risk: A HuGE Systematic Review and Meta-Analysis

PLoS ONE ◽

10.1371/journal.pone.0044441 ◽

2012 ◽

Vol 7 (9) ◽

pp. e44441 ◽

Cited By ~ 24

Author(s):

Ya Li ◽

Fei Liu ◽

Shi-Qiao Tan ◽

Yan Wang ◽

Shang-Wei Li

Keyword(s):

Systematic Review ◽

Cervical Cancer ◽

Cancer Risk ◽

Genetic Polymorphisms ◽

Meta Analysis ◽

X Ray ◽

Cervical Cancer Risk ◽

Group 1

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Association Between the XRCC3 Thr241Met Polymorphism and Cervical Cancer Risk: a Meta-analysis

Asian Pacific Journal of Cancer Prevention ◽

10.7314/apjcp.2013.14.11.6703 ◽

2013 ◽

Vol 14 (11) ◽

pp. 6703-6707 ◽

Cited By ~ 5

Author(s):

Ling-Yan Qin ◽

Xu Chen ◽

Ping Li ◽

Zheng Yang ◽

Wu-Ning Mo

Keyword(s):

Cervical Cancer ◽

Cancer Risk ◽

Meta Analysis ◽

Cervical Cancer Risk ◽

Xrcc3 Thr241met

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Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis

Disease Markers ◽

10.1155/2020/6723487 ◽

2020 ◽

Vol 2020 ◽

pp. 1-13 ◽

Cited By ~ 3

Author(s):

Xiaoyan Dong ◽

Wenyan Gao ◽

Xiaoling LV ◽

Yazhen Wang ◽

Qing Wu ◽

...

Keyword(s):

Gastric Cancer ◽

Cancer Risk ◽

Publication Bias ◽

Fixed Effects ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Biomedical Literature ◽

Cochrane Library ◽

Gastric Cancer Risk ◽

Lncrna Gas5

Purpose. Long noncoding RNAs (lncRNAs) have been widely studied, and single nucleotide polymorphisms (SNPs) in lncRNAs are considered to be genetic factors that influence cancer susceptibility. The lncRNA GAS5, MEG3, and PCAT-1 polymorphisms are shown to be possibly associated with cancer risk. The aim of this meta-analysis was to systematically evaluate this association. Methods. Studies were selected from PubMed, Web of Science, Embase, Google Scholar, Cochrane Library, the Chinese National Knowledge Infrastructure (CNKI), and the Chinese Biomedical Literature Database (CBM) through inclusion and exclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the random-effects model or fixed-effects model to assess the association between lncRNA polymorphisms and cancer susceptibility. Metaregression and publication bias analyses were also conducted. All analyses were performed using the Stata 12.0 software. Results. Sixteen articles (covering 13750 cases and 17194 controls) were included in this meta-analysis. A significant association between SNP rs145204276 and gastric cancer risk was observed (del vs. ins: OR=0.79, 95%CI=0.72‐0.86; del/del vs. ins/ins+del/ins: OR=0.74, 95%CI=0.59‐0.91; del/ins vs. ins/ins: OR=0.84, 95%CI=0.67‐1.05). For rs16901904, a decreased cancer risk was observed in three genetic models (C vs. T: OR=0.79, 95%CI=0.70‐0.90; CC vs. CT+TT: OR=0.49, 95%CI=0.37‐0.65; CC vs. TT: OR=0.49, 95%CI=0.37‐0.66). No statistical significance was found in the metaregression analysis. For all of the included SNPs, no publication bias was found in all genotype models. Conclusions. The rs145204276 SNP in lncRNA GAS5 is likely to be associated with gastric cancer risk, whereas the rs16901904 SNP in lncRNA PCAT-1 bears association with a decreased cancer risk.

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Association between HLA-DP Gene Polymorphisms and Cervical Cancer Risk: A Meta-Analysis

BioMed Research International ◽

10.1155/2018/7301595 ◽

2018 ◽

Vol 2018 ◽

pp. 1-13 ◽

Cited By ~ 4

Author(s):

Lin Cheng ◽

Yan Guo ◽

Shipeng Zhan ◽

Peiyuan Xia

Keyword(s):

Cervical Cancer ◽

Cancer Risk ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Human Leukocyte ◽

Cervical Cancer Risk ◽

Leukocyte Antigens ◽

Knowledge Infrastructure ◽

Increased Risk ◽

The Relationship

Objective. We aimed to derive a more precise estimation of the associations between human leukocyte antigens DP (HLA-DP) gene polymorphisms and cervical cancer risk by meta-analysis. Methods. PubMed, EMBASE, ScienceDirect, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases were systematically searched to identify studies investigating the relationship between HLA-DP gene polymorphisms and cervical cancer. The associations between them were evaluated by pooled OR and 95% CI. Results. A total of 11 studies including 5008 cases and 9322 controls with 11 HLA-DP alleles were included in the current meta-analysis. Results. The results showed that HLA-DPB1⁎03:01 was significantly associated with an increased risk of cervical cancer (OR=1.252, 95%CI: 1.116-1.403, Pz=0.001), while HLA-DPB1⁎04:02 and HLA-DP rs3117027 G allele were significantly associated with a decreased risk of cervical cancer (OR=0.744, 95%CI: 0.652-0.848, Pz=0.001; OR=0.790, 95%CI: 0.745-0.837, Pz=0.001), and HLA-DP rs9277535 G allele was significantly associated with a decreased risk of cervical cancer in Asia (OR=0.802, 95%CI: 0.753-0.855, Pz=0.001). Subgroup analyses based on race system showed that HLA-DPB1⁎13:01 was significantly associated with an increased risk of cervical cancer in Asia (OR=1.834, 95%CI: 1.107-3.039, Pz=0.019). No significant association was established for the HLA-DP following alleles: DPB1⁎02:01, DPB1⁎02:02, DPB1⁎04:01, DPB1⁎05:01, rs4282438, and rs3077. Conclusion. HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer.

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