Vitamin D Deficiency in Non-Autoimmune Hypothyroidism: A case-control study

Abstract Objectives: Although in many studies, the relationship between autoimmune hypothyroidism (Hashimoto) and Vitamin D deficiency was shown, no research has been performed on the role of vitamin D in non-autoimmune hypothyroidism. Design: This was a Retrospective case–control study in Endocrinology clinic of Jahrom (south of Iran). The patients with Hashimoto (n=633) and non-Hashimoto hypothyroidism (n=305), along with a control group (n=200) were evaluated. 25(OH)D level, T3 and T4 levels were studied and Anti TPO and Anti TG tests were performed. The results of vitamin D level were analyzed and interpreted using SPSS in terms of the cause of hypothyroidism (immune and non-immune). Results: The results of the study showed a significantly lower level of vitamin D in both immune and non-immune Hashimoto’s thyroiditis (HT) in comparison to healthy controls (P<0.05). We observed a significant inverse correlation between the vitamin D and TGAb level (p=0.001, r=-0.261) and a direct correlation of vitamin D with TSH level (p=0.008, r=0.108) in HT patients. Conclusion: Finally, the results indicated that non-autoimmune hypothyroidism, as well as HT, is associated with vitamin D deficiency. The role of vitamin D deficiency in HT was thought to be in the association of higher autoantibody (TGAb) level; while, there should be further studies determining vitamin D deficiency's role in non-immune hypothyroidism.

Vitamin D Deficiency in Non-Autoimmune Hypothyroidism: A case-control study

10.21203/rs.2.15826/v4 ◽

2020 ◽

Author(s):

Salma Ahi ◽

Mohammad Reza Dehdar ◽

Naser Hatami

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Case Control Study ◽

Inverse Correlation ◽

Case Control ◽

Control Group ◽

Retrospective Case ◽

Abstract Objectives: Although in many studies, the relationship between autoimmune hypothyroidism (Hashimoto) and Vitamin D deficiency was shown, no research has been performed on the role of vitamin D in non-autoimmune hypothyroidism. Design: This was a Retrospective case–control study in Endocrinology clinic of Jahrom (south of Iran). The patients with Hashimoto (n=633) and non-Hashimoto hypothyroidism (n=305), along with a control group (n=200) were evaluated. 25(OH)D level, T3 and T4 levels were studied and Anti TPO and Anti TG tests were performed. The results of vitamin D level were analyzed and interpreted using SPSS in terms of the cause of hypothyroidism (immune and non-immune). Results: The results of the study showed a significantly lower level of vitamin D in both immune and non-immune Hashimoto’s thyroiditis (HT) in comparison to healthy controls (P<0.05). We observed a significant inverse correlation between the vitamin D and TGAb level (p=0.001, r=-0.261) and a direct correlation of vitamin D with TSH level (p=0.008, r=0.108) in HT patients. Conclusion: Finally, the results indicated that non-autoimmune hypothyroidism, as well as HT, is associated with vitamin D deficiency. The role of vitamin D deficiency in HT was thought to be in the association of higher autoantibody (TGAb) level; while, there should be further studies determining vitamin D deficiency's role in non-immune hypothyroidism.

Vitamin D Deficiency in Non-Autoimmune Hypothyroidism: A case-control study

10.21203/rs.2.15826/v2 ◽

2019 ◽

Author(s):

Salma Ahi ◽

Mohammad Reza Dehdar ◽

Naser Hatami

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Case Control Study ◽

Inverse Correlation ◽

Case Control ◽

Control Group ◽

Retrospective Case ◽

Abstract Objectives: Although in many studies, the relationship between autoimmune hypothyroidism (Hashimoto) and Vitamin D deficiency was shown, no research has been performed on the role of vitamin D in non-autoimmune hypothyroidism. Design: This was a Retrospective case–control study in Endocrinology clinic of Jahrom (south of Iran). The patients with Hashimoto (n=633) and non-Hashimoto hypothyroidism (n=305), along with a control group (n=200) were evaluated. 25(OH)D level, T3 and T4 levels were studied and Anti TPO and Anti TG tests were performed. The results of vitamin D level were analyzed and interpreted using SPSS in terms of the cause of hypothyroidism (immune and non-immune). Results: The results of the study showed a significantly lower level of vitamin D in both immune and non-immune Hashimoto’s thyroiditis (HT) in comparison to healthy controls (P<0.05). We observed a significant inverse correlation between the vitamin D and TGAb level (p=0.001, r=-0.261) and a direct correlation of vitamin D with TSH level (p=0.008, r=0.108) in HT patients. Conclusion: Finally, the results indicated that non-autoimmune hypothyroidism, as well as HT, is associated with vitamin D deficiency. The role of vitamin D deficiency in HT was thought to be in the association of higher autoantibody (TGAb) level; while, there should be further studies determining vitamin D deficiency's role in non-immune hypothyroidism.

Vitamin D Deficiency in Non-Autoimmune Hypothyroidism: A case-control study

10.21203/rs.2.15826/v5 ◽

2020 ◽

Author(s):

Salma Ahi ◽

Mohammad Reza Dehdar ◽

Naser Hatami

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Case Control Study ◽

Inverse Correlation ◽

Hashimoto Thyroiditis ◽

Case Control ◽

Control Group ◽

Abstract Background: Although in many studies, the relationship between autoimmune hypothyroidism (Hashimoto) and Vitamin D deficiency was shown, no research has been performed on the role of vitamin D in non-autoimmune hypothyroidism.Methods: This was a case-control study in Endocrinology clinic of Jahrom (south of Iran). The patients with Hashimoto (n=633) and non-Hashimoto hypothyroidism (n=305), along with a control group (n=200) were evaluated. 25(OH) D level, T3 and T4 levels were studied and Anti TPO and Anti TG tests were performed. The results of vitamin D level were analyzed and interpreted using SPSS in terms of the cause of hypothyroidism (immune and non-immune).Results: The results of the study showed a significantly lower level of vitamin D in both immune and non-immune Hashimoto’s thyroiditis (HT) in comparison to healthy controls (P<0.05). We observed a significant inverse correlation between the vitamin D and TGAb level (p=0.001, r=-0.261) and a direct correlation of vitamin D with TSH level (p=0.008, r=0.108) in Hashimoto thyroiditis patients.Conclusion: Finally, the results indicated that non-autoimmune hypothyroidism, as well as HT, is associated with vitamin D deficiency. The role of vitamin D deficiency in Hashimoto thyroiditis was thought to be in the association of higher autoantibody (TGAb) level; while, there should be further studies determining vitamin D deficiency's role in non-immune hypothyroidism.

Vitamin D deficiency in non-autoimmune hypothyroidism: a case-control study

BMC Endocrine Disorders ◽

10.1186/s12902-020-0522-9 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Salma Ahi ◽

Mohammad Reza Dehdar ◽

Naser Hatami

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Case Control Study ◽

Case Control ◽

Role of Vitamin D Deficiency and Lack of Sun Exposure in the Incidence of Premenopausal Breast Cancer: a Case Control Study in Sabzevar, Iran

Asian Pacific Journal of Cancer Prevention ◽

10.7314/apjcp.2014.15.8.3391 ◽

2014 ◽

Vol 15 (8) ◽

pp. 3391-3396 ◽

Cited By ~ 20

Author(s):

Sepideh Arbabi Bidgoli ◽

Hamid Azarshab

Keyword(s):

Breast Cancer ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Case Control Study ◽

Sun Exposure ◽

Case Control ◽

Premenopausal Breast Cancer ◽

Effect of preoperative vitamin D deficiency on functional outcomes after high tibial osteotomy: a retrospective case control study

BMC Musculoskeletal Disorders ◽

10.1186/s12891-020-03295-1 ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Wonchul Choi ◽

Jae Hwa Kim ◽

Seong-Eun Byun ◽

Han-Seung Ryu ◽

David Rojas

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

High Tibial Osteotomy ◽

Functional Outcomes ◽

Case Control Study ◽

Case Control ◽

Tibial Osteotomy ◽

Retrospective Case ◽

Severe vitamin D deficiency is not related to SARS-CoV-2 infection but may increase mortality risk in hospitalized adults: a retrospective case–control study in an Arab Gulf country

Aging Clinical and Experimental Research ◽

10.1007/s40520-021-01831-0 ◽

2021 ◽

Author(s):

Abdullah M. Alguwaihes ◽

Shaun Sabico ◽

Rana Hasanato ◽

Mohammed E. Al-Sofiani ◽

Maram Megdad ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Mortality Risk ◽

Case Control Study ◽

Case Control ◽

Retrospective Case ◽

Increase Mortality Risk ◽

Severe Vitamin ◽

Gulf Country ◽

THE POSSIBLE LINK BETWEEN VITAMIN D LEVELS AND RESTLESS LEG SYNDROME: A HOSPITAL-BASED CASE-CONTROL STUDY FROM KASHMIR, INDIA

International Journal of Advanced Research ◽

10.21474/ijar01/12981 ◽

2021 ◽

Vol 9 (5) ◽

pp. 1362-1367

Author(s):

Rehana Amin ◽

◽

Seema Batool ◽

Yuman Kawoos ◽

Masood Maqbool ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Case Control Study ◽

Case Control ◽

Nervous System Development ◽

Control Group ◽

P Value ◽

Restless Leg Syndrome ◽

Vitamin D Levels ◽

Background & Objectives: Various pathophysiological mechanisms and risk factors have been identified in patients with restless leg syndrome and there exist other factors also that are yet to be identified and are under-researched. Evidence suggests a possible link between Vitamin D deficiency and Restless leg syndrome.The aim was to study the Vitamin D levels in patients diagnosed with RLS and to find a correlation between Vitamin D and RLS. Methods: This was a case-control study carried out in the outpatient department of the Institute of Mental Health and Neurosciences Kashmir.A total of 144 subjects were enrolled in the study. Fifty-one were diagnosed cases of RLS and 93 were healthy controls.The Vitamin D levels were analysed by the chemiluminescent immunoassay method in both cases as well as controls.The descriptive statistics were used for various socio-demographic and clinical variables.The data were analysed by chi-square test, t-test and multivariate logistic regression analysis. Results: The vitamin D levels were significantly low in the RLS group in comparison to the control group. There was a significant correlation between vitamin D levels, vitamin D deficiency and restless leg syndrome (OR= 1.01, p-value 0.005 and OR= 5.40, p-value <0.0001 respectively). Interpretation &conclusions: Vitamin D levels were low in patients with RLS. This signifies vitamin D may have some role in the pathophysiology of RLS.Vitamin D regulates the nervous system development and function therefore, its use can be considered in the management of RLS when other modalities cannot prove as a promising agent.