scholarly journals The Effects of Changing Meteorological Parameters on Fatal Aortic Catastrophes

2019 ◽  
Author(s):  
Brigitta Szilágyi ◽  
Márton Berczeli ◽  
Attila Lovas ◽  
Zoltán Oláh ◽  
Klára Törő ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Aortic Dissection ◽  
Atmospheric Pressure ◽  
Process Model ◽  
Meteorological Parameters ◽  
Acute Aortic Dissection ◽  
Occurrence Rate ◽  
Cox Process ◽  
The Relationship ◽  
Non Parametric

Abstract Introduction: Over the spam of the last decade, medical research has been increasingly putting greater emphasis on the study of meteorological parameters due to their connection to cardiovascular diseases. The main goal of this study was to explore the relationship between fatal aortic catastrophes and changes in atmospheric pressure and temperature. Methods: We used a Cox process model to quantify the effects of environmental factors on sudden deaths resulting from aortic catastrophes. We used transfer entropy to draw conclusion about the causal connection between mortality and meteorological parameters. Our main tool is a computer program which we developed earlier in order to evaluate the relationship between pulmonary embolism mortality and the weather on data sets comprised of aortic aneurysm (AA) and acute aortic dissection (AAD) cases, where one of these two medical conditions had led to the fatal rupture of the aorta. Our source for these cases were the autopsy databases of Semmelweis University, from the time period of 1994 to 2014. We have examined 160 aneurysm and 130 dissection cases in relation to changes in meteorological parameters. The algorithm implemented in our program is based on a non-parametric a Cox process model. It is capable to split slowly varying unknown global trends from fluctuations potentially caused by weather. Furthermore, it allows us to explore complex non-linear interactions between meteorological parameters and mortality. Results: The model measures the relative growth of the expected number of events on the nth day caused by the deviation of environmental parameters from its mean value. The connection between ruptured aortic aneurysms (rAA) and changes in atmospheric pressure is more significant than their connection with mean daily temperatures. With the increase in atmospheric pressure, the rate of rAA mortality also increased. The effects of meteorological parameters were weaker for deaths resulting from acute aortic dissections (AAD), although low mean daily temperatures increased the intensity of occurrence for AAD-related deaths. Conclusion: The occurrence rate of fatal aortic catastrophes showed a slight dependence on the two examined parameters within our groups. Keywords: acute aortic dissection; ruptured aortic aneurysm; Cox process model; non-parametric approach; statistical learning

scholarly journals The effects of changing meteorological parameters on fatal aortic catastrophes

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Brigitta Szilágyi ◽  
Márton Berczeli ◽  
Attila Lovas ◽  
Zoltán Oláh ◽  
Klára Törő ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Process Model ◽  
Meteorological Parameters ◽  
Main Tool ◽  
Environmental Parameters ◽  
Aortic Aneurysms ◽  
Occurrence Rate ◽  
Causal Connection ◽  
Cox Process ◽  
The Relationship

Abstract Background Over the span of the last decade, medical research has been increasingly putting greater emphasis on the study of meteorological parameters due to their connection to cardiovascular diseases. The main goal of this study was to explore the relationship between fatal aortic catastrophes and changes in atmospheric pressure and temperature. Methods We used a Cox process model to quantify the effects of environmental factors on sudden deaths resulting from aortic catastrophes. We used transfer entropy to draw conclusion about the causal connection between mortality and meteorological parameters. Our main tool was a computer program which we developed earlier in order to evaluate the relationship between pulmonary embolism mortality and weather on data sets comprised of aortic aneurysm (AA) and acute aortic dissection (AAD) cases, where one of these two medical conditions had led to fatal rupture of the aorta. Our source for these cases were the autopsy databases of Semmelweis University, from the time period of 1994 to 2014. We have examined 160 aneurysm and 130 dissection cases in relation to changes in meteorological parameters. The algorythm implemented in our program is based on a non-parametric a Cox process model. It is capable of splitting slowly varying unknown global trends from fluctuations potentially caused by weather. Furthermore, it allows us to explore complex non-linear interactions between meteorological parameters and mortality. Results Model measures the relative growth of the expected number of events on the nth day caused by the deviation of environmental parameters from its mean value. The connection between ruptured aortic aneurysms (rAA) and changes in atmospheric pressure is more significant than their connection with mean daily temperatures. With an increase in atmospheric pressure, the rate of rAA mortality also increased. The effects of meteorological parameters were weaker for deaths resulting from acute aortic dissections (AAD), although low mean daily temperatures increased the intensity of occurrence for AAD-related deaths. Conclusion The occurrence rate of fatal aortic catastrophes showed a slight dependence on the two examined parameters within our groups.

scholarly journals The Effects of Changing Meteorological Parameters on Fatal Aortic Catastrophes

2020 ◽  
Author(s):  
Brigitta Szilágyi ◽  
Márton Berczeli ◽  
Attila Lovas ◽  
Zoltán Oláh ◽  
Klára Törő ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Process Model ◽  
Meteorological Parameters ◽  
Main Tool ◽  
Environmental Parameters ◽  
Aortic Aneurysms ◽  
Occurrence Rate ◽  
Causal Connection ◽  
Cox Process ◽  
The Relationship

Abstract Introduction: Over the spam of the last decade, medical research has been increasingly putting greater emphasis on the study of meteorological parameters due to their connection to cardiovascular diseases. The main goal of this study was to explore the relationship between fatal aortic catastrophes and changes in atmospheric pressure and temperature. Methods: We used a Cox process model to quantify the effects of environmental factors on sudden deaths resulting from aortic catastrophes. We used transfer entropy to draw conclusion about the causal connection between mortality and meteorological parameters. Our main tool is a computer program which we developed earlier in order to evaluate the relationship between pulmonary embolism mortality and the weather on data sets comprised of aortic aneurysm (AA) and acute aortic dissection (AAD) cases, where one of these two medical conditions had led to the fatal rupture of the aorta. Our source for these cases were the autopsy databases of Semmelweis University, from the time period of 1994 to 2014. We have examined 160 aneurysm and 130 dissection cases in relation to changes in meteorological parameters. The algorithm implemented in our program is based on a non-parametric a Cox process model. It is capable to split slowly varying unknown global trends from fluctuations potentially caused by weather. Furthermore, it allows us to explore complex non-linear interactions between meteorological parameters and mortality. Results: The model measures the relative growth of the expected number of events on the n th day caused by the deviation of environmental parameters from its mean value. The connection between ruptured aortic aneurysms (rAA) and changes in atmospheric pressure is more significant than their connection with mean daily temperatures. With the increase in atmospheric pressure, the rate of rAA mortality also increased. The effects of meteorological parameters were weaker for deaths resulting from acute aortic dissections (AAD), although low mean daily temperatures increased the intensity of occurrence for AAD-related deaths. Conclusion: The occurrence rate of fatal aortic catastrophes showed a slight dependence on the two examined parameters within our groups.

scholarly journals Treatment and Outcome of Acute Aortic Dissection Associated with Atherosclerotic Aortic Aneurysm

2011 ◽  
Vol 40 (5) ◽  
pp. 221-226
Author(s):  
Hiroaki Sakamoto ◽  
Masataka Sato ◽  
Yasunori Watanabe
Keyword(s):  
Aortic Aneurysm ◽  
Aortic Dissection ◽  
Acute Aortic Dissection

A Case of Combined Acute Aortic Dissection and Abdominal Aortic Aneurysm with Hemolysis.

2002 ◽  
Vol 31 (3) ◽  
pp. 227-229
Author(s):  
Etsuro Suenaga ◽  
Kazuhisa Rikitake ◽  
Ryo Shiraishi ◽  
Tsuyoshi Itoh
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
Abdominal Aortic

scholarly journals Aortic wall thickness in patients with ascending aortic aneurysm versus acute aortic dissection

2015 ◽  
Vol 49 (3) ◽  
pp. 756-762 ◽  
Author(s):  
Joeri Van Puyvelde ◽  
Eric Verbeken ◽  
Peter Verbrugghe ◽  
Paul Herijgers ◽  
Bart Meuris
Keyword(s):  
Aortic Aneurysm ◽  
Aortic Dissection ◽  
Wall Thickness ◽  
Aortic Wall ◽  
Acute Aortic Dissection ◽  
Ascending Aortic Aneurysm ◽  
Aortic Wall Thickness

Acute Aortic Dissection Involving a Fusiform Abdominal Aortic Aneurysm

1999 ◽  
Vol 33 (3) ◽  
pp. 341-345
Author(s):  
Paul E. Y. Van Schil ◽  
Inez E. R. Rodrigus ◽  
Luc R. D. Haenen ◽  
Filip Van den Brande ◽  
Rudolphe G. M. T. Vanmaele ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
Abdominal Aortic

scholarly journals Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome

2021 ◽  
Author(s):  
Cristina I. Caescu ◽  
Jens Hansen ◽  
Brittany Crockett ◽  
Wenzhen Xiao ◽  
Pauline Arnaud ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Aortic Aneurysm ◽  
Aortic Dissection ◽  
Marfan Syndrome ◽  
Thoracic Aortic Aneurysm ◽  
Acute Aortic Dissection ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Aortic Disease ◽  
Computational Analyses

Objective: Despite considerable research, the goal of finding nonsurgical remedies against thoracic aortic aneurysm and acute aortic dissection remains elusive. We sought to identify a novel aortic protein kinase that can be pharmacologically targeted to mitigate aneurysmal disease in a well-established mouse model of early-onset progressively severe Marfan syndrome (MFS). Approach and Results: Computational analyses of transcriptomic data derived from the ascending aorta of MFS mice predicted a probable association between thoracic aortic aneurysm and acute aortic dissection development and the multifunctional, stress-activated HIPK2 (homeodomain-interacting protein kinase 2). Consistent with this prediction, Hipk2 gene inactivation significantly extended the survival of MFS mice by slowing aneurysm growth and delaying transmural rupture. HIPK2 also ranked among the top predicted protein kinases in computational analyses of genes differentially expressed in the dilated aorta of 3 MFS patients, which strengthened the clinical relevance of the experimental finding. Additional in silico analyses of the human and mouse data sets identified the TGF (transforming growth factor)-β/Smad3 signaling pathway as a potential target of HIPK2 in the MFS aorta. Chronic treatment of MFS mice with an allosteric inhibitor of HIPK2-mediated stimulation of Smad3 signaling validated this prediction by mitigating thoracic aortic aneurysm and acute aortic dissection pathology and partially improving aortic material stiffness. Conclusions: HIPK2 is a previously unrecognized determinant of aneurysmal disease and an attractive new target for antithoracic aortic aneurysm and acute aortic dissection multidrug therapy.

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