scholarly journals The potential interaction of hereditary and reproductive factors in the etiology of mammary gland hyperplasia: a case-control study

2019 ◽  
Author(s):  
hanlu gao ◽  
Chao Yang ◽  
Jinqing Fan ◽  
Li Lan ◽  
Da Pang
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
High Education ◽  
Family History ◽  
Reproductive Factors ◽  
Education Level ◽  
High Order ◽  
Breastfeeding Duration ◽  
High Education Level ◽  
History Of

Abstract Background: Family history of breast cancer and female reproductive factors may work together to influence hyperplasia of mammary gland (HMG) risk. However, the association with HMG risk is poorly characterized and might be important to understand the causation of HMG.Methods: A total of 1881 newly diagnosed HMG cases and 1900 controls were recruited between 2012 and 2017. We collected each participant's demographic characteristics, female reproductive factors and family history of breast cancer. A multi-analytic strategy combining unconditional logistic regression, multifactor dimensionality reduction (MDR) and crossover approaches were applied to systematically identify the interactions of family history of breast cancer and reproductive factors on HMG susceptibility.Results: In MDR analysis, high-order interactions among education level, breastfeeding duration and family history of breast cancer were identified among women (OR=7.069, 95%CI: 6.080-8.219). Similarly, in crossover analysis, compared with individuals having low education level and no family history of breast cancer, HMG risk increased significantly for those having high education level and family history of breast cancer (OR=36.389, 95%CI: 11.469-115.451), similar additive interaction effect was observed among short breastfeeding duration women (OR=27.699, 95%CI: 3.730-205.699).Conclusion: This study suggests high-order interactions of high education level, short breastfeeding duration and family history of breast cancer may synergistically increased HMG risk.

scholarly journals Hereditary and breastfeeding factors are positively associated with the aetiology of mammary gland hyperplasia: a case–control study

2020 ◽  
Author(s):  
Hanlu Gao ◽  
Chao Yang ◽  
Jinqing Fan ◽  
Li Lan ◽  
Da Pang
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Family History ◽  
Case Control Study ◽  
Reproductive Factors ◽  
Breastfeeding Duration ◽  
Crossover Analysis ◽  
History Of ◽  
Duration Of Breastfeeding ◽  
Control Study

Abstract Background Hyperplasia of mammary gland (HMG) has become a common disorder in women. A family history of breast cancer and female reproductive factors may work together to increase the risk of HMG. However, this specific relationship has not been fully characterized. Methods A total of 1881 newly diagnosed HMG cases and 1900 controls were recruited from 2012 to 2017. Demographic characteristics including female reproductive factors and a family history of breast cancer were collected. A multi-analytic strategy combining unconditional logistic regression, multifactor dimensionality reduction (MDR) and crossover approaches were applied to systematically identify the interaction effect of family history of breast cancer and reproductive factors on HMG susceptibility. Results In MDR analysis, high-order interactions among higher-level education, shorter breastfeeding duration and family history of breast cancer were identified (odds ratio [OR] 7.07 [95% confidence interval {CI} 6.08 to 8.22]). Similarly, in crossover analysis, HMG risk increased significantly for those with higher-level education (OR 36.39 [95% CI 11.47 to 115.45]), shorter duration of breastfeeding (OR 27.70 [95% CI 3.73 to 205.70]) and a family history of breast cancer. Conclusion Higher-level education, shorter breastfeeding duration and a family history of breast cancer may synergistically increase the risk of HMG.

scholarly journals The impact of reproductive factors and oral contraception on breast cancer risk in women with brca mutation or family history of breast cancer

2016 ◽  
Vol 27 ◽  
pp. iv59 ◽  
Author(s):  
A. Toss ◽  
G. Grandi ◽  
S. Pavesi ◽  
L. Marcheselli ◽  
E. De Matteis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Brca Mutation ◽  
Reproductive Factors ◽  
Oral Contraception ◽  
History Of ◽  
The Impact

Reproductive factors and family history of breast cancer in relation to plasma estrogen and prolactin levels in postmenopausal women in the Nurses' Health Study (United States)

1995 ◽  
Vol 6 (3) ◽  
pp. 217-224 ◽  
Author(s):  
Susan E. Hankinson ◽  
Graham A. Colditz ◽  
David J. Hunter ◽  
JoAnn E. Manson ◽  
Walter C. Willett ◽  
...  
Keyword(s):  
Breast Cancer ◽  
United States ◽  
Family History ◽  
Postmenopausal Women ◽  
Reproductive Factors ◽  
Health Study ◽  
History Of

WOMEN WITH BREAST CANCER ATTENDED IN PUBLIC HOSPITAL FROM MACAPÁ, AMAPÁ

2021 ◽  
Vol 9 (7) ◽  
pp. 35-47
Author(s):  
Emílio Daniel Pacheco de Sousa ◽  
Givago Da Silva Souza ◽  
Nely Deyse Santos Da Mata ◽  
Marlucilena Pinheiro Da Silva ◽  
José Mauro Secco
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Ductal Carcinoma ◽  
Public Health Problem ◽  
Education Level ◽  
Histological Type ◽  
Adequate Treatment ◽  
First Degree Relatives ◽  
Number Of Patients ◽  
History Of

Breast cancer is a disease of epidemiological concern worldwide, being considered a serious public health problem. Although it is well established that early diagnosis and adequate treatment interfere with mortality rates and the prevalence of cancer, few data are available regarding the descriptive epidemiology of breast cancer in Brazil, as well as in the various states of the federation, as is the State of Amapá. The general objective was to characterize the risk factors of breast cancer patients treated at Hospital de Clínicas Dr. Alberto Lima (HCAL) from January 2012 to December 2017 in the city of Macapá, Amapá. Cases of breast cancer were reviewed, with an analysis of 194 medical records, and the following variables were studied: age, education level, histological type of the neoplasia, age at first delivery, menarche and menopause, breastfeeding time, alcohol intake, smoking, family history of breast cancer in first-degree relatives. It was noted that the age group most affected was between 41-50 years old and with an education level of elementary education. In these women, the most frequent characteristics were: age at first delivery between 13-20 years, menarche between 10-13 years, menopause from 41-50 years with a significant number of patients at menace (outside menopause), breastfeeding time between 2-22 and 23-42 months, both intervals with the same number of records; most did not drink alcohol, were not smokers and had no family history of first-degree relatives of breast cancer. In the cases studied, the most frequently diagnosed histological type was invasive ductal carcinoma.

Menstrual and reproductive factors and breast cancer in women with family history of the disease

1992 ◽  
Vol 51 (5) ◽  
pp. 677-681 ◽  
Author(s):  
Fabio Parazzini ◽  
Carlo La Vecchia ◽  
Eva Negri ◽  
Silvia Franceschi ◽  
Luca Bocciolone
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Reproductive Factors ◽  
History Of

Variations in the risk of breast cancer associated with a family history of breast cancer according to age at onset and reproductive factors

1993 ◽  
Vol 46 (9) ◽  
pp. 973-980 ◽  
Author(s):  
N. Andrieu ◽  
F. Clavel ◽  
A. Auquier ◽  
M.G. Lê ◽  
B. Gairard ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Age At Onset ◽  
Reproductive Factors ◽  
History Of

Family history of breast cancer and local recurrence after breast conserving therapy

1998 ◽  
Vol 34 ◽  
pp. S12
Author(s):  
C.T.M. Brekelmans ◽  
A.C. Voogd ◽  
G. Botke ◽  
A.N. van Geel ◽  
P. Rodrigus ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Local Recurrence ◽  
Breast Conserving Therapy ◽  
History Of
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