scholarly journals Low levels of thyroid hormone may reduce the risk of breast cancer: evidence from a meta-analysis

2019 ◽  
Author(s):  
Bolin Wang ◽  
Yan Huang ◽  
Tao Lin
Keyword(s):  
Breast Cancer ◽  
Hormone Replacement Therapy ◽  
Thyroid Hormone ◽  
Replacement Therapy ◽  
Meta Analysis ◽  
Hormone Replacement ◽  
Thyroid Hormone Replacement ◽  
Thyroid Hormone Replacement Therapy ◽  
Low Levels ◽  
The Relationship

Abstract Background: At present, the relationship between hypothyroidism and the risk of breast cancer is still inconclusive. This meta-analysis was used to systematically assess the relationship between hypothyroidism and breast cancer risk, and to assess whether thyroid hormone replacement therapy can increase breast cancer risk.Methods: The relevant articles about hypothyroidism and the risk of breast cancer were obtained on the electronic database platform. Relevant data were extracted, and odd ratios with corresponding 95% confidence intervals(95% CI) were merged using Stata SE 12.0 software. A total of 19 related studies were included in the meta-analysis, including 6 cohort studies and 13 case-control studies.Result: The results show that hypothyroidism can reduce the risk of breast cancer(odd ratios= 0.90, 95% CI 0.77-1.03), but in Asian populations, patients with hypothyroidism have an increased risk of breast cancer(odd ratios=1.17, 95% CI 0.98-1.35). In addition, patients who received thyroid hormone replacement therapy had a lower risk of developing breast cancer(odd ratios=0.87, 95% CI 0.65-1.09).Conclusion: Hypothyroidism and thyroid hormone replacement therapy reduces the risk of breast cancer, suggesting that low levels of thyroid hormone may be beneficial to breast cancer prevention. Due to the limited number of studies included more large-scale, high-quality, long-term prospective cohort studies are needed.

scholarly journals MECHANISMS IN ENDOCRINOLOGY: Primary HT and risk for breast cancer: a systematic review and meta-analysis

2012 ◽  
Vol 166 (3) ◽  
pp. 373-381 ◽  
Author(s):  
Anna G Angelousi ◽  
Valsamo K Anagnostou ◽  
Michael K Stamatakos ◽  
Georgios A Georgiopoulos ◽  
Konstantinos C Kontzoglou
Keyword(s):  
Breast Cancer ◽  
Hormone Replacement Therapy ◽  
Thyroid Hormone ◽  
Replacement Therapy ◽  
Meta Analysis ◽  
Hormone Replacement ◽  
Thyroid Hormone Replacement ◽  
True Value ◽  
Pubmed Database ◽  
Thyroid Hormone Replacement Therapy

ObjectiveThe association between hypothyroidism and breast cancer has been described from very early on. Breast and thyroid tissue are interconnected on a molecular level mainly through activation of thyroid hormone receptors expressed on cells of the mammary gland as well as on the plasma membrane of breast cancer cells. Despite the experimental evidence the true value of hypothyroidism as a risk factor for breast cancer remains controversial.MethodsWe searched the PubMed database through February 2011 to identify studies that evaluated the association between hypothyroidism and risk for breast cancer as well as the effect of thyroid hormone replacement therapy on breast cancer incidence.ResultsA meta-analysis performed in 12 studies showed that hypothyroidism was not associated with risk for breast cancer (pooled risk ratio (RR)=1.06, 95% confidence intervals (CIs) 0.82–1.35, P=0.672). The effect of treatment was assessed in seven studies and no evidence for an association between thyroid hormone replacement and breast cancer was observed with an overall RR of 0.99 (95% CI 0.73–1.35, P=0.965).ConclusionsOur meta-analysis showed that hypothyroidism is not associated with increased risk for breast cancer and thyroid hormone replacement therapy does not reduce breast cancer prevalence; however, the heterogeneity of the studies analyzed precludes firm conclusions.

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