Predictors of Health-Related Quality of Life in Stroke Survivors After Inpatient rehabilitation
Abstract Background. Disordered and decreased quality of life is the most important consequence of stroke for stroke survivors. The aim of the study was to determine the predictors of the health-related quality of life (HRQOL) in stroke survivors six months after discharge from inpatient rehabilitation. Methods. We conducted prospective cohort study which involved 136 (48.5% males and 51.5% females) survivors. We examined seven potential predictors of HRQOL: age, sex, stroke type, stroke side, functional status (Barthel Index-BI and modified Rankin Scale-mRS), cognition (Mini-Mental State Examination; MMSE) and stroke severity (National Institutes of Health Stroke Scale; NIHSS). HRQOL was assessed by Stroke Impact Scale (SIS) 3.0. Using Pearson's correlation and multiple logistic regression analysis we described the relationships between mRS, NIHSS, BI, MMSE and HRQOL. Results. Baseline mRS and NIHSS scores negatively correlated with seven SIS domains except with strength. Baseline BI scores positively correlated with seven SIS domains except mobility and baseline MMSE scores positive correlated with memory, ADL, hand function and participation role and negatively correlated with emotion, communication and mobility domains. Decrease of both mRS and NIHSS scores during the observed period positively correlated with increase of all SIS domains. Ischaemic stroke positively correlated with emotion and communication and stroke in brainstem negatively correlated with communication domain. Memory domain positively correlated with female sex and with stroke in the right hemisphere. Age wasn't significantly associated with any SIS domain. Conclusion. We conclude that major factors in predicting the improvement of strength, physical functioning, mobility, hand function, ADL and participation role were increase of BI and decrease of mRS and NIHSS scores. Female sex, stroke in right hemisphere and increase of BI and MMSE scores predicted better memory. Baseline mRS and NIHSS scores were predictors for improvement of hand function and increase of mRS predicted decrease of hand function and participation role. Key words: stroke, survivors, health-related quality of life, inpatient rehabilitation