Spatial and Temporal Epidemiologic features analysis of pulmonary tuberculosis in Nanjing, China
Abstract Background This study aims to analyse the epidemiological features of tuberculosis in Nanjing and to identify possible risk factors associated with the spatial-temporal distribution.Methods Firstly, we used descriptive statistical method to study the epidemiologic features of confirmed PTB cases in 2017. Secondly, we explored Maxent method to construct the species distribution model with a high spatial resolution of 1km based on those confirmed cases and environmental features. Once again, we validated the performance of the species distribution model using ROC approach and spatial jackknife test, identified the key environmental factors associated with PTB occurrence. Finally, we created a prediction map under specific environmental factors by projecting the training model onto the research areas.Results The seasonal amount of PTB was not obvious. The key risk factors associated with PTB occurrence are monthly mean vapor pressure, solar radiation, monthly average temperature, and precipitation with suitable ranges. The economically developed central city is the high-burden area of tuberculosis with a high risk probability, and the economically backward Gaochun district is the high transmission area of tuberculosis with a high incidence. Epidemiologically, the farmers, the elderly, the floating population, and males are the focus groups for PTB prevention and control.Conclusion The combination of environmental factors with Maxent methods is an appropriate option to analyse and estimate the spatial and temporal distribution of PTB cases.