Viral Characteristics and Clinical Presentation in Dengue Co-infection—Findings from a Facility Based Observational Study in Odisha, India

2020 ◽  
Author(s):  
Jyotirmayee Turuk ◽  
Subrata Kumar Palo ◽  
Sonalika Rath ◽  
Jyotsnamayee Sabat ◽  
Subhra Subhadra ◽  
...  

Abstract Background: Dengue is a widespread disease affecting many countries and about two fifth of the world is at risk for this disease. In India, the dengue incidence has increased in recent past and emerged as an important health problem in many states including Odisha. Cases with dengue co-infection with other diseases usually have atypical clinical presentation.Methods: A facility based longitudinal study was carried out over a period of one year to determine the dengue co-infection and its outcome. The suspected cases were clinically assessed following a standard case report format and serological investigations including serotyping were carried out.Results: 33.6% samples were dengue positive of which 78.5% were positive for NS1 Ag, 26.6% positive for dengue IgM and 5.1% to both. Among the dengue positive cases, 60.9% were male and mean age was 31.52 (+/- 17.03) years. High occurrence of cases was during May to November with maximum in August. Among the 975 dengue positives, 57 (5.8%) were found to have co-infection. Chikungunya was the most common co-infection in 71.9%, followed by herpes simplex (HSV) (7%) and other diseases. Fever was the most common presenting symptom (98.2%), followed by myalgia (91.2%), pain abdomen (12.3%), Rash/lesion (8.8%), burning micturition (5.3%), Petechiae (1.7%) and Pruritus (1.7%) among the co-infected cases.While DEN-2 serotype was observed in majority (74.1%) more than two serotypes was found in 5.85% of dengue positives .Conclusions: All the four dengue serotypes were found to be circulating with DEN-2 as the most predominant one. About 5.8% of dengue cases have co-infection (mainly with chikungunya) and clinically present with atypical signs and symptoms.

2020 ◽  
Vol 7 (11) ◽  
pp. 3835
Author(s):  
Nawaz M. Dakhani ◽  
Yamanur P. Lamani

Gall bladder perforation (GBP) is a rare life-threatening complication with a high mortality due to atypical clinical presentation and delay in diagnosis due to atypical clinical presentation. Case report 1, 70-year-old female presented with complaints of pain abdomen, vomiting and blackish pigmentation over abdomen since a week. She was in shock on presentation, with necrotic patch over abdomen and abscess collection at umbilicus. Ultrasound revealed GBP at fundus with thick collection in gastrohepatic recess with overlying abdominal wall cellulitis. CECT was not possible and the patient could not be taken for surgery due to unstable vitals and expired the next day. Case report 2, a 68-year-old male presented with complaints of pain abdomen over right side with vomiting. Abdomen was tender diffusely with guarding in right hypochondrium. Ultrasound showed distended gall bladder (GB) with multiple calculi. Magnetic resonance cholangiopancreatography (MRCP) showed a GBP at fundus with pericholecystic collection extending into hepatogastric recess. He underwent total cholecystectomy and post-operative period was uneventful. Acute cholecystitis has a perforation rate of 2-11% due to cystic duct obstruction, ischemia and necrosis. Our first patient had type-III GBP and was in shock and did not survive due to bad condition on arrival whereas the second patient had type-I GBP and underwent cholecystectomy without any complications. Type-I and type-II GBP as proposed by Niemeier have better outcomes compared to type-III. Rapid diagnosis and surgical intervention are very much necessary for reducing mortality as they rarely present with typical signs and symptoms of perforation. 


2017 ◽  
Vol 7 (1) ◽  
pp. 1127-1129
Author(s):  
A Ghosh ◽  
G Ghartimagar ◽  
S Thapa ◽  
MK Shrestha ◽  
OP Talwar

Extracranial meningiomas may be subdivided into primary and secondary types based on absence or presence of intracranial attachments respectively. Primary sinonasal tract meningiomas are rare with unknown etiopathology and non-specific clinical presentation. Of these PEMs only 11.5% are in the nasal cavity and nasal septum. To our knowledge less than 50 cases of PEM of nasal cavity have been reported in the literature. We report a case of a 22 years old male who presented with epistaxis and increasing nasal stuffiness for the last one year.


2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Katayoun Haryalchi ◽  
Abtin Heidarzadeh ◽  
Mahmood Abedinzade ◽  
Sepehr Olangian Tehrani ◽  
Samaneh Ghazanfar Tehran

Background: Nowadays, the new coronavirus (SARS-CoV-2) and its complications are one of the main concerns of the world. One of the most severe complications of COVID-19 is hypoxemia. Objectives: This study aimed to assess the importance of happy hypoxemia in COVID-19. Methods: We systematically searched web of science, PubMed, and Google scholar databases to find articles related to COVID-19 and happy hypoxemia. Results: COVID-19 causes a type of hypoxemia named silent (happy) hypoxemia, which has an atypical clinical presentation. This type of hypoxemia has not been noted before in viral pneumonia, and there is no specific treatment for this serious complication. Patients with silent hypoxemia may develop severe hypoxemia without dyspnea and with near-normal lung compliance. These patients are awake, calm, and responsive. Although their lungs are not oxygenated efficiently, they are alert and cooperative. Their condition may be deteriorated rapidly without warning and causes death. Conclusions: According to the findings, paying attention to happy hypoxemia is important for improving the health status of COVID-19 patients.


1990 ◽  
Vol 80 (3) ◽  
pp. 145-150
Author(s):  
KM Pyatak-Hugar ◽  
RW Mendicino ◽  
TS Scott ◽  
DW Hugar

Although cutaneous larva migrans is more commonly seen in the southeastern US and tropical regions of the world, patients with such parasitic involvement may present in other non-endemic areas for various reasons, particularly travelers returning from tropical vacations. Awareness of the clinical presentation and symptomatology of cutaneous larva migrans is important for all physicians, including those practicing in northern climates, for prompt recognition and effective treatment of the disease. Furthermore, cutaneous larva migrans should be of particular interest to podiatrists, because the infestation commonly involves the feet, and a patient may initially present for treatment of secondary manifestations, ie, dermatitis, pruritus, or infection, as in this case report.


1994 ◽  
Vol 61 (2) ◽  
pp. 151-153
Author(s):  
M. Marcellini ◽  
R. Cantiani ◽  
G. Mainiero ◽  
L Neri

The Authors report a case of vesical hemangioma; it was typical for site and clinical presentation whereas the age of onset and gross appearance were atypical. A TUR biopsy was performed without complications, but did not confirm diagnosis. A partial cystectomy was performed. A one-year follow-up, negative for recurrence, confirmed this procedure as the definitive treatment of choice.


1993 ◽  
Vol 7 (6) ◽  
pp. 281-286
Author(s):  
Welby Winstead ◽  
Thomas V. Connely ◽  
Martin J. Raff

Rhinoscleroma is a chronic granulomatous inflammatory disease caused by Klebsiella rhinoscleromatis. Initially described as a lesion of the nose, rhinoscleroma may involve any part of the respiratory tract. Although it is endemic in many parts of the world, rhinoscleroma has been rarely recognized in the U.S. In this report, we present a case of rhinoscleroma that illustrates the diagnostic challenge and therapeutic dilemma this disease presents. The significance of laryngeal involvement is emphasized. We review the clinical presentation, diagnosis, and treatment of rhinoscleroma. Ciprofloxacin was found effective in controlling acute symptom; however, longterm, high dose treatment has not been curative.


Neurosurgery ◽  
1983 ◽  
Vol 13 (3) ◽  
pp. 322-326 ◽  
Author(s):  
Bruce Pendleton ◽  
Barton Carl ◽  
Michael Pollay

Abstract A lumbar spinal extradural ganglion cyst is reported, and the world literature on spinal ganglion cysts is reviewed. The clinical presentation, findings, etiology, and pathogenesis of these lesions are discussed.


Author(s):  
Hitesh Verma ◽  
Arjun Dass ◽  
Surinder K. Singhal ◽  
Nitin Gupta

<p class="abstract">We had a sixty years old male patient, who had one year history of foreign body sensation in throat and the history of odynophagia for the last ten days. The NCCT neck showed 3.08×2.28 cm homogenous calcified mass in left tonsillar fossa. The stone was removed and tonsillectomy was performed. Giant tonsillolith is a rare clinical entity. As per available literature, 54 cases of giant tonsilloliths have been reported and to the best of our knowledge, this is one of the largest tonsillolith in the world till date. </p><strong>Keywords:</strong> Tonsillolith, Oral cavity<strong></strong>


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