scholarly journals Long-term retrospective observation reveals stabilities and variations of hantavirus infection in Hebei, China

2019 ◽  
Author(s):  
Shiyou Liu ◽  
Yamei Wei ◽  
Xu Han ◽  
Yanan Cai ◽  
Zhanying Han ◽  
...  
Keyword(s):  
North China ◽  
Hemorrhagic Fever ◽  
Epidemiological Data ◽  
Hebei Province ◽  
Hantavirus Infection ◽  
Viral Glycoprotein ◽  
Susceptible Population ◽  
Local Case ◽  
Field Rodents

Abstract Background Hemorrhagic fever with renal syndrome (HFRS) is an emerging zoonotic infectious disease caused by hantaviruses which circulate worldwide. So far, it was still considered as one of serious public health problems in China. The present study aimed to reveal the stabilities and variations of hantavirus infection in Hebei province located in North China through a long-term retrospective observation. Methods The epidemiological data of HFRS cases from all eleven cities of Hebei province since 1981 through 2016 were collected and descriptively analyzed. The rodent densities, species compositions and virus-carrying rates of different regions were collected from six separated rodent surveillance points which set up since 2007. The molecular diversity and phylogenetic relationship of hantaviruses circulating among rodents were analyzed based on partial viral glycoprotein gene. Results HFRS cases have been reported every year in Hebei province, since the first local case was identified in 1981. The epidemic history can be artificially divided into three phases and a total of 55,507 HFRS cases with 374 deaths were reported during 1981-2016. The gender and occupational factors of susceptible population were invarible throughout, however age of that was gradually aging. The annual outbreak peak always present in spring, while the main epidemic region had gradully altered from south to northeast. Surveillance of rodents revealed that residential rodents significantly possessed higher density and virus-carring rate than field rodents. The house rat, Rattus norvegicus, was the dominant rodent species and Seoul virus S3 sub-genotype which is continued but slightly evolving perhaps to be the sole pathogen for local HFRS cases of Hebei province. Conclusions This long-term province-wide surveillance and epidemiological analysis has revealed the stabilities and variations of hantavirus infection in North China. In order to improve current prevention and control strategies of HFRS in China, all surveillance should be continuously enhanced and variations should be paid more attentions.

scholarly journals Long-term retrospective observation reveals stabilities and variations of hantavirus infection in Hebei, China

2019 ◽  
Author(s):  
Shiyou Liu ◽  
Yamei Wei ◽  
Xu Han ◽  
Yanan Cai ◽  
Zhanying Han ◽  
...  
Keyword(s):  
North China ◽  
Hemorrhagic Fever ◽  
Epidemiological Data ◽  
Hebei Province ◽  
Hantavirus Infection ◽  
Viral Glycoprotein ◽  
Susceptible Population ◽  
Local Case ◽  
Field Rodents

Abstract Background Hemorrhagic fever with renal syndrome (HFRS) is an emerging zoonotic infectious disease caused by hantaviruses which circulate worldwide. So far, it was still considered as one of serious public health problems in China. The present study aimed to reveal the stabilities and variations of hantavirus infection in Hebei province located in North China through a long-term retrospective observation. Methods The epidemiological data of HFRS cases from all eleven cities of Hebei province since 1981 through 2016 were collected and descriptively analyzed. The rodent densities, species compositions and virus-carrying rates of different regions were collected from six separated rodent surveillance points which set up since 2007. The molecular diversity and phylogenetic relationship of hantaviruses circulating among rodents were analyzed based on partial viral glycoprotein gene. Results HFRS cases have been reported every year in Hebei province, since the first local case was identified in 1981. The epidemic history can be artificially divided into three phases and a total of 55,507 HFRS cases with 374 deaths were reported during 1981-2016. The gender and occupational factors of susceptible population were invarible throughout, however age of that was gradually aging. The annual outbreak peak always present in spring, while the main epidemic region had gradully altered from south to northeast. Surveillance of rodents revealed that residential rodents significantly possessed higher density and virus-carring rate than field rodents. The house rat, Rattus norvegicus, was the dominant rodent species and Seoul virus S3 sub-genotype which is continued but slightly evolving perhaps to be the sole pathogen for local HFRS cases of Hebei province. Conclusions This long-term province-wide surveillance and epidemiological analysis has revealed the stabilities and variations of hantavirus infection in North China. In order to improve current prevention and control strategies of HFRS in China, all surveillance should be continuously enhanced and variations should be paid more attentions.

scholarly journals Long-term retrospective observation reveals stabilities and variations of hantavirus infection in Hebei, China

2019 ◽  
Author(s):  
Shiyou Liu ◽  
Yamei Wei ◽  
Xu Han ◽  
Yanan Cai ◽  
Zhanying Han ◽  
...  
Keyword(s):  
North China ◽  
Hemorrhagic Fever ◽  
Epidemiological Data ◽  
Hebei Province ◽  
Hantavirus Infection ◽  
Viral Glycoprotein ◽  
Susceptible Population ◽  
Local Case ◽  
Field Rodents

Abstract Background Hemorrhagic fever with renal syndrome (HFRS) is an emerging zoonotic infectious disease caused by hantaviruses which circulate worldwide. So far, it was still considered as one of serious public health problems in China. The present study aimed to reveal the stabilities and variations of hantavirus infection in Hebei province located in North China through a long-term retrospective observation. Methods The epidemiological data of HFRS cases from all eleven cities of Hebei province since 1981 through 2016 were collected and descriptively analyzed. The rodent densities, species compositions and virus-carrying rates of different regions were collected from six separated rodent surveillance points which set up since 2007. The molecular diversity and phylogenetic relationship of hantaviruses circulating among rodents were analyzed based on partial viral glycoprotein gene. Results HFRS cases have been reported every year in Hebei province, since the first local case was identified in 1981. The epidemic history can be artificially divided into three phases and a total of 55,507 HFRS cases with 374 deaths were reported during 1981-2016. The gender and occupational factors of susceptible population were invarible throughout, however age of that was gradually aging. The annual outbreak peak always present in spring, while the main epidemic region had gradully altered from south to northeast. Surveillance of rodents revealed that residential rodents significantly possessed higher density and virus-carring rate than field rodents. The house rat, Rattus norvegicus, was the dominant rodent species and Seoul virus S3 sub-genotype which is continued but slightly evolving perhaps to be the sole pathogen for local HFRS cases of Hebei province. Conclusions This long-term province-wide surveillance and epidemiological analysis has revealed the stabilities and variations of hantavirus infection in North China. In order to improve current prevention and control strategies of HFRS in China, all surveillance should be continuously enhanced and variations should be paid more attentions.

scholarly journals Long-term retrospective observation reveals stabilities and variations of hantavirus infection in Hebei, China

2019 ◽  
Author(s):  
Shiyou Liu ◽  
Yamei Wei ◽  
Xu Han ◽  
Yanan Cai ◽  
Zhanying Han ◽  
...  
Keyword(s):  
North China ◽  
Hemorrhagic Fever ◽  
Epidemiological Data ◽  
Hebei Province ◽  
Hantavirus Infection ◽  
Viral Glycoprotein ◽  
Susceptible Population ◽  
Local Case ◽  
Field Rodents

Abstract Background Hemorrhagic fever with renal syndrome (HFRS) is an emerging zoonotic infectious disease caused by hantaviruses which circulate worldwide. So far, it was still considered as one of serious public health problems in China. The present study aimed to reveal the stabilities and variations of hantavirus infection in Hebei province located in North China through a long-term retrospective observation. Methods The epidemiological data of HFRS cases from all eleven cities of Hebei province since 1981 through 2016 were collected and descriptively analyzed. The rodent densities, species compositions and virus-carrying rates of different regions were collected from six separated rodent surveillance points which set up since 2007. The molecular diversity and phylogenetic relationship of hantaviruses circulating among rodents were analyzed based on partial viral glycoprotein gene. Results HFRS cases have been reported every year in Hebei province, since the first local case was identified in 1981. The epidemic history can be artificially divided into three phases and a total of 55,507 HFRS cases with 374 deaths were reported during 1981-2016. The gender and occupational factors of susceptible population were invarible throughout, however age of that was gradually aging. The annual outbreak peak always present in spring, while the main epidemic region had gradully altered from south to northeast. Surveillance of rodents revealed that residential rodents significantly possessed higher density and virus-carring rate than field rodents. The house rat, Rattus norvegicus, was the dominant rodent species and Seoul virus S3 sub-genotype which is continued but slightly evolving perhaps to be the sole pathogen for local HFRS cases of Hebei province. Conclusions This long-term province-wide surveillance and epidemiological analysis has revealed the stabilities and variations of hantavirus infection in North China. In order to improve current prevention and control strategies of HFRS in China, all surveillance should be continuously enhanced and variations should be paid more attentions.

scholarly journals Hemorrhagic fever with renal syndrome among military personnel in Primorsky Krai

2019 ◽  
Vol 21 (3) ◽  
pp. 62-65
Author(s):  
O V Iunikhina ◽  
G G Kompanets ◽  
A L Solovei ◽  
N A Rybakova ◽  
E A Naduda
Keyword(s):  
Military Personnel ◽  
Clinical Course ◽  
Hemorrhagic Fever ◽  
Professional Activity ◽  
Hantavirus Infection ◽  
Primorsky Krai ◽  
Murine Rodents ◽  
Epizootic Process ◽  
The Relationship

A study was made of the specific features of the incidence of hemorrhagic fever with renal syndrome among military personnel in the territory of Primorsky Krai and the relationship between the manifestations of infection and the epizootic process among natural carriers of hantavirus. It was established that the incidence of this infection from 2001 to 2015 was characterized by a predominance of middle-aged persons, a connection between the severity of the clinical course and infection conditions, a seasonal and long-term distribution of cases and features of the epizootic process among murine rodents - natural carriers of hantavirus. Infection with ortho-hantavirus among military personnel took place both in domestic conditions and in the process of military professional activity. The circumstances of the most frequent occurrence of sporadic and group cases of diseases are revealed.

scholarly journals A Giant Ostrich from the Lower Pleistocene Nihewan Formation of North China, with a Review of the Fossil Ostriches of China

Diversity ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 47
Author(s):  
Eric Buffetaut ◽  
Delphine Angst
Keyword(s):  
Geographical Distribution ◽  
Late Pleistocene ◽  
North China ◽  
Hebei Province ◽  
Early Pleistocene ◽  
Wide Geographical Distribution ◽  
Lower Pleistocene ◽  
The Crimea

A large incomplete ostrich femur from the Lower Pleistocene of North China, kept at the Muséum National d’Histoire Naturelle (Paris), is described. It was found by Father Emile Licent in 1925 in the Nihewan Formation (dated at about 1.8 Ma) of Hebei Province. On the basis of the minimum circumference of the shaft, a mass of 300 kg, twice that of a modern ostrich, was obtained. The bone is remarkably robust, more so than the femur of the more recent, Late Pleistocene, Struthio anderssoni from China, and resembles in that regard Pachystruthio Kretzoi, 1954, a genus known from the Lower Pleistocene of Hungary, Georgia and the Crimea, to which the Nihewan specimen is referred, as Pachystruthio indet. This find testifies to the wide geographical distribution of very massive ostriches in the Early Pleistocene of Eurasia. The giant ostrich from Nihewan was contemporaneous with the early hominins who inhabited that region in the Early Pleistocene.

A long-term investigation of the variation in leaf wax n-alkanes responding to climate on Dongling Mountain, north China

2021 ◽  
Author(s):  
Minrui Shi ◽  
Jiamao Han ◽  
Guoan Wang ◽  
Jia Wang ◽  
Yaowen Han ◽  
...  
Keyword(s):  
North China ◽  
Leaf Wax

Future Costs of Long-term Care in Japan and Sweden

2017 ◽  
Vol 48 (1) ◽  
pp. 128-147 ◽  
Author(s):  
Mårten Lagergren ◽  
Noriko Kurube ◽  
Yasuhiko Saito
Keyword(s):  
Long Term Care ◽  
Population Change ◽  
Population Aging ◽  
Population Data ◽  
Epidemiological Data ◽  
The Other ◽  
Age Group ◽  
Term Care ◽  
And Gender

Population aging is expected to increase long-term care (LTC) costs in both Japan and Sweden. This study projected LTC costs for 2010 through 2040 for different assumptions of population change, LTC need by age group and gender, and LTC provided per level of need and cost in Japan and Sweden. Population data were taken from the official national forecasts. Needs projections were based on epidemiological data from the Nihon University Japanese Longitudinal Study of Aging and the Swedish Survey of Living Conditions. Data on LTC provision by need and cost were taken from nine Japanese municipalities collected by assessments in the LTC insurance system and from surveys in eight Swedish municipalities. Total initial costs were calibrated to official national figures. Two projections based on two different scenarios were made for each country from 2010 to 2040. The first scenario assumed a constant level of need for LTC by age group and gender, and the other assumed a continuation of the present LTC need trends until 2025. For Japan, this resulted in a projected cost increase of 93% for the one and 80% for the other; for Sweden it was 52% and 24%, respectively. The results reflected differences in population aging and health development.

MO426HANTA HEMORRHAGIC FEVER WITH RENAL SYNDROME CAUSED BY HANTAAN SEROTIPE IN BALKAN PENINSULA - AN UNESPECTED FINDING

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Gabriela Elena Lupusoru ◽  
Ioana-Georgiana Ailincai ◽  
Andreea Gabriella Andronesi ◽  
Mircea Lupusoru ◽  
Lavinia Maria Bernea ◽  
...  
Keyword(s):  
Kidney Biopsy ◽  
Hemorrhagic Fever ◽  
Balkan Peninsula ◽  
Secondary Hypertension ◽  
Blue Staining ◽  
Hantavirus Infection ◽  
Severe Thrombocytopenia ◽  
Toluidine Blue Staining ◽  
Foot Process ◽  
Hepatic Cytolysis

Abstract Background and Aims Hantavirus infection is a zoonosis rare in the Balkan Peninsula but with increasing frequency and geographic spread, causing two major syndromes, depending on the viral serotype: hemorrhagic fever with renal syndrome (HFRS) and cardiopulmonary syndrome (CPS). Because there is no specific treatment or vaccine for this condition, the key for minimizing the progression to chronic kidney disease, secondary hypertension or death is early diagnosis and prompt therapy. This paper presents a case of HFSR in which needle kidney biopsy played a major role in diagnosis and draws attention on this zoonosis that might be highly underdiagnosed in Balkan Peninsula. Method A 26-year-old female with no medical history was admitted in our department with acute kidney injury (AKI), nephritic syndrome with nephrotic range proteinuria, high blood pressure, hepatic cytolysis, severe thrombocytopenia, anemia and leukocytosis, elevated LDH, normal haptoglobin, positive Coombs test (Table 1). Immunological testing (C3, C4, ANA, ANCA, antiGBM), viral infection markers (hepatitis B/C, HIV, Epstein-Barr, Cytomegalovirus), IgA/M/G were all negative and ADAMTS13 activity was normal. Abdominal sonography showed both kidneys of normal size and shape. A kidney biopsy was performed. The biopsy specimen showed macroscopic features of hemorrhage in the renal medulla. In immunofluorescence the staining was negative for IgA, IgG, IgM, C1q, C3c, k and λ chains, albumin and fibrinogen. Light microscopy (LM) revealed normal glomeruli and arterioles, dilated proximal tubules with resorption droplets at the apical pole and erythrocytes in the lumen, important interstitial hemorrhage in the medulla, with no inflammation or interstitial fibrosis. The electron microscopy (EM) showed segmental foot process effacement, endotheliosis of the peritubular capillaries, rare plasmocytes and macrophages in the interstitium (Figure 1). The aspect of hemorrhagic interstitial nephritis suggested Hantavirus infection. Serological testing revealed both IgM and IgG antibodies for the Hantaan serotype (HTNV). The final diagnosis was HTNV hemorrhagic interstitial nephritis with intrinsic AKI and secondary hypertension. MO426   Figure 1: A, B LM, Toluidine Blue staining. Normal glomerulus. Resorption droplets in the proximal tubular cells. C, D LM, Toluidine Blue staining. Extensive interstitial hemorrhage in medulla, tubulitis. E EM. Interstitial extravasation of erythrocytes. F EM. Endothelial swelling, foot process effacement. Results The patient was treated with oral methylprednisolone 16mg/d for 2 weeks, with progressive tampering of the dose and removal after 2 months. She received antihypertensive and antiproteinuric treatment with ramipril. The evolution was good, with creatinine and liver enzymes returning to normal. Conclusion HFRS belongs to a group of rare zoonoses in Balkan Peninsula, the most involved serotypes being Dobrava and Puumala. This case had positive serology for HTNV usually being found in China and Russia, but our patient didn’t travel abroad before she got ill, so we can’t consider the case as being an imported infection. That highlights a possible underdiagnosis of the disease in this region and also the need to re-evaluate geographic distribution of different strains and changes in ecological aspects given that they may pose a major risk to public health. The disease begins with flu-like symptoms and progresses to AKI with severe thrombocytopenia, anemia and coagulation disorders, being easily mistaken for haemolytic uremic syndrome. In a region with sporadic cases, we face diagnosis difficulties related especially to the absence of initial diagnosis suspicion, so we emphasize the need to include this pathology in the differential diagnosis algorithm of diseases evolving with thrombocytopenia, anemia, hepatic cytolysis and renal injury.

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