scholarly journals Structural network topology correlates to cognitive impairment and iPTH level in End-stage renal disease patients with peritoneal dialysis

2019 ◽  
Author(s):  
Longsheng Wang ◽  
Liwei Zou ◽  
Hanqiu Wu ◽  
Yanqi Shan ◽  
Ru Zhao ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
End Stage Renal Disease ◽  
Cognitive Assessment ◽  
Path Length ◽  
Ipth Level ◽  
Structural Network ◽  
Stage Renal Disease ◽  
End Stage ◽  
The Brain ◽  
Esrd Patients

Abstract Objective: The burden of cognitive impairment in patients with end-stage renal disease (ESRD) undergoing peritoneal dialysis has received more attention lately. It is associated with hospitalization, mortality and poorer quality of life. We aimed to assess the topological alterations of the brain white matter structural network in ESRD and the correlation between network metrics with Montreal Cognitive Assessment scores and clinical data. Methods: The study included 25 ESRD patients with secondary hyperparathyroidism (SHPT group), 25 patients without SHPT (Non-SHPT group) and 25 healthy controls (HC group) of comparable age and sex. Montreal Cognitive Assessment was used to assess the cognitive function. The WM structural network was constructed by DTI technique, and then we used graph theoretical approaches to detect changes in the global and regional properties of the WM networks in these participants through deterministic tractography method. Results: ESRD patients showed cognitive impairment compared to HC, and the SHPT patients had lower cognitive scores than the Non-SHPT patients. The global topological organization and local efficiency of the WM network was significantly disrupted in the SHPT but not in the Non-SHPT patients compared with the HC group. Moreover, lower regional efficiency was found in the ESRD patients, mainly distributed in the frontal and parietal cortices. In addition, an association was found between iPTH, shortest path length and cognitive impairment, and the iPTH level was negatively correlated with small-worldness by two indexes, the normalized clustering coefficient and the normalized shortest path length. Conclusion: The present study indicated that the brain structural connectome in ESRD patients with high iPTH levels was disrupted in association with cognitive impairment and it is a potential connectome-based biomarker for early detection.

scholarly journals Structural network topology correlates to cognitive impairment and iPTH level in End-stage renal disease patients with peritoneal dialysis

2019 ◽  
Author(s):  
Longsheng Wang ◽  
Liwei Zou ◽  
Hanqiu Wu ◽  
Yanqi Shan ◽  
Ru Zhao ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
End Stage Renal Disease ◽  
Cognitive Assessment ◽  
Path Length ◽  
Ipth Level ◽  
Structural Network ◽  
Stage Renal Disease ◽  
End Stage ◽  
The Brain ◽  
Esrd Patients

Abstract Objective: The burden of cognitive impairment in patients with end-stage renal disease (ESRD) undergoing peritoneal dialysis has received more attention lately. It is associated with hospitalization, mortality and reduced quality of life. We aimed to assess the topological alterations of the brain white matter structural network in ESRD and the correlation between network metrics with Montreal Cognitive Assessment scores and clinical data. Methods: The study included 25 ESRD patients with secondary hyperparathyroidism (SHPT group), 25 patients without SHPT (Non-SHPT group) and 25 healthy controls (HC group) of comparable age and sex. Cognitive function was assessed using the Montreal Cognitive Assessment. The WM structural network was constructed by diffusion tensor imaging and a deterministic tractography method, and then we used graph theoretical approaches to investigate alterations in the global and regional properties of the WM networks in these participants. Results: ESRD patients showed cognitive impairment compared to HC, and the SHPT patients had lower cognitive scores than the Non-SHPT patients. The global topological organization and local efficiency of the WM network was significantly disrupted in the SHPT but not in the Non-SHPT patients compared with the HC group. Moreover, lower regional efficiency was found in the ESRD patients, mainly distributed in the frontal and parietal cortices. In addition, an association was found between iPTH, shortest path length and cognitive impairment, and the iPTH level was negatively correlated with small-worldness by two indexes, the normalized clustering coefficient and the normalized shortest path length. Conclusion: The present study indicated that the brain structural connectome in ESRD patients with high iPTH levels was disrupted in association with cognitive impairment and it is a potential connectome-based biomarker for early detection.

scholarly journals Structural network topology correlates to cognitive impairment and iPTH level in End-stage renal disease patients with peritoneal dialysis

2019 ◽  
Author(s):  
Longsheng Wang ◽  
Liwei Zou ◽  
Hanqiu Wu ◽  
Yanqi Shan ◽  
Ru Zhao ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
End Stage Renal Disease ◽  
Cognitive Assessment ◽  
Path Length ◽  
Ipth Level ◽  
Structural Network ◽  
Stage Renal Disease ◽  
End Stage ◽  
The Brain ◽  
Esrd Patients

Abstract Background: The burden of cognitive impairment in patients with end-stage renal disease (ESRD) undergoing peritoneal dialysis has received more attention lately. It associates with hospitalization, mortality and poorer quality of life. We aimed to assess the topological alterations of the brain white matter structural network in ESRD and the correlation between network metrics with Montreal Cognitive Assessment scores and clinical data. Methods: The study included 25 ESRD patients with secondary hyperparathyroidism (SHPT group), 25 patients without SHPT (Non-SHPT group) and 25 healthy controls (HC group) of comparable age and sex. Montreal Cognitive Assessment was used to assess the cognitive function. The white matter (WM) structural network was constructed by diffusion tensor imaging (DTI) technique, and then we used graph theoretical approaches to detect changes in the global and regional properties of the WM networks in these participants through deterministic tractography method. Results: ESRD patients showed cognitive impairment compared to HC, and the SHPT patients had lower cognitive scores than the Non-SHPT patients. The global topological organization and local efficiency of the WM network was significantly disrupted in the SHPT but not in the Non-SHPT patients compared with the HC group. Moreover, lower regional efficiency was found in the ESRD patients, mainly distributed in the frontal and parietal cortices. In addition, an association was observed between intact parathyroid hormone (iPTH), shortest path length and cognitive impairment, and the iPTH level was negatively correlated with small-worldness by two indexes, the normalized clustering coefficient and the normalized shortest path length. Conclusion: The present study indicated that the brain structural connectome in ESRD patients with high iPTH levels was disrupted in association with cognitive impairment and it is a potential connectome-based biomarker for early detection.

scholarly journals Structural network topology correlates to cognitive impairment and iPTH level in End-stage renal disease patients with peritoneal dialysis

2019 ◽  
Author(s):  
Longsheng Wang ◽  
Liwei Zou ◽  
Hanqiu Wu ◽  
Yanqi Shan ◽  
Ru Zhao ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
End Stage Renal Disease ◽  
Cognitive Assessment ◽  
Path Length ◽  
Ipth Level ◽  
Structural Network ◽  
Stage Renal Disease ◽  
End Stage ◽  
The Brain ◽  
Esrd Patients

Abstract Objective: The burden of cognitive impairment in patients with end-stage renal disease (ESRD) undergoing peritoneal dialysis has received more attention lately. It is associated with hospitalization, mortality and poorer quality of life. We aimed to assess the topological alterations of the brain white matter structural network in ESRD and the correlation between network metrics with Montreal Cognitive Assessment scores and clinical data. Methods: The study included 25 ESRD patients with secondary hyperparathyroidism (SHPT group), 25 patients without SHPT (Non-SHPT group) and 25 healthy controls (HC group) of comparable age and sex. Montreal Cognitive Assessment was used to assess the cognitive function. The WM structural network was constructed by DTI technique, and then we used graph theoretical approaches to detect changes in the global and regional properties of the WM networks in these participants through deterministic tractography method. Results: ESRD patients showed cognitive impairment compared to HC, and the SHPT patients had lower cognitive scores than the Non-SHPT patients. The global topological organization and local efficiency of the WM network was significantly disrupted in the SHPT but not in the Non-SHPT patients compared with the HC group. Moreover, lower regional efficiency was found in the ESRD patients, mainly distributed in the frontal and parietal cortices. In addition, an association was found between iPTH, shortest path length and cognitive impairment, and the iPTH level was negatively correlated with small-worldness by two indexes, the normalized clustering coefficient and the normalized shortest path length. Conclusion: The present study indicated that the brain structural connectome in ESRD patients with high iPTH levels was disrupted in association with cognitive impairment and it is a potential connectome-based biomarker for early detection.

scholarly journals Structural network topology correlates to cognitive impairment and iPTH level in End-stage renal disease patients with peritoneal dialysis

2019 ◽  
Author(s):  
Longsheng Wang ◽  
Liwei Zou ◽  
Hanqiu Wu ◽  
Yanqi Shan ◽  
Ru Zhao ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Peritoneal Dialysis ◽  
End Stage Renal Disease ◽  
Cognitive Assessment ◽  
Path Length ◽  
Ipth Level ◽  
Structural Network ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Abstract Objective: The burden of cognitive impairment in end-stage renal disease (ESRD) undergoing peritoneal dialysis received more attention, which associated with hospitalization, mortality and quality of life. We aimed to assess the topological alterations of brain white matter structural network in ESRD and the correlation between network metrics with Montreal Cognitive Assessment scores and clinical data. Methods: The study included 25 ESRD patients with secondary hyperparathyroidism (SHPT group), 25 patients without SHPT (Non-SHPT group) and 25 healthy controls (HC group) of comparable age and sex. Cognitive function was assessed using Montreal Cognitive Assessment. WM structural network constructed by diffusion tensor imaging and deterministic tractography method, and then used graph theoretical approaches to investigate alterations in the global and regional properties of the WM network in these participants. Results: ESRD patients showed cognitive impairment compared to HC and SHPT patients was lower cognitive scores than Non-SHPT patients. The global topological organization and local efficiency of WM network was significantly disrupted in SHPT but not in Non-SHPT patients, as compared with HC group. Moreover, lower regional efficiency was found in ESRD patients mainly distributed in the frontal and parietal cortices. In addition, association was found between iPTH, shortest path length and cognitive impairment, and iPTH level was negatively correlated with small-worldness by two indexes normalized clustering coefficient and normalized shortest path length. Conclusion: The present study indicated that brain structural connectome in ESRD patients with high iPTH level was disrupted as cognitive impairment and it has the potential connectome-based biomarkers for early detection.

scholarly journals The Allocation of Vertical Attention in Patients with End-Stage Renal Disease Receiving Dialysis

2021 ◽  
Vol 11 (12) ◽  
pp. 1549
Author(s):  
Aleksandra Mańkowska ◽  
Kenneth M. Heilman ◽  
Bogdan Biedunkiewicz ◽  
Alicja Dębska-Ślizień ◽  
John B. Williamson ◽  
...  
Keyword(s):  
Renal Disease ◽  
Spatial Attention ◽  
Attentional Bias ◽  
End Stage Renal Disease ◽  
Healthy Controls ◽  
Brain Mechanism ◽  
Stage Renal Disease ◽  
End Stage ◽  
The Brain ◽  
Esrd Patients

Objectives: Alterations of spatial attention can have adverse effects, such a greater probability of accidents. Patients with end-stage renal disease (ESRD) receiving dialysis have stronger left-sided spatial attentional bias, suggesting that this disorder or treatment alters the brain networks that mediate spatial attention. The hemispheric networks that mediate the allocation of horizontal attention may also influence the allocation of vertical attention. However, the allocation of vertical spatial attention has not been studied in ESRD patients. Methods: Twenty-three ESRD patients receiving dialysis and 23 healthy right-handed controls performed line bisections using 24 vertical lines (24 cm long and 2 mm thick) aligned with the intersection of their midsagittal and coronal planes. Results: Hemodialyzed ESRD patients had a significantly greater upward bias than healthy controls. The magnitude of this bias was correlated with the duration of the kidney disease. Conclusions: The reason why upward attentional bias is increased in hemodialyzed ESRD patients is not known. Further research is needed to better understand the brain mechanism that might account for this bias, as well as its treatment. However, hemodialyzed ESRD patients and their families-caregivers should be made aware of this disorder to avoid accidents such as tripping.

Neurovascular coupling dysfunction in end-stage renal disease patients related to cognitive impairment

2021 ◽  
pp. 0271678X2110079
Author(s):  
Peng Li ◽  
Junya Mu ◽  
Xueying Ma ◽  
Dun Ding ◽  
Shaohui Ma ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Neurovascular Coupling ◽  
Healthy Controls ◽  
Stage Renal Disease ◽  
End Stage ◽  
The Impact ◽  
The Relationship ◽  
Esrd Patients

We aimed to investigate the neurovascular coupling (NVC) dysfunction in end-stage renal disease (ESRD) patients related with cognitive impairment. Twenty-five ESRD patients and 22 healthy controls were enrolled. To assess the NVC dysfunctional pattern, resting-state functional MRI and arterial spin labeling were explored to estimate the coupling of spontaneous neuronal activity and cerebral blood perfusion based on amplitude of low-frequency fluctuation (ALFF)-cerebral blood flow (CBF), fractional ALFF (fALFF)-CBF, regional homogeneity (ReHo)-CBF, and degree centrality (DC)-CBF correlation coefficients. Multivariate partial least-squares correlation and mediation analyses were used to evaluate the relationship among NVC dysfunctional pattern, cognitive impairment and clinical characteristics. The NVC dysfunctional patterns in ESRD patients were significantly decreased in 34 brain regions compared with healthy controls. The decreased fALFF-CBF coefficients in the cingulate gyrus (CG) were associated positively with lower kinetic transfer/volume urea (Kt/V) and lower short-term memory scores, and were negatively associated with higher serum urea. The relationship between Kt/V and memory deficits of ESRD patients was partially mediated by the fALFF-CBF alteration of the CG. These findings reveal the NVC dysfunction may be a potential neural mechanism for cognitive impairment in ESRD. The regional NVC dysfunction may mediate the impact of dialysis adequacy on memory function.

scholarly journals Voxel-based morphometry and arterial spin labeling fMRI reveal neuropathic and neuroplastic features of brain processing of itch in end-stage renal disease

2014 ◽  
Vol 112 (7) ◽  
pp. 1729-1738 ◽  
Author(s):  
Alexandru D. P. Papoiu ◽  
Nichole M. Emerson ◽  
Tejesh S. Patel ◽  
Robert A. Kraft ◽  
Rodrigo Valdes-Rodriguez ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Gray Matter ◽  
End Stage Renal Disease ◽  
Matter Density ◽  
Gray Matter Density ◽  
Brain Responses ◽  
Stage Renal Disease ◽  
End Stage ◽  
The Brain ◽  
Esrd Patients

Pruritus of end-stage renal disease (ESRD) is a multifactorial symptom of complex etiology not yet fully understood. In this study we have investigated the cerebral perfusion patterns at rest in ESRD patients on hemodialysis, compared with those in healthy volunteers. We have also studied the brain responses evoked by experimental itch induction in ESRD, after stimulating the two distinct histamine and cowhage itch pathways, and compared them with the responses evoked in healthy volunteers. To identify potential structural alterations in ESRD patients compared with a group of age-matched healthy volunteers, we calculated the density of gray matter for the entire brain using a voxel-based morphometric analysis. Our results indicated that gray matter density was significantly reduced in ESRD patients in the frontal, parietal, temporal, and occipital cortices, as well as in the S1, precuneus, and insula, whereas the brain stem, hippocampus, amygdala, midcingulate cortex, and nucleus accumbens displayed an increased gray matter density. Functionally, we found a significantly higher brain perfusion at baseline associated with ESRD pruritus in the anterior cingulate, insula, claustrum, hippocampus, and nucleus accumbens. The brain responses evoked by cowhage itch, which are mediated by protease-activated receptors (PAR2), displayed significant differences compared with responses in healthy individuals and were correlated with perceived itch intensity in a dual, complex manner. The inverse correlations in particular suggested that a negative feedback mechanism modulated itch intensity, when elicited in a preexistent chronic itch background.

Tissue ischemia worsens during hemodialysis in end-stage renal disease patients

2016 ◽  
Vol 18 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Jan Malik ◽  
Jaroslav Kudlicka ◽  
Jana Lachmanova ◽  
Anna Valerianova ◽  
Katarina Rocinova ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Cognitive Deficit ◽  
Dialysis Access ◽  
Dialysis Patients ◽  
Tissue Ischemia ◽  
Stage Renal Disease ◽  
End Stage ◽  
The Brain ◽  
Esrd Patients

Background Cognitive deficit is a common problem in end-stage renal disease (ESRD) patients. Ultrafiltration and hemodialysis lead to profound hemodynamic changes. The aim of this pilot study was to describe brain and hand oxygenation values in ESRD patients and their changes during hemodialysis. Methods Twenty-seven patients treated by chronic hemodialysis and 17 controls patients of the same age were included in the study. Regional saturation of oxygen (SrO2) was measured at the brain frontal lobe and at the hand with dialysis access using the INVOS 5100C. In 17 of ESRD patients, SrO2 was also monitored throughout hemodialysis. Finger systolic blood pressure and basic hemodialysis and laboratory data were collected. Results Dialysis patients had lower brain and also hand SrO2 values at rest (51.5 ± 10.9 vs. 68 ± 7%, p<0.0001 and 55 ± 16 vs. 66 ± 8%, p = 0.03, respectively). Both values further decreased during the first 35 minutes of hemodialysis (brain SrO2 to 47 ± 8%, p<0.0001 and hand to 45 ± 14%, p<0.0001, respectively). The brain SrO2 decrease was related to the ultrafiltration rate, the hand SrO2 decrease to the finger pressure and to blood hemoglobin. Conclusions Chronic dialysis patients suffer from tissue ischemia and that even worsens after the beginning of hemodialysis. This observation may contribute to the understanding of cognitive deficit etiology.

Sign in / Sign up

Export Citation Format

Share Document