scholarly journals Quality of Life of Postmenopausal Women With Teriparatide, Denosumab And Alendronate: One-Year Prospective Study With A Propensity Score-Matched Comparison

2021 ◽  
Author(s):  
Pun Yuet Lam ◽  
Prudence Wing Hang Cheung ◽  
Sin Ting Lau ◽  
Jason Pui Yin Cheung
Keyword(s):  
Quality Of Life ◽  
Back Pain ◽  
Propensity Score ◽  
Physical Function ◽  
Postmenopausal Women ◽  
Propensity Score Analysis ◽  
Osteoporosis Treatment ◽  
Teriparatide Treatment ◽  
One Year

Abstract Background: To evaluate and compare the effects of parathyroid hormone analogues, receptor activator of nuclear factor kappa-B ligand inhibitors (RANKL inhibitors) and bisphosphonates on the quality of life of postmenopausal women.Methods: A prospective observational study of 23 matched post-menopausal women was conducted with propensity score analysis on quality of life (QOL). Baseline and 12-month follow-up data were compared. Visual analogue scale (VAS) for back pain, the Osteoporosis Assessment Questionnaire-Physical Function (OPAQ-PF), EuroQol 5-level 5-dimension (EQ-5D-5L) questionnaire, ambulatory status assessment and Adherence Evaluation of Osteoporosis treatment (ADEOS-12) were carried out as QOL or treatment adherence measurements. A general linear model with inverse probability of treatment weighting (IPTW) adjustment with propensity score was constructed to predict one-year average back pain progression.Results: Teriparatide use was associated with significant improvements in VAS back pain (most severe pain reduced from 8.0 to 0.0, p=0.029; average pain reduced from 6.0 to 0.0, p=0.006), EQ-5D-5L general health status (EQ-5D summary index scores increased from 0.47 to 0.87, p=0.001; EQ-VAS increased from 65.0 to 80.0, p=0.008) and OPAQ physical function (from 40.0 to 79.5, p<0.001), whereas denosumab and alendronate groups only demonstrated improved OPAQ scores but worsened back pain. Baseline average VAS back pain was the only significant factor predicting one-year average back pain progression (partial eta squared=0.617, p=0.001).Conclusions: One-year continuous teriparatide treatment is most effective in improving QOL outcomes in postmenopausal osteoporotic women, but baseline average VAS back pain remained the only predictive factor for one-year back pain progression in the IPTW adjusted model.

scholarly journals O16 THE TOR-CONCEPT (TRAINING-OPERATION-REHABILITATION) APPLIED TO A COHORT OF POST-PARTUM WOMEN WITH SYMPTOMATIC DRA (DIASTASIS RECTI ABDOMINIS). EVALUATION OF PHYSICAL FUNCTION AND QUALITY OF LIFE ONE YEAR AFTER SURGERY

2021 ◽  
Vol 108 (Supplement_8) ◽  
Author(s):  
Anders Olsson ◽  
Katarina Woxnerud ◽  
Gabriel Sandblom ◽  
Otto Stackelberg
Keyword(s):  
Quality Of Life ◽  
Physical Function ◽  
Surgical Repair ◽  
Post Partum ◽  
Rehabilitation Program ◽  
Diastasis Recti ◽  
Sf 36 ◽  
One Year ◽  
Diastasis Recti Abdominis

Abstract Aim Management of diastasis recti abdominis (DRA) differs regarding core training, surgical repair methods and post-operative rehabilitation. The purpose of this prospective cohort study was to evaluate the effect of a novel concept of treatment for DRA, the TOR-concept (Training, Operation and Rehabilitation). The concept includes preoperative evaluation of symptoms and instructed abdominal core training; tailored surgical repair of the DRA; and an individualized postoperative rehabilitation program. Material and Methods A cohort of seventy-five post-partum women with diagnosed DRA and training resistant core dysfunctions were evaluated and included to the study during 2018-2020. After surgery, all participants underwent an individualized supervised rehabilitation program with progressive increasing load for four months. Physical function was registered preoperatively and one year after surgery with the disability rating index (DRI) questionnaire. Quality of life (QoL) was assessed with the SF-36 questionnaire. The DRA and the surgical result were assessed with ultrasonography before and one year after surgery. Results Sixty-nine participants, 92%, completed the study. There were no DRA-recurrences at the 1-year follow-up. Early results shows that self-reported physical function, (DRI), improved in 88.8 % of patients, with a mean score improvement of 78.5 %. Quality of life, (SF-36), improved significantly compared with the preoperative scores, and reached a level similar to, or higher than, the normative Swedish female population. Conclusions In this cohort of post-partum women with DRA combined with core instability symptoms resistant to training, surgical reconstruction within the TOR-concept resulted in a significant improvement of physical function and QoL.

Effects of tai chi exercise on posturography, gait, physical function and quality of life in postmenopausal women with osteopaenia: a randomized clinical study

2010 ◽  
Vol 24 (12) ◽  
pp. 1080-1090 ◽  
Author(s):  
Ming-Chien Chyu ◽  
C. Roger James ◽  
Steven F Sawyer ◽  
Jean-Michel Brismée ◽  
Ke T Xu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Study ◽  
Physical Function ◽  
Postmenopausal Women ◽  
Tai Chi ◽  
Randomized Clinical Study ◽  
Tai Chi Exercise

scholarly journals Dry cupping in the treatment of individuals with non-specific chronic low back pain: a protocol for a placebo-controlled, randomised, double-blind study

BMJ Open ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. e032416 ◽  
Author(s):  
Hugo Jário de Almeida Silva ◽  
Bruno T Saragiotto ◽  
Rodrigo Scattone Silva ◽  
Caio Alano de Almeida Lins ◽  
Marcelo Cardoso de Souza
Keyword(s):  
Quality Of Life ◽  
Low Back Pain ◽  
Back Pain ◽  
Physical Function ◽  
Chronic Low Back Pain ◽  
Cupping Therapy ◽  
Double Blind Study ◽  
Low Back ◽  
Double Blind

BackgroundLow back pain is a very prevalent condition in the population and cupping therapy has been presented as a frequently used non-pharmacological treatment in this population. However, there is a lack of well-designed studies that evaluate the effects of this technique. This protocol describes a placebo-controlled, randomised, double-blind study that aims to evaluate the effect of dry cupping therapy on pain, physical function, trunk range of motion, quality of life and psychological symptoms in individuals with non-specific chronic low back pain.Methods and analysisNinety individuals with chronic non-specific low back pain, aged from 18 to 59 years, will be randomised into two groups: intervention group, which will be submitted to dry cupping therapy application with two suctions; and placebo group which will undergo placebo dry cupping therapy. Both applications will occur bilaterally in parallel to the vertebrae from L1 to L5. The application will be performed once a week for 8 weeks. The volunteers will be evaluated before the treatment (T0), immediately after the first intervention (T1), after 4 weeks of intervention (T4) and after 8 weeks of intervention (T8). The primary outcome will be pain intensity, and secondary outcomes will be physical function, lumbar range of motion, patient expectation, overall perception of effect, quality of life and psychological factors.Ethics and disseminationThis protocol has been approved by the Ethics Committee of FACISA/UFRN (number: 3639814). The results of the study will be disseminated to participants through social networks and will be submitted to a peer-reviewed journal and scientific meetings.Trial registration numberNCT03909672.

scholarly journals Effectiveness of Radial Extracorporeal Shockwave Therapy in Patients with Acute Low Back Pain — Randomized Controlled Trial

2021 ◽  
Author(s):  
Tobias Lange
Keyword(s):  
Quality Of Life ◽  
Back Pain ◽  
Physical Function ◽  
Sham Group ◽  
Extracorporeal Shockwave Therapy ◽  
Extracorporeal Shockwave ◽  
Shockwave Therapy ◽  
Acute Low Back Pain ◽  
Patient Reported

Abstract OBJECTIVE Aim of this study was to investigate the effect of radial Extracorporeal Shockwave Therapy (rESWT) primarily on acute lumbar back pain (aLBP) and secondarily on physical function and quality of life.METHODS This randomized, placebo-controlled, single-blinded trial with 12-week follow-up (FU) randomized 63 patients with aLBP 1 : 1 into two groups receiving either rESWT (intervention) or sham rESWT (placebo) with a manipulated shockwave head not delivering any shockwaves. Both, rESWT and sham procedure were carried out eight times for 4 weeks. Both groups received additional analgesics and physiotherapy twice a week.Primary patient-reported outcome measure (PROM) was the Visual Analogue Scale for aLBP (VAS-LBP). Secondary PROMs included Oswestry Disability Index (ODI), Roland & Morris Disability Questionnaire (RDQ), EuroQol EQ-5D-3L and the Beck Depression Index (BDI-II). Primary endpoint was a between-arm comparison of mean changes in VAS-LBP from baseline to final FU. RESULTS At randomization, there were no differences between the two groups in relation to age and PROMs. Both groups showed significant improvement in all PROMs at final FU. VAS-LBP declined by 60.7% (P < .001) in the intervention and by 86.4% (P < .001) in the sham group. The intervention group showed significantly less pain relief after 4 and 12 weeks. The EQ-5D submodality pain showed significantly inferior results for the intervention (1.5 (0.58)) compared to the sham group (1.1 (0.33)) (P < 0.014) after 8 weeks. No significant intergroup differences were observed for RDQ, ODI or BDI-II.CONCLUSIONS Additional rESWT alongside conventional guideline therapy in aLBP does not have any significant effects on pain intensity, physical function, or quality of life.IMPACT STATEMENT To the best of our knowledge, this is the first study with a high level of evidence reporting the efficacy of rESWT in aLBP treatment and will be a future basis for decision-making.

scholarly journals Effect of Addition of Epidural Ketamine to Steroid in Lumbar Radiculitis: One-Year Follow-Up

2011 ◽  
Vol 5;14 (5;9) ◽  
pp. 475-481
Author(s):  
Yasser Mohamed Amr
Keyword(s):  
Quality Of Life ◽  
Low Back Pain ◽  
Back Pain ◽  
Low Back ◽  
Pain Disability ◽  
Group I ◽  
Disability Questionnaire ◽  
Group Ii ◽  
One Year

Background: Treating sciatica with epidural steroid injection has been a common practice worldwide. N-methyl-D-aspartate (NMDA) receptors are an important component of pain pathways. Objectives: The aim of this study was to evaluate the safety and efficacy of epidurally administered NMDA receptor antagonists (ketamine) for the treatment of chronic low back pain secondary to radiculopathy and its effect on patients’ quality of life. Study Design: Randomized, double blind controlled trial. Setting: Hospital outpatient setting. Methods: Two hundred participants aged 25 to 50 years old with a diagnosis of lumbar radiculopathic pain secondary to disc herniation were randomized into 2 equal groups. Group I received 80 mg of triamcinolone (2 mL) and 0.25% bupivacaine (3 mL) plus 30 mg (3 mL) of preservative free ketamine. Group II received 80 mg of triamcinolone (2 mL) and 0.25% bupivacaine (3 mL) plus 3 mL of 0.9% saline. Pain scores were obtained before injection, immediately after injection, one week, one month, 3 months, 6 months , 9 months and one year post injection. The Oswestry Low Back Pain Disability Questionnaire was used at baseline and at one month, 3, 6, 9, and 12 months after injection for assessment of quality of life. Patients were asked to report any side effects, particularly those related to ketamine, including nausea, vomiting, visual or auditory hallucinations, and delirium. Results: Immediately after injection there was no statistically significant difference between Group I and II regarding pain scale scores. After one week of injection, pain relief was significantly better in Group I compared to Group II and then at all evaluation times. The Oswestry Low Back Pain Disability Questionnaire score decreased significantly (P < 0.05) from 72 (range 62- 83) and 70 (range 57- 82) to 8 (range 2 – 12) and 17 (range 9 – 27) at one month; 6 (range 4 – 12) and 18 (range 14 – 22) at 3 months; 12 (range 9 – 16) and 28 (range 22 – 34) at 6 months; 17 (range 9 – 24) and 31 (range 21 – 35) at 9 months; and 17 (range 8 – 22) and 33 (range 20 – 37) at 12 months in the groups, respectively. Six patients in the ketamine group showed short-lasting delusions lasting for 45 ± 12 minutes after injection. Limitations: The limitations include a lack of placebo control. Conclusion: Epidurally administrated ketamine seems to be a safe and useful adjunct to epidural corticosteroid therapy in chronic lumbar radicular pain. Key words: Ketamine, epidural, radiculopathic, pain, steroid

scholarly journals The Impact of Fracture Incidence on Health Related Quality of Life among Community-Based Postmenopausal Women

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
A. L. Barcenilla-Wong ◽  
J. S. Chen ◽  
M. J. Cross ◽  
L. M. March
Keyword(s):  
Quality Of Life ◽  
Physical Function ◽  
Postmenopausal Women ◽  
Fracture Incidence ◽  
Health Related Quality ◽  
Incident Fracture ◽  
Related Quality ◽  
Health Related ◽  
The Impact

This prospective study aimed to examine the impact of fracture incidence on health-related quality of life (HRQOL) among postmenopausal women. Study subjects were Australian female community-dwellers in the Global Longitudinal Study of Osteoporosis in Women (GLOW). Self-administered questionnaires were collected annually from 2007 to 2010. Outcomes were the Medical Outcomes Study Short Form-36 (SF-36 physical function (SF36PFS) and vitality (SF36VS) scores), European Quality of Life (EQ-5D), and self-reported general health (GH) of excellent/good. Questionnaires were divided into prior to, the 1st, the 2nd, and the 3rd year after incident fracture assessments. Generalized linear models with generalised estimating equations (GEE) were employed for the analysis. The 2,872 participants (age: median 65; interquartile range 60–73 years) provided a total of 10,436 assessments including 266, 165 and 76 assessments for the 1st, the 2nd, and the 3rd year after incident fracture, respectively. Multivariate adjustments showed reductions in HRQOL measures peaking at the 1st year for SF36VS (coefficient −3.0; 95% CI: −5.1, −0.8) and EQ-5D (coefficient −0.03; 95% CI: −0.06, −0.00) and at the 2nd year for SF36PFS (coefficient −3.0; 95% CI: −5.6, −0.5) and GH (odds ratio 0.92; 95% CI: 0.70, 1.19). Fracture incidence reduced HRQOL including vitality and physical function among relatively young, healthy postmenopausal women and the reduction in European Quality of Life measure was clinically important.

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