scholarly journals Association among Geriatric Nutrition Risk Index and functional prognosis in elderly patients with osteoporotic vertebral compression fractures: a retrospective cohort study

2020 ◽  
Author(s):  
Takako Nagai ◽  
Hiroshi Uei ◽  
Kazuyoshi Nakanishi
Keyword(s):  
Regression Analysis ◽  
Nutritional Status ◽  
Risk Index ◽  
Linear Regression Analysis ◽  
Compression Fracture ◽  
The Elderly ◽  
Vertebral Compression Fractures ◽  
Mineral Density ◽  
Nutritional Risk Index ◽  
The Relationship

Abstract Background Osteoporotic vertebral compression fracture (OVCF) is one of the most common fractures in the elderly and the number is increasing. In addition, nutritional status is associated with functional prognosis in the elderly. However, there are limited reports on the relationship between nutritional status and functional prognosis in OVCF. Furthermore, there are no reports that have examined the relationship between OVCF nutritional status and functional prognosis using geriatric nutritional risk index (GNRI) for nutritional assessment. The aim of this study was to investigate the association between nutritional status, activities of daily living (ADL), and fall after fracture in patients with OVCF. Methods The clinical information of 187 conservatively treated OVCF patients was retrospectively examined. This information included: age, sex, body mass index, total number of drugs used for treatment at admission, bone mineral density, use of drugs for osteoporosis, fracture type, comorbidity severity, nutritional status, Barthel Index (BI), and fall after OVCF. Subjects were divided into two groups according to their GNRI. Propensity score matching was used to confirm factors affecting BI and falls after OVCF. Results Sixty-eight patients (36.4%) presented with malnutrition at fracture. According to multiple linear regression analysis, GNRI positively affected BI gain (β = 0.283, 95% confidence interval [CI], -122.2 to -0.706, p = 0.001). Furthermore, on logistic regression analysis, fall after OVCF was associated with GNRI (odds ratio = 0.896, 95% CI, 0.832 to 0.964, p = 0.003). Conclusions Malnutrition in elderly OVCF patients decreases the acquisition of ADL and increases fall risk. Improvement of nutritional status during OVCF treatment may lead to improvement of ADL and prevention of falls.

scholarly journals Nutrition status and functional prognosis among elderly patients with distal radius fracture: a retrospective cohort study

2020 ◽  
Author(s):  
Takako Nagai ◽  
Koji Tanimoto ◽  
Yoshiaki Tomizuka ◽  
Hiroshi Uei ◽  
Masahiro Nagaoka
Keyword(s):  
Regression Analysis ◽  
Nutritional Status ◽  
Elderly Patients ◽  
Distal Radius ◽  
Risk Index ◽  
The Elderly ◽  
Nutrition Status ◽  
Mineral Density ◽  
Poor Prognostic Factor ◽  
Nutritional Risk Index

Abstract Background: Distal radius fractures (DRF) are common in the elderly and are typically caused falls. Malnutrition has also been identified as a poor prognostic factor in elderly patients with fractures. However, the relationship between nutritional status and subsequent falls and functional prognosis for DRF in the elderly is not clear. The aim of the present study was to investigate the association between nutritional status and functional prognosis in elderly patients with DRF. Methods: Study participants included 229 outpatients who required surgical treatment for DRF. The patients’ clinical information, including age, sex, body mass index, bone mineral density, Geriatric Nutritional Risk Index (GNRI), total number of drugs being treated with on admission, use of drugs for osteoporosis, comorbidity severity, the Barthel Index (BI), presence of subsequent falls, fracture type, postoperative follow-up period, and Mayo wrist score was reviewed. Subjects were further divided into two groups according to their GNRI: the malnutrition group and the normal group. Propensity score matching was used to confirm factors affecting the BI and subsequent falls. Results: Thirty-one patients (13.5%) presented with malnutrition before surgery for DRF. According to multiple liner regression analysis, the GNRI positively affected the efficiency of the BI (β = 0.392, 95% confidence interval [CI], 0.001 to 0.351, p = 0.039). Furthermore, on logistic regression analysis, subsequent falls were associated with serum albumin levels (odds ratio = 0.033, 95% CI, 0.002 to 0.477, p = 0.012). Conclusion: Malnutrition impaired improvement of activities of daily living (ADL) and increased the incidence of subsequent falls. Improvement of nutritional status before DRF surgery may further improve ADL and prevent falls.

scholarly journals Nutrition status and functional prognosis among elderly patients with distal radius fracture: a retrospective cohort study

2020 ◽  
Author(s):  
Takako Nagai ◽  
Koji Tanimoto ◽  
Yoshiaki Tomizuka ◽  
Hiroshi Uei ◽  
Masahiro Nagaoka
Keyword(s):  
Regression Analysis ◽  
Nutritional Status ◽  
Elderly Patients ◽  
Distal Radius ◽  
Risk Index ◽  
The Elderly ◽  
Nutrition Status ◽  
Mineral Density ◽  
Poor Prognostic Factor ◽  
Nutritional Risk Index

Abstract Background : Distal radius fractures (DRF) are common in the elderly and are typical of hand fractures during falls. Malnutrition has also been identified as a poor prognostic factor in elderly patients with fractures. However, the relationship between nutritional status and subsequent falls and functional prognosis for DRF in the elderly is not clear. The aim of the present study was to investigate the association between nutritional status and functional prognosis in elderly patients with DRF. Methods : Study participants included 229 outpatients who required surgical treatment for DRF. The patients’ clinical information, including age, sex, body mass index, bone mineral density, Geriatric Nutritional Risk Index (GNRI), total number of drugs being treated with on admission, use of drugs for osteoporosis, comorbidity severity, the Barthel Index (BI), presence of subsequent falls, fracture type, postoperative follow-up period, and Mayo wrist score was reviewed. Subjects were further divided into two groups according to their GNRI: the malnutrition group and the normal group. Propensity score matching was used to confirm factors affecting the BI and subsequent falls. Results: Thirty-one patients (13.5%) presented with malnutrition before surgery for DRF. According to multiple liner regression analysis, the GNRI positively affected the efficiency of the BI (β = 0.392, 95% confidence interval [CI], 0.001 to 0.351, p = 0.039). Furthermore, on logistic regression analysis, subsequent falls were associated with serum albumin levels (odds ratio = 0.033, 95% CI, 0.002 to 0.477, p = 0.012). Conclusion : Malnutrition impaired improvement of activities of daily living (ADL) and increased the incidence of subsequent falls. Improvement of nutritional status before DRF surgery may further improve ADL and prevent falls.

scholarly journals Nutrition status and functional prognosis among elderly patients with distal radius fracture: a retrospective cohort study

2020 ◽  
Author(s):  
takako nagai ◽  
Koji Tanimoto ◽  
Yoshiaki Tomizuka ◽  
Hiroshi Uei ◽  
Masahiro Nagaoka
Keyword(s):  
Regression Analysis ◽  
Confidence Interval ◽  
Nutritional Status ◽  
Elderly Patients ◽  
Distal Radius ◽  
The Elderly ◽  
Nutrition Status ◽  
Mineral Density ◽  
Poor Prognostic Factor ◽  
Nutritional Risk Index

Abstract Background Distal radius fractures (DRF) are common in the elderly and are typical of hand fractures during falls. Malnutrition has also been identified as a poor prognostic factor in elderly patients with fractures. However, the relationship between nutritional status and subsequent falls and functional prognosis in the elderly DRF is not clear. The aim of the present study was to investigate the association between nutritional status and functional prognosis in patients with elderly DRF. Methods Study participants included 229 outpatients who required surgical treatment with DRF. The patients’ clinical information, including age, sex, body mass index, bone mineral density, Geriatric Nutritional Risk Index (GNRI), total number of drugs being treated with on admission, use of drugs for osteoporosis, comorbidity severity, Barthel Index(BI), presence of subsequent falls, fracture type, postoperative follow-up period, and Mayo wrist score was reviewed. The subjects were further divided into two groups according to their GNRI: the malnutrition group and the normal group. Propensity score matching was used to confirm the factor affecting BI and subsequent fall. Results Thirty-one patients (13.5%) were malnutrition before surgery for DRF. According to the multiple liner regression analysis, GNRI positively affected BI efficiency (β=0.392, 95% confidence interval, 0.001 to 0.351, p=0.039). Furthermore, on logistic regression analysis, subsequent fall was correlated with the serum albumin (odds ratio=0.033, 95% confidence interval,0.002 to 0.477, p=0.012). Conclusion Malnutrition impaired the improvement of the activity of daily living (ADL) and increased the incidence of subsequent fall. Improvement of nutritional status before DRF surgery may further improve ADL and prevent falls.

scholarly journals Association Between Bone Mineral Density And Serum Creatinine In People < 46 Years Old

2021 ◽  
Author(s):  
Yanru Guo ◽  
Xianyang Zhu
Keyword(s):  
Bone Mineral Density ◽  
Regression Analysis ◽  
Linear Regression ◽  
Serum Creatinine ◽  
Bone Mineral ◽  
Linear Regression Analysis ◽  
Lumbar Bone Mineral Density ◽  
Multivariate Linear Regression Analysis ◽  
Mineral Density ◽  
The Relationship

Abstract Purpose: To research the relationship between serum creatinine and lumbar bone mineral density in people aged <46 years. Methods: A total of 10,968 subjects from the American Nhanes database were included in this cross-sectional study, including 5,744 males (mean age 26.2 years) and 5224 females (mean age 26.7 years). The exposure factor is the serum creatinine value, and the outcome indicator is the lumbar bone mineral density. This study mainly used multivariate linear regression analysis to test the relationship between lumbar bone mineral density and serum creatinine. Results: In the multivariate linear regression analysis, serum creatinine was positively correlated with lumbar bone mineral density (β = 0.122, 95%CI: 0.047-0.198), but in the subgroup analysis stratified by sex, this positive correlation only exists in the female population (Β = 0.186, 95%CI: 0.070-0.301).Conclusions: Our study found that in women aged <46 years with normal renal function, there is a positive correlation between serum creatinine and lumbar BMD. And in those people, the determination of serum creatinine can provide a sensitive biomarker for the early identification and treatment of Osteopenia or osteoporosis.

scholarly journals Lower Geriatric Nutritional Risk Index Are Associated With A Higher Incidence Of Osteoporosis In Northern China Type 2 Diabetes

2021 ◽  
Author(s):  
Yuan yuan Ji ◽  
Nan Geng ◽  
Yingchun Niu ◽  
Hang Zhao ◽  
Wenjie Fei ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Operating Characteristic ◽  
Risk Index ◽  
Northern China ◽  
Nutritional Risk ◽  
Geriatric Nutritional Risk Index ◽  
Nutritional Risk Index ◽  
The Relationship ◽  
Spearman’S Correlation

Abstract Introduction Geriatric Nutrition Risk Index（GNRI）assesses the risk of malnutrition and complications associated with nutritional status in older patients and is also an important predictor of many diseases. Osteoporosis is very general in the elderly population and can cause fractures and disability. Malnutrition is associated with osteoporosis. Therefore, we investigated the relationship between GNRI and osteoporosis in T2DM.Methods Study population of 610 patients with T2DM, collect general and laboratory data on the patient and measure BMD; GNRI is calculated based on serum albumin levels, actual weight and ideal weight. Spearman's correlation analysis, logistic regression analysis, receiver operating characteristic (ROC) curves were used to explore the relationship between GNRI and bone metabolism-related indicators.Results Spearman's correlation analysis yielded a positive correlation between GNRI and BMD, and a negative correlation between GNRI and ALP and PINP. After adjustment of age, duration of illness, TC, TG and uric acid et al confounding factors, a positively correlated with 25(OH)D and PTH (r=0.224, r=0.136, respectively) and negative correlation was found between GNRI and ALP and PINP (r=-0.178, r=-0.120, respectively). Regression analysis yields, GNRI was significantly associated with osteoporosis (in the age < 65 years group, odds ratio was 0.917, P < 0.05 and in the age≥65 years group, was 1.062, P<0.05). The area under the curve of the GNRI recipient operating characteristic curve was 0.584, and the optimal threshold for GNRI to assess the occurrence of osteoporosis was 107.2, the sensitivity was 89.63% and the specificity was 24.63%.Conclusions: Lower Geriatric Nutritional Risk Index among type 2 diabetic patients in northern China are associated with a higher Incidence of osteoporosis.

scholarly journals Better pulmonary function is associated with increased handgrip strength in a healthy Chinese Han population

2019 ◽  
Author(s):  
Liangmei Chen ◽  
Xiaomin Liu ◽  
Qian Wang ◽  
Linpei Jia ◽  
Kangkang Song ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Pulmonary Function ◽  
Vital Capacity ◽  
Handgrip Strength ◽  
Linear Regression Analysis ◽  
The Elderly ◽  
Multiple Linear Regression Analysis ◽  
Forced Expiratory Volume ◽  
Chinese Han ◽  
The Relationship

Abstract Background: The association between handgrip strength (HGS) and pulmonary function is still controversial, and this relationship has not yet been established among the healthy Chinese Han population.Methods: Data from 1519 healthy Han community dwellers in Beijing were analysed. Subjects were divided into two groups by age: the younger group (<60 years) and the elderly group (≥60 years). Bivariate correlation tests were run between parameters, and variables with a correlation coefficient ǀrǀ≥0.30 and p<0.01 were considered to be significantly correlated. Multiple linear regression analysis was used to adjust covariates in the relationship between HGS and pulmonary function.Results: The study included 623 males and 896 females. The values of HGS were greater in males than in females (40.2 kg vs 25.0 kg, p<0.01) and greater in the younger group than in the elderly group (33.3 kg vs 27.6 kg, p<0.01). HGS and parameters of pulmonary function were highly negatively correlated with age, especially forced expiratory volume in 1 second (r=-0.55, p<0.01), forced expiratory volume in 2 second (r=-0.53, p<0.01) and forced vital capacity (FVC) (r=-0.50, p<0.01). Parameters of pulmonary function were positively associated with HGS, especially the maximum value of vital capacity (VC max) (r=-0.72, p<0.01), forced expiratory volume in 3 second (FEV 3) (r=0.70, p<0.01) and FVC (r=0.69, p<0.01). Therefore, we selected VC max, FEV 3 and FVC as three representative parameters to analyse the relationship between HGS and pulmonary function. In the relationship between HGS and pulmonary function, in addition to gender and age, there were other covariates: height, pulse pressure and systolic blood pressure. After adjusting covariates in the multiple linear regression analysis, the standardized coefficients of HGS on VC max were 0.254 in males and 0.175 in females, and the standardized coefficients of HGS on FVC were 0.225 in males and 0.182 in females.Conclusions: Pulmonary function and HGS were both declined with age. HGS was an independent factor that affected pulmonary function, apart from age. Training in HGS may help to improve pulmonary function in healthy people.

scholarly journals Sex-related differences in the effects of nutritional status and body composition on functional disability in the elderly

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246276
Author(s):  
Mika Sawada ◽  
Naoto Kubota ◽  
Rie Sekine ◽  
Mitsutaka Yakabe ◽  
Taro Kojima ◽  
...  
Keyword(s):  
Body Composition ◽  
Regression Analysis ◽  
Nutritional Status ◽  
Muscle Mass ◽  
Linear Regression Analysis ◽  
The Elderly ◽  
Multiple Linear Regression Analysis ◽  
Abdominal Muscle ◽  
Body Fat Mass ◽  
Geriatric Ward

Background The aim of our study was to evaluate the influence of changes of nutritional status and body composition on the results of comprehensive geriatric assessment (CGA) in inpatients of a geriatric ward. Sex differences in these relationships were also investigated. Methods A total of 212 elderly patients (>65 years old) admitted to the geriatric ward at the University of Tokyo hospital between 2012 and 2019 were enrolled in this study. CGA (ADL, IADL, MMSE, GDS, Vitality Index) was performed, along with assessment of body compositions (appendicular muscle mass, abdominal muscle mass, body fat mass) and blood malnutrition biomarkers (serum albumin, pre-albumin, 25-hydroxy vitamin D, zinc, hemoglobin concentrations). Results Multiple linear regression analysis showed that upper, lower limbs and abdominal muscle masses were significantly associated with the score on ADL in men. On the other hand, abdominal muscle mass was negatively associated with the scores on GDS. Body fat mass was also negatively associated with the score on IADL. In contrast, in women, multiple linear regression analysis failed to show any significant associations between body composition parameters and scores on any domains of CGA. Unlike in men, however, blood malnutrition biomarkers were significantly associated with ADL, IADL, MMSE, and Vitality Index in women. Conclusions Our study findings revealed that the association of the nutritional status and body composition with the functional status in the elderly differs by sex. These results suggest that intensification of exercise in men and improvement of the nutritional status in women are particularly useful to maintain the functional status.

The Influences of Palindromes in mRNA on Protein Folding Rates

2020 ◽  
Vol 27 (4) ◽  
pp. 303-312 ◽  
Author(s):  
Ruifang Li ◽  
Hong Li ◽  
Sarula Yang ◽  
Xue Feng
Keyword(s):  
Protein Folding ◽  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Folding Rate ◽  
Folding Rates ◽  
Negative Linear Correlation ◽  
Protein Folding Rate ◽  
The Relationship ◽  
Structure Environment

Background: It is currently believed that protein folding rates are influenced by protein structure, environment and temperature, amino acid sequence and so on. We have been working for long to determine whether and in what ways mRNA affects the protein folding rate. A large number of palindromes aroused our attention in our previous research. Whether these palindromes do have important influences on protein folding rates and what’s the mechanism? Very few related studies are focused on these problems. Objective: In this article, our motivation is to find out if palindromes have important influences on protein folding rates and what’s the mechanism. Method: In this article, the parameters of the palindromes were defined and calculated, the linear regression analysis between the values of each parameter and the experimental protein folding rates were done. Furthermore, to compare the results of different kinds of proteins, proteins were classified into the two-state proteins and the multi-state proteins. For the two kinds of proteins, the above linear regression analysis were performed respectively. Results : Protein folding rates were negatively correlated to the palindrome frequencies for all proteins. An extremely significant negative linear correlation appeared in the relationship between palindrome densities and protein folding rates. And the repeatedly used bases by different palindromes simultaneously have an important effect on the relationship between palindrome density and protein folding rate. Conclusion: The palindromes have important influences on protein folding rates, and the repeatedly used bases in different palindromes simultaneously play a key role in influencing the protein folding rates.

The Relationship Between The Perception of Elderly’s Health Status and Health Behaviors in Nakhon Nayok Province, Thailand

2019 ◽  
Vol 12 (1) ◽  
pp. 420-423
Author(s):  
Prapada Watcharanat ◽  
Prasong Tanpichai ◽  
Ravee Sajjasophon
Keyword(s):  
Regression Analysis ◽  
Health Status ◽  
Health Behaviors ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Statistical Significance ◽  
The Elderly ◽  
Cross Sectional ◽  
Congenital Diseases ◽  
The Relationship

Purpose: This research aims to study the relationship between perception of elderly’s health and health behaviors in Nakhon Nayok province, Thailand Methods: This research was a cross-sectional study. The questionnaire was used to collect the data. This research was conducted in Nakhon Nayok province. The sample size was 270 which applied Taro Yamane's formula at a significant level 0.05. The descriptive statistics was implemented to describe the variables by presenting the frequency, percentage, mean and standard deviation. Furthermore, multiple regression analysis was applied to analyze the relationship between perception of elderly’s health and health behaviors. The statistical significance was considered to reject Hypothesis-null at < 0.05. Results: From a total of 270 people, more than 58.22% of the elderly perceived that they had moderate health conditions. Most elderly had congenital diseases (62.2%). The multiple regression analysis results showed that health status perception and health status perception when compared to their cohort related significantly to health behavior. Conclusion: The government should support the elderly on participation, trust, engagement, and cultural concern of the people in the community, which can contribute to promoting the physical, mental and social condition of the elderly.

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