Preparation of Polyethylene Glycol Monomethyl Ether Chitosan-diethylenetriamine Pentaacetic Acid and Its Effect on 89SrCl2 Excretion and Radiation Protection in the Digestive Tract of Rats

2021 ◽  
Author(s):  
Feng Zeng ◽  
Yao Xiao ◽  
Weilin Fu ◽  
Xiangyu Chen ◽  
Hao Zeng ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Protective Effect ◽  
Digestive Tract ◽  
Monomethyl Ether ◽  
Cross Linking ◽  
Effective Protection ◽  
Glycol Monomethyl Ether ◽  
Radiation Induced ◽  
Diethylenetriamine Pentaacetic Acid

Abstract In this study, hydrophilic polymer polyethylene glycol monomethyl ether chitosan-diethylenetriamine pentaacetic acid (mPEGCS-DTPA) was synthesized via chemical synthesis and cross-linking, and its cytotoxicity and radiation protective effect in vivo were studied. The results revealed that mPEGCS-DTPA exhibits good cytocompatibility and increases the excretion of radionuclides through the digestiveand urinary tracts. The pathological results of the small intestine revealed that mPEGCS-DTPA exerts a good radiation-protective effect and could reduce the α and β-emitting radiation-induced damage of the intestinal mucosa. MPEGCS-DTPA can increase the excretion of radionuclides in the digestive tract and exhibits effective protection against radiation.

Conformational Studies of Synthetic Polyethylene Glycol Bound Substance P and its Lower Analogues

1985 ◽  
Vol 40 (11) ◽  
pp. 1570-1574 ◽  
Author(s):  
Piotr Koziej ◽  
Manfred Mutter
Keyword(s):  
Polyethylene Glycol ◽  
Substance P ◽  
Gel Permeation Chromatography ◽  
Monomethyl Ether ◽  
Terminal Part ◽  
Binding Studies ◽  
Glycol Monomethyl Ether ◽  
Conformational Studies ◽  
In Vivo Assays

The synthesis of Substance P (SP) bound at the C-terminal methionine to polyethylene glycol monomethyl ether (M-PEG) is described. SP-PEG-M is obtained in good yield by the liquidphase peptide synthesis. Gel permeation chromatography reveals that aggregated forms of the PEG-bound peptides are absent in CHCl3. CD and IR spectra point to a β-turn located at the N-terminal part of SP-PEG-M. In binding studies and in vivo assays the described compounds are devoid of biological activity.

Preparation and Properties of a Hydrolytically Stable Cyclooctyne-Containing Polymer

Synlett ◽  
2018 ◽  
Vol 29 (19) ◽  
pp. 2535-2541
Author(s):  
Alex Adronov ◽  
Kelvin Li ◽  
Stuart McNelles
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Monomethyl Ether ◽  
Phenylene Vinylene ◽  
Cross Linking ◽  
Poly Ethylene Glycol ◽  
Ethylene Glycol Monomethyl Ether ◽  
Glycol Monomethyl Ether ◽  
Poly Ethylene

A poly[(phenylene vinylene)-co-dibenzocyclooctyne] polymer prepared by Wittig polymerization chemistry between dibenzocyclooctyne bisaldehyde [DIBO-(CHO)2] and bis(triethyleneglycol)phenylbis(tributylphosphonium) dibromide is reported. The resulting polymer exhibits moderate molecular weight (Mn: 10.5 kDa, Mw: 21.3 kDa, Ð: 2.02) and is fluorescent. It could be readily functionalized by strain-promoted alkyne-azide cycloadditon with different azides, and fluorescence of the polymer was preserved after functionalization. Grafting azide-terminated 5 kDa poly(ethylene glycol) monomethyl ether chains drastically affected the solubility of the polymer. Cross-linking the polymer with poly(ethylene glycol) that was terminated at both ends with azide groups gave access to a fluorescent organogel that could be dried and reswollen with water to form a hydrogel.

Preparation, Purification, and Spectrophotometric Characterization of Cytochrome P450 1A2 Conjugated with Polyethylene Glycol Monomethyl Ether

1996 ◽  
Vol 222 (2) ◽  
pp. 406-409 ◽  
Author(s):  
Roya Nakhgevany ◽  
Osei Bonsu ◽  
Jousephine Barber ◽  
Patricia Ann Mabrouk ◽  
Yune-Fang Ueng ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Polyethylene Glycol ◽  
Monomethyl Ether ◽  
Cytochrome P450 1A2 ◽  
Glycol Monomethyl Ether

Synthesis and Characterization of Novel Amphiphilic Helical Copolymer

2011 ◽  
Vol 239-242 ◽  
pp. 1711-1716 ◽  
Author(s):  
Dong Mei Yue ◽  
Dong Zhao ◽  
Ting Yu ◽  
Wei Min Wang ◽  
Li Qun Zhang
Keyword(s):  
Polyethylene Glycol ◽  
Optical Activity ◽  
Monomethyl Ether ◽  
Synthesis And Characterization ◽  
Glycol Monomethyl Ether ◽  
Amplification Effect ◽  
Molecular Weights ◽  
Chiral Amplification ◽  
Environmental Stimulation

The new comb-copolymers [polyacetylene–MPEG (polyethylene glycol monomethyl ether)] were synthesized with (nbd)Rh+[η6-C6H5B- (C6H5)3] as catalyst. The copolymers with moderate molecular weights (Mn) (13000-170000) and yields (31.6-47.3%) exhibited higher optical activities compared with chiral monomer, which accorded with the “Chiral Amplification” effect. The optical activity of the copolymers gradually decreased as the amount of MPEG increased. The maximum amounts of MPEG for successful copolymerization and optical activity of copolymers were 40%, 30%, 20%(mol%) as the Mn of MPEG was 350, 750,1900, respectively. The optical activity of copolymers could change at external environmental stimulation, e.g., decreased as methanol content increased.

Sign in / Sign up

Export Citation Format

Share Document