Preoperative Controlling Nutritional Status (CONUT) Score Predicts Short-Term Outcomes of Patients with Gastric Cancer after Laparoscopy-Assisted Radical Gastrectomy

Abstract Background: As an emerging prediction tool, the Controlling Nutritional Status (CONUT) score has shown good assessment ability of postoperative outcomes in cancer patients. This study assessed the role of the preoperative CONUT score in short-term outcomes of gastric cancer (GC) after laparoscopic gastrectomy.Methods: Three hundred and nine patients undergoing laparoscopic gastrectomy from January 2016 to June 2019 were analyzed, retrospectively. GC patients were divided into two groups according to the optimal cut-off value of the CONUT. The clinical characteristics and postoperative complications were analyzed and evaluated in two groups. The risk factors of complications were identified by univariate and multivariate analysis.Results: 309 patients received laparoscopic gastrectomy, and 91 (29.4%) patients suffered from postoperative complications. The preoperative CONUT score showed a good predictive ability for postoperative complications (area under the curve (AUC)=0.718, Youden index=0.343) compared with other indexes, with an optimal cut-off value of 2.5. Patients with high CONUT score suffered a significantly higher incidence of overall complications (P<0.001). Age, haemoglobin level, C-reactive protein level, red blood cell level, CONUT scores, type of operative procedure, pathological TNM classification of T1, T4, N0, and N3, and pathological stage of I and III were associated with postoperative complications (P<0.05). Furthermore, preoperative CONUT score was identified as an independent risk predictor of postoperative complications (P=0.012; OR=2.433; 95% CI: 1.218-4.862) after multivariate analysis.Conclusions: The preoperative CONUT score is a practical nutritional assessment for predicting short-term outcomes in patients with gastric cancer after laparoscopy-assisted gastrectomy.

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Preoperative Controlling Nutritional Status (CONUT) score predicts short-term outcomes of patients with gastric cancer after laparoscopy-assisted radical gastrectomy

World Journal of Surgical Oncology ◽

10.1186/s12957-021-02132-6 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Yun Qian ◽

Huaying Liu ◽

Junhai Pan ◽

Weihua Yu ◽

Jiemin Lv ◽

...

Keyword(s):

Gastric Cancer ◽

Postoperative Complications ◽

Nutritional Status ◽

Laparoscopic Gastrectomy ◽

Nutritional Assessment ◽

Tnm Classification ◽

Area Under The Curve ◽

Youden Index ◽

Short Term ◽

Conut Score

Abstract Background An emerging prediction tool, the Controlling Nutritional Status (CONUT) score, has shown good assessment ability of postoperative outcomes in cancer patients. This study evaluated the role of the preoperative CONUT score regarding the short-term outcomes of gastric cancer (GC) after laparoscopic gastrectomy. Methods Three hundred and nine GC patients undergoing laparoscopic gastrectomy from January 2016 to June 2019 were analysed, retrospectively. The patients were divided into two groups according to the CONUT optimal cut-off value. Clinical characteristics and postoperative complications in the two groups were analysed and evaluated. Risk factors for complications were identified by univariate and multivariate analyses. Results A total of 309 patients underwent laparoscopic gastrectomy; 91 (29.4%) patients experienced postoperative complications. The preoperative CONUT score showed a good predictive ability for postoperative complications (area under the curve (AUC) = 0.718, Youden index = 0.343) compared with other indices, with an optimal cut-off value of 2.5. Patients with high CONUT score had a significantly higher incidence of overall complications (P < 0.001). Age, haemoglobin, C-reactive protein, red blood cell levels, CONUT scores, surgical procedure type, T1, T4, N0 and N3 pathological TNM classification, and pathological stages of I and III were associated with postoperative complications (P < 0.05). Furthermore, the preoperative CONUT score was identified as an independent risk predictor of postoperative complications (P = 0.012; OR = 2.433; 95% CI, 1.218-4.862) after multivariate analysis. Conclusions The preoperative CONUT score is a practical nutritional assessment for predicting short-term outcomes in GC patients after laparoscopy-assisted gastrectomy.

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Preoperative Controlling Nutritional Status (CONUT) Score Predicts Short-term Surgical Outcomes in Patients with Gastric Cancer After Laparoscopy-assisted Radical Gastrectomy

10.21203/rs.3.rs-99695/v1 ◽

2020 ◽

Author(s):

Yun Qian ◽

Huaying Liu ◽

Junhai Pan ◽

Weihua Yu ◽

Jiemin Lv ◽

...

Keyword(s):

Gastric Cancer ◽

Postoperative Complications ◽

Nutritional Status ◽

Assessment Tool ◽

Nutritional Assessment ◽

Area Under The Curve ◽

Predictive Ability ◽

Youden Index ◽

Short Term ◽

Conut Score

Abstract Background: The Controlling Nutritional Status (CONUT) score is an emerging nutrition assessment tool that is useful in gastric cancer (GC) patients. The aim of our study was to assess the predictive ability of the preoperative CONUT score for short-term outcomes in GC patients undergoing laparoscopy-assisted gastrectomy.Methods: We retrospectively reviewed the medical records of 309 patients who underwent curative laparoscopy-assisted gastrectomy. The patients were divided into two groups according to the optimal cut-off value of the CONUT score. The clinical characteristics and postoperative complications were evaluated and analysed in the low- and high-score groups. The risk factors for complications were identified by univariate and multivariate analysis.Results: The preoperative CONUT score showed a good predictive ability for postoperative complications (area under the curve (AUC)=0.718, Youden index=0.343) compared with other indexes, with an optimal cut-off value of 2.5. Patients with high CONUT scores had a higher incidence of overall complications (P<0.001) and mild complications (P<0.001). Univariate and multivariate analyses revealed that the CONUT score was independently associated with postoperative complications (P=0.012; odds ratio (OR)=2.433; 95% confidence interval (CI): 1.218-4.862).Conclusions: The preoperative CONUT score is a reliable and useful nutritional assessment tool for predicting short-term outcomes in GC patients after laparoscopy-assisted gastrectomy.

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Preoperative Controlling Nutritional Status (CONUT) Score Predicts Short-Term Surgical Prognosis in Patients with Gastric Cancer After Laparoscopy-Assisted Radical Gastrectomy

10.21203/rs.3.rs-53990/v1 ◽

2020 ◽

Author(s):

Yun Qian ◽

Huaying Liu ◽

Junhai Pan ◽

Weihua Yu ◽

Jiemin Lv ◽

...

Keyword(s):

Gastric Cancer ◽

Multivariate Analysis ◽

Postoperative Complications ◽

Nutritional Status ◽

Assessment Tool ◽

Predictive Ability ◽

Short Term ◽

Optimal Cutoff ◽

Cutoff Value ◽

Conut Score

Abstract Background: The Controlling Nutritional Status (CONUT) score is an emerging nutrition assessment tool that is very useful in patients with gastric cancer who usually experience weight loss and malnutrition. The aim of our study was to assess the predictive ability of the preoperative CONUT score for short-term prognosis in patients with gastric cancer undergoing laparoscopy-assisted gastrectomy.Methods: We retrospectively reviewed medical records of 309 patients who underwent curative laparoscopy-assisted gastrectomy. The patients were divided into two groups according to the optimal cutoff value of the CONUT score. The clinical association for the CONUT score, characteristics, and postoperative complications were evaluated and analyzed. The risk factors for complications were identified by univariate and multivariate analysis.Results: The preoperative CONUT score showed a good predictive ability for postoperative complications (AUC=0.718，Youden index=0.343)，with an optimal cutoff value of 2.5. The patients with high CONUT scores had a higher incidence of overall complications (P<0.001) and mild complications (P<0.001). Univariate and multivariate analysis revealed that the CONUT score was independently associated with postoperative complications (P=0.012；OR=2.433；95%CI：1.218-4.862).Conclusions：The preoperative CONUT score was identified as a reliable nutritional assessment tool for predicting short-term prognosis in patients with gastric cancer after laparoscopy-assisted gastrectomy.

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Controlling Nutritional Status (CONUT) score as a predictive marker for short-term complications following gastrectomy of gastric cancer: a retrospective study

BMC Gastroenterology ◽

10.1186/s12876-021-01682-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Feng Sun ◽

Chen Zhang ◽

Zhijian Liu ◽

Shichao Ai ◽

Wenxian Guan ◽

...

Keyword(s):

Gastric Cancer ◽

Postoperative Complications ◽

Nutritional Status ◽

Multivariate Analyses ◽

Independent Predictor ◽

Predictive Marker ◽

Hospital Charges ◽

Youden Index ◽

Short Term ◽

Conut Score

Abstract Background It is well established that the controlling nutritional status (CONUT) score was correlated with long-term outcomes in gastric cancer (GC), but the significance of CONUT for postoperative short-term outcomes remains unclear. The study aimed to characterize the relationship between CONUT and short-term complications following gastrectomy of GC. Methods We collected data on 1479 consecutive GC patients at Nanjing Drum Tower Hospital between January 2016 and December 2018. Univariate and multivariate analyses of predictive factors for postoperative complications were performed. The cutoff value of the CONUT score was determined by Youden index. Results Among all of the patients, 431 (29.3%) patients encountered postoperative complications. Multivariate analyses identified CONUT was an independent predictor for postoperative short-term complications (OR 1.156; 95% CI 1.077–1.240; P < 0.001). Subgroup analysis elucidated that CONUT was related to postoperative complications both in early gastric cancer and advanced gastric cancer. We further explored that patients with high CONUT score had prolonged hospital stay (12.3 ± 6.0 vs 11.1 ± 4.6, P < 0.001) and more total hospital charges (7.6 ± 2.4 vs 7.1 ± 1.6, P < 0.001). Conclusions The present study demonstrated that the preoperative CONUT was an independent predictor for short-term complications following gastrectomy of GC.

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Preoperative Nutritional Assessment by Controlling Nutritional Status (CONUT) and Postoperative Complications for Gastric Cancer

The Japanese Journal of Gastroenterological Surgery ◽

10.5833/jjgs.2013.0171 ◽

2014 ◽

Vol 47 (6) ◽

pp. 305-312 ◽

Cited By ~ 1

Author(s):

Katsuyoshi Kudoh ◽

Chikashi Shibata ◽

Hiroaki Musya ◽

Naoki Tanaka ◽

Shinobu Ohnuma ◽

...

Keyword(s):

Gastric Cancer ◽

Postoperative Complications ◽

Nutritional Status ◽

Nutritional Assessment

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Clinical significance of controlling nutritional status score (CONUT) in evaluating outcome of postoperative patients with gastric cancer

Scientific Reports ◽

10.1038/s41598-021-04128-4 ◽

2022 ◽

Vol 12 (1) ◽

Author(s):

Qi Xiao ◽

Xiaoqing Li ◽

Baojun Duan ◽

Xiaofan Li ◽

Sida Liu ◽

...

Keyword(s):

Gastric Cancer ◽

Regression Analysis ◽

Risk Factor ◽

Postoperative Complications ◽

Nutritional Status ◽

Independent Risk Factor ◽

Multivariate Regression Analysis ◽

Psychological Status ◽

The Relationship ◽

Conut Score

AbstractThe stomach is the main digestive organ in humans. Patients with gastric cancer often develop digestive problems, which result in poor nutrition. Nutritional status is closely related to postoperative complications and quality of life (QoL) in patients with gastric cancer. The controlling nutritional status (CONUT) score is a novel tool to evaluate the nutritional status of patients. However, the relationship of the CONUT score with postoperative complications, QoL, and psychological status in patients with gastric cancer has not been investigated. The present follow-up study was conducted in 106 patients who underwent radical gastrectomy in our hospital between 2014 and 2019. The CONUT score, postoperative complications, psychological status, postoperative QoL scores, and overall survival (OS) of patients with gastric cancer were collected, and the relationship between them was analyzed. A significant correlation was observed between the CONUT score and postoperative complications of gastric cancer (P < 0.001), especially anastomotic leakage (P = 0.037). The multivariate regression analysis exhibited that the CONUT score (P = 0.002) is an independent risk factor for postoperative complications. The CONUT score was correlated with the state anxiety questionnaire (S-AI) for evaluating psychological status (P = 0.032). However, further regression analysis exhibited that the CONUT score was not an independent risk factor for psychological status. Additionally, the CONUT score was associated with postoperative QoL. The multivariate regression analysis exhibited that the CONUT score was an independent risk factor for the global QoL (P = 0.048). Moreover, the efficiency of CONUT score, prognostic nutrition index, and serum albumin in evaluating complications, psychological status, and QoL was compared, and CONUT score was found to outperform the other measures (Area Under Curve, AUC = 0.7368). Furthermore, patients with high CONUT scores exhibited shorter OS than patients with low CONUT scores (P = 0.005). Additionally, the postoperative complications (HR 0.43, 95% CI 0.21–0.92, P = 0.028), pathological stage (HR 2.26, 95% CI 1.26–4.06, P = 0.006), and global QoL (HR 15.24, 95% CI 3.22–72.06, P = 0.001) were associated with OS. The CONUT score can be used to assess the nutritional status of patients undergoing gastric cancer surgery and is associated with the incidence of postoperative complications and QoL.

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SUN-LB041: Preoperative Prediction on Postoperative Complications and Prognosis by Nutritional Status Assessed by Controlling Nutritional Status (CONUT) Score

Clinical Nutrition ◽

10.1016/s0261-5614(15)30762-7 ◽

2015 ◽

Vol 34 ◽

pp. S249-S250

Author(s):

T. Nakano ◽

K. Kamiya ◽

T. Kamei ◽

Y. Taniyama ◽

T. Sakurai ◽

...

Keyword(s):

Postoperative Complications ◽

Nutritional Status ◽

Preoperative Prediction ◽

Conut Score

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The Presurgical Controlling Nutritional Status (CONUT) Score is Independently Associated with Severe Peristomal Skin Disorders: A Single-center Retrospective Cohort Study

10.21203/rs.3.rs-343567/v1 ◽

2021 ◽

Author(s):

Takuya Shiraishi ◽

Hiroomi Ogawa ◽

Chika Katayama ◽

Katsuya Osone ◽

Takuhisa Okada ◽

...

Keyword(s):

Risk Factors ◽

Multivariate Analysis ◽

Nutritional Status ◽

Laparoscopic Approach ◽

Skin Disorders ◽

Nutritional Interventions ◽

Stoma Creation ◽

Peristomal Skin ◽

The Impact ◽

Conut Score

Abstract Purpose: While nutritional interventions may potentially lower the risk of peristomal skin disorders (PSDs) and their exacerbation, no prior studies have evaluated the relationship between PSDs and nutritional status using the Controlling Nutritional Status (CONUT) score. Therefore, the purpose of this study was to assess the impact of preoperative nutritional status on stoma development, and determine risk factors for postoperative PSDs and their increased severity. Methods: A retrospective analysis was performed in 116 consecutive patients with rectal cancer who underwent radical surgery with stoma creation, including ileostomy and colostomy. Results: PSDs were diagnosed in 32 patients (27.6%); 10 (8.7%) cases were defined as severe based on the ABCD-stoma score. A multivariate analysis indicated that the laparoscopic approach (odds ratio [OR], 3.221; 95% confidence interval [CI], 1.001–10.362; P = 0.050) and ileostomy (OR, 3.394; 95% CI, 1.349–8.535; P = 0.009) were both independent risk factors for PSD. In a separate multivariate analysis for severe PSD, the only independent risk factor was the CONUT score (OR, 11.298; 95% CI, 1.382–92.373; P = 0.024). Conclusion: Severe PSDs are associated with preoperative nutritional disorders, as determined via the CONUT score. Furthermore, PSDs may potentially increase in severity, regardless of stoma type.

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