Acute Symptomatic Vitreous Floaters Assessed With Ultra-Wide Field Scanning Laser Ophthalmoscopy and Spectral Domain Optical Coherence Tomography

Posterior Vitreous Detachment ◽

Spectral Domain ◽

Scanning Laser ◽

Wide Field ◽

Optical Coherence ◽

Vitreous Opacity ◽

Vitreous Floaters ◽

First Time

Abstract Purpose: To describe the eyes with vitreous floaters and to analyze the development of acute symptomatic posterior vitreous detachment (PVD). Methods: A retrospective review of medical records was performed on patients with the vitreous floater developed for the first time of their life. Peripapillary vitreous opacity (pVO) was searched in Ultra-wide field (UWF) scanning laser ophthalmoscopy and PVD stage was assessed through spectral-domain optical coherence tomography (SD-OCT). Results: 196 patients (55 males and 141 females), who were 58.4(±9.1) on years old, visited a retinal clinic 9.4 (±9.1) days after they experienced vitreous floaters. (pVO) was noticed in 62.2% at UWF and PVD was initiated more than 94.3%. Symptomatic eyes had more prevalence of peripapillary vitreous opacity (63.2% vs 18.4%, p=0.040) and more advance staged PVD (p<0.001) than symptom free eyes. Eyes with floaters were more myopic (-0.7±2.2D vs -0.5±1.9D, p=0.02), and had lower IOP (14.7±3.2mmHg vs 15.2±3.0mmHg, p=0.02) than the other symptom free eyes. Conclusion: In patients with first floater symptoms, PVD was in progress in most of the eyes not only the symptomatic eyes but also on the contralateral symptom free eyes. Eyes with vitreous floaters were more myopic and had lower IOP than the opposite symptom free eyes.

Acute symptomatic vitreous floaters assessed with ultra-wide field scanning laser ophthalmoscopy and spectral domain optical coherence tomography

Scientific Reports ◽

10.1038/s41598-021-88371-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Gisung Son ◽

Joonhong Sohn ◽

Mingui Kong

Keyword(s):

Posterior Vitreous Detachment ◽

Spectral Domain ◽

Scanning Laser ◽

Wide Field ◽

Optical Coherence ◽

Vitreous Opacity ◽

Vitreous Floaters ◽

Sd Oct

AbstractTo describe the eyes with vitreous floaters and to analyze the development of acute symptomatic posterior vitreous detachment (PVD). A retrospective review of medical records was performed on patients with the vitreous floater developed for the first time of their life. Peripapillary vitreous opacity (pVO) was searched in Ultra-wide field (UWF) scanning laser ophthalmoscopy and PVD stage was assessed through spectral-domain optical coherence tomography (SD-OCT). 196 patients (55 males and 141 females), who were 58.4 (± 9.1) years old, visited a retinal clinic 9.4 (± 9.1) days after they experienced vitreous floaters. In 196 eyes, pVO was noticed in 122 eyes (62.2%) at UWF. In 106 eyes where SD-OCT data were available, PVD was noticed in 100 eyes (94.3%). Symptomatic eyes showed more advanced stage of PVD (p < 0.001) than symptom free eyes. Eyes with floaters were more myopic (− 0.7 ± 2.2D vs − 0.5 ± 1.9D, p = 0.02), and had lower intraocular pressure (IOP) (14.7 ± 3.2 mmHg vs 15.2 ± 3.0 mmHg, p = 0.02) than the other symptom free eyes. In patients with first floater symptoms, PVD was in progress in most of the eyes not only the symptomatic eyes but also on the contralateral symptom free eyes. Eyes with vitreous floaters were more myopic and had lower IOP than the opposite symptom free eyes.

Retinal Features in Cynomolgus Macaques (Macaca fascicularis) Assessed by Using Scanning Laser Ophthalmoscopy and Spectral Domain Optical Coherence Tomography

Comparative Medicine ◽

10.30802/aalas-cm-19-000088 ◽

2020 ◽

Vol 70 (2) ◽

pp. 145-151

Author(s):

Nora Denk ◽

Peter M Maloca ◽

Guido Steiner ◽

Helen Booler ◽

Christian Freichel ◽

...

Keyword(s):

Posterior Vitreous Detachment ◽

Spectral Domain ◽

Scanning Laser ◽

Optical Coherence ◽

Imaging Data ◽

Data Set ◽

Cynomolgus Monkeys ◽

Cynomolgus Macaques

Cynomolgus macaques are an important and commonly used species in preclinical toxicology studies, but structural reports of in vivo retinal findings are rare in this species. The purpose of this study was to diminish this gap and document optical coherence tomography and scanning laser ophthalmoscopy imaging data in the healthy posterior pole of cynomolgus monkeys' eyes at predose examinations. The current study is a retrospective assessment of baseline spectral domain OCT data obtained from the 768 eyes of 384 cynomolgus monkeys (192 males and 192 females) of Mauritian origin. The data set was obtained from studies conducted over a 4-y period in the context of ocular safety evaluations of various compounds under preclinical development. The most prevalent findings were the presence of Bergmeister papilla and intravitreal hyperreflective spots. Less common findings included disorganization of retinal zones, abnormalities of the retinal vasculature, partial posterior vitreous detachment, and abnormally shaped foveal pits. Thoughtful consideration of these physiologic findings will aid in distinguishing normal features from toxic outcomes in future preclinical ophthalmic studies.

Comparison of Retinal Nerve Fiber Layer Imaging by Spectral Domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

Ophthalmology ◽

10.1016/j.ophtha.2011.03.035 ◽

2011 ◽

Vol 118 (11) ◽

pp. 2196-2202 ◽

Cited By ~ 20

Author(s):

Cong Ye ◽

Elaine To ◽

Robert N. Weinreb ◽

Marco Yu ◽

Shu Liu ◽

...

Keyword(s):

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Spectral Domain ◽

Scanning Laser ◽

Optical Coherence ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Retinal Nerve Fiber

The influence of axial length on confocal scanning laser ophthalmoscopy and spectral-domain optical coherence tomography size measurements: a pilot study

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-014-2578-6 ◽

2014 ◽

Vol 252 (4) ◽

pp. 589-593 ◽

Cited By ~ 4

Author(s):

T. Röck ◽

B. Wilhelm ◽

K. U. Bartz-Schmidt ◽

D. Röck

Keyword(s):

Pilot Study ◽

Axial Length ◽

Spectral Domain ◽

Scanning Laser ◽

Optical Coherence ◽

Confocal Scanning Laser Ophthalmoscopy ◽

Confocal Scanning ◽

Confocal Scanning Laser

Ultra-wide-field scanning laser ophthalmoscopy and optical coherence tomography in FEVR: findings and its diagnostic ability

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2020-316226 ◽

2020 ◽

pp. bjophthalmol-2020-316226

Author(s):

Ting Zhang ◽

Zhirong Wang ◽

Limei Sun ◽

Songshan Li ◽

Li Huang ◽

...

Keyword(s):

Diagnostic Test ◽

Clinical Significance ◽

Screening Strategy ◽

Scanning Laser ◽

Youden Index ◽

Wide Field ◽

Healthy Controls ◽

Optical Coherence

Background/Aims To describe some novel vitreoretinal microstructural findings in patients with mild familial exudative vitreoretinopathy (FEVR) on ultra-wide-field scanning laser ophthalmoscopy (UWF-SLO) and UWF optical coherence tomography (UWF-OCT) and to evaluate their clinical significance.MethodsA total of 32 patients and 32 healthy controls were studied. An additional independent 40 FEVR patients, 44 patients with non-FEVR retinopathies and 40 healthy controls participated in a diagnostic test to validate the abilities of novel findings in FEVR screening.ResultsA novel anatomic change, named Temporal Mid-Peripheral Vitreoretinal Interface Abnormality (TEMPVIA), was found on UWF-SLO in 88.3% of FEVR patients and in none of the healthy controls. The clinical significance of TEMPVIA was further validated by a diagnostic test in new independent cases, with satisfying sensitivity (91.5%) and specificity (98.8%) and Youden Index 0.90. In addition to foveal hypoplasia, some previously unrecognised, novel clinical changes in FEVR, for instance, retinoschisis, focal retinal thickening, sudden thinning of the retina and retinal ridge, were identified using UWF-OCT.ConclusionThe results of this study have led to an update of the clinical spectrum of FEVR and have improved our understanding of its pathogenesis. TEMPVIA is therefore suggested to be a useful biomarker in the screening strategy for mild FEVR.