scholarly journals Respiratory syncytial virus infection is an underestimated cause of viral pneumoniae in adults

2021 ◽  
Author(s):  
Lorenz Schubert ◽  
Johanna Steininger ◽  
Felix Lötsch ◽  
Anna Nele Herdina ◽  
Redlberger-Fritz Monika ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Chronic Diseases ◽  
Respiratory Disease ◽  
Detection Rate ◽  
Correct Diagnosis ◽  
Advanced Age ◽  
Syncytial Virus ◽  
The Impact

Abstract Respiratory syncytial virus (RSV) testing is generally available in most care centres, but it is rarely performed because clinicians’ seldom suspect RSV to be the underlying pathogen in adults with respiratory disease. Here, we evaluate the impact of broad combined influenza/RSV testing on the clinical practice. Overall, 103 patients were tested positively for RSV. Our study indicates that positively tested patients were mostly of advanced age and suffered from chronic diseases. Mortality was significant in our cohort and higher in patients with advanced age. Further, we report a significant increase in detected RSV cases but also in detection rate. Together, these findings suggest that implementation of a combined influenza/RSV testing led to a significant increase in detection rate, supported clinicians establishing the correct diagnosis and allowed a safe and controlled handling of RSV patients.

scholarly journals Surveillance of respiratory syncytial virus infections in adults, Austria, 2017 to 2019

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lorenz Schubert ◽  
Johanna Steininger ◽  
Felix Lötsch ◽  
Anna Nele Herdina ◽  
Monika Redlberger-Fritz ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Respiratory Syncytial Virus ◽  
Chronic Diseases ◽  
Respiratory Disease ◽  
Detection Rate ◽  
Correct Diagnosis ◽  
Advanced Age ◽  
Virus Infections ◽  
Syncytial Virus ◽  
The Impact

AbstractRespiratory syncytial virus (RSV) testing is generally available in most care centres, but it is rarely performed because clinicians’ seldom suspect RSV to be the underlying pathogen in adults with respiratory disease. Here, we evaluate the impact of broad combined influenza/RSV testing on the clinical practice. Overall, 103 patients were tested positively for RSV. Our study indicates that positively tested patients were mostly of advanced age and suffered from chronic diseases. Mortality was significant in our cohort and higher in patients with advanced age. Further, we report a significant increase in detected RSV cases but also in detection rate. Together, these findings suggest that implementation of a combined influenza/RSV testing led to a significant increase in detection rate, supported clinicians establishing the correct diagnosis and allowed a safe and controlled handling of RSV patients.

scholarly journals Comparison of 11 respiratory pathogens among hospitalized children before and during the COVID-19 epidemic in Shenzhen, China

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Li Li ◽  
Heping Wang ◽  
Ailiang Liu ◽  
Rongjun Wang ◽  
Tingting Zhi ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Multiplex Pcr ◽  
Detection Rate ◽  
Human Metapneumovirus ◽  
Human Respiratory Syncytial Virus ◽  
Hospitalized Children ◽  
Respiratory Pathogens ◽  
Detection Rates ◽  
Syncytial Virus ◽  
The Impact

Abstract Background The effect of SARS-CoV-2 on existing respiratory pathogens in circulation remains uncertain. This study aimed to assess the impact of SARS-CoV-2 on the prevalence of respiratory pathogens among hospitalized children. Methods This study enrolled hospitalized children with acute respiratory infections in Shenzhen Children’s Hospital from September to December 2019 (before the COVID-19 epidemic) and those from September to December 2020 (during the COVID-19 epidemic). Nasopharyngeal swabs were collected, and respiratory pathogens were detected using multiplex PCR. The absolute case number and detection rates of 11 pathogens were collected and analyzed. Results A total of 5696 children with respiratory tract infection received multiplex PCR examination for respiratory pathogens: 2298 from September to December 2019 and 3398 from September to December 2020. At least one pathogen was detected in 1850 (80.5%) patients in 2019, and in 2380 (70.0%) patients in 2020; the detection rate in 2020 was significantly lower than that in 2019.The Influenza A (InfA) detection rate was 5.6% in 2019, but 0% in 2020. The detection rates of Mycoplasma pneumoniae, Human adenovirus, and Human rhinovirus also decreased from 20% (460), 8.9% (206), and 41.8% (961) in 2019 to 1.0% (37), 2.1% (77), and 25.6% (873) in 2020, respectively. In contrast, the detection rates of Human respiratory syncytial virus, Human parainfluenza virus, and Human metapneumovirus increased from 6.6% (153), 9.9% (229), and 0.5% (12) in 2019 to 25.6% (873), 15.5% (530), and 7.2% (247) in 2020, respectively (p < 0.0001). Conclusions Successful containment of seasonal influenza as a result of COVID-19 control measures will ensure we are better equipped to deal with future outbreaks of both influenza and COVID-19.Caused by virus competition, the detection rates of Human respiratory syncytial virus, Human parainfluenza virus, and Human metapneumovirus increased in Shenzhen,that reminds us we need to take further monitoring and preventive measures in the next epidemic season.

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