scholarly journals Sentinel Lymph Node Biopsy using Indocyanine Green and Blue Dye in Male Breast Cancer: A Case Report of 5 Patients

2021 ◽  
Author(s):  
Jun Yang ◽  
Xu-Li Meng ◽  
Yong Yu ◽  
Lei Pan ◽  
Jun Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Indocyanine Green ◽  
Male Breast Cancer ◽  
Clinical Stage ◽  
Male Breast ◽  
Axillary Lymph Nodes ◽  
Blue Dye ◽  
Axillary Lymph

Abstract Background: Male breast cancer is extremely rare and optimal treatments remain unclear. Most of research findings about breast cancer are derived from female patients and has not been rigorously investigated in male patients. The aim of article is to introduce the utility of indocyanine green (ICG) and blue dye mapping for sentinel lymph node (SLN) biopsy and to determine its clinical usefulness in male breast cancer. Case presentation: A total of 5 consecutive male breast cancer patients with clinical stage ranging from I to IIA in the Tongde Hospital of Zhejiang Province during March 2013 to May 2016 were included in the present study. All patients underwent SLN biopsy with ICG and blue dye. Planed surgical resection with axillary lymph node dissection was performed. Surgically excised sentinel nodes were subjected to conventional histopathology. All of 5 cases with male breast cancer were successfully identified SLNs. Among them, 4 cases were detected by blue dye and all cases were detected by indocyanine green. A total of 10 SLNs were retrieved with an average nodal count of 2 per patient. Metastases were present in 2 nodes within 1 patients. Conclusions: These results provide evidence that the SLN biopsy mapping with ICG and blue dye is accurate in predicting axillary lymph nodes metastases and has the potential to be a reliable criteria for staging of the axilla in patients with male breast cancer.

Combination Technique Is Superior to Dye Alone in Identification of the Sentinel Lymph Node in Male Breast Cancer

2018 ◽  
Vol 84 (12) ◽  
pp. 1957-1960 ◽  
Author(s):  
Osman Simsek ◽  
Ahmet K. Belli ◽  
Fatih Aydogan ◽  
Adem Karatas ◽  
Emel Canbay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Cancer Patients ◽  
Male Breast Cancer ◽  
Detection Rate ◽  
Male Breast ◽  
Blue Dye ◽  
Breast Cancer Patients ◽  
Combination Technique

Sentinel lymph node (SLN) biopsy is the main method in staging the axilla. There are insufficient data available regarding the accuracy of an SLN biopsy in male breast cancer. The aim of this study is to evaluate whether the combination of dye and radiotracer would improve the detection rate of SLNs versus dye alone in male breast cancer patients. From February 2009 to January 2012, our SLN biopsy database was retrospectively reviewed to identify male breast cancer cases. Of the 890 SLN procedures contained in the database, 10 male breast cancer patients were identified. Patient age, body mass index, SLN biopsy technique, SLN identification, number of SLN excised, and pathology reports were reviewed. Mean age was 57.2 (34–85) years with a mean tumor size was 2.2 (1.0–4.0) cm. SLN detection ratios were two in four with blue dye and six in six with the combination technique. Overall, SLNs were identified in 8 of the 10 patients. SLN biopsy is applicable in male breast cancer cases. The addition of a radiotracer to the dye in SLN biopsy increases the detection rate of sentinel nodes in male breast cancer patients.

scholarly journals Sentinel lymph node biopsy after neoadjuvant treatment of breast cancer using blue dye, radioisotope, and indocyanine green: Prospective cohort study

2020 ◽  
Vol 59 ◽  
pp. 156-160
Author(s):  
Prakasit Chirappapha ◽  
Tanet Chatmongkonwat ◽  
Panuwat Lertsithichai ◽  
Wiriya Pipatsakulroj ◽  
Chanika Sritara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Indocyanine Green ◽  
Neoadjuvant Treatment ◽  
Lymph Node Biopsy ◽  
Blue Dye ◽  
Node Biopsy

scholarly journals Rate of sentinel lymph node identification using isosulfan blue dye in breast cancer patients at Charoenkrung Pracharak Hospital, Thailand

2014 ◽  
Vol 8 (4) ◽  
pp. 517-524
Author(s):  
Kampol Ratchaworapong ◽  
Sarawut Thanawut ◽  
Sirisanpang Yodavudh ◽  
Suthat Chottanapund
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Cancer Patients ◽  
Primary Breast Tumor ◽  
Blue Dye ◽  
Axillary Lymph ◽  
Isosulfan Blue ◽  
Breast Cancer Patients ◽  
Isosulfan Blue Dye

Abstract Background: The sentinel lymph node (SLN) is the first lymph node to receive lymphatic drainage from a primary breast tumor. If the SLN contains no metastatic tumor, then it is unlikely other lymph nodes will contain breast cancer metastasis. When the SLN does contains metastasis, an axillary lymph node dissection (ALND) is recommended to further stage the axilla and to maintain locoregional control. SLNs can be identified by using a dye, radioisotope, or combined techniques. Objective: To determine the rate of SLN identification using isosulfan blue dye in breast cancer patients at Charoenkrung Pracharak Hospital, Thailand, and factors that affect it. Methods: This prospective study of 106 consecutive cases breast cancer enrolled 105 women (1 bilateral breast cancer case) between October 2011 and October 2013 at Charoenkrung Pracharak Hospital. Clinical and pathological features were analyzed for the effectiveness of SLN identification using isosulfan blue dye. Results: The rate of SLN identification using isosulfan blue dye in breast cancer patients at Charoenkrung Pracharak Hospital was 92%. The method was safe and well tolerated in early-stage breast cancer patients. Conclusion: The effectiveness of sentinel node identification using isosulfan blue dye in breast cancer patients at Charoenkrung Pracharak Hospital is consistent with that shown in studies from other countries.

scholarly journals Preoperative Nomogram for Predicting Sentinel Lymph Node Metastasis Risk in Breast Cancer: A Potential Application on Omitting Sentinel Lymph Node Biopsy

2021 ◽  
Vol 11 ◽  
Author(s):  
Xi’E Hu ◽  
Jingyi Xue ◽  
Shujia Peng ◽  
Ping Yang ◽  
Zhenyu Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Biopsy ◽  
Curve Analysis ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Large Tumor ◽  
Invasive Approach ◽  
Decision Curve Analysis

BackgroundSentinel lymph node (SLN) biopsy is feasible for breast cancer (BC) patients with clinically negative axillary lymph nodes; however, complications develop in some patients after surgery, although SLN metastasis is rarely found. Previous predictive models contained parameters that relied on postoperative data, thus limiting their application in the preoperative setting. Therefore, it is necessary to find a new model for preoperative risk prediction for SLN metastasis to help clinicians facilitate individualized clinical decisions.Materials and MethodsBC patients who underwent SLN biopsy in two different institutions were included in the training and validation cohorts. Demographic characteristics, preoperative tumor pathological features, and ultrasound findings were evaluated. Multivariate logistic regression was used to develop the nomogram. The discrimination, accuracy, and clinical usefulness of the nomogram were assessed using Harrell’s C-statistic and ROC analysis, the calibration curve, and the decision curve analysis, respectively.ResultsA total of 624 patients who met the inclusion criteria were enrolled, including 444 in the training cohort and 180 in the validation cohort. Young age, high BMI, high Ki67, large tumor size, indistinct tumor margins, calcifications, and an aspect ratio ≥1 were independent predictive factors for SLN metastasis of BC. Incorporating these parameters, the nomogram achieved a robust predictive performance with a C-index and accuracy of 0.92 and 0.85, and 0.82 and 0.80 in the training and validation cohorts, respectively. The calibration curves also fit well, and the decision curve analysis revealed that the nomogram was clinically useful.ConclusionsWe established a nomogram to preoperatively predict the risk of SLN metastasis in BC patients, providing a non-invasive approach in clinical practice and serving as a potential tool to identify BC patients who may omit unnecessary SLN biopsy.

scholarly journals Nodal micrometastases in early stage breast cancer: two case reports

2009 ◽  
Vol 12 (3) ◽  
Author(s):  
J. Reeder ◽  
S. Puhalla ◽  
V. Vogel
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Early Stage ◽  
Case Reports ◽  
Early Stage Breast Cancer ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Nodal Disease ◽  
Micrometastatic Disease

AbstractThe most important predictor of outcome for women with early stage breast cancer is the presence or absence of metastases in the axillary lymph nodes. In the era of sentinel lymph node biopsies and improved pathology techniques, micrometastatic disease can be diagnosed. The question of whether or not to treat these women as if they have nodal disease remains in doubt. In order to further explore this topic, we identified two cases of women with nodal micrometastases at our institution. A literature review of PUBMED and SABCS abstracts was then performed. In this article, we discuss our results and the emerging clinical debate about the management of nodal micrometastases.

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