Pre- and Post-operative Differences Between Genders in Idiopathic Macular Holes

Abstract Background To compare idiopathic macular holes (IMHs) between male and female before and after surgery. Methods Patients with IMHs of stage 3 and stage 4 who underwent 23-gauge vitrectomy were retrospectively enrolled. Pre-operative clinical features like age of onset, and best-corrected visual acuity (BCVA) were reviewed. Optical coherence tomography parameters including minimum linear diameter (MLD), central macular thickness and some other indexes were measured and calculated. Main surgical outcomes included the primary closure rate, the highest BCVA during follow-up, and the recovery duration. All the metrics mentioned above were compared between genders with appropriate statistical methods. Results A total of 298 eyes from 280 patients (male: 51; female: 229) were enrolled. Compared with men, women demonstrated a significantly higher ratio of stage3/stage4 (P = 0.045), larger horizontal MLD (P = 0.009), but similar surgical outcomes except for a relatively longer recovery duration (P = 0.024). For stage 3 IMHs, women exhibited significantly younger age of onset (P = 0.023), larger MLD (P = 0.003), and smaller height of the hole (P = 0.029). However, for stage 4 IMHs, all the pre- and post-operative metrics showed no differences between genders. Conclusions Female IMHs seem to demonstrate an earlier age of onset and larger size of hole, especially in IMHs of stage 3. However, these differences, which may owe to normal gender-related variations, have limited influence on the surgical outcomes.

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Pre- and Post-operative Differences Between Genders in Idiopathic Macular Holes

10.21203/rs.3.rs-20553/v3 ◽

2020 ◽

Author(s):

Jing Wang ◽

Yanping Yu ◽

Xida Liang ◽

Zengyi Wang ◽

Biying Qi ◽

...

Keyword(s):

Surgical Outcomes ◽

Age Of Onset ◽

Closure Rate ◽

Recovery Duration ◽

Macular Holes ◽

Younger Age ◽

Stage 4 ◽

Before And After ◽

Idiopathic Macular Holes ◽

23 Gauge

Abstract Background: To compare idiopathic macular holes (IMHs) between male and female before and after surgery.Methods: Patients with IMHs of stage 3 and stage 4 who underwent 23-gauge vitrectomy were retrospectively enrolled. Pre-operative clinical features like age of onset, and best-corrected visual acuity (BCVA) were reviewed. Optical coherence tomography parameters including minimum linear diameter (MLD), central macular thickness and some other indexes were measured and calculated. Main surgical outcomes included the primary closure rate, the highest BCVA during follow-up, and the recovery duration. All the metrics mentioned above were compared between genders with appropriate statistical methods. Results: A total of 298 eyes from 280 patients (male: 51; female: 229) were enrolled. Compared with men, women demonstrated a significantly higher ratio of stage3/stage4 (P=0.045), larger horizontal MLD (P=0.009), but similar surgical outcomes except for a relatively longer recovery duration (P=0.024). For stage 3 IMHs, women exhibited significantly younger age of onset (P=0.023), larger MLD (P=0.003), and smaller height of the hole (P=0.029). However, for stage 4 IMHs, all the pre- and post-operative metrics showed no differences between genders.Conclusions: Female IMHs seem to demonstrate an earlier age of onset and larger size of hole, especially in IMHs of stage 3. However, these differences, which may owe to normal gender-related variations, have limited influence on the surgical outcomes.

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Pre- and Post-operative Differences Between Genders in Idiopathic Macular Holes

10.21203/rs.3.rs-20553/v1 ◽

2020 ◽

Author(s):

Jing Wang ◽

Yanping Yu ◽

Xida Liang ◽

Zengyi Wang ◽

Biying Qi ◽

...

Keyword(s):

Surgical Outcomes ◽

Age Of Onset ◽

Closure Rate ◽

Recovery Duration ◽

Macular Holes ◽

Younger Age ◽

Stage 4 ◽

Before And After ◽

Idiopathic Macular Holes

Abstract Background: To compare idiopathic macular holes (IMHs) between male and female before and after surgery.Methods: Patients with IMHs of stage 3 and stage 4 who underwent 23-guage vitrectomy were retrospectively enrolled. Pre-operative clinical features like age of onset, and best-corrected visual acuity (BCVA) were reviewed. Optical coherence tomography parameters including minimum linear diameter (MLD), central macular thickness and some other indexes were measured and calculated. Main surgical outcomes included the primary closure rate, the highest BCVA during follow-up, and the recovery duration. All the metrics mentioned above were compared between genders with appropriated statistical methods. Results: A total of 298 eyes from 280 patients (male: 51; female: 229) were enrolled. Compared with men, women demonstrated a significantly higher ratio of stage3/stage4 (P=0.045), larger horizontal MLD (P=0.009), but similar surgical outcomes except for a relatively longer recovery duration (P=0.024). For stage 3 IMHs, women exhibited significantly younger age of onset (P=0.023), larger MLD (P=0.003), and smaller height of the hole (P=0.029). However, for stage 4 IMHs, all the pre- and post-operative metrics showed no differences between genders.Conclusions: Female IMHs seem to demonstrate an earlier age of onset and larger size of hole, especially in IMHs of stage 3. However, these differences, which may owe to normal gender-related variations, have limited influence on the surgical outcomes.

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Autologous internal limiting membrane transplant for recurrent idiopathic macular holes

European Journal of Ophthalmology ◽

10.1177/1120672120906391 ◽

2020 ◽

pp. 112067212090639 ◽

Cited By ~ 1

Author(s):

Tommaso Rossi ◽

Carlandrea Trillo ◽

Guido Ripandelli

Keyword(s):

Visual Acuity ◽

Macular Hole ◽

Outer Segment ◽

Internal Limiting Membrane ◽

Control Group ◽

Closure Rate ◽

Internal Limiting Membrane Peeling ◽

Membrane Peeling ◽

Macular Holes ◽

Idiopathic Macular Holes

Purpose: To report a series of recurrent idiopathic macular holes treated by means of a free autologous internal limiting membrane flap and compare visual and anatomic results to a control group undergoing further internal limiting membrane peeling and novel gas tamponade. Methods: Retrospective surgical series of 15 consecutive patients receiving autologous internal limiting membrane flap compared to 14 patients operated on for internal limiting membrane peeling enlargement. Autologous internal limiting membrane flap was created after brilliant blue G staining, internal limiting membrane lifting, perfluorocarbon bubble injection and creation of a wide internal limiting membrane free flap translocated underneath perfluorocarbon liquid, to the macular hole bed. Both groups were tamponated with 20% SF6 and positioned face down for 4 h a day for 3 days. Results: Macular hole closed in 14/15 (93.3%) patients of the autologous internal limiting membrane group and 9/14 (64.2%) controls (p < 0.05). Visual acuity increased from 0.05 ± 0.03 to 0.23 ± 0.13 Snellen in the autologous internal limiting membrane group and from 0.05 ± 0.03 to 0.14 ± 0.10 Snellen of controls (p < 0.05 for both). Vision of the autologous internal limiting membrane group improved more than controls at 1 month (p = 0.043) and 3 months (p = 0.045). Inner segment/outer segment interruption at 3 months was smaller in the autologous internal limiting membrane group than controls, reducing from 1230 ± 288 µm at baseline to 611 ± 245 and 547 ± 204 µm at 3 months versus 1196 ± 362, 745 ± 222 and 705 ± 223 µm, respectively (p < 0.05). Conclusion: Autologous internal limiting membrane flap can effectively close recurrent idiopathic macular holes with a higher closure rate, smaller residual inner segment/outer segment line interruption and higher visual acuity at 3 months than previous standard of care.

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Idiopathic macular holes and direction of vitreomacular traction: structural changes and surgical outcomes

Eye ◽

10.1038/eye.2017.141 ◽

2017 ◽

Vol 31 (12) ◽

pp. 1689-1696 ◽

Cited By ~ 4

Author(s):

C-Y Tsai ◽

Y-T Hsieh ◽

T-T Lai ◽

C-M Yang

Keyword(s):

Surgical Outcomes ◽

Structural Changes ◽

Vitreomacular Traction ◽

Macular Holes ◽

Idiopathic Macular Holes

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Comparative study of combined vitrectomy with phacoemulsification versus vitrectomy alone for primary full-thickness macular hole repair

BMC Ophthalmology ◽

10.1186/s12886-021-01918-2 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Christophe Valmaggia ◽

Filip Kostadinov ◽

Corina Lang ◽

Josef Guber

Keyword(s):

Visual Acuity ◽

Pars Plana Vitrectomy ◽

Primary Outcome Measure ◽

Secondary Outcome ◽

Full Thickness ◽

Closure Rate ◽

Macular Holes ◽

Pars Plana ◽

23 Gauge ◽

N 93

Abstract Background To assess the effectiveness and safety of 23-gauge pars plana vitrectomy combined with phacoemulsification versus vitrectomy alone in patients over 50 years with primary full-thickness macular holes (FTMH). Methods We retrospectively reviewed the medical records related to 406 consecutive vitrectomies performed for primary FTMH. Phacovitrectomy was performed in 294 phakic eyes whereas vitrectomy alone in 112 pseudophakic eyes. The cases were divided into three groups according to the stage of the FTMH: stage 2 (n = 93), stage 3 (n = 270), or stage 4 (n = 43). The primary outcome measure was the closure of the FTMH. The secondary outcome measures were the evolution of visual acuity as well as intraoperative and postoperative complications. Results Neither the primary nor the secondary outcomes differed between phacovitrectomy and vitrectomy alone for all three stages. The FTMH were closed in 375 eyes (92.4 %) after a first operation. The closure rate was higher for stage 2 (96.8 %) than for stages 3 (91.1 %) or 4 (90.75 %), but not significantly (P = 0.189). The mean visual acuity increased significantly from preoperatively LogMAR 0.68 (± SD 0.2) to LogMAR 0.43 (± SD 0.24) at the end of the follow-up (p < 0.001). Conclusions Combined 23-gauge pars plana vitrectomy with phacoemulsification for primary FTMH repair in patients over 50 years is as efficient and safe when compared with vitrectomy only. Trial registration The study was approved on 30th April 2020 by the local ethics committee (Ethikkommission Ostschweiz, EKOS 20/074; BASEC Nr. 2020-01033).

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Characteristics of fixation patterns and their relationship with visual function of patients with idiopathic macular holes after vitrectomy

Scientific Reports ◽

10.1038/s41598-021-87286-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yuyan Liu ◽

Ying Wang ◽

Yi Dong ◽

Dongqing Liang ◽

Shiyong Xie ◽

...

Keyword(s):

Visual Acuity ◽

Visual Function ◽

Retrospective Case ◽

Integrity Assessment ◽

Fixation Location ◽

Macular Holes ◽

Significant Difference ◽

Before And After ◽

Fixation Locations ◽

Idiopathic Macular Holes

AbstractTo analyze the relationships between the fixation location and the visual function of idiopathic macular hole (IMH) patients with macular integrity assessment (MAIA) examination preoperatively and 3 months postoperatively. This was a retrospective case analysis. Forty-three eyes of 43 patients diagnosed with IMH were included in this study. The best corrected visual acuity (BCVA) assessments, optical coherence tomography (OCT) and MAIA examinations were performed before surgery and 1 week, 1 month and 3 months after surgery. The relationships between MAIA parameters and visual acuity were assessed by correlation analysis. Grouping by fixation location with the foveola (2°) as the centre, the locations could be divided into five groups, including foveolar, temporal, nasal, inferior and superior fixation. The mean macular sensitivity (MMS) of the macular area was correlated with the BCVA in the IMH patients before and 3 months after surgery (before surgery P = 0.00, after surgery P = 0.00). The MMS could be used as a good indicator for evaluating visual function in IMH patients. There was a significant difference in fixation location before and after the operation (P = 0.01). The preoperative fixation location of IMH patients was mainly in the superior area, while postoperatively moved to the foveola and nasal areas. Paying attention to the changes of fixation locations in IMH patients may provide new clues for further improving postoperative visual function.

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Role of Microperimetry in Observation and Treatment in Patients with Macular Holes

Ophthalmology in Russia ◽

10.18008/1816-5095-2021-1-90-95 ◽

2021 ◽

Vol 18 (1) ◽

pp. 90-95

Author(s):

A. S. Zotov ◽

A. S. Balalin ◽

S. V. Balalin ◽

A. M. Marukhnenko ◽

T. G. Efremova

Keyword(s):

Surgical Treatment ◽

Fundus Photography ◽

Non Invasive ◽

Corrected Visual Acuity ◽

Dynamic Observation ◽

Macular Holes ◽

Before And After ◽

Idiopathic Macular Holes

Purpose: to assess the role of microperimetry in dynamic observation and treatment of patients with macular holes.Patients and Methods. Retrospective study of the microinvasive vitrectomy results using 25G or 27G technologies in 29 patients (29 eyes) with idiopathic macular holes (IMH). The examination included the determination of the best corrected visual acuity (BCVA), tonometry, perimetry, ultrasound biometry, optical coherence tomography, fundus photography, microperimetry.Results. After surgical treatment all patients have shown a significant improvement in BCVA and retinal photosensitivity (p < 0.05). A formula was derived for the dependence of BCVA after treatment on the initial retinal photosensitivity and the minimum IMH size, which can be applied to predict the results of surgical treatment.Conclusion. Microperimetry is a modern non-invasive examination method that allows with a higher density and resolution to localize central defects of the visual field and to carry out thorough monitoring before and after surgical treatment. The study of the retinal photosensitivity in the macular region and the minimum IMH size before treatment allow to predict BCVA in the postoperative period.

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Combined Idiopathic Macular Hole Vitrectomy with Phacoemulsification without Face-Down Positioning

Journal of Ophthalmology ◽

10.1155/2012/571748 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 5

Author(s):

Fumihiko Yagi ◽

Seiji Takagi ◽

Goji Tomita

Keyword(s):

Visual Acuity ◽

Case Series ◽

Functional Results ◽

Idiopathic Macular Hole ◽

Closure Rate ◽

Postoperative Visual Acuity ◽

Macular Holes ◽

Idiopathic Macular Holes ◽

The Mean ◽

Final Closure

Purpose. To evaluate the outcome of combined vitrectomy with phacoemulsification without postoperative face-down positioning for idiopathic macular holes (MHs).Design. Retrospective, observational case series.Participants. Forty-two eyes of 42 patients with MH.Methods. We studied 42 eyes of 42 cases followed up for 6 months postoperatively. MH closure rate and preoperative and postoperative visual acuity (VA) were evaluated.Main Outcome Measures. MH closure rate and VA were evaluated after combined vitrectomy with phacoemulsification without postoperative face-down positioning.Results. Of the 42 holes, 40 (95.2%) were initially closed, and the final closure rate was 100%. Compared with preoperative VA, the mean VA was significantly improved at 1 month and the improvement was maintained for at least 6 months postoperatively.Conclusions. Combined vitrectomy with phacoemulsification without postoperative face-down positioning produced favorable anatomic and functional results for MH repair. Improvement in VA can be expected for up to at least 6 months postoperatively.

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