scholarly journals Role of Microperimetry in Observation and Treatment in Patients with Macular Holes

2021 ◽  
Vol 18 (1) ◽  
pp. 90-95
Author(s):  
A. S. Zotov ◽  
A. S. Balalin ◽  
S. V. Balalin ◽  
A. M. Marukhnenko ◽  
T. G. Efremova
Keyword(s):  
Surgical Treatment ◽  
Fundus Photography ◽  
Non Invasive ◽  
Corrected Visual Acuity ◽  
Dynamic Observation ◽  
Macular Holes ◽  
Before And After ◽  
Idiopathic Macular Holes

Purpose: to assess the role of microperimetry in dynamic observation and treatment of patients with macular holes.Patients and Methods. Retrospective study of the microinvasive vitrectomy results using 25G or 27G technologies in 29 patients (29 eyes) with idiopathic macular holes (IMH). The examination included the determination of the best corrected visual acuity (BCVA), tonometry, perimetry, ultrasound biometry, optical coherence tomography, fundus photography, microperimetry.Results. After surgical treatment all patients have shown a significant improvement in BCVA and retinal photosensitivity (p < 0.05). A formula was derived for the dependence of BCVA after treatment on the initial retinal photosensitivity and the minimum IMH size, which can be applied to predict the results of surgical treatment.Conclusion. Microperimetry is a modern non-invasive examination method that allows with a higher density and resolution to localize central defects of the visual field and to carry out thorough monitoring before and after surgical treatment. The study of the retinal photosensitivity in the macular region and the minimum IMH size before treatment allow to predict BCVA in the postoperative period.

Differentiated Approach to Strategies of Surgical Treatment of Idiopathic Macular Holes

The Eye ◽  
2021 ◽  
Vol 23 (4) ◽  
pp. 12-16
Author(s):  
R. Z. Shamratov ◽  
L. Sh. Ramazanova ◽  
O. A. Napylova
Keyword(s):  
Surgical Treatment ◽  
Vitreoretinal Surgery ◽  
Internal Limiting Membrane ◽  
Pathological Process ◽  
Hole Diameter ◽  
Corrected Visual Acuity ◽  
Macular Holes ◽  
Idiopathic Macular Holes ◽  
Anatomical Outcome ◽  
Clinical Cases

Background. 25G or 27G three-port vitrectomy, followed by staining and removal of the internal limiting membrane with vitreous cavity air or gas tamponade, is one of the main modern vitreoretinal surgery principles for primary macular holes. However, not all patients manage to obtain a functional outcome when the anatomical outcome is achieved. Purpose. To  present clinical cases of surgical treatment of idiopathic macular holes (IMH) exhibiting a differentiated approach.Matherials and methods. This article analyzes clinical cases of four patients with primary idiopathic macular holes, differing in terms of development, hole diameter and the presence of comorbidities. Results. The results of surgical treatment were evaluated 14 days and 1 month after surgery. In all clinical cases, surgical treatment resulted in a positive anatomical outcome by blocking a retinal defect. Best corrected visual acuity increased, on average, from 0.08 ± 0.05 to 0.4 ± 0.05.Conclusion. The analysis of the presented clinical cases clearly demonstrates the need for a timely and differentiated approach to the treatment of patients with IMH, that considers etiology of the pathological process, period of its existence as well as concomitant and general somatic pathologies.

scholarly journals A Retrospective Analysis of the Results of Microinvasive Posterior Vitrectomy in the Surgical Treatment of Non-Full Thickness Macular Holes

2018 ◽  
Vol 15 (2S) ◽  
pp. 239-245 ◽  
Author(s):  
Y. V. Bayborodov ◽  
K. S. Zhogolev ◽  
L. I. Balashevich ◽  
I. E. Panova ◽  
D. R. Mirsaitova
Keyword(s):  
Visual Acuity ◽  
Surgical Treatment ◽  
Retrospective Analysis ◽  
Retinal Thickness ◽  
Maximum Diameter ◽  
Full Thickness ◽  
Ellipsoid Zone ◽  
Corrected Visual Acuity ◽  
Macular Holes ◽  
Before And After

Purpose:to study the effectiveness of the posterior microinvasive vitrectomy in the surgical treatment of non-full thickness macular holes on the basis of the retrospective analysis of the retina changes, identified by OCT, and functional outcomes of surgical treatment.Patients and Methods. A retrospective analysis of outcomes of posterior microinvasive vitrectomy was performed in 30 patients operated about non-full thickness macular holes. The following features were assessed: maximum diameter of the non-full thickness macular holes, the diameter at the base of the hole, the minimum thickness of the retina before and after operation, the maximum thickness of the retina before and after surgery. In addition, the configuration of the hole edges before surgery, the presence of intraretinal cysts before and after surgery, the integrity of the ellipsoid zone of the photoreceptors before and after the operation and the restoration of fovea centralis as a result of surgical treatment were assessed.Results. As a result of surgical treatment the closure of non-full thickness macular holes was reached in all cases. The most corrected visual acuity in the postoperative period was ranged from 0.1 to 1.0 (0,66 ± 0,04). The visual acuity improved in 20 cases (64.5%), remained at the same level in 8 cases (25.8%) and decreased in 3 cases (9.6%, in 1 case due to the development of cataracts). The results of correlation analysis has allowed to establish correlation between the initial BCVA and the maximum retinal thickness (R = –0.4), and residual retinal thickness in the area of the hole (R = –0.3). The increase in visual acuity after surgical treatment significantly affected the recovery of the ellipsoid zone of the photoreceptors (RD = 0.833), regression of the retinal thickness (R = 0.42). In addition, the initial diameter of non-full thickness macular holes, both external and at the base, also had an impact on the increase in BCVA (R = –0.3 and R = –0.25, respectively).Conclusion. Posterior microinvasive vitrectomy in the surgical treatment of non-full thickness macular holes is a highly effective method of treatment, as evidenced by the closure of the defect and improvement or stabilization of the most corrected visual acuity 90.4% cases. On the basis of the retrospective analysis it is found that the most significant increase in the most corrected visual acuity was increased in patients with low visual acuity. The recovery of the ellipsoid zone of photoreceptors, regression of the retinal thickness and the diameter of non-full thickness macular holes, both external and at the base mostly influences nn the recovery of the most corrected visual acuity. 

Morphofunctional analysis of the retina in the surgical treatment of idiopathic macular holes

2021 ◽  
pp. 48-52
Author(s):  
A.S. Zotov ◽  
◽  
A.S. Balalin ◽  
S.V. Balalin ◽  
S.M. Purshak ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Surgical Treatment ◽  
Macular Hole ◽  
Practical Importance ◽  
Functional Results ◽  
Hole Diameter ◽  
Optical Coherence ◽  
Macular Holes ◽  
Idiopathic Macular Holes ◽  
Morphofunctional Analysis

Purpose. To evaluate the role of microperimetry and optical coherence tomography (OCT) in the morphofunctional analysis of the retina after surgical treatment of idiopathic macular holes (IMH). Materials and methods. A retrospective study of 33 patient's treatment results (33 eyes) with IMH was carried out. All patients underwent minimally invasive with 25G or 27G vitrectomy. Best corrected visual acuity (BCVA), macular photosensitivity, fixation stability, macular neuroepithelial (NE) volume and minimal macular hole diameter were analyzed. Follow-up period: 6 months. Results. A complete closure of the macular hole was achieved in all cases post-op. The patients had reliable improvement of BCVA, retinal photosensitivity and decrease of macular NE volume. Based on a multifactor correlation analysis with the purpose to predict the results of surgical treatment, the dependence of post-op BCVA on the pre-op photosensitivity of the retina and the minimal diameter of the macular hole was revealed. Conclusions. Microperimetry and OCT are modern non-invasive research methods allowing to estimate anatomical and functional results of surgical IMH treatment. The study of retinal photosensitivity in the macula and minimal macular hole diameter pre-op allows to predict post-op BCVA, which has a practical importance. Keywords: idiopathic macular hole, vitrectomy, microperimetry, optical coherence tomography.

scholarly journals Experimental evidence of spatial memory and home range affinity in White-tailed Deer (Odocoileus virginianus)

2015 ◽  
Vol 129 (1) ◽  
pp. 1 ◽  
Author(s):  
Michael E. Nelson
Keyword(s):  
Home Range ◽  
Spatial Memory ◽  
Experimental Evidence ◽  
Odocoileus Virginianus ◽  
Spatial Ecology ◽  
Home Ranges ◽  
Directional Movement ◽  
Before And After

The role of spatial memory in the movement of animals through landscapes remains elusive. To examine spatial memory and home range affinity of White-tailed Deer (Odocoileus virginianus) in northeastern Minnesota during 1995–2007, I translocated 17 adult does with known home ranges to unfamiliar sites and radio-tracked them after their release. Twelve does wearing transmitting radio-collars returned to their home ranges. Death and collar expiration precluded determination of whether the remaining five does would have returned to home ranges. Three of five does wearing global positioning system collars traveled throughout hundreds of square kilometres, circling, backtracking, and returning to release sites, while two others exhibited directional movement for tens of kilometres. Four does that survived to parturition stopped traveling and moved at hourly rates similar to those of control does during the first three weeks of the typical fawn-rearing period, but continued traveling later. Their aberrant extensive travel before and after interruption by parturition suggests that they recognized they were in unfamiliar areas, demonstrating both their capacity and propensity to search for and occupy the familiar space of their individual home ranges. Their successful return to home ranges provided experimental evidence of spatial memory and further elucidated its pervasive role in White-tailed Deer spatial ecology.

scholarly journals Assessment of the Role of Snowmelt in a Flood Event in a Gauged Catchment

Water ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 506 ◽  
Author(s):  
Jesús Mateo-Lázaro ◽  
Jorge Castillo-Mateo ◽  
José Sánchez-Navarro ◽  
Víctor Fuertes-Rodríguez ◽  
Alejandro García-Gil ◽  
...  
Keyword(s):  
Hydrological Cycle ◽  
Digital Terrain Model ◽  
Terrain Model ◽  
Rain Gauges ◽  
Digital Terrain ◽  
Before And After ◽  
Thawing Process ◽  
Rainfall Model

An actual event that happened in the Roncal valley (Spain) is investigated and the results are compared between models with and without snowmelt. A distributed rainfall model is generated with the specific data recorded by the rain gauges of the catchment during the episode. To describe the process of water routing in the hydrological cycle of the basin, a model is used based on combinations of parallel linear reservoirs (PLR model), distribution by the basin, and tip-out into its drainage network configured using a digital terrain model (DTM). This PLR model allows simulation of the different actual reservoirs of the basin, including the snow and the contribution due to its melting which, in the model, depends on the temperature. The PLR model also allows for a water budget of the episode where, in addition to the effective rainfall contribution, the water that comes from the thaw is taken into account. The PLR model also allows determination of the amount of water that exists in the basin before and after the episode, data of great interest. When comparing the simulations with and without taking into account the thawing process, it is evident that the intervention of the snow reservoir has been decisive in causing a flood to occur.

Step-by-step creation of internal limiting membrane fragment for surgical treatment of large idiopathic macular holes

2016 ◽  
Vol 132 (1) ◽  
pp. 23
Author(s):  
Yu. A. Belyy ◽  
A. V. Tereshchenko ◽  
D. O. Shkvorchenko ◽  
E. V. Erokhina ◽  
N. M. Shilov
Keyword(s):  
Surgical Treatment ◽  
Internal Limiting Membrane ◽  
Membrane Fragment ◽  
Macular Holes ◽  
Idiopathic Macular Holes

scholarly journals Modern notions about the tactics of treatment of patients with non-full thickness macular holes: to observe or to operate?

2019 ◽  
Vol 12 (1) ◽  
pp. 37-44
Author(s):  
Konstantin S. Zhogolev ◽  
Yaroslav V. Bayborodov
Keyword(s):  
Visual Acuity ◽  
Surgical Treatment ◽  
Functional State ◽  
Visual Function ◽  
Full Thickness ◽  
Dynamic Observation ◽  
Macular Holes ◽  
Tangential Traction ◽  
Decrease In Visual Acuity

In this review, the opinions of different authors on the problem of non-full thickness macular holes are discussed in detail. Currently, there are three different approaches to the management of this condition. Dynamic observation allows assessing the degree of their progression, to determine some or other anatomical indicators which influence the functional state of the retina and visual function. Pharmacological vitreolysis in some cases allows eliminating vertical and tangential traction in a least invasive mannor. To resolve this problem in a radical way is possible by surgical treatment posterior vitrectomy, but this is also related to certain surgical risks, and does not always lead to an increase in visual acuity. As a rule, it is recommended to patients with a significant decrease in visual acuity. Currently, indications for surgical treatment of patients with high visual function are ambiguous.

Biliary Drainage Before and After Liver Resection for Perihilar Cholangiocarcinoma

2020 ◽  
Vol 86 (6) ◽  
pp. 628-634
Author(s):  
Laura M. Enomoto ◽  
Matthew E. B. Dixon ◽  
Allene Burdette ◽  
Niraj J. Gusani
Keyword(s):  
Biliary Drainage ◽  
Future Liver Remnant ◽  
Preoperative Biliary Drainage ◽  
Perihilar Cholangiocarcinoma ◽  
Patient Specific ◽  
Liver Remnant ◽  
Biliary Sepsis ◽  
Before And After

Perihilar cholangiocarcinoma (PHC) is a rare tumor that requires surgical resection for a potential cure. The role of preoperative biliary drainage has long been debated, given its treatment of biliary sepsis and decompression of the future liver remnant (FLR), but high procedure-specific morbidity. The indications, methods, and outcomes for preoperative biliary drainage are discussed to serve as a guide for perioperative management of patients with resectable PHC. Multiple studies from the literature related to perihilar cholangiocarcinoma, biliary drainage, and management of the FLR were reviewed. Commonly employed preoperative biliary drainage includes endoscopic biliary stenting and percutaneous transhepatic biliary drainage. Drainage of the FLR remains controversial, with most experts recommending drainage of the only in patients with an FLR <50%. Biliary drainage for resectable PHC requires a patient-specific approach with careful determination of the FLR and balancing of potential morbidity with the benefits of drainage.

Expression and role of miR-637 before and after lymphadenectomy for thyroid carcinoma

2021 ◽  
Vol 11 (7) ◽  
pp. 1245-1253
Author(s):  
Yanqing Qu ◽  
Xiaoyu Chu ◽  
Cuihong Dong ◽  
Weijiao Wang ◽  
Xiaojian Zhang
Keyword(s):  
Cell Proliferation ◽  
Thyroid Carcinoma ◽  
Biological Significance ◽  
Negative Control ◽  
Luciferase Reporter ◽  
Proliferation And Apoptosis ◽  
Before And After ◽  
Proliferation And Invasion

Thyroid carcinoma (TC) is a common endocrine malignancy that can be partially relieved by surgery, but its recurrence rate remains high. It is speculated that miR-637 exerts certain influence in its occurrence and development. Accordingly, we included 87 TC patients and 72 concurrent healthy controls as the research participants and purchased human papillary thyroid carcinoma cells with which to study and analyze the biological significance of miR-637. The determination of miR-637 and SH2B1 in peripheral blood and tissues was performed using nanoparticle-assisted polymerase chain reaction assay, and the identification of cell proliferation and apoptosis was made by MTT, Transwell, and flow cytometry. The results indicated that after transfection of miR-637 into TPC-1, the cell proliferation and invasion capacities in the mimics-miR-637 group were significantly reduced as compared to that of the inhibition-miR-637 and negative control (NC)-miR groups (P < 0.05). While transfection of SH2B1 into TPC-1 cells led to significantly enhanced cell proliferation and invasion capacities in sh-SH2B1 group than in si-SH2B1 and NC groups (P < 0.05). Finally, a double luciferase reporter assay identified enormously inhibited fluorescence activity of SH2B1-WT by mimics-miR-637. According to the experimental results, it is concluded that miR-637 expression was low in TC but increased after lymphadenectomy for TC. Moreover, by targeting SH2B1, miR-637 interferes with TC progression, which carries significant implications for future diagnosis and treatment of the disease.

Role of Posterior Vitreous Detachment in Idiopathic Macular Holes

Ophthalmology ◽  
1990 ◽  
Vol 97 (12) ◽  
pp. 1610-1613 ◽  
Author(s):  
Jun Akiba ◽  
Miguel A. Quiroz ◽  
Clement L. Trempe
Keyword(s):  
Posterior Vitreous Detachment ◽  
Vitreous Detachment ◽  
Macular Holes ◽  
Idiopathic Macular Holes
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