Network Pharmacology Study of Curcuma Longa: Potential Target Proteins and their Functional Enrichment Analysis.
Abstract Objective: This study’s primary goal is unraveling the mechanism of action of bioactives of Curcuma longa L. at the molecular level using protein-protein interaction network.Results: We used target proteins to create protein-protein interaction network (PPI) and identified significant node and edge attributes of PPI. To find the function module, we identified the cluster of proteins which were further queried to GO enrichment analysis. Closeness centrality and jaccard score identified as most important node and edge attribute of the protein-protein interaction network respectively. The mapped pathways of various function module of the network were overlapped and showed synergistic mechanism of action. Three most important identified pathways were Gonadotropin-releasing hormone receptor pathway, Endothelin signaling pathway, and Inflammation mediated by chemokine and cytokine signaling pathway.