Effect of activity level after a posterior-stabilized TKA on the relative bone mineral density measured on standard radiographs in periprosthetic tibial bone

Abstract Background: The aim of this study was to evaluate the effect of activity level after a posterior-stabilized total knee arthroplasty (TKA) on the relative bone mineral density (rBMD) measured on standard radiographs in periprosthetic tibial bone. Methods: A retrospective review identified 110 patients (110 knees，20 men/90 women) who underwent PS TKA with 5 years follow-up. Patients activity level was evaluated by University of California Los Angeles (UCLA) activity score, and the rBMD in periprosthetic tibial bone was measured on anteroposterior X-ray images. Clinical assessments included Western Ontario and McMaster Universities (WOMAC), Knee Society score (KSS) and visual analogue scale (VAS). Nonlinear regression analysis was used to assess the impact of activity levels on periprosthesis bone density.Results: During 5-year follow-up period, the bone density in the medial, lateral and distal areas decreased compared with that before surgery (p<0.0001). There was a U-shaped distribution between UCLA activity rating and rBMD loss, with the lowest rBMD loss when the UCLA activity score was between 6-8 at 1 and 3 years. The curve fitting of UCLA activity level and rBMD% showed there was a parabolic relationship between UCLA activity level and rBMD% at 1 and 3 years after surgery (P<0.001, P=0.001), while there was no significant relationship between UCLA activity level and rBMD% at 5 years after surgery (P=0.436).Conclusions: We found that physical activity had a significant effect on radiographic measurements of BMD at 1 and 3 years but not at 5 years. Moderate activity may be associated with less proximal tibial BMD loss after TKA, therefore it may be the most appropriate activity intensity for patients with TKA.

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Effect of activity level after a posterior-stabilized TKA on the relative bone mineral density measured on standard radiographs in periprosthetic tibial bone: a five-year follow-up study

10.21203/rs.3.rs-37186/v3 ◽

2020 ◽

Author(s):

Yong Liu ◽

Peiheng He ◽

Xing Li ◽

Yongheng Ye ◽

Minghao Liu ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Density ◽

Activity Level ◽

Activity Score ◽

Posterior Stabilized ◽

Mineral Density ◽

Ucla Activity Score ◽

Tibial Bone ◽

Standard Radiographs

Abstract Background: The aim of this study was to evaluate the effect of activity level after a posterior-stabilized TKA on the relative bone mineral density measured on standard radiographs in periprosthetic tibial bone. Methods: A retrospective review identified 110 patients (110 knees，20 men/90 women) who underwent PS TKA with 5-year follow-up. Patients activity level was evaluated by University of California Los Angeles (UCLA) activity score, and the relative BMD in periprosthetic tibial bone was measured by ImageJ software on anteroposterior X-ray images. Clinical assessments included Western Ontario and McMaster Universities (WOMAC), Knee Society score, VAS score and UCLA activity score. Nonlinear regression analysis was used to assess the impact of activity levels on periprosthesis bone density.Results: During 5-year follow-up period, the bone density in the medial, lateral and distal areas decreased compared with that before surgery (p<0.0001). There was a U-shaped distribution between UCLA activity rating and rBMD loss, with the lowest rBMD loss when the UCLA activity score was between 6-8 at 1 and 3 years. The curve fitting of UCLA activity level and rBMD% showed there was a parabolic relationship between UCLA activity level and rBMD% at 1 and 3 years after surgery (P<0.001, P=0.001), while there was no significant relationship between UCLA activity level and rBMD% at 5 years after surgery (P=0.436).Conclusions: We found that activity level had a significant effect on radiographic measurements of BMD at early years after surgery and moderate activity was associated with a minimal reduction in proximal tibial BMD.

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Effect of activity level after a posterior-stabilized TKA on the relative bone mineral density measured on standard radiographs in periprosthetic tibial bone: a five-year follow-up study

10.21203/rs.3.rs-37186/v2 ◽

2020 ◽

Author(s):

Yong Liu ◽

Peiheng He ◽

Xing Li ◽

Yongheng Ye ◽

Minghao Liu ◽

...

Keyword(s):

Bone Mineral Density ◽

Activity Level ◽

Moderate Activity ◽

Posterior Stabilized ◽

Mineral Density ◽

Ucla Activity Score ◽

Tibial Bone ◽

Significant Difference ◽

Standard Radiographs

Abstract Background: The aim of this study was to evaluate the effect of activity level after a posterior-stabilized TKA on the relative bone mineral density measured on standard radiographs in periprosthetic tibial bone. Methods: A retrospective review identified 121 patients (121 knees，19 men/102 women) that underwent PS TKA with 5-year follow-up. Patients activity level was evaluated by University of California Los Angeles (UCLA) activity score, and the relative BMD in periprosthetic tibial bone was measured by ImageJ software on anteroposterior X-ray images. Clinical assessments included Western Ontario and McMaster Universities (WOMAC), Knee Society, VAS score and UCLA activity score. Nonlinear regression analysis was used to assess the impact of activity levels on periprosthesis bone density.Results: Activity level significantly affected rBMD in the proximal tibia, with the smallest reduction in rBMD observed with moderate activity. The difference in rBMD% between the lateral and medial metaphysis was significant. The regions with a significant difference in rBMD% between the lateral and medial metaphysis were closest to the base plate of the prosthesis. The lateral and medial regions closest to the stem of the prosthesis showed no significant difference in rBMD%.Conclusions: We found that activity level had a significant effect on radiographic measurements of BMD at 1 and 3 years but not at 5 years and moderate activity was associated with a minimal reduction in proximal tibial BMD.

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Low Regional Tibial Bone Density in Athletes with Medial Tibial Stress Syndrome Normalizes after Recovery from Symptoms

The American Journal of Sports Medicine ◽

10.1177/03635465030310042001 ◽

2003 ◽

Vol 31 (4) ◽

pp. 596-600 ◽

Cited By ~ 31

Author(s):

Håkan I. Magnusson ◽

Henrik G. Ahlborg ◽

Caroline Karlsson ◽

Fredrik Nyquist ◽

Magnus K. Karlsson

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Medial Tibial Stress Syndrome ◽

Mineral Density ◽

Male Athletes ◽

Tibial Bone ◽

Control Subjects ◽

Low Bone Mineral Density ◽

Stress Syndrome

Background Although the exact cause of medial tibial stress syndrome is unclear, changes in bone metabolism are likely to be involved. Hypothesis Localized low bone mineral density at the junction of the middle and distal thirds of the tibia in patients with medial tibial stress syndrome develops in conjunction with the symptoms; these changes are reversible and are not inherited. Study Design Prospective cohort study. Methods Bone mineral density in 14 adult male athletes with long-standing medial tibial stress syndrome was measured when they were symptomatic and after recovery (mean follow-up, 5.7 years). Repeat measurements were also made prospectively in 13 nonathlete control subjects and single measurements were made in 18 healthy athletes. Results Bone mineral density was 9% ± 11% higher in the proximal tibia but 11% ± 12% lower in the tibial region corresponding to pain in patients when compared with nonathlete control subjects. It increased by 19% ± 11% in the region of pain after recovery from symptoms and, at follow-up, was no lower than in nonathlete control subjects. Conclusion Athletes with medial tibial stress syndrome and increased scintigraphic uptake regain normal tibial bone mineral density after recovery from symptoms. Initially localized low bone mineral density is not an inherited condition, but instead may develop in conjunction with the symptoms.

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Periprosthetic tibial bone mineral density changes after total knee arthroplastyOne-year follow-up study of 69 patients

Acta Orthopaedica Scandinavica ◽

10.1080/00016470410001493 ◽

2004 ◽

Vol 75 (5) ◽

pp. 600-605 ◽

Cited By ~ 52

Author(s):

Tarja Soininvaara ◽

Hannu Miettinen ◽

Jukka Jurvelin ◽

Olavi Suomalainen ◽

Esko Alhava ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Mineral Density ◽

Follow Up Study ◽

Tibial Bone ◽

Total Knee

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Clinical significance of osteodensitometry in patients with sarcoidosis

Medicinski pregled ◽

10.2298/mpns13s1067b ◽

2013 ◽

Vol 66 (suppl. 1) ◽

pp. 67-71

Author(s):

Ivana Bozic ◽

Svetozar Damjanovic ◽

Djuro Macut ◽

Violeta Mihailovic-Vucinic

Keyword(s):

Bone Mineral Density ◽

Bone Density ◽

Bone Strength ◽

Bone Mineral ◽

Vertebral Fractures ◽

Mineral Density ◽

Normal Bone Mineral Density ◽

Osseous Involvement ◽

Mineral Bone Density

Introduction. Sarcoidosis is a chronic, multi-organ, inflammatory disease which predominantly affects the lungs. Although direct osseous involvement in sarcoidosis is rare, patients with this disease, regardless of the presence of osseous lesions, are at a great risk of developing osteoporosis. Osteoporosis is a consequence of the disease itself, as well as of its treatment. Osteodensitometry. Osteodensitometry is the gold standard for osteoporosis diagnosis, and it is based on the assessment of the bone mineral density. One of the main drawbacks of osteodensitometry as a method for osteoporosis verification is its inability to determine bone micro-architectonics, which is a significant element of bone strength. Mineral Bone Density in Patients with Sarcoidosis. It has been shown that newly diagnosed, yet untreated patients with sarcoidosis have rapid bone remodeling, although their mineral bone density is normal or low to normal. This suggests that the low bone strength in patients with sarcoidosis is a consequence of mechanisms that predominantly disturb the bone micro-architectonics, but they do not have a significant effect on the bone mineral density at the same time. Vertebral Fractures and their Diagnosis in Patients with Sarcoidosis. Normal bone mineral density in patients with sarcoidosis does not preclude skeletal fractures, primarily vertebral fractures. Osteodensitometry devices allow a relatively easy detection of vertebral fractures in patients with sarcoidosis. Conclusion. Osteodensitometry is recommended in every patient with sarcoidosis initially as well as during the follow up and treatment. Even if osteodensitometry is normal, the possibility of vertebral fractures should not be overlooked in these patients.

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PO-091 5-year changes and effects of bone mineral density in 6-year-old children

Exercise Biochemistry Review ◽

10.14428/ebr.v1i3.11653 ◽

2018 ◽

Vol 1 (3) ◽

Author(s):

Yue Liang ◽

Hong Ren

Keyword(s):

Bone Mineral Density ◽

Body Weight ◽

Bone Density ◽

Bone Mineral ◽

Partial Correlation ◽

Mineral Density ◽

Forearm Bone Mineral Density ◽

Obesity Rate ◽

Forearm Bone

Objective To explore the development and developmental characteristics of forearm bone mineral density in childhood, to understand the effects of body composition and developmental type on bone mineral density, and to provide a basis for studying the changes of human forearm bone mineral density. Methods Bone development follow-up study of Huilongguan primary school affiliated to Capital Normal University in 2013 enrolled in primary school for five years (2013, 2014, 2015, 2016 and 2017), tracking test indicators: height, weight, body fat composition, forearm bone density. Bone age testing was conducted in 2013 and 2017. Data were analyzed for students who were 6 years old at the end of the first year of the test date. The effective data was 297 (age 6.6 ± 0.2 years), including 147 boys and 150 girls. Results 1. Forearm bone mineral density(g/cm2)for the boys and girls were 0.237±0.061 and 0.221±0.059 for children aged 6, 0.220±0.042 and 0.201±0.032 for 7 years old children, 0.219±0.040 and 0.198±0.038 for 8 years old children, 0.236±0.051 and 0.208±0.043 for 9 years old children ,while 0.237±0.044 and 0.213±0.047 when children were 10 years old. An independent sample t-test was performed on bone mineral density in boys and girls. At 7 years, 8 years, 9 years, and 10 years, the bone mineral density of boys was greater than that of girls, and the difference was statistically significant (p<0.05). 2. The same batch of child follow-up studies found that girls and boys aged 6 to 8 had a decreasing trend, and the decline of girls was greater than that of boys; girls and boys aged 8 to 10 have risen again, and the increase in girls is less than that of boys; body weight and BMI are factors influencing the forearm bone density of children aged 6-10 years. Height changes and weight changes have a certain effect on changes in forearm bone density. 3. There was no statistically significant difference between bone mineral density and height. The partial correlation with body weight was statistically significant between 6 and 10 years old, r=0.200 (p<0.01), r=0.124 (p<0.05), r =0.176 (p<0.01), r=0.110 (p<0.05), r=0.162 (p<0.05); the partial correlation with BMI was statistically significant, r=0.223 (p<0.01), r =0.134 (p<0.01), r=0.183 (p<0.01), r=0.150 (p<0.05)r=0.208 (p<0.01); As for the relationships between body fat ratio、FFM ratio and bone mineral density, there are no partial correlations(p＞0.05). 4. The partial correlation between bone mineral density change and height change (6-8 years old) and body weight change (8-10 years old) was statistically significant, r=-0.138 (p<0.05), r=0.178(p <0.01), the change in bone mineral density of the children with highest 25% and the lowest 25% with different indicators, only the height of the independent sample t-test results was statistically significant. 5. After multiple stepwise linear regression model. At the age of 7, the adjustment of R2 is the highest. The gender and body mass index entered the model. 6. The overweight and obesity rate of 6-10 years old is more than 40% for boys and over 30% for girls. The obesity rate for boys aged 6 to 10 is reduced from 21.9% to 23.8%; the obesity rate for girls is from 20.3% to 17.3%. Conclusions The same batch of child follow-up studies found that girls and boys aged 6 to 8 had a decreasing trend, with the decline of girls greater than that of boys; girls and boys between the ages of 8 and 10 were rising again, and the increase in girls was less than that of boys; Weight and BMI are factors influencing the forearm bone mineral density of children aged 6-10 years. Height changes and weight changes have a certain effect on changes in forearm bone density.

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Bone mineral density 10 years after a Zweymüller uncemented stem prosthesis

Hip International ◽

10.1177/112070000301300402 ◽

2003 ◽

Vol 13 (4) ◽

pp. 205-214 ◽

Cited By ~ 7

Author(s):

T. M.J.S. Vervest ◽

W. H.J.C. Van Heeswijk ◽

P. G. Anderson ◽

J. Van Limbeek

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Activity Level ◽

Harris Hip Score ◽

Moderate Activity ◽

Mineral Density ◽

Class B ◽

Charnley Class

The effect of a Zweymüller uncemented stem prosthesis on the long-term bone remodelling of femoral bone was examined using dual-energy X-ray absorptiometry (DEXA). Thirty-two patients (11 males, 21 females) with a unilateral prosthesis (18 Hochgezogen and 14 Stepless) were scanned at an average of 129.8 months after the initial operation. The average follow-up Harris Hip Score was 93.7: ten patients were classified as Charnley Class A, two patients as class B and 20 patients as class C. The group as a whole showed a moderate activity level and most patients were satisfied with the result of the operation. All stem prostheses were osseo-integrated. The non-operated contralateral femur was used as a control for the bone mineral density (BMD) changes in the femur around the prosthesis. A decrease of bone mineral density on the prosthesis side was found at the region of the calcar femoris, without any clinical decline or any radiographic anomalies.

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Efficacy and safety of once-monthly ibandronate treatment in patients with low bone mineral density – ESTHER study: 24 months of follow-up

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh1212722s ◽

2012 ◽

Vol 140 (11-12) ◽

pp. 722-727 ◽

Cited By ~ 2

Author(s):

Katarina Simic-Pasalic ◽

Study ESTHER

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Economic Problem ◽

Activity Level ◽

New Drugs ◽

Efficacy And Safety ◽

Mineral Density ◽

Low Bone Mineral Density ◽

History Of

Introduction. Osteoporosis is a major health and economic problem worldwide. The use of new drugs, such as ibandronate, is aimed at improving treatment of osteoporosis and currently poor compliance with BP therapy. Objective. To investigate efficacy and safety of ibandronate applied monthly, orally, in women with low bone mineral density (BMD). Methods. The prospective study was conducted in 34 centers in Serbia and included 77 women treated for 24 months with monthly ibandronate. The efficacy of treatment was assessed by change in bone mass values obtained by BMD measurement at the end of 24 months follow-up versus baseline and 12-months follow-up values. Compliance and safety, i.e. adverse effects (AE) were recorded. Results. Participants were postmenopausal (96%), osteoporotic (79.7%) females, diagnosed by lumbar spine DXA measurement (81%), with history of prior BP therapy in 33.8% women. The physical activity level significantly increased to the substantial level of activity (5.2% vs. 21.3%, p=0.003) during the study. After 12 and 24 months of treatment, BMD values significantly increased (p=0.002 and p<0.001). BP experienced patients improved more than BP na?ve patients at both time points (p=0.012 and p=0.027, respectively). During the second 12 months of treatment the adherence was 96%; AE were recorded as mild gastrointestinal disturbances in 3.9%. Conclusion. Treatment by using ibandronate once monthly for 24 months was generally well tolerated and led to a significant increase in BMD in women with low BMD.

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Increase in Physical Activity after Resurfacing Hip Arthroplasty is Associated with Calcar and Acetabular Bone Mineral Density Changes

Hip International ◽

10.5301/hipint.5000433 ◽

2017 ◽

Vol 27 (2) ◽

pp. 140-146 ◽

Cited By ~ 3

Author(s):

Davey M.J.M. Gerhardt ◽

Gerjon Hannink ◽

Ton Rijnders ◽

Job L.C. Van Susante

Keyword(s):

Physical Activity ◽

Bone Mineral Density ◽

Bone Mineral ◽

Hip Arthroplasty ◽

Activity Level ◽

Harris Hip Score ◽

Mineral Density ◽

Ucla Activity Score ◽

Bone Preservation ◽

Resurfacing Hip Arthroplasty

Purpose Bone preservation is an important advantage of the resurfacing hip arthroplasty (RHA) concept. We hypothesised that patients’ increase in physical activity level after RHA would positively relate with periprosthetic bone mineral density (BMD) changes and thus facilitate bone preservation. Methods BMD-changes were prospectively recorded in 38 patients after RHA. Dual-energy absorptiometry was used to quantify BMD-changes in 6 periprosthetic regions of interest preoperatively, at 6 months, 1, 2 and 3 years postoperative. The effect estimates of patients’ physical activity, according to their Harris Hip Score (HHS) and University of California at Los Angeles (UCLA) Activity Score, on these BMD changes were assessed in linear mixed models. Results The UCLA (coefficient = 0.02 (95% CI, 0.010-0.034); p<0.001) and HHS (coefficient = 0.002 (95% CI, 0.001-0.003); p<0.001) were associated with the BMD in the calcar region. As for BMD changes in the femoral neck only the HHS was associated (coefficient = 0.0006 (95% CI, <0.0001-0.001); p = 0.04). Both the UCLA and the HHS were inversely associated with BMD in the medial acetabular region (UCLA: coefficient = -0.02 (95% CI, -0.038 to -0.007); p = 0.005, HHS: coefficient = -0.002 (95% CI, -0.003 to -0.001), the same accounted for the HHS to BMD-change cranial to the acetabulum (-0.001 [95% CI, -0.0018 to -0.0001]; p = 0.03). For the caudal acetabular and femoral subtrochanteric region no relation with BMD-changes was found. Conclusions The increase in activity scores after RHA was indeed associated with an increase in BMD in the calcar region, however unexpectedly also with a BMD decrease on the acetabular side. Stress shielding from the implant is the most likely causative factor.

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