scholarly journals Comparison of frontal alpha asymmetry among schizophrenia patients, major depressive disorder patients, and healthy controls

2020 ◽  
Author(s):  
Kuk-In Jang ◽  
Chany Lee ◽  
Sangmin Lee ◽  
Seung Huh ◽  
Jeong-Ho Chae
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Left Hemisphere ◽  
Rating Scales ◽  
Healthy Controls ◽  
Major Depressive ◽  
Alpha Asymmetry ◽  
Alpha Frequency ◽  
Frontal Alpha Asymmetry ◽  
The Difference

Abstract Background: Electroencephalography (EEG) frontal alpha asymmetry (FAA) has been observed in several psychiatric disorders. Dominance in left or right frontal alpha activity remains inconsistent in patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls. This study compared FAA among patients with MDD and schizophrenia, and healthy controls.Methods: We recruited 20 patients with MDD, 18 patients with schizophrenia, and 16 healthy individuals. The EEG alpha frequency ranged from 8 Hz to 12 Hz. FAA was expressed as the difference between absolute power values of right and left hemisphere electrodes in the alpha frequency range (common-log-transformed frontal right- and left-hemisphere electrodes: F4–F3, F8–F7, FP2–FP1, AF4–AF3, F6–F5, and F2–F1). Hamilton depression and anxiety rating scales were evaluated in patients with MDD. Positive and negative syndrome scales were evaluated in patients with schizophrenia.Results: Patients with schizophrenia showed significantly lower left FAA than healthy controls (F4–F3, schizophrenia vs. healthy controls: -0.10 ± 0.04 vs. -0.05 ± 0.05). There were no significant differences in FAA between patients with schizophrenia and MDD as well as between patients with MDD and healthy controls.Conclusions: The present study suggests that FAA indicates a relatively lower activation of left frontal electrodes in schizophrenia. The left-lateralized FAA could be a neuropathological attribute in patients with schizophrenia, but a lack of sample size and information such as medication and duration of illness might obscure the interpretation and generalization of our findings. Thus, further studies to verify the findings would be warranted.

scholarly journals Comparison of frontal alpha asymmetry among schizophrenia patients, major depressive disorder patients, and healthy controls

2020 ◽  
Author(s):  
Kuk-In Jang ◽  
Chany Lee ◽  
Sangmin Lee ◽  
Seung Huh ◽  
Jeong-Ho Chae
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Left Hemisphere ◽  
Rating Scales ◽  
Healthy Controls ◽  
Major Depressive ◽  
Alpha Asymmetry ◽  
Alpha Frequency ◽  
Frontal Alpha Asymmetry ◽  
The Difference

Abstract Background: Electroencephalography (EEG) frontal alpha asymmetry (FAA) has been observed in several psychiatric disorders. Dominance in left or right frontal alpha activity remains inconsistent in patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls. This study compared FAA among patients with MDD and schizophrenia, and healthy controls.Methods: We recruited 20 patients with MDD, 18 patients with schizophrenia, and 16 healthy individuals. The EEG alpha frequency ranged from 8 Hz to 12 Hz. FAA was expressed as the difference between absolute power values of right and left hemisphere electrodes in the alpha frequency range (common-log-transformed frontal right- and left-hemisphere electrodes: F4–F3, F8–F7, FP2–FP1, AF4–AF3, F6–F5, and F2–F1). Hamilton depression and anxiety rating scales were evaluated in patients with MDD. Positive and negative syndrome scales were evaluated in patients with schizophrenia.Results: Patients with schizophrenia showed significantly lower left FAA than healthy controls (F4–F3, schizophrenia vs. healthy controls: -0.10 ± 0.04 vs. -0.05 ± 0.05). There were no significant differences in FAA between patients with schizophrenia and MDD as well as between patients with MDD and healthy controls.Conclusions: The present study suggests that FAA indicates a relatively lower activation of left frontal electrodes in schizophrenia. The left-lateralized FAA could be a neuropathological attribute in patients with schizophrenia, but a lack of sample size and information such as medication and duration of illness might obscure the interpretation and generalization of our findings. Thus, further studies to verify the findings would be warranted.

scholarly journals Comparison of frontal alpha asymmetry among schizophrenia patients, major depressive disorder patients, and healthy controls

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Kuk-In Jang ◽  
Chany Lee ◽  
Sangmin Lee ◽  
Seung Huh ◽  
Jeong-Ho Chae
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Left Hemisphere ◽  
Rating Scales ◽  
Healthy Controls ◽  
Major Depressive ◽  
Alpha Asymmetry ◽  
Alpha Frequency ◽  
Frontal Alpha Asymmetry ◽  
The Difference

Abstract Background Electroencephalography (EEG) frontal alpha asymmetry (FAA) has been observed in several psychiatric disorders. Dominance in left or right frontal alpha activity remains inconsistent in patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls. This study compared FAA among patients with MDD and schizophrenia, and healthy controls. Methods We recruited 20 patients with MDD, 18 patients with schizophrenia, and 16 healthy individuals. The EEG alpha frequency ranged from 8 Hz to 12 Hz. FAA was expressed as the difference between absolute power values of right and left hemisphere electrodes in the alpha frequency range (common-log-transformed frontal right- and left-hemisphere electrodes: F4–F3, F8–F7, FP2–FP1, AF4–AF3, F6–F5, and F2–F1). Hamilton depression and anxiety rating scales were evaluated in patients with MDD. Positive and negative syndrome scales were evaluated in patients with schizophrenia. Results Patients with schizophrenia showed significantly lower left FAA than healthy controls (F4–F3, schizophrenia vs. healthy controls: − 0.10 ± 0.04 vs. -0.05 ± 0.05). There were no significant differences in FAA between patients with schizophrenia and MDD as well as between patients with MDD and healthy controls. Conclusions The present study suggests that FAA indicates a relatively lower activation of left frontal electrodes in schizophrenia. The left-lateralized FAA could be a neuropathological attribute in patients with schizophrenia, but a lack of sample size and information such as medication and duration of illness might obscure the interpretation and generalization of our findings. Thus, further studies to verify the findings would be warranted.

scholarly journals Comparison of frontal alpha asymmetry among schizophrenia patients, major depressive disorder, and healthy controls

2020 ◽  
Author(s):  
Kuk-In Jang ◽  
Chany Lee ◽  
Sangmin Lee ◽  
Seung Huh ◽  
Jeong-Ho Chae
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Left Hemisphere ◽  
Rating Scales ◽  
Healthy Controls ◽  
Major Depressive ◽  
Alpha Asymmetry ◽  
Alpha Frequency ◽  
Frontal Alpha Asymmetry ◽  
The Difference

Abstract Background: Electroencephalography (EEG) frontal alpha asymmetry (FAA) has been observed in several psychiatric disorders. Dominance in left or right frontal alpha activity remains inconsistent in patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls. This study compared FAA among patients with MDD and schizophrenia, and healthy controls.Methods: We recruited 20 patients with MDD, 18 patients with schizophrenia, and 16 healthy individuals. The EEG alpha frequency ranged from 8 Hz to 12 Hz. FAA was expressed as the difference between absolute power values of right and left hemisphere electrodes in the alpha frequency range (common-log-transformed frontal right- and left-hemisphere electrodes: F4–F3, F8–F7, FP2–FP1, AF4–AF3, F6–F5, and F2–F1). Hamilton depression and anxiety rating scales were evaluated in patients with MDD. Positive and negative syndrome scales were evaluated in patients with schizophrenia.Results: Patients with schizophrenia showed significantly lower left FAA than healthy controls (F4–F3, schizophrenia vs. healthy controls: -0.10 ± 0.04 vs. -0.05 ± 0.05). There were no significant differences in FAA between patients with schizophrenia and MDD as well as between patients with MDD and healthy controls.Conclusions: The present study suggests that FAA indicates a relatively lower activation of left frontal electrodes in schizophrenia. The left-lateralized FAA could be a neuropathological attribute in patients with schizophrenia, but a lack of sample size and information such as medication and duration of illness might obscure the interpretation and generalization of our findings. Thus, further studies to verify the findings would be warranted.

scholarly journals Comparison of Frontal Alpha Asymmetry Among Schizophrenia Patients, Major Depressive Disorder, and Healthy Controls

2020 ◽  
Author(s):  
Kuk-In Jang ◽  
Chany Lee ◽  
Sangmin Lee ◽  
Seung Huh ◽  
Jeong-Ho Chae
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Rating Scales ◽  
Rhythmic Activity ◽  
Healthy Controls ◽  
Major Depressive ◽  
Left Frontal Lobe ◽  
Alpha Asymmetry ◽  
Alpha Frequency ◽  
Frontal Alpha Asymmetry

Abstract Background Electroencephalography (EEG) frontal alpha asymmetry (FAA) has been observed in several psychiatric disorders. However, dominance in left or right frontal alpha activity remains inconsistent in patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls. This study compared FAA among patients with MDD, schizophrenia, and healthy control. Methods We recruited 20 patients with MDD, 18 patients with schizophrenia, and 16 healthy individuals. The EEG alpha frequency ranged from 8.0 to 12.0 Hz. FAA was expressed as the difference between absolute power values in both the right and left electrodes in the alpha frequency range (common-log-transformed F4–F3 and F8–F7). Hamilton depression and anxiety rating scales were evaluated in patients with MDD. Positive and negative syndrome scales were evaluated in patients with schizophrenia. Results Patients with schizophrenia showed significantly lower left frontal lobe activity than healthy controls (FAA, schizophrenia vs. healthy: -0.10 ± 0.05 vs. -0.05 ± 0.05). There were no significant differences in FAA between patients with schizophrenia and MDD as well as between patients with MDD and healthy controls. Conclusions The present study suggests that frontal alpha asymmetry indicates a breaking neural activity in schizophrenia. Breaking rhythmic activity as a left-lateralized FAA can be a neuropathological attribute in patients with schizophrenia but lack of sample size and information such as medication and duration of illness, all of which could make it difficult generalize finding.

scholarly journals Frontal Alpha Asymmetry Correlates with Suicidal Behavior in Major Depressive Disorder

2019 ◽  
Vol 17 (3) ◽  
pp. 377-387 ◽  
Author(s):  
Yeonsoo Park ◽  
Wookyoung Jung ◽  
Sungkean Kim ◽  
Hyunjin Jeon ◽  
Seung-Hwan Lee
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Suicidal Behavior ◽  
Major Depressive ◽  
Alpha Asymmetry ◽  
Frontal Alpha Asymmetry

scholarly journals Confusion Effects of Facial Expression Recognition in Patients With Major Depressive Disorder and Healthy Controls

2021 ◽  
Vol 12 ◽  
Author(s):  
Fan Mo ◽  
Jingjin Gu ◽  
Ke Zhao ◽  
Xiaolan Fu
Keyword(s):  
Major Depressive Disorder ◽  
Facial Expression ◽  
Depressive Disorder ◽  
Facial Expressions ◽  
Facial Expression Recognition ◽  
Negative Emotion ◽  
Expression Recognition ◽  
Healthy Controls ◽  
Major Depressive ◽  
The Difference

Facial expression recognition plays a crucial role in understanding the emotion of people, as well as in social interaction. Patients with major depressive disorder (MDD) have been repeatedly reported to be impaired in recognizing facial expressions. This study aimed to investigate the confusion effects between two facial expressions that presented different emotions and to compare the difference of confusion effect for each emotion pair between patients with MDD and healthy controls. Participants were asked to judge the emotion category of each facial expression in a two-alternative forced choice paradigm. Six basic emotions (i.e., happiness, fear, sadness, anger, surprise, and disgust) were examined in pairs, resulting in 15 emotion combinations. Results showed that patients with MDD were impaired in the recognition of all basic facial expressions except for the happy expression. Moreover, patients with MDD were more inclined to confuse a negative emotion (i.e., anger and disgust) with another emotion as compared to healthy controls. These findings highlight the importance that patients with MDD show a deficit of sensitivity in distinguishing specific two facial expressions.

scholarly journals Phosphodiesterase 8A to discriminate in blood samples depressed patients and suicide attempters from healthy controls based on A-to-I RNA editing modifications

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nicolas Salvetat ◽  
Fabrice Chimienti ◽  
Christopher Cayzac ◽  
Benjamin Dubuc ◽  
Francisco Checa-Robles ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Rna Editing ◽  
Whole Blood ◽  
Healthy Controls ◽  
Major Depressive ◽  
Suicide Attempters ◽  
Blood Samples ◽  
Depressed Patients ◽  
The Brain

AbstractMental health issues, including major depressive disorder, which can lead to suicidal behavior, are considered by the World Health Organization as a major threat to global health. Alterations in neurotransmitter signaling, e.g., serotonin and glutamate, or inflammatory response have been linked to both MDD and suicide. Phosphodiesterase 8A (PDE8A) gene expression is significantly decreased in the temporal cortex of major depressive disorder (MDD) patients. PDE8A specifically hydrolyzes adenosine 3′,5′-cyclic monophosphate (cAMP), which is a key second messenger involved in inflammation, cognition, and chronic antidepressant treatment. Moreover, alterations of RNA editing in PDE8A mRNA has been described in the brain of depressed suicide decedents. Here, we investigated PDE8A A-to-I RNA editing-related modifications in whole blood of depressed patients and suicide attempters compared to age-matched and sex-matched healthy controls. We report significant alterations of RNA editing of PDE8A in the blood of depressed patients and suicide attempters with major depression, for which the suicide attempt took place during the last month before sample collection. The reported RNA editing modifications in whole blood were similar to the changes observed in the brain of suicide decedents. Furthermore, analysis and combinations of different edited isoforms allowed us to discriminate between suicide attempters and control groups. Altogether, our results identify PDE8A as an immune response-related marker whose RNA editing modifications translate from brain to blood, suggesting that monitoring RNA editing in PDE8A in blood samples could help to evaluate depressive state and suicide risk.

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