Frontal Alpha Asymmetry Moderated by Suicidal Ideation in Patients with Major Depressive Disorder: A Comparison with Healthy Individuals

Abstract Background: Electroencephalography (EEG) frontal alpha asymmetry (FAA) has been observed in several psychiatric disorders. Dominance in left or right frontal alpha activity remains inconsistent in patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls. This study compared FAA among patients with MDD and schizophrenia, and healthy controls.Methods: We recruited 20 patients with MDD, 18 patients with schizophrenia, and 16 healthy individuals. The EEG alpha frequency ranged from 8 Hz to 12 Hz. FAA was expressed as the difference between absolute power values of right and left hemisphere electrodes in the alpha frequency range (common-log-transformed frontal right- and left-hemisphere electrodes: F4–F3, F8–F7, FP2–FP1, AF4–AF3, F6–F5, and F2–F1). Hamilton depression and anxiety rating scales were evaluated in patients with MDD. Positive and negative syndrome scales were evaluated in patients with schizophrenia.Results: Patients with schizophrenia showed significantly lower left FAA than healthy controls (F4–F3, schizophrenia vs. healthy controls: -0.10 ± 0.04 vs. -0.05 ± 0.05). There were no significant differences in FAA between patients with schizophrenia and MDD as well as between patients with MDD and healthy controls.Conclusions: The present study suggests that FAA indicates a relatively lower activation of left frontal electrodes in schizophrenia. The left-lateralized FAA could be a neuropathological attribute in patients with schizophrenia, but a lack of sample size and information such as medication and duration of illness might obscure the interpretation and generalization of our findings. Thus, further studies to verify the findings would be warranted.

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Frontal Alpha Asymmetry Correlates with Suicidal Behavior in Major Depressive Disorder

Clinical Psychopharmacology and Neuroscience ◽

10.9758/cpn.2019.17.3.377 ◽

2019 ◽

Vol 17 (3) ◽

pp. 377-387 ◽

Cited By ~ 2

Author(s):

Yeonsoo Park ◽

Wookyoung Jung ◽

Sungkean Kim ◽

Hyunjin Jeon ◽

Seung-Hwan Lee

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Suicidal Behavior ◽

Major Depressive ◽

Alpha Asymmetry ◽

Frontal Alpha Asymmetry

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Comparison of frontal alpha asymmetry among schizophrenia patients, major depressive disorder patients, and healthy controls

10.21203/rs.3.rs-37400/v4 ◽

2020 ◽

Author(s):

Kuk-In Jang ◽

Chany Lee ◽

Sangmin Lee ◽

Seung Huh ◽

Jeong-Ho Chae

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Left Hemisphere ◽

Rating Scales ◽

Healthy Controls ◽

Major Depressive ◽

Alpha Asymmetry ◽

Alpha Frequency ◽

Frontal Alpha Asymmetry ◽

The Difference

Abstract Background: Electroencephalography (EEG) frontal alpha asymmetry (FAA) has been observed in several psychiatric disorders. Dominance in left or right frontal alpha activity remains inconsistent in patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls. This study compared FAA among patients with MDD and schizophrenia, and healthy controls.Methods: We recruited 20 patients with MDD, 18 patients with schizophrenia, and 16 healthy individuals. The EEG alpha frequency ranged from 8 Hz to 12 Hz. FAA was expressed as the difference between absolute power values of right and left hemisphere electrodes in the alpha frequency range (common-log-transformed frontal right- and left-hemisphere electrodes: F4–F3, F8–F7, FP2–FP1, AF4–AF3, F6–F5, and F2–F1). Hamilton depression and anxiety rating scales were evaluated in patients with MDD. Positive and negative syndrome scales were evaluated in patients with schizophrenia.Results: Patients with schizophrenia showed significantly lower left FAA than healthy controls (F4–F3, schizophrenia vs. healthy controls: -0.10 ± 0.04 vs. -0.05 ± 0.05). There were no significant differences in FAA between patients with schizophrenia and MDD as well as between patients with MDD and healthy controls.Conclusions: The present study suggests that FAA indicates a relatively lower activation of left frontal electrodes in schizophrenia. The left-lateralized FAA could be a neuropathological attribute in patients with schizophrenia, but a lack of sample size and information such as medication and duration of illness might obscure the interpretation and generalization of our findings. Thus, further studies to verify the findings would be warranted.

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Comparison of frontal alpha asymmetry among schizophrenia patients, major depressive disorder patients, and healthy controls

BMC Psychiatry ◽

10.1186/s12888-020-02972-8 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Kuk-In Jang ◽

Chany Lee ◽

Sangmin Lee ◽

Seung Huh ◽

Jeong-Ho Chae

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Left Hemisphere ◽

Rating Scales ◽

Healthy Controls ◽

Major Depressive ◽

Alpha Asymmetry ◽

Alpha Frequency ◽

Frontal Alpha Asymmetry ◽

The Difference

Abstract Background Electroencephalography (EEG) frontal alpha asymmetry (FAA) has been observed in several psychiatric disorders. Dominance in left or right frontal alpha activity remains inconsistent in patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls. This study compared FAA among patients with MDD and schizophrenia, and healthy controls. Methods We recruited 20 patients with MDD, 18 patients with schizophrenia, and 16 healthy individuals. The EEG alpha frequency ranged from 8 Hz to 12 Hz. FAA was expressed as the difference between absolute power values of right and left hemisphere electrodes in the alpha frequency range (common-log-transformed frontal right- and left-hemisphere electrodes: F4–F3, F8–F7, FP2–FP1, AF4–AF3, F6–F5, and F2–F1). Hamilton depression and anxiety rating scales were evaluated in patients with MDD. Positive and negative syndrome scales were evaluated in patients with schizophrenia. Results Patients with schizophrenia showed significantly lower left FAA than healthy controls (F4–F3, schizophrenia vs. healthy controls: − 0.10 ± 0.04 vs. -0.05 ± 0.05). There were no significant differences in FAA between patients with schizophrenia and MDD as well as between patients with MDD and healthy controls. Conclusions The present study suggests that FAA indicates a relatively lower activation of left frontal electrodes in schizophrenia. The left-lateralized FAA could be a neuropathological attribute in patients with schizophrenia, but a lack of sample size and information such as medication and duration of illness might obscure the interpretation and generalization of our findings. Thus, further studies to verify the findings would be warranted.

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Comparison of Frontal Alpha Asymmetry Among Schizophrenia Patients, Major Depressive Disorder, and Healthy Controls

10.21203/rs.3.rs-37400/v1 ◽

2020 ◽

Author(s):

Kuk-In Jang ◽

Chany Lee ◽

Sangmin Lee ◽

Seung Huh ◽

Jeong-Ho Chae

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Rating Scales ◽

Rhythmic Activity ◽

Healthy Controls ◽

Major Depressive ◽

Left Frontal Lobe ◽

Alpha Asymmetry ◽

Alpha Frequency ◽

Frontal Alpha Asymmetry

Abstract Background Electroencephalography (EEG) frontal alpha asymmetry (FAA) has been observed in several psychiatric disorders. However, dominance in left or right frontal alpha activity remains inconsistent in patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls. This study compared FAA among patients with MDD, schizophrenia, and healthy control. Methods We recruited 20 patients with MDD, 18 patients with schizophrenia, and 16 healthy individuals. The EEG alpha frequency ranged from 8.0 to 12.0 Hz. FAA was expressed as the difference between absolute power values in both the right and left electrodes in the alpha frequency range (common-log-transformed F4–F3 and F8–F7). Hamilton depression and anxiety rating scales were evaluated in patients with MDD. Positive and negative syndrome scales were evaluated in patients with schizophrenia. Results Patients with schizophrenia showed significantly lower left frontal lobe activity than healthy controls (FAA, schizophrenia vs. healthy: -0.10 ± 0.05 vs. -0.05 ± 0.05). There were no significant differences in FAA between patients with schizophrenia and MDD as well as between patients with MDD and healthy controls. Conclusions The present study suggests that frontal alpha asymmetry indicates a breaking neural activity in schizophrenia. Breaking rhythmic activity as a left-lateralized FAA can be a neuropathological attribute in patients with schizophrenia but lack of sample size and information such as medication and duration of illness, all of which could make it difficult generalize finding.

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Comparison of frontal alpha asymmetry among schizophrenia patients, major depressive disorder, and healthy controls

10.21203/rs.3.rs-37400/v2 ◽

2020 ◽

Author(s):

Kuk-In Jang ◽

Chany Lee ◽

Sangmin Lee ◽

Seung Huh ◽

Jeong-Ho Chae

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Left Hemisphere ◽

Rating Scales ◽

Healthy Controls ◽

Major Depressive ◽

Alpha Asymmetry ◽

Alpha Frequency ◽

Frontal Alpha Asymmetry ◽

The Difference

Abstract Background: Electroencephalography (EEG) frontal alpha asymmetry (FAA) has been observed in several psychiatric disorders. Dominance in left or right frontal alpha activity remains inconsistent in patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls. This study compared FAA among patients with MDD and schizophrenia, and healthy controls.Methods: We recruited 20 patients with MDD, 18 patients with schizophrenia, and 16 healthy individuals. The EEG alpha frequency ranged from 8 Hz to 12 Hz. FAA was expressed as the difference between absolute power values of right and left hemisphere electrodes in the alpha frequency range (common-log-transformed frontal right- and left-hemisphere electrodes: F4–F3, F8–F7, FP2–FP1, AF4–AF3, F6–F5, and F2–F1). Hamilton depression and anxiety rating scales were evaluated in patients with MDD. Positive and negative syndrome scales were evaluated in patients with schizophrenia.Results: Patients with schizophrenia showed significantly lower left FAA than healthy controls (F4–F3, schizophrenia vs. healthy controls: -0.10 ± 0.04 vs. -0.05 ± 0.05). There were no significant differences in FAA between patients with schizophrenia and MDD as well as between patients with MDD and healthy controls.Conclusions: The present study suggests that FAA indicates a relatively lower activation of left frontal electrodes in schizophrenia. The left-lateralized FAA could be a neuropathological attribute in patients with schizophrenia, but a lack of sample size and information such as medication and duration of illness might obscure the interpretation and generalization of our findings. Thus, further studies to verify the findings would be warranted.

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Characteristics of hospital encounters and associated economic burden of patients with major depressive disorder and acute suicidal ideation or behavior

Hospital Practice ◽

10.1080/21548331.2021.1886496 ◽

2021 ◽

pp. 1-8

Author(s):

Cheryl Neslusan ◽

Jennifer Voelker ◽

Melissa Lingohr-Smith ◽

Jay Lin

Keyword(s):

Major Depressive Disorder ◽

Suicidal Ideation ◽

Depressive Disorder ◽

Economic Burden ◽

Major Depressive

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Predictors of Suicidal Ideation and Attempt among Patients with Major Depressive Disorder at a Tertiary Care Hospital, Puducherry

Journal of Neurosciences in Rural Practice ◽

10.1055/s-0040-1721558 ◽

2021 ◽

Vol 12 (01) ◽

pp. 122-128

Author(s):

Ralte Lalthankimi ◽

Padmavathi Nagarajan ◽

Vikas Menon ◽

Jeby Jose Olickal

Keyword(s):

Major Depressive Disorder ◽

Suicidal Ideation ◽

Depressive Disorder ◽

Rating Scale ◽

Tertiary Care ◽

Severe Depression ◽

Care Hospital ◽

Suicidal Behaviors ◽

Major Depressive ◽

Severity Of Depression

Abstract Objectives Mental disorders have a large impact on death by suicide. Hence, this study aims to determine the prevalence of suicidal behaviors among major depressive disorder (MDD) patients and the associated factors. Materials and Methods This cross-sectional analytical study was conducted among individuals aged 18 to 65 years, diagnosed with MDD in the Psychiatry Outpatient Department of a Tertiary Care Center, Puducherry during March to October 2019. Severity of depression was assessed using Hamilton Depression Rating Scale and Columbia-Suicide Severity Rating Scale was used to find the suicidal behaviors. Results For 166 participants in the study, mean (standard deviation) age was 40 (11) years and majority were females (76%). More than one-third (37%) had severe or very severe depression, and the prevalence of suicidal ideation, plan, and attempts were 83, 24, and 35%, respectively. After adjusting the covariates, the severity of depression and unemployment were significantly associated with suicidal attempts (adjusted prevalence ratios [aPR] = 11.4 and 1.9), and very severe depression was associated with suicidal ideation (aPR = 1.6). Among 140 individuals with suicidal ideation, 45 (32%) had an ideation frequency of 2 to 3 times/week, 69 (50%) had ideation for 1 hour, 36 (26%) could control ideation with little difficulty, and 12% had suicidal ideation mostly to end or stop their pain. Conclusion Suicidal ideation and attempts were significantly high in MDD patients, and the severity of depression was significantly associated with it. Early identification of high-risk suicidal behavior and implementation of effective preventive interventions are necessary to reduce death by suicide in these groups.

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