scholarly journals Hippocampal spatial and sequential representations of event structure scaffold precise episodic temporal order memory

2020 ◽  
Author(s):  
Chuqi Liu ◽  
Zhifang Ye ◽  
Chuansheng Chen ◽  
Nikolai Axmacher ◽  
Gui Xue
Keyword(s):  
Temporal Order ◽  
Event Structure ◽  
Pattern Separation ◽  
Activation Patterns ◽  
Mnemonic Strategy ◽  
Method Of Loci ◽  
Hippocampal Ca1 ◽  
Temporal Order Memory ◽  
Sequence Boundaries ◽  
Spatial Locations

Abstract The hippocampus plays an important role in representing spatial locations and sequences and for transforming representations via pattern separation and completion. How these representational structures and operations support memory for the temporal order of random items is still poorly understood. We addressed this question by leveraging the method of loci (MOL), a powerful mnemonic strategy for temporal order memory that particularly recruits hippocampus-dependent computations of spatial locations and associations. Applying representational similarity analysis to fMRI activation patterns revealed that hippocampal subfields contained representations of both temporal context and multiple features of sequence structure, including location identity, distance, and sequence boundaries. Critically, the hippocampal CA1 and CA23DG exhibited spatial and sequential pattern separation, respectively, enabling the encoding of multiple items in the same location and reducing swap errors across adjacent locations. Our results suggest that the hippocampus can flexibly reconfigure multiplexed event structure representations to support accurate temporal order memory.

scholarly journals Effectiveness of the method of loci is only minimally related to factors that should influence imagined navigation

2019 ◽  
Vol 72 (10) ◽  
pp. 2541-2553
Author(s):  
Jeremy B Caplan ◽  
Eric LG Legge ◽  
Bevin Cheng ◽  
Christopher R Madan
Keyword(s):  
Virtual Environments ◽  
Open Field ◽  
Verbal Memory ◽  
Spatial Information ◽  
Alternative Hypothesis ◽  
Spatial Navigation ◽  
Radial Arm Maze ◽  
Mnemonic Strategy ◽  
Method Of Loci ◽  
Special Case

The method of loci is arguably the most famous mnemonic strategy and is highly effective for memorising lists of non-spatial information in order. As described and instructed, this strategy apparently relies on a spatial/navigational metaphor. The user imagines moving through an environment, placing (study) and reporting (recall) list items along the way. However, whether the method relies critically on this spatial/navigation metaphor is unknown. An alternative hypothesis is that the navigation component is superfluous to memory success, and the method of loci is better viewed as a special case of a larger class of imagery-based peg strategies. Training participants on three virtual environments varying in their characteristics (an apartment, an open field, and a radial-arm maze), we asked participants to use each trained environment as the basis of the method of loci to learn five 11-word lists. Performance varied significantly across environment. However, the effects were small in magnitude. Further tests suggested that navigation-relevant knowledge and ability were not major determinants of success in verbal memory, even for participants who were confirmed to have been compliant with the strategy. These findings echo neuroimaging findings that navigation-based cognition does occur during application of the method of loci, but imagined navigation is unlikely to be directly responsible for its effectiveness. Instead, the method of loci may be best viewed as a variant of peg methods.

The dopamine D1 receptor agonist SKF 38393 improves temporal order memory performance in maternally deprived rats

2013 ◽  
Vol 106 ◽  
pp. 268-273 ◽  
Author(s):  
Stéphanie Lejeune ◽  
Nathalie Dourmap ◽  
Marie-Pascale Martres ◽  
Bruno Giros ◽  
Valérie Daugé ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Temporal Order ◽  
Memory Performance ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Skf 38393 ◽  
Temporal Order Memory

Time decay of object, place and temporal order memory in a paradigm assessing simultaneously episodic-like memory components in mice

2015 ◽  
Vol 286 ◽  
pp. 80-84 ◽  
Author(s):  
Hassina Belblidia ◽  
Abdelmalek Abdelouadoud ◽  
Christelle Jozet-Alves ◽  
Hélène Dumas ◽  
Thomas Freret ◽  
...  
Keyword(s):  
Temporal Order ◽  
Time Decay ◽  
Temporal Order Memory

Temporal order memory deficits prior to clinical diagnosis in Huntington’s disease

2009 ◽  
Vol 15 (5) ◽  
pp. 662-670 ◽  
Author(s):  
EVA PIROGOVSKY ◽  
JODY GOLDSTEIN ◽  
GUERRY PEAVY ◽  
MARK W. JACOBSON ◽  
JODY COREY-BLOOM ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Clinical Diagnosis ◽  
Temporal Order ◽  
Random Sequence ◽  
Memory Task ◽  
Study Phase ◽  
Phase Sequence ◽  
Choice Phase ◽  
Temporal Order Memory

AbstractThe current study examined temporal order memory in preclinical Huntington’s disease (pre-HD). Participants were separated into less than 5 years (pre-HD near) and more than 5 years (pre-HD far) from estimated age of clinical diagnosis. Participants completed a temporal order memory task on a computerized radial eight-arm maze. On the study phase of each trial, participants viewed a random sequence of circles appearing one at a time at the end of each arm. On the choice phase, participants viewed two circles at the end of the study phase arms and chose the circle occurring earliest in the sequence. The task involved manipulations of the temporal lag, defined as the number of arms occurring in the sample phase sequence between the two choice phase arms. Research suggests that there is more interference for temporally proximal stimuli relative to temporally distal stimuli. There were no significant differences between the pre-HD far group and controls on the temporal order memory task. The pre-HD near group demonstrated significant impairments relative to the other groups on closer temporal lags, but were normal on the furthest temporal lag. Therefore, temporal order memory declines with increased temporal interference in pre-HD close to estimated diagnosis of HD. (JINS, 2009, 15, 662–670.)

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