The Impact of New-onset Atrial Fibrillation on Short-term and Long-term Mortality of Critically ill Patients with Candidemia

Abstract Background Both new-onset atrial fibrillation (NOAF) and candidemia occurred frequently in critically ill patients, which are associated with poor outcomes. But, the association between NOAF and critically ill patients with candidemia is still uncertain. This study is try to identify the impact of NOAF on short-term and long-term mortality of critically ill patients with candidemia. Methods We retrospectively identified NOAF in all patients with candidemia admitted to a non-cardiac intensive care unit (ICU) from January 2011 to March 2018 in a teaching hospital. We categorized these patients into 3 groups (NOAF, Prior AF, No AF) and compared clinical information between groups. Risk factors for these patients’ short-term and long-term mortality were also analyzed. Results Ninety-two patients with candidemia were identified from 2011 to 2018. Among these patients, 26 (28.3%) developed NOAF during their hospital stay. The multivariable logistic regression analysis indicated that stroke, anemia, Sequential Organ Failure Assessment (SOFA) score and NOAF were independent risk factors for in-hospital mortality and NOAF was also the independent risk factor for 1 year mortality. Conclusions There was a high incidence of NOAF in critically ill patients with candidemia, which was associated with in-hospital mortality and 1 year mortality after hospital discharge. Further multicenter studies should be conducted to help confirm this relationship and to find effective interventions that reduce short-term and long-term mortality.

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The Impact of New-Onset Atrial Fibrillation on Short-Term and Long-Term Mortality of Critically Ill Patients with Candidemia

10.21203/rs.3.rs-415657/v2 ◽

2021 ◽

Author(s):

Zengli Xiao ◽

Anqi Du ◽

Youzhong An

Keyword(s):

Risk Factors ◽

Atrial Fibrillation ◽

Critically Ill ◽

Critically Ill Patients ◽

Short Term ◽

The Impact ◽

Onset Atrial Fibrillation ◽

Long Term Mortality ◽

New Onset

Abstract Background: Both new-onset atrial fibrillation (NOAF) and candidemia occurred frequently in critically ill patients, which are associated with poor outcomes. But, the association between NOAF and critically ill patients with candidemia is still uncertain. This study is try to identify the impact of NOAF on short-term and long-term mortality of critically ill patients with candidemia.Methods: We retrospectively identified NOAF in all patients with candidemia admitted to a non-cardiac intensive care unit (ICU) from January 2011 to March 2018 in a teaching hospital. We categorized these patients into 3 groups (NOAF, Prior AF, No AF) and compared clinical information between groups. Risk factors for these patients’ short-term and long-term mortality were also analyzed.Results: Ninety-two patients with candidemia were identified from 2011 to 2018. Among these patients, 26 (28.3%) developed NOAF during their hospital stay. The multivariable logistic regression analysis indicated that stroke, anemia, Sequential Organ Failure Assessment (SOFA) score and NOAF were independent risk factors for in-hospital mortality and NOAF was also the independent risk factor for 1 year mortality.Conclusions: There was a high incidence of NOAF in critically ill patients with candidemia, which was associated with in-hospital mortality and 1 year mortality after hospital discharge. Further multicenter studies should be conducted to help confirm this relationship and to find effective interventions that reduce short-term and long-term mortality.

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New-Onset Atrial Fibrillation is an Independent Predictor of Mortality in Patients With Candidemia

10.21203/rs.3.rs-941836/v1 ◽

2021 ◽

Author(s):

Zengli Xiao ◽

Anqi Du ◽

Youzhong An

Keyword(s):

Risk Factors ◽

Atrial Fibrillation ◽

Hospital Mortality ◽

Critically Ill ◽

Critically Ill Patients ◽

Independent Predictor ◽

Long Term Outcome ◽

Onset Atrial Fibrillation ◽

New Onset

Abstract Background: Candidemia, or invasive candidiasis infection, is prevalent in critically ill patients and significantly contributes to the mortality and morbidity of such patients. New-onset atrial fibrillation (NOAF) also occurs frequently in critically ill patients. However, the association between NOAF and candidemia is still uncertain. This study aims to determine whether NOAF could increase the mortality rate of critically ill patients who have candidemia.Methods: We retrospectively identified NOAF in all patients who were admitted into a non-cardiac intensive care unit (ICU) and diagnosed as candidemia from January 2011 to March 2018. These patients were divided into 3 groups (NOAF, Prior AF, No AF). Clinical information and long-term outcome were collected and compared between three groups . Risk factors for these patients’ short-term and long-term mortality were also analyzed.Results: Ninety-two patients with candidemia were included from 2011 to 2018. Among these patients, 26 (28.3%) developed NOAF during their ICU hospitalization. Patients with NOAF had lower survival rate than those who never developed AF. The multivariate logistic regression analysis indicated that stroke, anemia, Sequential Organ Failure Assessment (SOFA) score and NOAF were independent risk factors for in-hospital mortality and NOAF was also an independent risk factor for 1 year mortality. Conclusions: There was a high incidence of NOAF in patients with candidemia. In this study, we found NOAF was an independent predictor of in-hospital mortality and 1 year mortality after hospital discharge for patients with candidemia.

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