Two updates on adenocarcinoma of gastroesophageal junction from the fifth WHO classification of tumors of the digestive system: alteration of gastroesophageal junction definition and the emphasis on HER2 test.

2020 ◽  
Author(s):  
Yunzhu Li ◽  
Jiayu Li ◽  
Manji Li
Keyword(s):  
Gastric Adenocarcinoma ◽  
Who Classification ◽  
Gastroesophageal Junction ◽  
Clinicopathological Features ◽  
Gastric Body ◽  
Clinicopathological Parameters ◽  
Her2 Expression ◽  
Fourth Edition ◽  
Gastric Tumors

Abstract Background: The incidence of gastroesophageal junction (GEJ) adenocarcinoma has increased rapidly but remains controversial over the last decades. There are two crucial updates of the fifth WHO classification including the alteration of GEJ location and the emphasize on human epidermal growth factor receptor 2 (HER2) test.Methods: We retrospectively analyzed the clinicopathological features of 566 patients suffered from gastric adenocarcinoma. We comprehensively compared the clinicopathological features among GEJ and non-GEJ tumors, GEJ and proximal and distal gastric tumors with fourth and fifth edition, respectively. Besides, we discussed the correlation of the HER2 expression with clinicopathological features according to the fifth WHO classification.Results: The results showed that the difference was mainly between GEJ and distal adenocarcinoma in the fourth edition, but some were between proximal and distal adenocarcinoma in the fifth edition. Tumors with longer invasion of the oesophagus were still mainly concentrated in GEJ tumors. The expression of HER2 in GEJ and proximal gastric adenocarcinoma was still higher than that in gastric body and distal site, which was basically consistent with the conclusion of the fourth edition classification.Conclusions: The clinicopathological parameters of the GEJ tumors partly changed with the narrowing scope of the GEJ adenocarcinoma. The proximal gastric tumors rather than GEJ tumors tended to be more invasive. But the GEJ tumors with longer oesophageal invasion required additional management. The HER2-expression of GEJ adenocarcinoma is still higher than that of other gastric sites. The classification of the fifth edition is reasonable and worthy of recommendation.

Two Updates on Oesophagogastric Junction Adenocarcinoma from the Fifth WHO Classification of Tumors of the Digestive System: Alteration of Definition and Emphasis on HER2 Test.

2020 ◽  
Author(s):  
Yunzhu Li ◽  
Jiayu Li ◽  
Manji Li
Keyword(s):  
Gastric Adenocarcinoma ◽  
Who Classification ◽  
Clinicopathological Features ◽  
World Health ◽  
Gastric Body ◽  
Clinicopathological Parameters ◽  
Her2 Expression ◽  
Gastric Tumors ◽  
Oesophagogastric Junction

Abstract Background: The incidence of oesophagogastric junction adenocarcinoma has increased rapidly but remains controversial over the last decades. There are two crucial updates of the fifth World Health Organization(WHO) classification, including the alteration of its definition and the emphasize on human epidermal growth factor receptor 2 (HER2) test.Methods: A total of 566 clinicopathological samples from patients who were diagnosed with gastric adenocarcinoma were retrospectively analyzed. We comprehensively compared the clinicopathological features of oesophagogastric junction adenocarcinoma between fourth (V4.0) and fifth (V5.0) WHO version. The clinicalpathological features among oesophagogastric junction, proximal and distal gastric tumors with fourth and fifth edition were also compared, respectively. Besides, we discussed the correlation of the HER2-expression with clinicopathological features according to the V5.0. Results: The results showed that the difference was mainly between oesophagogastric junction and distal adenocarcinoma in V4.0, while some were found between proximal and distal adenocarcinoma in V5.0. Tumors invading oesophagus more than 3cm were still mainly oesophagogastric junction tumors. The expression of HER2 in oesophagogastric junction and proximal gastric adenocarcinoma was still higher than that in gastric body and distal site.Conclusions: The clinicopathological parameters of the oesophagogastric junction tumors changed to some extent in the updated WHO version. The proximal gastric tumors tended to be more invasive, rather than that located in oesophagogastric junction. But the latter with oesophageal invasion required additional management. The HER2-expression of oesophagogastric junction adenocarcinoma is the highest. The classification of the V5.0 is reasonable and worth a recommendation.

scholarly journals The Impact of the Fourth Edition of the WHO Classification of Lung Tumours on Histological Classification of Resected Pulmonary NSCCs

2016 ◽  
Vol 11 (6) ◽  
pp. 862-872 ◽  
Author(s):  
Patrick Micke ◽  
Johanna Sofia Margareta Mattsson ◽  
Dijana Djureinovic ◽  
Björn Nodin ◽  
Karin Jirström ◽  
...  
Keyword(s):  
Who Classification ◽  
Histological Classification ◽  
Fourth Edition ◽  
Lung Tumours ◽  
The Impact

scholarly journals Uncommon Variants of Mature T-Cell Lymphomas (MTCLs): Imaging and Histopathologic and Clinical Features with Updates from the Fourth Edition of the World Health Organization (WHO) Classification of Lymphoid Neoplasms

Cancers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 5217
Author(s):  
Ahmed Ebada Salem ◽  
Yehia H. Zaki ◽  
Gamal El-Hussieny ◽  
Khaled I. ElNoueam ◽  
Akram M. Shaaban ◽  
...  
Keyword(s):  
T Cell ◽  
Molecular Biology ◽  
Who Classification ◽  
Rare Variants ◽  
World Health ◽  
Complex Nature ◽  
Imaging Features ◽  
Fourth Edition ◽  
T Cell Lymphomas

Understanding the pathogenesis and molecular biology of malignant lymphomas is challenging, given the complex nature and incongruity of these disorders. The classification of lymphoma is continually evolving to account for advances in clinical, pathological, molecular biology and cytogenetic aspects, which impact our understanding of these disorders. The latest fourth edition of the WHO classification of lymphoid malignancies was released in 2016 to account for these changes. Additionally, unlike B-cell lymphomas (BCL), T-cell lymphomas (TCL) are uncommon, and may be sporadically experienced in clinical practice. These disorders are rare, thus early diagnosis is challenging for both physicians and radiologists, owing to the overlap in clinical and imaging features with other, more common disorders. We aim to discuss some rare variants of T-cell lymphomas, including clinicopathologic and imaging features, as well as to give a glimpse of the updates contained within the new 2016 WHO classification.

scholarly journals Gastric epithelial neoplasm of fundic-gland mucosa lineage: proposal for a new classification in association with gastric adenocarcinoma of fundic-gland type

2021 ◽  
Author(s):  
Hiroya Ueyama ◽  
Takashi Yao ◽  
Yoichi Akazawa ◽  
Takuo Hayashi ◽  
Koichi Kurahara ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Clinicopathological Features ◽  
Low Grade ◽  
Fundic Gland ◽  
New Classification ◽  
Histopathological Classification ◽  
Gland Type ◽  
Epithelial Neoplasm

Abstract Background Gastric adenocarcinoma of fundic-gland type (GA-FG) is a rare variant of gastric neoplasia. However, the etiology, classification, and clinicopathological features of gastric epithelial neoplasm of fundic-gland mucosa lineage (GEN-FGML; generic term of GA-FG related neoplasm) are not fully elucidated. We performed a large, multicenter, retrospective study to establish a new classification and clarify the clinicopathological features of GEN-FGML. Methods One hundred GEN-FGML lesions in 94 patients were collected from 35 institutions between 2008 and 2019. We designed a new histopathological classification of GEN-FGML using immunohistochemical analysis and analyzed via clinicopathological, immunohistochemical, and genetic evaluation. Results GEN-FGML was classified into 3 major types; oxyntic gland adenoma (OGA), GA-FG, and gastric adenocarcinoma of fundic-gland mucosa type (GA-FGM). In addition, GA-FGM was classified into 3 subtypes; Type 1 (organized with exposure type), Type 2 (disorganized with exposure type), and Type 3 (disorganized with non-exposure type). OGA and GA-FG demonstrated low-grade epithelial neoplasm, and GA-FGM should be categorized as an aggressive variant of GEN-FGML that demonstrated high-grade epithelial neoplasm (Type 2 > 1, 3). The frequent presence of GNAS mutation was a characteristic genetic feature of GEN-FGML (7/34, 20.6%; OGA 1/3, 33.3%; GA-FG 3/24, 12.5%; GA-FGM 3/7, 42.9%) in mutation analysis using next-generation sequencing. Conclusions We have established a new histopathological classification of GEN-FGML and propose a new lineage of gastric epithelial neoplasm that harbors recurrent GNAS mutation. This classification will be useful to estimate the malignant potential of GEN-FGML and establish an appropriate standard therapeutic approach.

scholarly journals Classification of AIDS-related lymphoma cases between 1987 and 2012 in Japan based on the WHO classification of lymphomas, fourth edition

2014 ◽  
Vol 3 (1) ◽  
pp. 143-153 ◽  
Author(s):  
Yasunori Ota ◽  
Tsunekazu Hishima ◽  
Makoto Mochizuki ◽  
Yoshinori Kodama ◽  
Suzuko Moritani ◽  
...  
Keyword(s):  
Who Classification ◽  
Fourth Edition ◽  
Aids Related Lymphoma
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