scholarly journals The Predictive Role of Platelet-to-Lymphocyte Ratio and Systemic Immune-Inflammation Index in Young and Middle-Aged Patients with Tibial Plateau Fractures

2021 ◽  
Author(s):  
Qingcheng Song ◽  
Hongzhi Hu ◽  
Xiangtian Deng ◽  
Xin Xing ◽  
Wei Chen ◽  
...  
Keyword(s):  
Tibial Plateau ◽  
Tibial Plateau Fractures ◽  
Imaging Data ◽  
Middle Aged ◽  
Platelet To Lymphocyte Ratio ◽  
Aged Patients ◽  
Lymphocyte Ratio ◽  
Schatzker Classification ◽  
Immune Inflammation

Abstract Background There is suggestive evidence that the platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) are related to the severity of fracture. The purpose of this study was to investigate the role of PLR and SII in predicting fracture severity in young and middle-aged patients with tibial plateau fractures (TPFs). Methods The retrospective cohort study involving 229 isolated TPFs was performed between January 2015 and December 2019. Medical records of hospitalized patients were extracted from the electronic case system. Three experienced orthopedic surgeons classified the imaging data according to the Schatzker classification. All the patients were divided into two groups: group1 consisted of fractures of mild to moderate severity (Schatzker types I-IV), and group2 consisted of fractures of severe severity (Schatzker types V-VI). Platelet, neutrophil, and lymphocyte values at admission were obtained. The PLR = platelet/lymphocyte counts and the SII = platelet × neutrophil/lymphocyte counts were noted. Patients in groups 1 and 2 were statistically compared in terms of PLR and SII value on hospital admission. Results There were significant differences in the blood PLR, SII, Na+ and K+ levels, and neutrophil count between the two groups. According to the receiver operating characteristic (ROC) curve, the cut-off of PLR and SII were 157.9 and 923.9, respectively. Our results showed that high PLR and SII were remarkably associated with the severity of TPFs. The sensitivity was 60% and the specificity was 86.9% when using the PLR ≥ 157.9 to predict the severity of the TPFs whereas the sensitivity was 63.3% and the specificity was 74.4% to predict the severity of TPFs at SII ≥ 923.9. In the multivariate analyses, the high preoperative PLR and SII were identified as independent predictors of severe TPFs. Conclusions The PLR and SII are simple and economical biomarkers that can be calculated from routine blood tests and can be used to predict the severity of tibial plateau fractures.

Neutrophil to lymphocyte ratio and fracture severity in young and middle-aged patients with tibial plateau fractures

2020 ◽  
Vol 44 (12) ◽  
pp. 2769-2777
Author(s):  
Zhongzheng Wang ◽  
Siyu Tian ◽  
Kuo Zhao ◽  
Ruipeng Zhang ◽  
Yingchao Yin ◽  
...  
Keyword(s):  
Tibial Plateau ◽  
Tibial Plateau Fractures ◽  
Neutrophil To Lymphocyte Ratio ◽  
Middle Aged ◽  
Aged Patients ◽  
Lymphocyte Ratio

scholarly journals Are postoperative NLR and PLR associated with the magnitude of surgery-related trauma in young and middle-aged patients with bicondylar tibial plateau fractures? A retrospective study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Zhongzheng Wang ◽  
Yanwei Wang ◽  
Yuchuan Wang ◽  
Wei Chen ◽  
Yingze Zhang
Keyword(s):  
Internal Fixation ◽  
Roc Curve ◽  
Tibial Plateau ◽  
Operative Time ◽  
Laboratory Data ◽  
Tibial Plateau Fractures ◽  
Middle Aged ◽  
Aged Patients ◽  
Lymphocyte Ratio ◽  
Bicondylar Tibial Plateau

Abstract Background The invasiveness of different surgical procedures is variable. The purpose of this study was to investigate the value of the postoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as biomarkers in assessing the magnitude of surgery-related trauma in young and middle-aged patients with bicondylar tibial plateau fractures (TPFs). Methods A total of 136 young and middle-aged patients with bicondylar TPFs who underwent surgical treatment between May 2016 and April 2020 were included. Details about demographic information, pre- and postoperative laboratory data, and surgical variables were obtained from the electronic database of our level I trauma center. According to the different surgery programs, all patients were divided into two groups: group 1, which represented minimally invasive reduction and internal fixation (MIRIF), and group 2, which represented open reduction and internal fixation (ORIF). Univariate and multivariate logistic regression and ROC curve analyses were used. Results The operative time, intraoperative tourniquet use, intraoperative blood loss, length of incision, postoperative NLR, PLR, RBC and HCRP were significantly different between the two groups (P < 0.05). In the multivariate analysis, postoperative PLR ≥ 223.9, surgical incision > 19.0 cm and operative time > 130 min were closely related to severe surgery-related trauma. The ROC curve analysis indicated that postoperative PLR could predict severe surgery-related trauma with a specificity of 76.0 % and a sensitivity of 55.7 %. Conclusions Postoperative PLR appears to be a useful biomarker that is closely associated with magnitude of surgery-related trauma in young and middle-aged patients with bicondylar TPFs.

scholarly journals Prognostic role of platelet to lymphocyte ratio in non-small cell lung cancers: A meta-analysis including 3,720 patients

2016 ◽  
Vol 139 (1) ◽  
pp. 164-170 ◽  
Author(s):  
Qing-Tao Zhao ◽  
Zheng Yuan ◽  
Hua Zhang ◽  
Xiao-Peng Zhang ◽  
Hui-En Wang ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Prognostic Role ◽  
Platelet To Lymphocyte Ratio ◽  
Lung Cancers ◽  
Lymphocyte Ratio

Age-associated features of the development of fibrosis and inflamaging in patients with arterial hypertension and ischemic stroke

2022 ◽  
pp. 879-884
Author(s):  
О.А. Осипова ◽  
Е.В. Гостева ◽  
О.Н. Белоусова ◽  
Н.И. Жернакова ◽  
Н.И. Клюшников ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Elderly Patients ◽  
Arterial Hypertension ◽  
Old Age ◽  
Control Group ◽  
Cerebral Stroke ◽  
Middle Aged ◽  
Aged Patients ◽  
Tnf Α ◽  
Immune Inflammation

В статье рассмотрены вопросы развития фиброза и иммунного воспаления у больных артериальной гипертензией (АГ) с острым ишемическим инсультом (ИИ) в пожилом возрасте. Цель исследования - изучение возраст-ассоциированных особенностей концентрации маркеров фиброза (металлопротеиназы-9, тканевого ингибитора матриксных металлопротеиназ-1, их соотношения ММП-9/ТИМП-1), иммунного воспаления (TNF-α, IL-1β, INF-γ) у больных АГ с ИИ. В исследование были включены 86 больных АГ II степени, из которых 42 человека - среднего возраста (53±5 лет) и 44 - пожилого (66±5 лет), контрольную группу составили 22 пациента пожилого возраста с АГ без ИИ в анамнезе. Критерии включения - пациенты с АГ, поступившие в стационар в остром периоде первого церебрального инсульта. Установлено, что у пожилых больных АГ с ИИ показатели инфламэйджинга и маркеры фиброза были достоверно выше, чем у лиц среднего возраста. Уровень IL-1β был выше на 31,7 % (р<0,01), TNF-α - на 55,7 % (р<0,001), INF-γ - на 36,6 % (р<0,01), уровень ММП-9 - на 46,4 % (р<0,01), ТИМП-1 - на 21,2 % (р<0,01), ММП-9/ТИМП-1 - на 19,6 % (р<0,01) в пожилом возрасте по сравнению с больными среднего возраста с АГ и острым ИИ. Таким образом, установлено, что больные АГ с ИИ имеют нарушения процессов инфламейджинга, синтеза и деградации внеклеточного матрикса, особенно выраженные в пожилом возрасте. The article deals with the development of fibrosis and immune inflammation in patients with arterial hypertension and acute ischemic stroke in old age. The aim of the study was to study age-associated features of the concentration of fibrosis markers (metalloproteinase-9, tissue inhibitor of matrix metalloproteinases-1, their ratio MMP-9/TIMP-1), immune inflammation (TNF-α, IL-1β, INF-γ) in patients with arterial hypertension and ischemic stroke (AI). The study included 86 patients with arterial hypertension (AH) of the 2nd degree, of which 42 were middle-aged (53±5 years) and 44 elderly (66±5 years). The control group consisted of 22 elderly patients with AH without a history of AI. The criteria for inclusion in the study are patients with hypertension who were admitted to the hospital in the acute period of the first cerebral stroke. It was found that in elderly patients with hypertension with AI, the indicators of inflamaging and fibrosis markers were significantly higher than in middle-aged people. The level of IL-1β was 31,7 % higher (p<0,01), TNF-α by 55,7 % (p<0,001), INF-γ by 36,6 % (p<0,01), the level of MMP-9 was 46,4 % higher (p<0,01), TIMP-1 by 21,2 % (p<0,01), MMP-9/TIMP-1 by 19,6 % (p<0,01) in the elderly compared to middle-aged patients with hypertension and acute AI. Thus, it was found that patients with arterial hypertension and ischemic stroke have violations of the processes of inflamaging, synthesis and degradation of the extracellular matrix, especially pronounced in old age.

scholarly journals Prognostic role of platelet to lymphocyte ratio in hepatocellular carcinoma: a systematic review and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (14) ◽  
pp. 22854-22862 ◽  
Author(s):  
Yongzhao Zhao ◽  
Guangyan Si ◽  
Fengshang Zhu ◽  
Jialiang Hui ◽  
Shangli Cai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Meta Analysis ◽  
Prognostic Role ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals Clinical Analysis of Classification for Tibial Plateau Fractures and Popliteal Artery Injury

2020 ◽  
Author(s):  
Yilun Yao ◽  
Xiaoshu Wu ◽  
Lei Wu ◽  
Lei Yang ◽  
Chunzhi Jiang ◽  
...  
Keyword(s):  
Tibial Plateau ◽  
Clinical Analysis ◽  
Tibial Plateau Fractures ◽  
Artery Injury ◽  
Type Iv ◽  
Schatzker Type ◽  
Schatzker Classification ◽  
Tibial Head ◽  
Type V

Abstract Background To explore the association between the classification for tibial plateau fractures (TPF) and the popliteal artery injury (PAI).Methods 22 TPF patients accompanied by PAI who were treated from May 2012 to July 2019 were retrospectively analyzed. There were 19 males and 3 females with an average age of 49.43 years. The Schatzker classification and three-column classification were performed for TPF. The severity of extremity injury was evaluated using the mangled extremity severity score (MESS). Except 3 patients treated with amputation, the remaining patients underwent surgical repair of popliteal artery and fracture external fixation. The outcome was evaluated using the Rasmussen score for tibial head fractures.Results There were 10 cases of Schatzker type IV fractures, 1 case of type V fractures and 11 cases of type VI fractures. Based on the three-column classification, the posterior column was involved in 22 cases, 2 columns in 15 cases and 3 columns in 6 cases. The MESS was 6-10 points, with an average of 7.59 points. Except 1 case directly receiving amputation, 3 cases of segment P1 injury was observed via preoperative DSA + intraoperative exploration, while segment P2 in 6 cases and segment P3 in 12 cases. Popliteal artery was found completely ruptured in 11 cases, partially ruptured in 1 case, and severely contused with thrombosis in 10 cases. The Rasmussen score was given to 19 patients at the last follow-up, except for the cases undergoing amputation. The outcome was satisfied in 14 cases, unsatisfied in 5 cases.Conclusion: In patients with complex TPF, the risk of PAI becomes higher with the increase of Schatzker classification level. Knee CT scan is helpful in determining the severity of fractures and evaluating PAI. Based on the three-column classification, PAI should be suspected when the fractures involve the medial and posterior column.PAI is mainly in the segment P3, and artery rupture or severe contusion with extensive thrombosis may occur.

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