scholarly journals EQ-5D-3L health state utility values in transfusion-dependent thalassemia patients in Malaysia : A cross-sectional assessment

2020 ◽  
Author(s):  
Asrul Akmal Shafie ◽  
Irwinder Kaur Chhabra ◽  
Jacqueline Hui Yi Wong ◽  
Noor Syahireen Mohammed
Keyword(s):  
Iron Overload ◽  
Public Hospitals ◽  
Health State Utility ◽  
Economic Evaluations ◽  
Health State ◽  
Utility Value ◽  
Cross Sectional ◽  
Utility Values ◽  
Health State Utility Values ◽  
Chelating Therapy

Abstract Purpose: There is a gap of information describing the health state utility values (HSUVs) of Transfusion-dependent Thalassemia (TDT) patients in Malaysia. These values are useful in the assessment of health-related quality of life (HRQoL), economic evaluations and provide guidance to disease management decisions. The objective of this study was to estimate and derive HSUVs associated with the treatment and complications of TDT patients in Malaysia using the EQ-5D-3L instrument.Methods: A cross-sectional survey using the EQ-5D-3L instrument was conducted between May to September 2018 across various public hospitals in Malaysia. Using a multi-stage sampling, patients diagnosed with TDT and receiving iron chelating therapy were sampled. The findings on the EQ-5D-3L survey were converted into utility values using local tariff values. A two-part model was used to examine and derive the HSUVs associated with the treatment and complications of iron overload in TDT.Results: A total of 585 patients were surveyed. The unadjusted mean (SD) EQ-5D-3L utility value for TDT patients were 0.893 (0.167) while mean (SD) EQ VAS score was 81.22 (16.92). Patients who had more than two iron overload complications had a significant decline in HRQoL. Patients who were on oral monotherapy had a higher utility value of 0.9180 compared to other regimen combinations.Conclusion: Lower EQ-5D-3L utility values were associated with patients who developed iron overload complications and were on multiple iron chelating agents. Emphasizing compliance to iron chelating therapy to prevent the development of complications is crucial in the effort to preserve the HRQoL of TDT patients.

scholarly journals EQ-5D-3L health state utility values in transfusion-dependent thalassemia patients in Malaysia: a cross-sectional assessment

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Asrul Akmal Shafie ◽  
Irwinder Kaur Chhabra ◽  
Jacqueline Hui Yi Wong ◽  
Noor Syahireen Mohammed
Keyword(s):  
Iron Overload ◽  
Public Hospitals ◽  
Health State Utility ◽  
Economic Evaluations ◽  
Health State ◽  
Utility Value ◽  
Cross Sectional ◽  
Utility Values ◽  
Health State Utility Values ◽  
Chelating Therapy

Abstract Purpose There is a gap of information describing the health state utility values (HSUVs) of transfusion-dependent thalassemia (TDT) patients in Malaysia. These values are useful in the assessment of health-related quality of life (HRQoL), economic evaluations and provide guidance to disease management decisions. The objective of this study was to estimate and derive HSUVs associated with the treatment and complications of TDT patients in Malaysia using the EQ-5D-3L instrument. Methods A cross-sectional survey using the EQ-5D-3L instrument was conducted between May to September 2018 across various public hospitals in Malaysia. Using a multi-stage sampling, patients diagnosed with TDT and receiving iron chelating therapy were sampled. The findings on the EQ-5D-3L survey were converted into utility values using local tariff values. A two-part model was used to examine and derive the HSUVs associated with the treatment and complications of iron overload in TDT. Results A total of 585 patients were surveyed. The unadjusted mean (SD) EQ-5D-3L utility value for TDT patients were 0.893 (0.167) while mean (SD) EQ VAS score was 81.22 (16.92). Patients who had more than two iron overload complications had a significant decline in HRQoL. Patients who were on oral monotherapy had a higher utility value of 0.9180 compared to other regimen combinations. Conclusion Lower EQ-5D-3L utility values were associated with patients who developed iron overload complications and were on multiple iron chelating agents. Emphasizing compliance to iron chelating therapy to prevent the development of complications is crucial in the effort to preserve the HRQoL of TDT patients.

scholarly journals EQ-5D-3L Health State Utility Values in Transfusion-dependent thalassemia Patients in Malaysia: A Cross-sectional Assessment

2020 ◽  
Author(s):  
Asrul Akmal Shafie ◽  
Irwinder Kaur Chhabra ◽  
Jacqueline Hui Yi Wong ◽  
Noor Syahireen Mohammed
Keyword(s):  
Iron Overload ◽  
Public Hospitals ◽  
Health State Utility ◽  
Economic Evaluations ◽  
Health State ◽  
Utility Value ◽  
Cross Sectional ◽  
Utility Values ◽  
Health State Utility Values ◽  
Chelating Therapy

Abstract Purpose: There is a gap of information describing the health state utility values (HSUVs) of Transfusion-dependent Thalassemia (TDT) patients in Malaysia. These values are useful in the assessment of health-related quality of life (HRQoL), economic evaluations and provide guidance to disease management decisions. The objective of this study was to estimate and derive HSUVs associated with the treatment and complications of TDT patients in Malaysia using the EQ-5D-3L instrument.Methods: A cross-sectional survey using the EQ-5D-3L instrument was conducted between May to September 2018 across various public hospitals in Malaysia. Using a multi-stage sampling, patients diagnosed with TDT and receiving iron chelating therapy were sampled. The findings on the EQ-5D-3L survey were converted into utility values using local tariff values. A two-part model was used to examine and derive health state utility values associated with the treatment and complications of iron overload in TDT. Results: A total of 585 patients were surveyed. The unadjusted mean (SD) EQ-5D-3L utility value for TDT patients were 0.893 (0.167) while mean (SD) EQ VAS score was 81.22 (16.92). Patients who had more than two iron overload complications had a significant decline in HRQoL. Patients who were on oral monotherapy had a higher utility value of 0.9180 compared to other regimen combinations.Conclusion: Lower EQ-5D-3L utility values were associated with patients who developed iron overload complications and were on multiple iron chelating agents. Emphasizing compliance to iron chelating therapy to prevent the development of complications is crucial in the effort to preserve the HRQoL of TDT patients.

scholarly journals EQ-5D-3L health state utility values in transfusion-dependent thalassemia patients in Malaysia : A cross-sectional assessment

2020 ◽  
Author(s):  
Asrul Akmal Shafie ◽  
Irwinder Kaur Chhabra ◽  
Jacqueline Wong Hui Yi ◽  
Noor Syahireen Mohammed
Keyword(s):  
Iron Overload ◽  
Public Hospitals ◽  
Health State Utility ◽  
Economic Evaluations ◽  
Health State ◽  
Utility Value ◽  
Cross Sectional ◽  
Utility Values ◽  
Health State Utility Values ◽  
Chelating Therapy

Abstract Purpose: There is a gap of information describing the health state utility values (HSUVs) of Transfusion-dependent Thalassemia (TDT) patients in Malaysia. These values are useful in the assessment of health-related quality of life (HRQoL), economic evaluations and provide guidance to disease management decisions. The objective of this study was to estimate and derive HSUVs associated with the treatment and complications of TDT patients in Malaysia using the EQ-5D-3L instrument.Methods: A cross-sectional survey using the EQ-5D-3L instrument was conducted between May to September 2018 across various public hospitals in Malaysia. Using a multi-stage sampling, patients diagnosed with TDT and receiving iron chelating therapy were sampled. The findings on the EQ-5D-3L survey were converted into utility values using local tariff values. A two-part model was used to examine and derive the HSUVs associated with the treatment and complications of iron overload in TDT. Results: A total of 585 patients were surveyed. The unadjusted mean (SD) EQ-5D-3L utility value for TDT patients were 0.893 (0.167) while mean (SD) EQ VAS score was 81.22 (16.92). Patients who had more than two iron overload complications had a significant decline in HRQoL. Patients who were on oral monotherapy had a higher utility value of 0.9180 compared to other regimen combinations.Conclusion: Lower EQ-5D-3L utility values were associated with patients who developed iron overload complications and were on multiple iron chelating agents. Emphasizing compliance to iron chelating therapy to prevent the development of complications is crucial in the effort to preserve the HRQoL of TDT patients.

Burden and health state utility values of eating disorders: results from a population-based survey

2019 ◽  
pp. 1-8
Author(s):  
Long Khanh-Dao Le ◽  
Cathrine Mihalopoulos ◽  
Lidia Engel ◽  
Stephen Touyz ◽  
David Alejandro González-Chica ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Binge Eating ◽  
Health State Utility ◽  
Economic Evaluations ◽  
Health State ◽  
Life Questionnaire ◽  
Healthy Weight ◽  
Utility Values ◽  
Life Years ◽  
Health State Utility Values

Abstract Background There are no published estimates of the health state utility values (HSUVs) for a broad range of eating disorders (EDs). HSUVs are used in economic evaluations to determine quality-adjusted life years or as a measure of disorder burden. The main objective of the current study is to present HSUVs for a broad range of EDs based on DSM-5 diagnoses. Methods We used pooled data of two Health Omnibus Surveys (2015 and 2016) including representative samples of individuals aged 15 + years living in South Australia. HSUVs were derived from the SF-6D (based on the SF-12 health-related quality of life questionnaire) and analysed by ED classification, ED symptoms (frequency of binge-eating or distress associated to binge eating) and weight status. Multiple linear regression models, adjusted for socio-demographics, were used to test the differences of HSUVs across ED groups. Results Overall, 18% of the 5609 individuals met criteria for ED threshold and subthreshold. EDs were associated with HSUV decrements, especially if they were severe disorders (compared to non-ED), binge ED: −0.16 (95% CI −0.19 to −0.13), bulimia nervosa: −0.12, (95% CI −0.16 to −0.08). There was an inverse relationship between distress related binge eating and HSUVs. HSUVs were lower among people with overweight/obese compared to those with healthy weight regardless of ED diagnosis. Conclusions EDs were significantly associated with lower HSUVs compared to people without such disorders. This study, therefore, provides new insights into the burden of EDs. The derived HSUVs can also be used to populate future economic models.

The impact of acute pneumococcal disease on health state utility values: a systematic review

2021 ◽  
Author(s):  
Ryan O’Reilly ◽  
Sayako Yokoyama ◽  
Justin Boyle ◽  
Jeffrey C. Kwong ◽  
Allison McGeer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pneumococcal Disease ◽  
Health State Utility ◽  
Health State ◽  
Utility Values ◽  
Health State Utility Values ◽  
The Impact

The impact of multiple sclerosis severity on health state utility values: Evidence from Australia

2016 ◽  
Vol 23 (8) ◽  
pp. 1157-1166 ◽  
Author(s):  
Hasnat Ahmad ◽  
Bruce V Taylor ◽  
Ingrid van der Mei ◽  
Sam Colman ◽  
Beth A O’Leary ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Disease Severity ◽  
Severe Disease ◽  
Health Utility ◽  
Health State Utility ◽  
Health State ◽  
Utility Values ◽  
Health State Utility Values ◽  
Economic Analyses ◽  
The Impact

Background: The measurement of health state utility values (HSUVs) for a representative sample of Australian people with multiple sclerosis (MS) has not previously been performed. Objectives: Our main aim was to quantify the HSUVs for different levels of disease severities in Australian people with MS. Method: HSUVs were calculated by employing a ‘judgement-based’ method that essentially creates EQ-5D-3L profiles based on WHOQOL-100 responses and then applying utility weights to each level in each dimension. A stepwise linear regression was used to evaluate the relationship between HSUVs and disease severity, classified as mild (Expanded Disability Status Scale (EDSS) levels: 0–3.5), moderate (EDSS levels: 4–6) and severe (EDSS levels: 6.5–9.5). Results: Mean HSUV for all people with MS was 0.53 (95% confidence interval (CI): 0.52–0.54). Utility decreased with increasing disease severity: 0.61 (95% CI: 0.60–0.62), 0.51 (95% CI: 0.50–0.52) and 0.40 (95% CI: 0.38–0.43) for mild, moderate and severe disease, respectively. Adjusted differences in mean HSUV between the three severity groups were statistically significant. Conclusion: For the first time in Australia, we have quantified the impact of increasing severity of MS on health utility of people with MS. The HSUVs we have generated will be useful in further health economic analyses of interventions that slow progression of MS.

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