The impact of acute pneumococcal disease on health state utility values: a systematic review

Background: The measurement of health state utility values (HSUVs) for a representative sample of Australian people with multiple sclerosis (MS) has not previously been performed. Objectives: Our main aim was to quantify the HSUVs for different levels of disease severities in Australian people with MS. Method: HSUVs were calculated by employing a ‘judgement-based’ method that essentially creates EQ-5D-3L profiles based on WHOQOL-100 responses and then applying utility weights to each level in each dimension. A stepwise linear regression was used to evaluate the relationship between HSUVs and disease severity, classified as mild (Expanded Disability Status Scale (EDSS) levels: 0–3.5), moderate (EDSS levels: 4–6) and severe (EDSS levels: 6.5–9.5). Results: Mean HSUV for all people with MS was 0.53 (95% confidence interval (CI): 0.52–0.54). Utility decreased with increasing disease severity: 0.61 (95% CI: 0.60–0.62), 0.51 (95% CI: 0.50–0.52) and 0.40 (95% CI: 0.38–0.43) for mild, moderate and severe disease, respectively. Adjusted differences in mean HSUV between the three severity groups were statistically significant. Conclusion: For the first time in Australia, we have quantified the impact of increasing severity of MS on health utility of people with MS. The HSUVs we have generated will be useful in further health economic analyses of interventions that slow progression of MS.

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Health state utility values in locally advanced and metastatic breast cancer by treatment line: a systematic review

Expert Review of Pharmacoeconomics & Outcomes Research ◽

10.1080/14737167.2016.1222907 ◽

2016 ◽

Vol 16 (5) ◽

pp. 549-559 ◽

Cited By ~ 8

Author(s):

Noman Paracha ◽

Per-Olof Thuresson ◽

Santiago G. Moreno ◽

Katherine S. MacGilchrist

Keyword(s):

Breast Cancer ◽

Systematic Review ◽

Metastatic Breast Cancer ◽

Locally Advanced ◽

Metastatic Breast ◽

Health State Utility ◽

Health State ◽

Utility Values ◽

Treatment Line ◽

Health State Utility Values

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Health state utility values among children and adolescents with disabilities: protocol for a systematic review

BMJ Open ◽

10.1136/bmjopen-2017-019978 ◽

2018 ◽

Vol 8 (2) ◽

pp. e019978

Author(s):

Lucy Kanya ◽

Nana Anokye ◽

Jennifer M Ryan

Keyword(s):

Systematic Review ◽

Psychometric Properties ◽

Children And Adolescents ◽

English Language ◽

Health State Utility ◽

Health State ◽

Summary Statistics ◽

Quality Of Reporting ◽

Utility Values ◽

Health State Utility Values

IntroductionIncreasingly, assessment of healthcare technologies and interventions requires the assessment of both costs and utilities. Health state utility values (HSUVs) are measured using a range of generic and condition-specific measures. While reviews have identified that generic measures of HSUVs may lack validity in adults with conditions that result in physical disability, there is little information available on the methods used to obtain HSUVs in children and adolescents with disabilities. The objectives of this systematic review are to describe the methods used to obtain HSUVs, including mode of administration and psychometric properties, and provide summary statistics for HSUVs among children and adolescents with disabilities.Methods and analysisThe following databases will be searched from inception for English-language studies of any design: PubMed, PsychInfo, Medline, Scopus, CINAHL Plus, Econlit and EMBASE databases. Two reviewers will independently screen titles, abstracts and full text articles for studies reporting HSUVs and/or data on the psychometric properties of preference-based measures for children and adolescents with disabilities aged up to 19 years. Two reviewers will independently extract data items including descriptors of the study methods and sample, instruments used to capture HSUVs, summary statistics for HSUVs and items relating to the quality of reporting. A descriptive summary of results from included studies and summary statistics for HSUVs will be presented. If sufficient data is identified, we will pool summary statistics for HSUVs according to the method used to obtain the HSUV using a random effects model. In addition, we will explore the determinants of the HSUVs using a meta-regression.Ethics and disseminationEthical approval will not be required as no original data will be collected as part of this review. The completed review will be submitted for publication in a peer-reviewed journal and presentation at conferences.PROSPERO registration numberCRD42018086574.

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A Systematic Review and Meta-Analysis of Health State Utility Values in Psoriasis

Value in Health ◽

10.1016/j.jval.2018.07.810 ◽

2018 ◽

Vol 21 ◽

pp. S107

Author(s):

Z Yang ◽

S Li ◽

X Wang ◽

G Chen

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Health State Utility ◽

Health State ◽

Utility Values ◽

Health State Utility Values

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Health State Utility Values in Schizophrenia: A Systematic Review and Meta-Analysis: A Letter to the Editor

Value in Health ◽

10.1016/j.jval.2020.09.020 ◽

2021 ◽

Author(s):

Amanda L. Neil ◽

Vaughan J. Carr ◽

Adriana G. Nevarez-Flores ◽

Helen Herrman ◽

Vera A. Morgan

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Health State Utility ◽

Health State ◽

Utility Values ◽

Letter To The Editor ◽

Health State Utility Values

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Corrigendum

Multiple Sclerosis Journal ◽

10.1177/1352458516676455 ◽

2016 ◽

Vol 22 (14) ◽

pp. NP13-NP13

Keyword(s):

Multiple Sclerosis ◽

Health State Utility ◽

Health State ◽

Utility Values ◽

Health State Utility Values ◽

The Impact

Ahmad H, Taylor BV, van der Mei I et al. (2016). The impact of multiple sclerosis severity on health state utility values: Evidence from Australia. Mult Scler. Epub ahead of print. DOI: 10.1177/1352458516672014

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Health state utility values in schizophrenia: protocol for a systematic review and meta-analysis

Evidence-Based Mental Health ◽

10.1136/ebmental-2019-300089 ◽

2019 ◽

Vol 22 (4) ◽

pp. 142-144 ◽

Cited By ~ 1

Author(s):

David Aceituno ◽

Mark Pennington ◽

Barbara Iruretagoyena ◽

Matthew A Prina ◽

Paul McCrone

Keyword(s):

Systematic Review ◽

Task Force ◽

Meta Analysis ◽

Cost Effective ◽

Health State Utility ◽

Health State ◽

Utility Values ◽

Life Years ◽

Health State Utility Values

IntroductionCost-effectiveness analyses that use quality-adjusted life-years (QALYs) allow comparing the value for money of interventions across different health problems. Health state utility values (HSUVs) are crucial to calculate QALYs. These are weights attached to a given health state reflecting preferences in health-related quality of life (HRQoL). In schizophrenia, there is extensive evidence about the consequences of this condition on HRQoL. Besides, several interventions have claimed to be cost-effective in terms of QALYs gained. Despite this evidence, a systematic review of HSUVs has not been conducted. Therefore, we aim to synthesise the evidence about HSUVs in schizophrenia.Methods and analysisWe will conduct a systematic review of the literature about HSUVs in people with schizophrenia following the Preferred Reporting Items for Systematic review and Meta-Analysis and the International Society for Pharmacoeconomics and Outcomes Research task force recommendations. The submissions records of eight electronic peer-reviewed databases and three health technology assessment (HTA) agencies will be searched. Quantitative synthesis will be carried out in comparable studies, using random-effects meta-analysis. Heterogeneity will be explored using meta-regression if more than 10 studies per covariate are found. A narrative synthesis and methodological quality of included studies will be also reported.DiscussionThis review will provide a synthesis of the HSUVs estimated for different states experienced by people with schizophrenia. This will inform analysts when calculating QALYs, using values in a more transparent and accountable manner. Finally, it will shed light on evidence gaps and limitations about this measure in mental health.PROSPERO registration numberCRD42019123582.

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