scholarly journals Insulin Smart Drug Delivery Nanoparticles of Aminophenylboronic acid–POSS Molecule at Neutral pH

2021 ◽  
Author(s):  
Won Jung Kim ◽  
Yong Jin Kwon ◽  
Sang Kyu Ye ◽  
Kyu Oh Kim
Keyword(s):  
Diabetes Management ◽  
Entrapment Efficiency ◽  
Fast Response ◽  
Endocrine Function ◽  
Triggered Release ◽  
Polyhedral Oligosilsesquioxane ◽  
Neutral Ph ◽  
Pancreatic Endocrine Function ◽  
Aminophenylboronic Acid ◽  
Hdf Cells

Abstract Self-regulated “smart” insulin administration system that mimic pancreatic endocrine function would be highly desirable for diabetes management. Here, a glucose-responsive continuous insulin delivery system is developed, where novel polyhedral oligosilsesquioxane (POSS) modified with 3-aminophenylboronic acid (APBA) were used to encapsulate insulin (insulin entrapment efficiency : 73.2%; loading capacity : 50.5%) to prepare a fast response, high stability, good distribution, and excellent biocompatible system. Micelles self‐assembled from these molecules possess glucose‐responsiveness at varying glucose concentrations. The interaction of the PBA and diol containing insulin via boronate ester bond and its interchange with glucose was investigated by FT-IR, 1H NMR and XPS. Furthermore, the successful glucose-triggered release of insulin from the POSS-APBA micelles was investigated at neutral pH. A linear graph was plotted with the measured released insulin vs glucose concentrations, with a linear correlation coefficient (R2) value close to 1. When confirming intracellular apoptosis signaling, cleaved caspase 3 and caspase 9 were not increased by 640 µg/ml POSS-APBA and POSS-APBA@Insulin in HeLa cells and HDF cells. Application in the biomedical field for controlled delivery of insulin appear to be promising.

scholarly journals Insulin smart drug delivery nanoparticles of aminophenylboronic acid–POSS molecule at neutral pH

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Won Jung Kim ◽  
Yong Jin Kwon ◽  
Chung-Hyun Cho ◽  
Sang-Kyu Ye ◽  
Kyu Oh Kim
Keyword(s):  
Diabetes Management ◽  
Entrapment Efficiency ◽  
Fast Response ◽  
Cd Spectroscopy ◽  
Endocrine Function ◽  
Triggered Release ◽  
Polyhedral Oligosilsesquioxane ◽  
Neutral Ph ◽  
Insulin Activity ◽  
Aminophenylboronic Acid

AbstractSelf-regulated “smart” insulin administration system that mimic pancreatic endocrine function would be highly desirable for diabetes management. Here, a glucose-responsive continuous insulin delivery system is developed, where novel polyhedral oligosilsesquioxane (POSS) modified with 3‐aminophenylboronic acid (APBA) were used to encapsulate insulin (insulin entrapment efficiency: 73.2%) to prepare a fast response, high stability, good distribution, and excellent biocompatible system. Due to the strong hydrophobicity of POSS, the POSS moiety is located at the core in aqueous solution and combines with the boronic group of APBA and the diol generated in PEG-insulin to form a nanomicelle structure, that is, nanoparticles naturally. Micelles self‐assembled from these molecules possess glucose‐responsiveness at varying glucose concentrations. The interaction of the PBA and diol containing insulin via boronate ester bond and its interchange with glucose was investigated by FT-IR, 1H NMR and XPS. Furthermore, the successful glucose-triggered release of insulin from the POSS-APBA micelles was investigated at neutral pH. A linear graph was plotted with the measured released insulin vs glucose concentrations, with a linear correlation coefficient (R2) value close to 1. Circular dichroism (CD) spectroscopy analysis was performed to measure insulin activity by comparing secondary structures of insulin, PEG-Insulin, and POSS-APBA@insulin. When confirming intracellular apoptosis signaling, cleaved caspase 3 and caspase 9 were not increased by 640 μg/ml POSS-APBA and POSS-APBA@insulin in HeLa, HDF and HUVE cells. Application in the biomedical field for controlled delivery of insulin appear to be promising.

Pancreatic Endocrine Function in Leukemic Children Treated with L-Asparaginase

1981 ◽  
Vol 15 (4) ◽  
pp. 237-241 ◽  
Author(s):  
Franco Meschi ◽  
Berardo di Natale ◽  
Gian Filippo Rondanini ◽  
Cornelio Uderzo ◽  
Momcilo Jankovic ◽  
...  
Keyword(s):  
Endocrine Function ◽  
Pancreatic Endocrine Function

scholarly journals Prominent pancreatic endocrinopathy and altered control of food intake disrupt energy homeostasis in prion diseases

2008 ◽  
Vol 197 (2) ◽  
pp. 251-263 ◽  
Author(s):  
J D Bailey ◽  
J G Berardinelli ◽  
T E Rocke ◽  
R A Bessen
Keyword(s):  
Body Weight ◽  
Energy Homeostasis ◽  
Prion Diseases ◽  
Glucagon Secretion ◽  
Type Ii Diabetes Mellitus ◽  
Serum Glucose ◽  
Endocrine Function ◽  
Prion Infection ◽  
Control Food ◽  
Pancreatic Endocrine Function

Prion diseases are fatal neurodegenerative diseases that can induce endocrinopathies. The basis of altered endocrine function in prion diseases is not well understood, and the purpose of this study was to investigate the spatiotemporal relationship between energy homeostasis and prion infection in hamsters inoculated with either the 139H strain of scrapie agent, which induces preclinical weight gain, or the HY strain of transmissible mink encephalopathy (TME), which induces clinical weight loss. Temporal changes in body weight, feed, and water intake were measured as well as both non-fasted and fasted concentrations of serum glucose, insulin, glucagon, β-ketones, and leptin. In 139H scrapie-infected hamsters, polydipsia, hyperphagia, non-fasted hyperinsulinemia with hyperglycemia, and fasted hyperleptinemia were found at preclinical stages and are consistent with an anabolic syndrome that has similarities to type II diabetes mellitus and/or metabolic syndrome X. In HY TME-infected hamsters, hypodipsia, hypersecretion of glucagon (in both non-fasted and fasted states), increased fasted β-ketones, fasted hypoglycemia, and suppressed non-fasted leptin concentrations were found while feed intake was normal. These findings suggest a severe catabolic syndrome in HY TME infection mediated by chronic increases in glucagon secretion. In both models, alterations of pancreatic endocrine function were not associated with PrPSc deposition in the pancreas. The results indicate that prominent endocrinopathy underlies alterations in body weight, pancreatic endocrine function, and intake of food. The prion-induced alterations of energy homeostasis in 139H scrapie- or HY TME-infected hamsters could occur within areas of the hypothalamus that control food satiety and/or within autonomic centers that provide neural outflow to the pancreas.

CANINE PANCREATIC ENDOCRINE FUNCTION AFTER INTERRUPTION OF PANCREATIC EXOCRINE DRAINAGE

1983 ◽  
Vol 36 (3) ◽  
pp. 246-251 ◽  
Author(s):  
MICHAEL BEWICK ◽  
BRENDA H. R. MILLER ◽  
FREDERICK J. COMPTON ◽  
MIGUEL GONZALES-CARILLO ◽  
ALEXANDER AVGOUSTIS ◽  
...  
Keyword(s):  
Endocrine Function ◽  
Pancreatic Endocrine Function ◽  
Pancreatic Exocrine

scholarly journals The promise of stem cell-derived islet replacement therapy

Diabetologia ◽  
2021 ◽  
Author(s):  
Douglas Melton
Keyword(s):  
Endocrine Cells ◽  
Diabetes Management ◽  
Insulin Pump ◽  
Glucose Monitoring ◽  
Endocrine Function ◽  
Blood Glucose Monitoring ◽  
Directed Differentiation ◽  
Insulin Independence ◽  
Insulin Dependent

AbstractPresent-day treatments for people that are insulin dependent require multiple insulin injections, sometimes with an insulin pump, coupled with regular blood glucose monitoring. The availability of modified insulins, each with peaks of activity at varying times, has improved diabetes management. On the other hand, there have been impressive results leading to insulin independence by transplantation of cadaveric islets coupled with immune suppression. This review focuses on the possibility of treating diabetes with cellular transplants, specifically with the use of pluripotent stem cells, to produce a virtually unlimited and uniform supply of human islet-like clusters by directed differentiation. Prospects for improving the in vitro differentiation of human endocrine cells for the study of endocrine function and their possible clinical uses are also discussed. Graphical abstract

Effect of Solid and Liquid Carbohydrates upon Postprandial Pancreatic Endocrine Function*

1981 ◽  
Vol 53 (1) ◽  
pp. 16-20 ◽  
Author(s):  
V. SCHUSDZIARRA ◽  
G. DANGEL ◽  
M. KLIER ◽  
I. HENRICHS ◽  
E. F. PFEIFFER
Keyword(s):  
Endocrine Function ◽  
Pancreatic Endocrine Function

scholarly journals Subtotal Pancreatectomy for Cancer: Closure of the Pancreatic Remnant With Staplers

HPB Surgery ◽  
1990 ◽  
Vol 2 (1) ◽  
pp. 29-39 ◽  
Author(s):  
Bo Ahrén ◽  
Karl-G. Tranberg ◽  
Åke Andrén-Sandberg ◽  
Stig Bengmark
Keyword(s):  
Fatal Outcome ◽  
Endocrine Function ◽  
Periampullary Cancer ◽  
Gastric Stasis ◽  
Subtotal Pancreatectomy ◽  
Pancreatic Remnant ◽  
Number Of Patients ◽  
Long Term Follow Up ◽  
Pancreatic Endocrine Function

This paper presents a 2-year series of 26 consecutive pancreatectomies for periampullary cancer where the pancreatic tail was closed with a stapler in order to avoid complications related to a pancreatico-digestive anastomosis. The follow-up period was 14 months or more. Seven patients developed operative complications. Pancreatic fistulas developed in 3 patients. The fistulas closed spontaneously in 2 of the patients after 2-4 months, lntraabdominal abscesses developed in 4 patients and required surgical drainage. In 1 of these patients, the abscess eroded a large vessel with a fatal outcome resulting in an operative mortality rate of 3.8%. A transient postoperative gastric stasis was observed in seven patients. Postoperative hospital median stay was 27 days (range 10–83 days). Eighteeen patients have died after 4–30 months in recurrent disease and seven patients are alive after a follow-up period of 15–29 months. Pancreatic endocrine function seemed well preserved; diabetes mellitus has developed in only one patient. In conclusion, it appears that subtotal pancreatectomy with closure of the pancreatic remnant with staples gives a low morbidity and mortality. Although the conclusion should be tempered by the small number of patients, the results justify continued evaluation of this technique with long-term follow-up.

Effect of Ivacaftor on Pancreatic Endocrine Function

2018 ◽  
Vol 42 (5) ◽  
pp. S61
Author(s):  
Nada Alhashemi ◽  
Julie Gilmour ◽  
Jenna Sykes ◽  
Elizabeth Tullis
Keyword(s):  
Endocrine Function ◽  
Pancreatic Endocrine Function
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