Olanzapine (5 mg) Plus Standard Triple Antiemetic Therapy for the Prevention of Multiple-Day Cisplatin Chemotherapy-Induced Nausea and Vomiting: A Prospective Randomized Controlled Study

Abstract Objective A prospective randomized controlled trial was conducted to compare 5 mg olanzapine plus standard triple antiemetic therapy for the prevention of nausea and vomiting induced by multiple-day cisplatin chemotherapy. Methods Patients received 3-day cisplatin-based chemotherapy(25mg/m2/d) were given either 5mg olanzapine quadruple therapy (aprepitant, tropisetron, dexamethasone) or 5mg olanzapine-based triplet therapy. The primary end-point was the complete response(CR) in the overall phase(OP)(0-120h) between quadruple regimen group and triplet regimen group. The secondary end-points were the CR in the acute phase(AP)(0-24h), delayed phase(DP)(25-120h) between two groups. The first time of vomiting was also compared by Kaplan-Meier curves. The impact of chemotherapy induced nausea and vomiting(CINV) on the quality of life was assessed by the Functional Living Index-Emesis(FLIE). Aprepitant-related adverse effects (AEs) was also recorded. Results (1) The primary end-point CR during overall phase was 76.0% (45/59) vs 67.0% (41/61) between the quadruple regimen group and triplet regimen group(P =0.271). The secondary end-point CR during the AP was significantly higher in the quadruple group than in the triple group, which was 100.0%(59/59) vs 93.0%(57/61)(P=0.045). The difference between the groups was especially greater in the delayed phase(quadruple group 76.0% (45/59) vs triple group 67.0%(41/61)(P=0.271)). The rate of patients who achieved total protection in the overall phase was also larger in the quadruple group than in the triple group(28.8% (17/59) vs 23.0%(14/61)(P=0.463)). During the OP, the incidence of no vomiting in quadruple group and triple group was 93.2%(55/59) vs 80.3%(49/61)(P=0.038)respectively.(2) Kaplan-Meier curves of time to first emesis were obviously longer in the quadruple group than in the triple group(P=0.031). According to FLIE, no impact of CINV on daily life was defined as total score of questionnaire >108, this study exhibited identical life quality in quadruple group and the triplet group.(3) The most common aprepitant- and olanzapine-related AEs included sedation, fatigue and constipation. The occurrences between two groups were identical. Conclusion It may been recommended that combined 5mg olanzapine with aprepitant, tropisetron, dexamethasone quadruple therapy for the prevention of multiple-day cisplatin induced nausea and vomiting due to the better CINV control rate and safety.

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Biofeedback Intervention for Stress and Anxiety among Nursing Students: A Randomized Controlled Trial

ISRN Nursing ◽

10.5402/2012/827972 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 30

Author(s):

Paul Ratanasiripong ◽

Nop Ratanasiripong ◽

Duangrat Kathalae

Keyword(s):

Nursing Students ◽

Stress Level ◽

Clinical Training ◽

Intervention Program ◽

Controlled Trial ◽

Controlled Study ◽

Control Group ◽

Moderate Increase ◽

Randomized Controlled ◽

The Impact

Purpose. It has been well documented that nursing students across the world experience stress and anxiety throughout their education and training. The purpose of this randomized controlled study is to investigate the impact of biofeedback intervention program on nursing students' levels of stress and anxiety during their first clinical training. Methods. Participants consisted of 60 second-year baccalaureate nursing students. The 30 participants in the biofeedback group received training on how to use the biofeedback device to assist in stress and anxiety management for 5 weeks while the 30 in the control group did not receive any training. Findings. Results indicated that the biofeedback group was able to maintain the stress level while the control group had a significant increase in the stress level over the 5-week period of clinical training. Additionally, the biofeedback group had a significant reduction in anxiety, while the control group had a moderate increase in anxiety. Conclusions. The better the nursing students can manage their stress and anxiety, the more successful they can be in their clinical training. Ultimately, the more psychologically healthy the nursing students are, the more likely they will flourish and graduate to become productive and contributing members of the nursing profession.

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The Impact of Preoperative α-Adrenergic Antagonists on Ureteral Access Sheath Insertion Force and the Upper Limit of Force Required to Avoid Ureteral Mucosal Injury: A Randomized Controlled Study

The Journal of Urology ◽

10.1016/j.juro.2017.09.173 ◽

2018 ◽

Vol 199 (6) ◽

pp. 1622-1630 ◽

Cited By ~ 12

Author(s):

Kyo Chul Koo ◽

Jun-Ho Yoon ◽

No-Cheol Park ◽

Hye Sun Lee ◽

Hyun Kyu Ahn ◽

...

Keyword(s):

Mucosal Injury ◽

Controlled Study ◽

Insertion Force ◽

Ureteral Access Sheath ◽

Access Sheath ◽

Randomized Controlled ◽

Upper Limit ◽

Adrenergic Antagonists ◽

Sheath Insertion ◽

The Impact

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MP27-13 THE IMPACT ON THE TYPE OF URETERAL STENT TO PATIENTS¡¯ SYMPTOM USING USSQ: A PROSPECTIVE RANDOMIZED CONTROLLED STUDY

The Journal of Urology ◽

10.1016/j.juro.2014.02.376 ◽

2014 ◽

Vol 191 (4S) ◽

Author(s):

Hyoungkeun Park ◽

Sangrak Bae ◽

Sunghyun Paick ◽

Hyunwoo Kim ◽

Jutae Seo ◽

...

Keyword(s):

Ureteral Stent ◽

Randomized Controlled Study ◽

Controlled Study ◽

Randomized Controlled ◽

The Impact

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The impact of the using high-fidelity simulation and standardized patients to management of postpartum hemorrhage in undergraduate nursing students: A randomized controlled study in Turkey

Health Care For Women International ◽

10.1080/07399332.2019.1583229 ◽

2019 ◽

Vol 40 (5) ◽

pp. 597-612

Author(s):

Merve Mert Karadas ◽

Fusun Terzioglu

Keyword(s):

Nursing Students ◽

Postpartum Hemorrhage ◽

Standardized Patients ◽

Controlled Study ◽

High Fidelity ◽

High Fidelity Simulation ◽

Undergraduate Nursing Students ◽

Randomized Controlled ◽

Undergraduate Nursing ◽

The Impact

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Pedicle screw insertion in spine: a randomized controlled study for robot-assisted spinal surgery

10.29007/nbg2 ◽

2018 ◽

Cited By ~ 1

Author(s):

Wei Tian ◽

Mingxing Fan ◽

Yajun Liu

Keyword(s):

Pedicle Screw ◽

Spinal Surgery ◽

Entry Point ◽

Randomized Controlled Study ◽

Controlled Study ◽

Mean Deviation ◽

Robot Assisted ◽

Group Assessment ◽

Randomized Controlled ◽

End Point

To introduce a new robot-assisted surgical system for spinal posterior fixation which called TiRobot, based on intraoperative three-dimensional images. TiRobot has three components: the planning and navigation system, optical tracking system and robotic arm system. By combining navigation and robot techniques, TiRobot can guide the screw trajectories for orthopedic surgeries.In this randomized controlled study approved by the Ethics Committee, 40 patients were involved and all has been fully informed and sign the informed consent. 17 patients were treated by free-hand fluoroscopy-guided surgery, and 23 patients were treated by robot-assisted spinal surgery.A total of 190 pedicle screws was implanted. The overall operation time were not different for both groups. None of the screws necessitated re-surgery for revised placement. In the robot-assisted group, assessment of pedicle screw accuracy showed that 102 of 102 screws (100%) were safely placed (<2 mm, category A+B). And mean deviation in entry point was 1.70 +/- 0.83mm, mean deviation in end point was 1.84 +/- 1.04mm. In the conventional freehand group, assessment of pedicle screw accuracy showed that 87 of 88 (98.9%) were safely placed (<2 mm, category A+B), 1 screw fall in category C, mean deviation in entry point was 3.73 +/- 2.28mm, mean deviation in end point was 4.11 +/- 2.31mm.This randomized controlled study verified that robot-assisted pedicle screw placement with real-time navigation is a more accuracy and safer method, also revealed great clinical potential of robot-assisted surgery in the future.

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