scholarly journals Morphological Analysis of Medullary Cavity for Designing Personalized Femoral Stem

2021 ◽  
Author(s):  
Lin Wang ◽  
Kaijin Guo ◽  
Hong Zhu ◽  
Kunjin He ◽  
Weizhong Geng
Keyword(s):  
Bone Marrow ◽  
Monte Carlo ◽  
Probability Model ◽  
Femoral Stem ◽  
Region Of Interest ◽  
Morphological Parameters ◽  
Femoral Bone ◽  
Marrow Cavity ◽  
Bone Marrow Cavity ◽  
Femoral Bone Marrow

Abstract To improve the quality and efficiency of femoral stem prosthesis design, a Monte Carlo method based on femoral bone marrow cavity analysis is proposed to measure morphological parameters using anatomical semantics. The region of interest is the femur, which includes the medullary cavity and cortical region. After this region is extracted, the size of the cavity and region is simulated using the Monte Carlo method. Finally, based on clinical needs, the morphological parameters are calculated and analyzed based on the size of the region of interest. From the perspective of the probability model, the non-random problem of solving the cross-section area of the femoral marrow cavity is transformed into one having a random nature so that a probability model can be used. The experimental results show that this method is simple, flexible, and efficient. It provides a new and reasonable scientific method for comprehensively understanding the anatomical morphological changes of the femoral marrow cavity. The measurement and analysis of the morphological parameters of the femoral bone marrow cavity in this paper provide the necessary scientific theoretical support for improved morphologic research, design, and clinical selection of femoral stem prostheses and has important significance and application value in clinical practice.

scholarly journals Acetabular and femoral bone marrow in patients with hip osteoarthrosis: Cellular landscape of immune and stromal compartments

Bone Reports ◽  
2021 ◽  
Vol 14 ◽  
pp. 100844
Author(s):  
Drenka Trivanovic ◽  
Janek Hader ◽  
Maximilian Leucht ◽  
Theresa Kreuzahler ◽  
Bianca Schlierf ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Femoral Bone ◽  
Femoral Bone Marrow

scholarly journals FEMORAL BONE MARROW BIOPSY IN THE ALBINO RAT

Blood ◽  
1948 ◽  
Vol 3 (3) ◽  
pp. 292-294 ◽  
Author(s):  
D. G. CAMERON ◽  
G. M. WATSON
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Biopsy ◽  
Femoral Bone ◽  
Albino Rat ◽  
Femoral Bone Marrow ◽  
Differential Counts

Abstract A technic for repeated femoral bone marrow biopsy in the rat is detailed. Differential counts confirmed the distribution of the cellular elements as described by other authors.

scholarly journals Influence of Cobalt, Sheep Erythropoietin and Several Hormones on Erythropoiesis in Bone Marrows of Isolated Perfused Hind Limbs of Dogs

Blood ◽  
1964 ◽  
Vol 23 (1) ◽  
pp. 87-98 ◽  
Author(s):  
JAMES W. FISHER ◽  
B. L. ROH ◽  
CHARLES COUCH ◽  
W. O. NIGHTINGALE
Keyword(s):  
Bone Marrow ◽  
Growth Hormone ◽  
Erythroid Cell ◽  
Femoral Bone ◽  
Perfusion System ◽  
Cell Counts ◽  
Hind Limbs ◽  
Erythroid Hyperplasia ◽  
Dog Blood ◽  
Femoral Bone Marrow

Abstract A technic has been developed for studying the femoral bone marrow of the dog by perfusing the isolated hind limb. With the use of this method, bone marrows were perfused for 4-6 hours with donor dog blood alone and blood containing sheep erythropoietin, cobalt, growth hormone, hydrocortisone, 3,5,3'-triiodothyronine or testosterone. Significant increases were seen in nucleated erythroid cell counts within femoral marrows perfused with blood containing sheep erythropoietin and cobalt. A slight increase was also noted in the bone marrows from limbs in which growth hormone was added to the perfusion system. It may be concluded from these experiments that erythropoietin, cobalt and growth hormone are capable of stimulating erythroid hyperplasia in the bone marrow directly.

scholarly journals Qnantitation of Femoral Bone Marrow Cellularity of Rats with Acute Chloroleukemia

Blood ◽  
1965 ◽  
Vol 26 (3) ◽  
pp. 309-316 ◽  
Author(s):  
EVELYN E. VARSA ◽  
EUGENE S. HANDLER ◽  
ALBERT S. GORDON
Keyword(s):  
Bone Marrow ◽  
Leukemic Cells ◽  
Femoral Bone ◽  
Progressive Decrease ◽  
Cell Numbers ◽  
Bone Marrow Cellularity ◽  
Acute Form ◽  
Long Evans ◽  
Marrow Cellularity ◽  
Femoral Bone Marrow

Abstract Procedures of bone marrow quantitation have been applied to the study of the pathogenesis of a leukemia in rats. Mature Long-Evans rats developed an acute form of the Shay Chloroleukemia after intravenous administration of leukemic cells. Assessment of total nucleated cell numbers (normal and leukemic) per mg. of femoral bone marrow was made during the course of the pathogenesis (20 days). Reductions in the numbers of normal marrow elements were observed prior to significant increases in chloroleukemic cells. A progressive decrease in total marrow cellularity was noted in all subsequent stages. In animals surviving 17-20 days, the total number of hemic cells in the femoral marrow was found to be approximately 40 per cent of that seen in normal animals. The leukemia developed more rapidly in young than in adult animals. Using total and differential bone marrow cellularity as a criterion for the stage of pathogenesis, standardized leukemic rats can be prepared for experimentation.

The Bone Marrow Cavity Is Suitable for Islet Transplantation in Diabetic Rhesus Monkey.

2014 ◽  
Vol 98 ◽  
pp. 360-361
Author(s):  
L. Yan-rong ◽  
C. Wang ◽  
X. Du ◽  
S. He ◽  
Y. Chen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Rhesus Monkey ◽  
Islet Transplantation ◽  
Marrow Cavity ◽  
Bone Marrow Cavity

Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice

Blood ◽  
2000 ◽  
Vol 95 (11) ◽  
pp. 3363-3370 ◽  
Author(s):  
Hisashi Tagaya ◽  
Takahiro Kunisada ◽  
Hidetoshi Yamazaki ◽  
Toshiyuki Yamane ◽  
Takeshi Tokuhisa ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mouse Strains ◽  
B Lymphopoiesis ◽  
Hematopoietic Growth Factors ◽  
Newborn Mice ◽  
Marrow Cavity ◽  
Interleukin 7 ◽  
Neonatal Stage ◽  
Bone Marrow Cavity ◽  
B Lineage

Adult bone marrow is a major site for hematopoiesis, and reduction of the bone marrow cavity induces hematopoiesis in extramarrow tissues. To investigate the rudimentary intramarrow and the compensatory extramarrow hematopoiesis, particularly B lymphopoiesis, we used 3 osteopetrotic mouse strains [op/op, mi/mi, and Fos(−/−)], which are severely deficient in functional osteoclasts and therefore form inadequate bone marrow cavities. We found that bone marrow in these osteopetrotic mice supports myelopoiesis but not B lymphopoiesis, although cells that have the potential to differentiate into B lineage cells are present in the bone marrow. Although B lymphopoiesis normally occurs both in the spleen and liver of newborn mice, compensatory B lymphopoiesis in adultop/op and mi/mi mice is observed only in the liver, while myelopoiesis is enhanced in both organs. Interestingly, mice lacking the Fos proto-oncogene exhibit B lymphopoiesis in the spleen as well as liver. The amounts of expression of steel factor, Flt3/Flk-2 ligand, and interleukin-7 in the bone marrow, spleen, or liver were not significantly affected in these osteopetrotic mutants. These findings suggest that the volume of the bone marrow cavity regulates B lymphopoiesis without affecting the production of certain hematopoietic growth factors. The splenic microenvironments that support both myelopoiesis and B lymphopoiesis in the neonatal stage are lost in adults and are not reactivated even in the osteopetrotic adults unless the Fos gene is disrupted.

Sign in / Sign up

Export Citation Format

Share Document