scholarly journals Effects of Concentrated Growth Factor on Gingival Thickness in Periodontal Accelerated Osteogenic Orthodontics: A 6-Month Randomized Controlled Trial

2021 ◽  
Author(s):  
Lei Qi ◽  
Weiwen Ge ◽  
Ningning Cao ◽  
Shoupeng Wang ◽  
Yifeng Qian ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Growth Factor ◽  
Alveolar Bone ◽  
Controlled Trial ◽  
Test Group ◽  
Control Group ◽  
Gingival Thickness ◽  
Randomized Controlled ◽  
Intergroup Comparison ◽  
Gingival Phenotype

Abstract Background: Earlier studies have not given clear results of concentrated growth factor (CGF) on gingival thickness (GT) in periodontal accelerated osteogenic orthodontics (PAOO). This randomized controlled trial aimed to evaluate the effects of CGF on GT in patients with thin gingival phenotype undergoing PAOO.Methods: 44 patients with 264 surgical sites were recruited at baseline. All patients were randomly allocated to either a control (collagen matrix memberane) or test (CGF) group and received PAOO. GT, gingival height (GH), buccal alveolar bone thickness (BT), and buccal alveolar bone height (BH) were evaluated depending on cross-sectional CBCT images at t0 (before surgery) and t1(6 months after surgery). Results: GT were increased in both groups at t1 compared to t0. Yet, higher values were observed in the test group (from 0.95±0.26 to 1.29±0.34mm) compared to the control group (from 0.92±0.25 to 1.01±0.18mm) (p < 0.05). Moreover, in the intergroup comparison, GT at t1 in the test group was significantly higher compared to the control group (p < 0.01). Furthermore, the GT of central incisors, lateral incisors and canine teeth all showed significantly changes compared with baseline and the test group showed higher increase (p < 0.01). No statistically significant difference were found in GH, BT, BH and all clinical parameters between two groups at t1 (p > 0.05). Conclusions: Within the limitation of this study, gingival thickness could be increased by using CGF in PAOO for the patients with thin gingival phenotype. Trial registration The study was registered in Chinese Clinical Trial Registry（http://www.chictr.org.cn/index.aspx）under the number ChiCTRINR17013346, Registered 11 November 2017.

scholarly journals Effects of autologous concentrated growth factor on gingival thickness in periodontal accelerated osteogenic orthodontics: a 6-month randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lei Qi ◽  
Weiwen Ge ◽  
Ningning Cao ◽  
Shoupeng Wang ◽  
Yifeng Qian ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Growth Factor ◽  
Alveolar Bone ◽  
Controlled Trial ◽  
Test Group ◽  
Control Group ◽  
Gingival Thickness ◽  
Randomized Controlled ◽  
Intergroup Comparison ◽  
Gingival Phenotype

Abstract Background Earlier studies have not given clear results of concentrated growth factor (CGF) on gingival thickness (GT) in periodontal accelerated osteogenic orthodontics (PAOO). This randomized controlled trial aimed to evaluate the effects of CGF on GT in patients with thin gingival phenotype undergoing PAOO. Methods Forty four patients presenting 264 anterior mandibular teeth were recruited and randomly allocated to one of the groups: test—positioning of autologous CGF after PAOO or control—positioning of a collagen membrane after PAOO. GT, gingival height (GH), buccal alveolar bone thickness (BT), and buccal alveolar bone height (BH) were evaluated depending on cross-sectional CBCT images at t0 (before surgery) and t1(6 months after surgery). Results GT were increased in both groups at t1 compared to t0. Yet, higher values were observed in the test group (from 0.94 ± 0.23 to 1.31 ± 0.33 mm) compared to the control group (from 0.94 ± 0.19 to 1.02 ± 0.16 mm) (p < 0.05). Moreover, in the intergroup comparison, GT at t1 in the test group was significantly higher compared to the control group (p < 0.01). Furthermore, the GT of central incisors, lateral incisors and canine teeth all showed significantly changes compared with baseline and the test group showed higher increase (p < 0.01). No statistically significant difference were found in GH, BT, BH and all clinical parameters between two groups at t1 (p > 0.05). Conclusions Within the limitation of this study, gingival thickness could be increased by using CGF in PAOO for the patients with thin gingival phenotype. Trial registration The study was registered in Chinese Clinical Trial Registry (http://www.chictr.org.cn/index.aspx) under the number ChiCTRINR17013346, Registered 11 November 2017.

scholarly journals Efficacy of nano-carbonate apatite dentifrice in relief from dentin hypersensitivity following non-surgical periodontal therapy: A randomized controlled trial

2019 ◽  
Author(s):  
Pei-Hui Ding ◽  
Anna Dai ◽  
Hua-Jiao Hu ◽  
Jia-Ping Huang ◽  
Jia-Mei Liu ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Test Group ◽  
Periodontal Therapy ◽  
Control Group ◽  
Carbonate Apatite ◽  
Dentine Hypersensitivity ◽  
Randomized Controlled ◽  
At Home

Abstract Background: Dentine hypersensitivity (DH) could occur or intensify after non-surgical periodontal therapy because of the exposure of dentine tubules. It has been demonstrated that nano-sized particles could seal these the dentine tubules. This randomized controlled trial aimed to investigate the efficacy of dentifrice containing nano-carbonate apatite (n-CAP) in reducing dentine hypersensitivity (DH) after non-surgical periodontal therapy. Methods: 48 periodontitis patients with DH were included in this clinical trial. After non-surgical periodontal therapy, patients included were randomized to test and control group and the respective dentifrices were applied at chairside, after which they were instructed to brush teeth with the allocated dentifrices twice a day at home. Periodontal parameters were recorded at baseline and the last follow-up. DH was measured by air-blast test and recorded by visual analogue scale (VAS) and Schiff sensitivity scale at baseline, after polishing (0 week) and 2/4/6 weeks. Results: 45 participants completed the follow-up. Periodontal parameters were improved and comparable between groups. Significant reduction in DH was observed in both groups at all time-points compared to baseline in terms of VAS and Schiff score. The test group achieved significantly greater relief from hypersensitivity compared with the control group after 4-week at-home use (for VAS, test group: 0.66 ± 0.68 versus control group: 0.84 ± 0.78, p = 0.005; for Schiff score, test group: 0.69 ± 0.71 versus control group: 0.97 ± 0.77, p < 0.001). Conclusions: Home-use of n-CAP based dentifrice provided a significantly better alleviation of DH following non-surgical periodontal therapy after 4 weeks compared to the control product. Trail registration: Chinese Clinical Trials Registry (No. ChiCTR-IPR-17011678, http://www.chictr.org.cn/, registered 16 June, 2017)

scholarly journals Home ovulation test use and stress during subfertility evaluation: Subarm of a randomized controlled trial

2019 ◽  
Vol 15 ◽  
pp. 174550651983836
Author(s):  
Sarah Weddell ◽  
Georgina L Jones ◽  
Sheila Duffy ◽  
Cameron Hogg ◽  
Sarah Johnson ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Confidence Interval ◽  
Average Length ◽  
Controlled Trial ◽  
Test Group ◽  
Well Being ◽  
Control Group ◽  
Psychological Well Being ◽  
Randomized Controlled ◽  
The Impact

Objectives: A prospective, randomized controlled trial in women seeking to conceive examined the impact of using ovulation tests on self-reported levels of stress, psychological well-being, and quality of life in women with unexplained infertility. Method: The test group used a home ovulation test to detect the day of ovulation, whereas the control group were provided with a predicted day of ovulation based on the average length of menstrual cycle reported during study recruitment. Volunteers collected their first morning urine samples to evaluate biochemical levels of stress (urinary cortisol and estrone-3-glucouronide) and completed questionnaires over two complete menstrual cycles. Results: Overall, the use of digital ovulation tests by sub-fertile women under medical care had negligible negative effects and no detectable positive benefit on psychological well-being, according to multiple measurements of stress by questionnaire and biochemical markers. No significant differences were found between groups for all stress measures at the various study time points, except in relation to “couple concordance” where the test group scored much higher than the control group (mean difference at end of study was 21.25 (95% confidence interval: 9.25, 33.25; P = 0.0015)). The maximum difference in log cortisol: creatinine ratio between the test and control groups was −0.28 (95% confidence interval: −0.69, 0.13). Conclusions: These results do not support propositions that using digital ovulation tests can cause stress in women trying to conceive.

scholarly journals Efficacy of nano-carbonate apatite dentifrice in relief from dentin hypersensitivity following non-surgical periodontal therapy: A randomized controlled trial

2020 ◽  
Author(s):  
Pei-Hui Ding ◽  
Anna Dai ◽  
Hua-Jiao Hu ◽  
Jia-Ping Huang ◽  
Jia-Mei Liu ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Test Group ◽  
Periodontal Therapy ◽  
Control Group ◽  
Dentin Hypersensitivity ◽  
Carbonate Apatite ◽  
Dentine Hypersensitivity ◽  
Randomized Controlled

Abstract Background: Dentine hypersensitivity (DH) could occur or intensify after non-surgical periodontal therapy because of the exposure of dentine tubules, but currently no gold standard exists to treat DH. It has been demonstrated that nano-sized particles presented potential for dentine tubules blocking and remineralization. This randomized controlled trial aimed to investigate the efficacy of dentifrice containing nano-carbonate apatite (n-CAP) in reducing dentine hypersensitivity (DH) after non-surgical periodontal therapy. Methods: 48 periodontitis patients with DH were included in this clinical trial. After non-surgical periodontal therapy, patients included were randomized to test and control group and the respective dentifrices were applied at chairside, after which they were instructed to brush teeth with the allocated dentifrices twice a day at home. Periodontal parameters were recorded at baseline and the last follow-up. DH was measured by air-blast test and recorded by visual analogue scale (VAS) and Schiff sensitivity scale at baseline, after polishing (0 week) and 2/4/6 weeks. Results: 45 participants completed the follow-up. Periodontal parameters were improved and comparable between groups. Significant reduction in DH was observed in both groups at all time-points compared to baseline in terms of VAS and Schiff score. The test group achieved significantly greater relief from hypersensitivity compared with the control group after 4-week at-home use (for change of VAS, test group: 2.27 ± 2.47 versus control group: 1.68 ± 2.24, p = 0.036; for change of Schiff, test group: 0.94 ± 0.92 versus control group: 0.61 ± 0.83, p < 0.001). The 6-week results showed borderline significance between groups in terms of change of Schiff (p = 0.027) and no significance in terms of change of VAS (p = 0.256). Conclusions: Home-use of n-CAP based dentifrice had some benefit on alleviation of DH following non-surgical periodontal therapy after 4 weeks compared to the control product. Trial registration: Chinese Clinical Trials Registry (No. ChiCTR-IPR-17011678, http://www.chictr.org.cn/, registered 16 June, 2017) Keywords: dentin hypersensitivity; dentifrices; randomized controlled trial; periodontitis

Smartphone application-assisted oral hygiene of orthodontic patients: a multicentre randomized controlled trial in adolescents

2020 ◽  
Vol 42 (6) ◽  
pp. 605-611 ◽  
Author(s):  
Marine Deleuse ◽  
Catherine Meiffren ◽  
Annick Bruwier ◽  
Nathalie Maes ◽  
Michel Le Gall ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Oral Hygiene ◽  
Controlled Trial ◽  
Test Group ◽  
Smartphone Application ◽  
Control Group ◽  
Randomized Controlled ◽  
Academic Hospitals ◽  
Orthodontic Patients ◽  
Electric Toothbrush

Summary Objective The aim of this trial was to test whether the use of a smartphone application (app) connected to a toothbrush improves the oral hygiene compliance of adolescent orthodontic patients. Design The study was designed as a multicentre, randomized, controlled clinical trial. Setting Two academic hospitals. Ethical approval The study was approved by the ethics committee. Subjects and methods This multicentre randomized controlled trial was conducted on 38 adolescents aged 12–18 years with full-fixed orthodontic appliances. Participants were randomly assigned either to a test group that used an interactive oscillating/rotating electric toothbrush connected to a brushing aid app or to a control group that used an oscillating/rotating electric toothbrush alone. At baseline, all patients received verbal and written oral hygiene instructions. Outcome measurements Data collection was performed at T1 (baseline), T2 (6 weeks), T3 (12 weeks) and T4 (18 weeks—end of the study). At each time point, the plaque index (PI), gingival index (GI) and white spot lesion (WSL) score were recorded. Several app-related parameters were evaluated. Patient-related outcome measures were investigated in the test group. Results Test and control groups were similar at baseline except for WSL score. Between T1 and T4, PI and GI decreased significantly in both groups but evolutions were globally similar in both groups. Interestingly, at T3 (12 weeks), the PI was significantly lower in the app group than in the control group (P = 0.014). Data showed a marked decline in the use of the app over time in the test group. Conclusions This trial, conducted over 18 weeks in two academic hospitals, showed no significant effect of the use of the app in promoting oral hygiene. Trial registration Not registered

Effects of mirror therapy on motor aphasia after acute cerebral infarction: A randomized controlled trial

2021 ◽  
pp. 1-15
Author(s):  
Qingmei Chen ◽  
Wenjun Shen ◽  
Haiwei Sun ◽  
Dan Shen ◽  
Xiuying Cai ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Functional Connectivity ◽  
Cerebral Infarction ◽  
Controlled Trial ◽  
Test Group ◽  
Control Group ◽  
Mirror Therapy ◽  
Motor Aphasia ◽  
Randomized Controlled

BACKGROUND: Mirror therapy (MT) has proven to be beneficial for treating patients suffering from motor aphasia after stroke. However, the impacts of MT on neuroplasticity remain unexplored. OBJECTIVE: In this paper we conducted a randomized controlled trial to evaluate the treatment using the MT on motor aphasia following acute cerebral infarction. METHODS: We randomly assigned 30 patients into test and control groups, with test group patients treated with MT, whereas control group patients were treated with sham MT. At 24 hours prior to and after the intervention, we obtained functional magnetic resonance imaging (fMRI) data from study subjects. At baseline, after treatment and 12-week follow-up, we additionally evaluated patients with the Modified Rankin Scale (mRS), the National Institutes of Health Stroke Scale (NIHSS), and the aphasia quotient (AQ) in the western aphasia test. RESULTS: After 2 weeks of treatment, the test group demonstrated significant improvements in AQ values, naming, repetition, spontaneous speech, and mRS scores compared to the control group (P <  0.05). Furthermore, in the follow-up time point (12 weeks), we found that the test group exhibited significantly better NIHSS scores and AQ evaluation indicators than the control group (P <  0.05). Specifically, the fMRI study shows that functional connectivity significantly improved in test group patients mainly among frontal, temporal, and parietal lobes of the left hemisphere with each other than controls group. Meanwhile, we found significantly enhanced functional connectivity with the hippocampus (P <  0.01). CONCLUSIONS: Our results indicate that the MT can expedite the recovery of language function during the early phases of stroke recovery. These findings may elucidate the underlying mechanism of MT and the application of this therapy as an adjunct rehabilitation technique in language recovery.

scholarly journals A Randomized Controlled Trial and Radiographic Evaluation of Adjunctive Periodontal Treatment with Calcium and Vitamin D Supplementation

2016 ◽  
Vol 5 (1) ◽  
pp. 50-55
Author(s):  
Arpapan Bundit ◽  
Pusadee Yotnuengnit ◽  
Sirinun Wisetsin ◽  
Apichart Chittacharoen
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Test Group ◽  
Vitamin D Supplementation ◽  
Periodontal Treatment ◽  
Radiographic Evaluation ◽  
Control Group ◽  
Bony Defect ◽  
Randomized Controlled

ABSTRACT Aim The objective of this study was to use clinical parameters, digital subtraction analysis, and computer intensity measurement to evaluate the effect of calcium and vitamin D supplementation in adult periodontitis patients with vertical bony defect after initial therapy. Materials and methods A total of 31 systemically healthy patients with moderate to severe chronic periodontitis and normal serum calcium level were included. The most obvious proximal vertical bony defect was selected in each patient as an area of interest (AOI). Subjects received initial periodontal therapy. They were randomized into two groups. The test group (n= 17) received calcium (600 mg twice daily) and vitamin D (0.25 µg once daily) supplements for 6 months. The control group (n= 14) received placebos. At baseline and 6 months, probing pocket depth (PPD), clinical attachment level (CAL), and standardized vertical bitewing radiographs were recorded for the AOI. Results A greater percentage of patients in the test group (64.7%) than in the control group (35.7%) gained bone according to both radiographic evaluation methods. At baseline and 6 months, no significant intragroup or intergroup differences in PPD and CAL were observed. Slightly greater PPD reduction and CAL gain were noted in the test group. Conclusion Periodontal healing of vertical bony defects was better among patients who used calcium and vitamin D supplements than among control patients. Although the difference was not statistically different between the groups, the test group tended toward more improvement. How to cite this article Bundit A, Yotnuengnit P, Wisetsin S, Chittacharoen A. A Randomized Controlled Trial and Radiographic Evaluation of Adjunctive Periodontal Treatment with Calcium and Vitamin D Supplementation. Int J Experiment Dent Sci 2016;5(1):50-55.

Evaluation of a collaborative protocolized approach by community pharmacies and general medical practitioners for an Australian minor ailments scheme: study protocol for a cluster-randomized controlled trial (Preprint)

2019 ◽  
Author(s):  
Sarah Dineen-Griffin ◽  
Victoria Garcia Cardenas ◽  
Kylie Williams ◽  
Shalom Isaac Benrimoj
Keyword(s):  
Randomized Controlled Trial ◽  
Usual Care ◽  
Controlled Trial ◽  
Self Care ◽  
Cluster Randomized Controlled Trial ◽  
Control Group ◽  
Community Pharmacies ◽  
Randomized Controlled ◽  
Minor Ailments ◽  
Cluster Randomized

BACKGROUND Internationally, governments have been investing in supporting pharmacists to take on an expanded role to support self-care for health system efficiency. There is consistent evidence that minor ailment schemes (MAS) promote efficiencies within the healthcare system. The cost savings and health outcomes demonstrated in the UK and Canada opens up new opportunities for pharmacists to effect sustainable changes through MAS delivery in Australia. OBJECTIVE This trial is evaluating the clinical, economic and humanistic impact of an Australian minor ailments service (AMAS), compared with usual pharmacy care in a cluster-randomized controlled trial in Western Sydney, Australia. METHODS The cluster-randomized controlled trial design has an intervention and a control group, comparing individuals receiving a structured intervention with those receiving usual care for specific common ailments. Participants will be community pharmacies, general practices and patients located in Western Sydney Primary Health Network region. 30 community pharmacies will be randomly assigned to either intervention or control group. Each will recruit 24 patients seeking, aged 18 years or older, presenting to the pharmacy in person with a symptom-based or product-based request for one of the following ailments (reflux, cough, common cold, headache (tension or migraine), primary dysmenorrhoea and low back pain). Intervention pharmacists will deliver protocolized care to patients using clinical treatment pathways with agreed referral points and collaborative systems boosting clinician-pharmacist communication. Patients recruited in control pharmacies will receive usual care. The co-primary outcomes are rates of appropriate use of nonprescription medicines and rates of appropriate medical referral. Secondary outcomes include self-reported symptom resolution, time to resolution of symptoms, health services resource utilization and EQ VAS. Differences in the primary outcomes between groups will be analyzed at the individual patient level accounting for correlation within clusters with generalized estimating equations. The economic impact of the model will be evaluated by cost analysis compared with usual care. RESULTS The study began in July 2018. At the time of submission, 30 community pharmacies have been recruited. Pharmacists from the 15 intervention pharmacies have been trained. 27 general practices have consented. Pharmacy patient recruitment began in August 2018 and is ongoing and monthly targets are being met. Recruitment will be completed March 31st, 2019. CONCLUSIONS This study may demonstrate the utilization and efficacy of a protocolized intervention to manage minor ailments in the community, and will assess the clinical, economic and humanistic impact of this intervention in Australian pharmacy practice. Pharmacists supporting patient self-care and self-medication may contribute greater efficiency of healthcare resources and integration of self-care in the health system. The proposed model and developed educational content may form the basis of a MAS national service, with protocolized care for common ailments using a robust framework for management and referral. CLINICALTRIAL Registered with Australian New Zealand Clinical Trials Registry (ANZCTR) and allocated the ACTRN: ACTRN12618000286246. Registered on 23 February 2018.

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