scholarly journals Trend Analysis of Hepatitis B and C Among Patients Visiting Health Facility of Tigrai, Ethiopia, 2014-2019

2021 ◽  
Author(s):  
Haftom Legese ◽  
Brhane Berhe ◽  
Gebre Adhanom ◽  
Tsega Kahsay ◽  
Aderajew Gebrewahd ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Hepatitis B ◽  
Binary Logistic Regression ◽  
P Value ◽  
Binary Logistic Regression Analysis ◽  
Chi Square ◽  
Effective Prevention ◽  
Modes Of Transmission

Abstract Background: Hepatitis B and C viruses are the major public health concerns of the globe. The two hepatotropic viruses share common modes of transmission and their co-infection is common. Despite the provision of an effective prevention mechanism, the infections caused by these viruses’ remains a significant problem worldwide, particularly among the developing countries like Ethiopia.Methods: Institutional based retrospective study design was conducted from January 2014 to December 2019 from documented serology laboratory logbooks and patient charts at the serology laboratory of Adigrat general hospital, Tigrai, Ethiopia. The collected data were checked for completeness on daily based, coded, entered and cleaned using Epinfo version 7.1 and exported and analyzed using SPSS version 23. Binary logistic regression analysis and Chi-square test (X2) were used to assess the association between dependent and independent variables. The corresponding variables with P-value (P <0.05) with a 95% confidence interval were considered as statistically significant. Results: Out of 20935 clinically suspected specimens tested for hepatitis B and C viruses with total completeness of 20622 were included in this study with a total completeness 98.5%. The overall prevalence of hepatitis B and hepatitis C virus was found to be 3.57 % (689/19,273) and 2.13% (30/1,405) respectively. The positivity rate of hepatitis B virus was 8.0% (106/1317) and 3.24% (583/17,956) among males and females respectively. Additionally, 2.49 %( 12/481) of males and 1.94% (18/924) females were positive for hepatitis C virus infection. The overall prevalence of co-infection for both hepatitis B and hepatitis C virus was 7.4% (4/54). Sex and age were significantly associated with hepatitis B and C virus infection. Conclusions: The overall prevalence of hepatitis B and C is low intermediate according to the WHO criteria. Both hepatitis B and C share similar routes of transmission and affects all age and male sex. Therefore, awareness creation of the community about the methods of transmission, education about prevention, and control of hepatitis B and C virus infection, improving coverage of youth-friendly services in the health facilities should be strengthened.

High prevalence of occult hepatitis C virus infection in patients with chronic hepatitis B virus infection

2013 ◽  
Vol 62 (8) ◽  
pp. 1235-1238 ◽  
Author(s):  
Inmaculada Castillo ◽  
Javier Bartolomé ◽  
Juan Antonio Quiroga ◽  
Vicente Carreño
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Hcv Infection ◽  
Hbv Infection ◽  
Chronic Hepatitis B Virus ◽  
B Virus

Hepatitis C virus (HCV) infection in the absence of detectable antibodies against HCV and of viral RNA in serum is called occult HCV infection. Its prevalence and clinical significance in chronic hepatitis B virus (HBV) infection is unknown. HCV RNA was tested for in the liver samples of 52 patients with chronic HBV infection and 21 (40 %) of them were positive for viral RNA (occult HCV infection). Liver fibrosis was found more frequently and the fibrosis score was significantly higher in patients with occult HCV than in negative ones, suggesting that occult HCV infection may have an impact on the clinical course of HBV infection.

Risk Factors and Seroprevalence of Hepatitis B Virus, Hepatitis C Virus, and Human Immunodeficiency Virus Infection in Uzbekistan

Intervirology ◽  
2001 ◽  
Vol 44 (6) ◽  
pp. 327-332 ◽  
Author(s):  
Ruslan Ruzibakiev ◽  
Hideaki Kato ◽  
Ryuzo Ueda ◽  
Nodira Yuldasheva ◽  
Tatyana Hegay ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Immunodeficiency Virus ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Virus Hepatitis ◽  
B Virus ◽  
Immunodeficiency Virus

scholarly journals Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kazuhiro Murai ◽  
Hayato Hikita ◽  
Yugo Kai ◽  
Yasuteru Kondo ◽  
Makoto Fukuoka ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Virus Replication ◽  
Hepatitis C Virus Infection ◽  
B Virus

scholarly journals Hepatitis B vaccine efficacy in patients with chronic liver disease by hepatitis C virus

2004 ◽  
Vol 41 (3) ◽  
pp. 180-184 ◽  
Author(s):  
Angelo Alves de Mattos ◽  
Eliana Buksztejn Gomes ◽  
Cristiane Valle Tovo ◽  
Cláudio Osmar Pereira Alexandre ◽  
José Oscar dos Reis Remião
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Virus Infection ◽  
Hepatitis B ◽  
Chronic Liver Disease ◽  
Chronic Hepatitis C ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus

BACKGROUND: Considering the immunosuppression of patients with chronic liver disease, their response to vaccination is discussed in literature. AIMS: To evaluate the response of hepatitis B vaccine in patients with chronic hepatitis C virus infection. METHODS: This is a prospective study in which 85 patients with chronic hepatitis C virus infection (46.8 ± 9.4 years, 44.7% males) and 46 healthy adults (36.7 ± 11.1 years; 39.1% males) were evaluated. Confirmation of hepatitis C virus was obtained by the technique of polymerase chain reaction. Viral load was determined by the branched DNA method in 74 patients, and genotype was determined by sequencing in 73 patients. All patients and healthy adults received three doses of Engerix B® vaccine IM (at 0, 30 and 180 days). Serological responses to the vaccine were divided into three categories: seroprotection, when anti-HBs was >100 mUI/mL; seroconversion, when anti-HBs was 10-99 mUI/mL, and non-reagent, when anti-HBs was <10 mUI/mL. RESULTS: The response of hepatitis B vaccine as determined 1 month following dose 3 was seroprotection in 37.7%, seroconversion in 17.6% and non-reagent in 44.7% among patients and 84.8%, 13.0%, 2.2%, respectively in healthy adults. The number of non-reagent responses was significantly higher among those patients with chronic liver disease. Sixty-five patients with chronic hepatitis were compared to 20 compensated cirrhotic patients in concern to the response to vaccine, but no difference was found. The response to vaccine in patients with genotypes 2 or 3 (n = 40) was better than in those with genotype 1 (n = 33). Response was not related to serum HCV-RNA concentration. CONCLUSION: The number of non-responders was higher in patients with chronic hepatitis C virus infection, irrespective of histological status and viral load. It is suggested that such patients should receive a double dose of vaccine, particularly the ones with genotype 1.

Prevalence and Risk Factors for Bloodborne Exposure and Infection in Correctional Healthcare Workers

2007 ◽  
Vol 28 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Robyn R. M. Gershon ◽  
Martin Sherman ◽  
Clifford Mitchell ◽  
David Vlahov ◽  
Melissa J. Erwin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Hepatitis B ◽  
Healthcare Workers ◽  
Hepatitis B Vaccination ◽  
Hepatitis C Virus Infection ◽  
Job Duties ◽  
Correctional Healthcare

Objective.To determine the prevalence and risk factors for bloodborne exposure and infection in correctional healthcare workers (CHCWs).Design.Cross-sectional risk assessment study with a confidential questionnaire and serological testing performed during 1999-2000.Setting.Correctional systems in 3 states.Results.Among 310 participating CHCWs, the rate of percutaneous injury (PI) was 32 Pis per 100 person-years overall and 42 Pis per 100 person-years for CHCWs with clinical job duties. Underreporting was common, with only 25 (49%) of 51 Pis formally reported to the administration. Independent risk factors for experiencing PI included being age 45 or older (adjusted odds ratio [aOR], 2.41 (95% confidence interval (CI), 1.31-4.46]) and having job duties that involved needle contact (aOR, 3.70 [95% CI, 1.28-10.63]) or blood contact (aOR, 5.05 [95% CI, 1.45-17.54]). Overall, 222 CHCWs (72%) reported having received a primary hepatitis В vaccination series; of these, 150 (68%) tested positive for anti-hepatitis B surface antigen, with negative results significantly associated with receipt of last dose more than 5 years previously. Serologic markers of hepatitis В virus infection were identified in 31 individuals (10%), and the prevalence of hepatitis B virus infection was 2% (n = 7). The high hepatitis B vaccination rate limited the ability to identify risk factors for infection, but hepatitis C virus infection correlated with community risk factors only.Conclusion.Although the wide coverage with hepatitis B vaccination and the decreasing rate of hepatitis C virus infection in the general population are encouraging, the high rate of exposure in CHCWs and the lack of exposure documentation are concerns. Continued efforts to develop interventions to reduce exposures and encourage reporting should be implemented and evaluated in correctional healthcare settings. These interventions should address infection control barriers unique to the correctional setting.

Sign in / Sign up

Export Citation Format

Share Document