scholarly journals Analysis of Risk Factors for Changes in The Doppler Echocardiographic Indexes of Patients With Gout

2021 ◽  
Author(s):  
Wantai Dang ◽  
Danling Luo ◽  
Hui Luo ◽  
Jing Hu ◽  
Xiaohui Xu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Function ◽  
Left Atrial Volume ◽  
Left Ventricular ◽  
Volume Index ◽  
Wall Thickening ◽  
Course Of Disease ◽  
Left Ventricular Structure ◽  
Ventricular Structure ◽  
Mitral Annulus Velocity

Abstract Objective: The analysis of risk factors for changes in the Doppler echocardiographic indexes of patients with gout with different serum uric acid (SUA) levels were explored to provide clinical evidence for the early diagnosis and treatment of abnormal heart function in this patients.Methods: We obtained information of 227 patients with primary gout (intermittent period), the left ventricular structure and functional index were measured using echocardiography and multivariate logistics regression was used to analyze the risk factors related to changes in heart function in patients with gout.Results: Logistic regression analysis showed that the course of disease and cystatin C (Cys-C) were risk factors for the increase of left atrial volume index (LAVI) (OR=1.14, 105.47; 95% CI, 1.01-1.28, 1.18-9468.03). Age, body mass index (BMI), course of disease, and diabetes were risk factors for the increase of the ratio of diastolic peak early transmission flow velocity to peak early diastolic mitral annulus velocity (E/Em) (OR=1.04, 1.17, 1.14, 4.82; 95% CI, 1.01-1.08, 1.03-1.33, 1.02-1.27, 1.07-21.71). However, the percentage of neutrophils percentage (NE%) and lymphocytes percentage (LY%) might reduce the risk of left ventricular wall thickening, whereas HGB might reduce the risk of increasing E/Em (OR=0.80, 0.75, 0.94; 95% CI, 0.66-0.96, 0.60-0.93, 0.89-1.00).Conclusion: Our findings suggest that BMI, course of disease, diabetes, and Cys-C are risk factors for decreased left ventricular function. Furthermore, HGB, NE%, and LY% appear to have a weak protective effect for the remodeling of left ventricular structure and function.

scholarly journals Relationships Among HIV Infection, Metabolic Risk Factors, and Left Ventricular Structure and Function

2013 ◽  
Vol 29 (8) ◽  
pp. 1151-1160 ◽  
Author(s):  
William Todd Cade ◽  
Edgar Turner Overton ◽  
Kristin Mondy ◽  
Lisa de las Fuentes ◽  
Victor G. Davila-Roman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hiv Infection ◽  
Left Ventricular ◽  
Structure And Function ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Left Ventricular Structure ◽  
Ventricular Structure ◽  
And Function

Abstract 4201: A New Echo Index, Left Atrial Volume Index Over Late Diastolic Mitral Annulus Velocity Can Predict Elevated Left Ventricular Filling Pressures And Clinical Outcomes

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Hun-Jun Park ◽  
Mahn-Won Park ◽  
Byung-Joo Shim ◽  
Mi-Jung Lee ◽  
Jae-Hong Park ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Clinical Outcomes ◽  
Left Atrial Volume ◽  
Mitral Annulus ◽  
Left Ventricular ◽  
Volume Index ◽  
Atrial Volume ◽  
Left Atrial Volume Index ◽  
Mitral Annulus Velocity ◽  
Ventricular Filling

Background: Another non-invasive method for prediction of elevated left ventricular filling pressure (LVFP) have attracted attention in clinical practice. Objectives: This study was to verify the clinical usefulness of left atrial volume index over late diastolic mitral annulus velocity (LAVi/A′) for the predictors of advanced (pseudonormal to restrictive physiology) diastolic dysfunction in the presence of elevated LVFP and clinical outcomes using right heart catheterization (RHC). Methods: 163 patients (95 men, mean age 61±13 years) with dyspnea underwent comprehensive Doppler echocardiography, RHC and B-type natriuretic peptide (BNP) measurement. Using ROC curve, we compared the areas under the curves (AUC) of LAVi/A′, transmitral early diastolic/annular velocity ratio (E/E′), and BNP level for the prediction of advanced diastolic dysfunction. During a median follow-up of 13.3 months, the incidence of the composite outcomes of cardiac death or re-hospitalization for heart failure was compared based on the optimal cut-off value of LAVi/A′. Results: The AUC of LAVi/A′ was comparable to that of BNP (0.91 vs. 0.90; p=0.78) and E/E′ (0.91 vs. 0.93; p=0.78) for prediction of advanced diastolic dysfunction. 68/163 (41.7%) patients had LAVi/A′ ≥4.0 and they had significantly higher BNP level and longer time difference between atrial reversal flow of pulmonary vein and transmitral late diastolic flow (AR dur -A dur ) compared with those of LAVi/A′ <4.0 (BNP: 1207±1212 vs. 176±365 pg/ml; AR dur -A dur: 24.6±21.1 vs. −3.3±15.9 msec, p<0.001, respectively). The LAVi/A′ had a reasonable correlation with mean PCWP (r=0.64, r 2 =0.41, p=0.001), which was comparable to that of E/E′ (r=0.60, r 2 =0.36, p=0.002). On Cox proportional hazard analysis, EF<50%, age ≥65 years, and LAVi/A′ ≥4.0 were independent outcome predictors with odds ratios of 4.8 (95% CI: 2.0 to 11.7), 3.8 (95% CI: 1.8 to 7.8), and 3.9 (95% CI: 1.5 to 9.8), respectively (p<0.01 for all). Conclusions: LAVi/A′ ≥4.0 is useful clinical predictors for advanced diastolic dysfunction in the presence of elevated LVFP and clinical outcomes.

Abstract 14622: Longitudinal Changes in Left Ventricular Diastolic Function in Late Life: The Atherosclerosis Risk in Communities (ARIC) Study

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Li Zhao ◽  
Brian Claggett ◽  
Kunihiro Matsushita ◽  
Dalane W Kitzman ◽  
Aaron R Folsom ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Diastolic Function ◽  
Left Atrial Volume ◽  
Late Life ◽  
Left Ventricular ◽  
Volume Index ◽  
Left Atrial Volume Index ◽  
Longitudinal Changes ◽  
Aric Study

Introduction: Diastolic dysfunction is a potent risk factor for heart failure (HF). However, there is limited data regarding longitudinal changes of diastolic function in the very old, who are at the highest risk for HF. Methods: We studied 2,559 community-based elderly participants in the prospective ARIC study who underwent protocol echocardiography, were in sinus rhythm at study Visits 5 (2011-2013) and 7 (2018-2019), and did not have an interval myocardial infarction. The primary diastolic measures were Tissue Doppler e’, E/e’ ratio, and left atrial volume index (LAVi). Results: Mean age at Visit 5 was 74±4 years, 59% were women, and 25% black. At Visit 5, mean e’ was 5.8±1.4 cm/s, E/e’ 11.8±3.6, and LAVi 24.3±6.7 ml/m 2 . Over a mean of 6.5±3.1 years, e’ decreased by 0.6±1.4 cm/s, E/e’ increased by 3.1±4.5, and LAVi increased by 1.4±7.7 ml/m 2 . Using validated ARIC-based cut-points, there was significant increase in the proportion of participants with abnormal e’ (18% at Visit 5 to 34 % at Visit 7), E/e’ (20% vs 46%), LAVi (17% vs 25%; all p<0.01), and in the number of abnormal diastolic measures ( Figure ). Compared to participants free of cardiovascular (CV) risk factors or CV diseases (n=237), those with CV risk factors or diseases at Visit 5 (n=2,210) demonstrated greater increases in E/e’ (2.3±3.9 vs 3.1±4.5 respectively; p=0.006) and LAVi (0.0±7.0 vs 1.5±7.7 ml/m 2 ; p=0.008) while increases in E/e’ (5.0±5.1; p<0.001) and LAVi (4.6±8.7 ml/m 2 ; p<0.001) were the most prominent in those who developed HF between Visits 5 and 7 (n=60). Conclusions: Diastolic function progressively worsens over 6.5 years in late life, particularly among persons with CV risk factors. Further studies are necessary to determine if risk factor prevention or control will mitigate these changes.

scholarly journals Superior cardiac mechanics without structural adaptations in pre-adolescent soccer players

2019 ◽  
Vol 27 (14) ◽  
pp. 1494-1501 ◽  
Author(s):  
Alexander Beaumont ◽  
David Oxborough ◽  
Keith George ◽  
Thomas W Rowland ◽  
Nicholas Sculthorpe ◽  
...  
Keyword(s):  
Structure Function ◽  
Wall Thickness ◽  
Cardiac Mechanics ◽  
Left Ventricular ◽  
Soccer Players ◽  
Volume Index ◽  
Cross Sectional ◽  
Left Ventricular Structure ◽  
End Diastolic Volume ◽  
Ventricular Structure

Aims This study aimed to evaluate left ventricular structure, function and mechanics, in highly-trained, pre-adolescent soccer players compared with age- and sex-matched controls. Design The study design was a prospective, cross-sectional comparison of left ventricular structure, function and mechanics. Methods Twenty-two male soccer players from two professional youth soccer academies (age: 12.0 ± 0.3 years) and 22 recreationally active controls (age: 11.7 ± 0.3 years) were recruited. Two-dimensional conventional and speckle tracking echocardiography were used to quantify left ventricular structure, function and peak/temporal values for left ventricular strain and twist, respectively. Results End-diastolic volume index was larger in soccer players (51 ± 8 mm/(m2)1.5 vs. 45 ± 6 mm/(m2)1.5; p = 0.007) and concentricity was lower in soccer players (4.3 ± 0.7 g/(mL)0.667 vs. 4.9 ± 1.0 g/(mL)0.667; p = 0.017), without differences in mean wall thickness between groups (6.0 ± 0.4 mm vs. 6.1 ± 0.5 mm; p = 0.754). Peak circumferential strain at the base (–22.2% ± 2.5% vs. –20.5% ± 2.5%; p = 0.029) and papillary muscle levels (–20.1% ± 1.5% vs. –18.3% ± 2.5%; p = 0.007) were greater in soccer players. Peak left ventricular twist was larger in soccer players (16.92° ± 7.55° vs. 12.34° ± 4.99°; p = 0.035) and longitudinal early diastolic strain rate was greater in soccer players (2.22 ± 0.40 s–1 vs. 2.02 ± 0.46 s–1; p = 0.025). Conclusions Highly-trained soccer players demonstrated augmented cardiac mechanics with greater circumferential strains, twist and faster diastolic lengthening in the absence of differences in wall thickness between soccer players and controls.

scholarly journals EXPRESS: Partitioning risk factors for embolic stroke of undetermined source (ESUS) using exploratory factor analysis

2021 ◽  
pp. 174749302110098
Author(s):  
Jon Davis Perkins ◽  
Naveed Akhtar ◽  
Rajvir Singh ◽  
Assad Kamran ◽  
Saadat Ilyas
Keyword(s):  
Risk Factors ◽  
Factor Analysis ◽  
Aortic Arch ◽  
Exploratory Factor Analysis ◽  
Heart Function ◽  
Left Ventricular ◽  
Embolic Stroke ◽  
Volume Index ◽  
Left Heart ◽  
Latent Factors

Background Embolic stroke of undetermined source (ESUS) accounts for up to 25% of strokes. Understanding risk factors associated with ESUS is important in reducing stroke burden worldwide. However, ESUS patients are younger and present with fewer traditional risk factors. Significant global variation in ESUS populations also exists making the clinical picture of this type of stroke unclear. Methods and Results ESUS patients were pair matched for age, sex and ethnicity with a group of all other strokes (both n=331). Exploratory factor analysis was applied in both groups to 14 risk and clinical factors to identify latent factors. In ESUS patients, two latent factors emerged consisting primarily of heart related variables such as left ventricular wall motion abnormalities, reduced ejection fraction and increased left atrial volume index, as well as, aortic arch atherosclerosis. This is in comparison to the all other strokes group, which was dominated by traditional stroke risk factors. Conclusions Our findings support the existence of a unique pattern of risk factors specific to ESUS. We show that LVWMA and corresponding changes in left heart function are a potential source of emboli in these patients. In addition, the clustering of aortic arch atherosclerosis with left heart factors suggests a causal link. Through the application of exploratory factor analysis, this work contributes to a further understanding of stroke mechanisms in ESUS.

Immunoglobulins and Left Ventricular Structure and Function in Pediatric HIV Infection

Circulation ◽  
1995 ◽  
Vol 92 (8) ◽  
pp. 2220-2225 ◽  
Author(s):  
Steven E. Lipshultz ◽  
E. John Orav ◽  
Stephen P. Sanders ◽  
Steven D. Colan
Keyword(s):  
Hiv Infection ◽  
Left Ventricular ◽  
Structure And Function ◽  
Pediatric Hiv ◽  
Left Ventricular Structure ◽  
Ventricular Structure ◽  
And Function
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