Prevalence of Anti-Phospholipid Autoantibodies and Their Association with Respiratory SOFA Component in Patients with COVID-19 Pneumonia: A Prospective Cohort Analysis in Tunisia

Abstract Purpose: The aim of our study was to evaluate the prevalence of aPLAs among Tunisian critically-ill covid19 and non-covid19 patients and to investigate the clinical significance of aPLAs by determining the SOFA score and their respiratory failure during their ICU stay. Methods: We conducted a prospective observational cohort study including critically ill COVID-19 patients and non-COVID-19 patients with pulmonary origin sepsis, admitted to the intensive care unit. Blood samples were collected on days 1, 3, 5, 8 and 10 of hospitalization in order to measure titers of anti-cardiolipin (aCL), anti-phosphatidylserine (aPS) by chemiluminescence immunoassay. Results: We enrolled 43 COVID-19 patients and 31 non COVID-19 with pulmonary origin sepsis. In-hospital mortality rate was significantly higher (p=0.026) in COVID-19 patients (79%). 58.8% of COVID-19 patients were aPLA positive; however, only 22.5% of the non-COVID-19 were positive for aPLA (p=0.002). A significant positive correlation existed between respiratory SOFA component at days 3, 5, 8 and 10 and anti-phospholipid antibodies concentrations. Conclusion: Based on our results, for the first time, anti-phospholipid antibodies may be used as an independent indicator of respiratory organ failure in critically ill patients, to stratify and assess the prognosis of pulmonary origin sepsis and COVID-19.

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Incidence and short-term consequences of delirium in critically ill patients: A prospective observational cohort study

International Journal of Nursing Studies ◽

10.1016/j.ijnurstu.2011.11.016 ◽

2012 ◽

Vol 49 (7) ◽

pp. 775-783 ◽

Cited By ~ 103

Author(s):

Mark van den Boogaard ◽

Lisette Schoonhoven ◽

Johannes G. van der Hoeven ◽

Theo van Achterberg ◽

Peter Pickkers

Keyword(s):

Cohort Study ◽

Critically Ill ◽

Critically Ill Patients ◽

Observational Cohort Study ◽

Prospective Observational Cohort Study ◽

Short Term ◽

Observational Cohort

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Systemic and Urinary Neutrophil Gelatinase-Associated Lipocalins Are Poor Predictors of Acute Kidney Injury in Unselected Critically Ill Patients

Critical Care Research and Practice ◽

10.1155/2012/712695 ◽

2012 ◽

Vol 2012 ◽

pp. 1-8 ◽

Cited By ~ 4

Author(s):

Annick A. Royakkers ◽

Catherine S. Bouman ◽

Pauline M. Stassen ◽

Joke C. Korevaar ◽

Jan M. Binnekade ◽

...

Keyword(s):

Acute Kidney Injury ◽

Critically Ill ◽

Critically Ill Patients ◽

Secondary Analysis ◽

Kidney Injury ◽

Observational Cohort Study ◽

Prospective Observational Cohort Study ◽

Neutrophil Gelatinase Associated Lipocalin ◽

Observational Cohort ◽

Neutrophil Gelatinase

Background. Neutrophil gelatinase-associated lipocalin (NGAL) in serum and urine have been suggested as potential early predictive biological markers of acute kidney injury (AKI) in selected critically ill patients.Methods. We performed a secondary analysis of a multicenter prospective observational cohort study of unselected critically ill patients.Results. The analysis included 140 patients, including 57 patients who did not develop AKI, 31 patients who developed AKI, and 52 patients with AKI on admission to the ICU. Levels of sNGAL and uNGAL on non-AKI days were significantly lower compared to levels of sNGAL on RIFLERISKdays, RIFLEINJURYdays, and RIFLEFAILUREdays. The AUC of sNGAL for predicting AKI was low: 0.45 (95% confidence interval (CI) 0.27–0.63) and 0.53 (CI 0.38–0.67), 2 days and 1 day before development of AKI, respectively. The AUC of uNGAL for predicting AKI was also low: 0.48 (CI 0.33–0.62) and 0.48 (CI 0.33–0.62), 2 days and 1 day before development of AKI, respectively. AUC of sNGAL and uNGAL for the prediction of renal replacement therapy requirement was 0.47 (CI 0.37–0.58) and 0.26 (CI 0.03–0.50).Conclusions. In unselected critically ill patients, sNGAL and uNGAL are poor predictors of AKI or RRT.

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