scholarly journals Association of Antibiotics Exposure Within the First 2 Years After Birth with Subsequent Childhood Type 1 Diabetes

2021 ◽  
Author(s):  
Dahye Lee ◽  
Seulggie Choi ◽  
Jooyoung Chang ◽  
Young Jun Park ◽  
Jae Hyun Kim ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetes Risk ◽  
Defined Daily Dose ◽  
Final Study ◽  
Significant Difference ◽  
Long Term Follow Up ◽  
Study Population ◽  
Nationally Representative ◽  
Childhood Type 1 Diabetes

Abstract Purpose: Antibiotics prescription in early life can cause dysbiosis, an imbalance of gut microbiota. We aimed to reveal the relationship between antibiotics exposure during the first 2 years after birth and type 1 diabetes risk in children under 8 years of age using a nationally representative data from South Korea. Methods: The final study population consisted of 63,434 children from the National Health Insurance Service (NHIS) database from 2008 to 2015. The primary exposure of interest was antibiotics prescription in first 2 years after birth. The analysis was conducted with cumulative defined daily dose (cDDD; 0-29, 30-59, ≥ 60 cDDD), the number of antibiotics classes (0-3, 4, ≥ 5 classes), and age at first antibiotics prescription (0-119, 120-239, ≥ 240 days). Age, sex, household income, and overweight were considered as potential confounding covariates. Results: Compared to those within the less than 30 cDDD, other groups that were prescribed more antibiotics did not have a significant difference in diabetes risk (aHR 0.86, 95% CI 0.37-2.02 in ≥ 60 cDDD). The number of antibiotics classes and age at first antibiotics prescriptions were also not associated with the risk of type 1 diabetes. The development of diabetes was not related to the cDDD, the number of antibiotics classes, and age at first antibiotics prescription according to subgroup analysis which was stratified by overweight. Conclusions: Antibiotics exposure within the first 2 years of life was not associated with subsequent diabetes risk. Future studies using a larger number of long-term follow-up data are needed.

scholarly journals Cesarean Section and Interferon-Induced Helicase Gene Polymorphisms Combine to Increase Childhood Type 1 Diabetes Risk

Diabetes ◽  
2011 ◽  
Vol 60 (12) ◽  
pp. 3300-3306 ◽  
Author(s):  
E. Bonifacio ◽  
K. Warncke ◽  
C. Winkler ◽  
M. Wallner ◽  
A.-G. Ziegler
Keyword(s):  
Type 1 Diabetes ◽  
Cesarean Section ◽  
Gene Polymorphisms ◽  
Diabetes Risk ◽  
Helicase Gene ◽  
Childhood Type 1 Diabetes ◽  
Childhood Type

scholarly journals Birth order and childhood type 1 diabetes risk: a pooled analysis of 31 observational studies

2010 ◽  
Vol 40 (2) ◽  
pp. 363-374 ◽  
Author(s):  
C. R. Cardwell ◽  
L. C. Stene ◽  
G. Joner ◽  
M. K. Bulsara ◽  
O. Cinek ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Birth Order ◽  
Observational Studies ◽  
Pooled Analysis ◽  
Diabetes Risk ◽  
Childhood Type 1 Diabetes ◽  
Childhood Type

scholarly journals Interbirth Interval Is Associated With Childhood Type 1 Diabetes Risk

Diabetes ◽  
2012 ◽  
Vol 61 (3) ◽  
pp. 702-707 ◽  
Author(s):  
C. R. Cardwell ◽  
J. Svensson ◽  
T. Waldhoer ◽  
J. Ludvigsson ◽  
V. Sadauskaite-Kuehne ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetes Risk ◽  
Interbirth Interval ◽  
Childhood Type 1 Diabetes ◽  
Childhood Type

Abstract #288 Dyslipidemia in Childhood Type 1 Diabetes in India: Prevalence Correlates and Management Challenges in a Resource Limited Setting

2019 ◽  
Vol 25 ◽  
pp. 117
Author(s):  
S Chandraprabha ◽  
T Jayalakshmi ◽  
Reshma Vijay ◽  
Kavitha Muniraj ◽  
Muralidhara Krishna ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Resource Limited Setting ◽  
Resource Limited ◽  
Childhood Type 1 Diabetes ◽  
Childhood Type ◽  
Limited Setting

Immunization profiles and progression of islet autoimmunity in children at type 1 diabetes risk

2012 ◽  
Vol 7 (S 01) ◽  
Author(s):  
R Chmiel ◽  
S Krause ◽  
A Knopff ◽  
C Matzke ◽  
D Höfelmann ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetes Risk ◽  
Islet Autoimmunity

Type 1 Diabetes-related Autoantibodies in Different Forms of Diabetes

2019 ◽  
Vol 15 (3) ◽  
pp. 199-204 ◽  
Author(s):  
Elin Pettersen Sørgjerd
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Autoimmune Diabetes ◽  
Acid Decarboxylase ◽  
Adult Onset ◽  
Latent Autoimmune Diabetes ◽  
Childhood Type 1 Diabetes ◽  
Childhood Type

Autoantibodies against Glutamic Acid Decarboxylase (GADA), insulinoma antigen-2 (IA- 2A), insulin (IAA) and the most recently Zinc Transporter 8 (ZnT8A) are one of the most reliable biomarkers for autoimmune diabetes in both children and adults. They are today the only biomarkers that can distinguish Latent Autoimmune Diabetes in Adults (LADA) from phenotypically type 2 diabetes. As the frequency of autoantibodies at diagnosis in childhood type 1 diabetes depends on age, GADA is by far the most common in adult onset autoimmune diabetes, especially LADA. Being multiple autoantibody positive have also shown to be more common in childhood diabetes compared to adult onset diabetes, and multiple autoantibody positivity have a high predictive value of childhood type 1 diabetes. Autoantibodies have shown inconsistent results to predict diabetes in adults. Levels of autoantibodies are reported to cause heterogeneity in LADA. Reports indicate that individuals with high levels of autoantibodies have a more type 1 diabetes like phenotype and individuals with low levels of autoantibody positivity have a more type 2 diabetes like phenotype. It is also well known that autoantibody levels can fluctuate and transient autoantibody positivity in adult onset autoimmune diabetes have been reported to affect the phenotype.

Humor and A1C: the interaction between humor and diabetes control

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
David S. Greene ◽  
Nancy Dunavant King
Keyword(s):  
Type 1 Diabetes ◽  
American Diabetes Association ◽  
Good Control ◽  
Diabetes Control ◽  
Humor Styles ◽  
Psychological Benefits ◽  
Significant Difference ◽  
Aggressive Humor ◽  
College Educated

Abstract There is increasing evidence of specific medical and psychological benefits associated with humor within diabetes populations. The benefits of maintaining good diabetes control are also well established. The more general relationship between humor and diabetes control however remains unexplored. The purpose of this study was to examine if there was a difference between people with diabetes with an A1C ≤ 6.99% versus those ≥7.0% on four disparate types of humor. The sample consisted of 284 participants, 65.5% with type 1 diabetes, 68.3% female, 89.1% Caucasian, and 68.7% college educated. Participants completed the Humor Styles Questionnaire (HSQ) and were divided into two groups, A1C ≤ 6.99% and A1C ≥ 7.0%. The A1C ≤ 6.99% group scored significantly higher on both types of positive humor, affiliative humor (P < 0.01) and self-enhancing humor (P < 0.05). There was no significant difference between participants on either type of negative humor, aggressive humor (P > 0.05) or self-defeating humor (P > 0.05). Results indicate that good control (A1C ≤ 6.99%) is associated with positive humor. These findings provide evidence that there is an association between American Diabetes Association recommended levels of control and positive humor styles. Implications regarding positive humor and good diabetes control are discussed.

scholarly journals Incidence of childhood type 1 diabetes mellitus in Yamanashi Prefecture, Japan, 1986‐2018

2020 ◽  
Author(s):  
Tomohiro Saito ◽  
Koji Kobayashi ◽  
Kisho Kobayashi ◽  
Mie Mochizuki ◽  
Hideaki Yagasaki ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Childhood Type 1 Diabetes ◽  
Childhood Type
Sign in / Sign up

Export Citation Format

Share Document